Volker Siffrin

Volker Siffrin

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Volker Siffrin

Volker Siffrin

Publications by authors named "Volker Siffrin"

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40Publications

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Comparison of RNA isolation procedures for analysis of adult murine brain and spinal cord astrocytes.

J Neurosci Methods 2020 Mar 9;333:108545. Epub 2019 Dec 9.

Experimental and Clinical Research Center (ECRC), Charité - Universitätsmedizin Berlin und Max Delbrück Center or Molecular Medicine in the Helmholtz Association, Berlin Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2019.108545DOI Listing
March 2020

Disease Modification in Multiple Sclerosis by Flupirtine-Results of a Randomized Placebo Controlled Phase II Trial.

Front Neurol 2018 9;9:842. Epub 2018 Oct 9.

NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.

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https://www.frontiersin.org/article/10.3389/fneur.2018.00842
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http://dx.doi.org/10.3389/fneur.2018.00842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190842PMC
October 2018

CCR7 on CD4 T Cells Plays a Crucial Role in the Induction of Experimental Autoimmune Encephalomyelitis.

J Immunol 2018 04 16;200(8):2554-2562. Epub 2018 Mar 16.

Department of Neurology, Focus Program Translational Neuroscience and Immunotherapy, Rhine Main Neuroscience Network, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

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http://dx.doi.org/10.4049/jimmunol.1701419DOI Listing
April 2018

Phenotype of Antigen Unexperienced T Cells in the Inflamed Central Nervous System in Experimental Autoimmune Encephalomyelitis.

J Neuroimmune Pharmacol 2017 06 10;12(2):305-313. Epub 2016 Nov 10.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University, Langenbeckstrasse 1, Building 708, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s11481-016-9718-1DOI Listing
June 2017

Role of IL-17-producing lymphocytes in severity of multiple sclerosis upon natalizumab treatment.

Mult Scler 2017 Apr 21;23(4):567-576. Epub 2016 Jul 21.

Focus Program Translational Neurosciences (FTN), Rhine-Main Neuroscience Network (rmn2), Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1177/1352458516658559DOI Listing
April 2017

Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis.

J Autoimmun 2017 01 2;76:108-114. Epub 2016 Oct 2.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn(2)), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2016.09.008DOI Listing
January 2017

Flow cytometric analysis of T cell/monocyte ratio in clinically isolated syndrome identifies patients at risk of rapid disease progression.

Mult Scler 2016 Apr 10;22(4):483-93. Epub 2015 Jul 10.

Neurology Department, Johannes Gutenberg University Mainz, Germany/Charité - Universitätsmedizin Berlin, Germany

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http://dx.doi.org/10.1177/1352458515593821DOI Listing
April 2016

The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients.

Neuroimage Clin 2015 10;8:110-6. Epub 2015 Apr 10.

Department of Neurology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany ; Neuroimage Center (NIC) of the Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1016/j.nicl.2015.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473264PMC
March 2016

In vivo and in vitro effects of multiple sclerosis immunomodulatory therapeutics on glutamatergic excitotoxicity.

J Neurochem 2016 Mar 11;136(5):971-80. Epub 2016 Jan 11.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn²), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1111/jnc.13456DOI Listing
March 2016

Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation.

EMBO J 2016 Jan 26;35(1):89-101. Epub 2015 Nov 26.

Department of Neurology, Focus Program Translational Neurosciences (FTN), Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn²) University Medical Center of the Johannes Gutenberg University, Mainz, Germany

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http://dx.doi.org/10.15252/embj.201591488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718005PMC
January 2016

Role of Sortilin in Models of Autoimmune Neuroinflammation.

J Immunol 2015 Dec 13;195(12):5762-9. Epub 2015 Nov 13.

Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany;

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http://dx.doi.org/10.4049/jimmunol.1403156DOI Listing
December 2015

FRET based ratiometric Ca(2+) imaging to investigate immune-mediated neuronal and axonal damage processes in experimental autoimmune encephalomyelitis.

J Neurosci Methods 2015 Jul 10;249:8-15. Epub 2015 Apr 10.

Neurology Department, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

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http://dx.doi.org/10.1016/j.jneumeth.2015.04.005DOI Listing
July 2015

New candidates for CD4 T cell pathogenicity in experimental neuroinflammation and multiple sclerosis.

Brain 2015 Apr 9;138(Pt 4):902-17. Epub 2015 Feb 9.

1 Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn), University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany

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http://dx.doi.org/10.1093/brain/awu408DOI Listing
April 2015

Cross-recognition of a myelin peptide by CD8+ T cells in the CNS is not sufficient to promote neuronal damage.

J Neurosci 2015 Mar;35(12):4837-50

Department of Neurology, Research Center Translational Neurosciences, Rhine Main Neuroscience Network (rmn), and Molecular Neurology Group, Max Delbrueck Center for Molecular Medicine Berlin-Buch, 13125 Berlin, Germany, Charité University Medicine Berlin, ECRC, 13125 Berlin, Germany, and

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http://dx.doi.org/10.1523/JNEUROSCI.3380-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705380PMC
March 2015

Experimental applications of TNF-reporter mice with far-red fluorescent label.

Methods Mol Biol 2014 ;1155:151-62

German Rheumatism Research Center, a Leibniz Institute, Berlin, Germany.

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http://dx.doi.org/10.1007/978-1-4939-0669-7_13DOI Listing
December 2014

Cardiotoxicity of mitoxantrone treatment in a german cohort of 639 multiple sclerosis patients.

J Clin Neurol 2014 Oct 6;10(4):289-95. Epub 2014 Oct 6.

Department of Neurology, Focus Program Translational Neuroscience, Rhine Main Neuroscience Network, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Germany.

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http://dx.doi.org/10.3988/jcn.2014.10.4.289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198709PMC
October 2014

How to treat tumefactive demyelinating disease?

Mult Scler 2014 Apr 17;20(5):631-3. Epub 2013 Dec 17.

Department of Neurology, Johannes Gutenberg University Mainz, Germany.

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http://dx.doi.org/10.1177/1352458513516891DOI Listing
April 2014

Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.

J Neurosci Res 2014 Mar 9;92(3):275-86. Epub 2013 Dec 9.

Cellular Neurosciences, Max Delbrück Centre for Molecular Medicine, Berlin, Germany; Department of Neurology, Charité, Universitätsmedizin Berlin, Charité Campus Virchow, Berlin, Germany.

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http://dx.doi.org/10.1002/jnr.23288DOI Listing
March 2014

Microglial activation milieu controls regulatory T cell responses.

J Immunol 2013 Dec 21;191(11):5594-602. Epub 2013 Oct 21.

Institute for Cell Biology and Neurobiology, Charité-University Medicine Berlin, 10117 Berlin, Germany;

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http://dx.doi.org/10.4049/jimmunol.1203331DOI Listing
December 2013

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

Authors:
Ashley H Beecham Nikolaos A Patsopoulos Dionysia K Xifara Mary F Davis Anu Kemppinen Chris Cotsapas Tejas S Shah Chris Spencer David Booth An Goris Annette Oturai Janna Saarela Bertrand Fontaine Bernhard Hemmer Claes Martin Frauke Zipp Sandra D'Alfonso Filippo Martinelli-Boneschi Bruce Taylor Hanne F Harbo Ingrid Kockum Jan Hillert Tomas Olsson Maria Ban Jorge R Oksenberg Rogier Hintzen Lisa F Barcellos Cristina Agliardi Lars Alfredsson Mehdi Alizadeh Carl Anderson Robert Andrews Helle Bach Søndergaard Amie Baker Gavin Band Sergio E Baranzini Nadia Barizzone Jeffrey Barrett Céline Bellenguez Laura Bergamaschi Luisa Bernardinelli Achim Berthele Viola Biberacher Thomas M C Binder Hannah Blackburn Izaura L Bomfim Paola Brambilla Simon Broadley Bruno Brochet Lou Brundin Dorothea Buck Helmut Butzkueven Stacy J Caillier William Camu Wassila Carpentier Paola Cavalla Elisabeth G Celius Irène Coman Giancarlo Comi Lucia Corrado Leentje Cosemans Isabelle Cournu-Rebeix Bruce A C Cree Daniele Cusi Vincent Damotte Gilles Defer Silvia R Delgado Panos Deloukas Alessia di Sapio Alexander T Dilthey Peter Donnelly Bénédicte Dubois Martin Duddy Sarah Edkins Irina Elovaara Federica Esposito Nikos Evangelou Barnaby Fiddes Judith Field Andre Franke Colin Freeman Irene Y Frohlich Daniela Galimberti Christian Gieger Pierre-Antoine Gourraud Christiane Graetz Andrew Graham Verena Grummel Clara Guaschino Athena Hadjixenofontos Hakon Hakonarson Christopher Halfpenny Gillian Hall Per Hall Anders Hamsten James Harley Timothy Harrower Clive Hawkins Garrett Hellenthal Charles Hillier Jeremy Hobart Muni Hoshi Sarah E Hunt Maja Jagodic Ilijas Jelčić Angela Jochim Brian Kendall Allan Kermode Trevor Kilpatrick Keijo Koivisto Ioanna Konidari Thomas Korn Helena Kronsbein Cordelia Langford Malin Larsson Mark Lathrop Christine Lebrun-Frenay Jeannette Lechner-Scott Michelle H Lee Maurizio A Leone Virpi Leppä Giuseppe Liberatore Benedicte A Lie Christina M Lill Magdalena Lindén Jenny Link Felix Luessi Jan Lycke Fabio Macciardi Satu Männistö Clara P Manrique Roland Martin Vittorio Martinelli Deborah Mason Gordon Mazibrada Cristin McCabe Inger-Lise Mero Julia Mescheriakova Loukas Moutsianas Kjell-Morten Myhr Guy Nagels Richard Nicholas Petra Nilsson Fredrik Piehl Matti Pirinen Siân E Price Hong Quach Mauri Reunanen Wim Robberecht Neil P Robertson Mariaemma Rodegher David Rog Marco Salvetti Nathalie C Schnetz-Boutaud Finn Sellebjerg Rebecca C Selter Catherine Schaefer Sandip Shaunak Ling Shen Simon Shields Volker Siffrin Mark Slee Per Soelberg Sorensen Melissa Sorosina Mireia Sospedra Anne Spurkland Amy Strange Emilie Sundqvist Vincent Thijs John Thorpe Anna Ticca Pentti Tienari Cornelia van Duijn Elizabeth M Visser Steve Vucic Helga Westerlind James S Wiley Alastair Wilkins James F Wilson Juliane Winkelmann John Zajicek Eva Zindler Jonathan L Haines Margaret A Pericak-Vance Adrian J Ivinson Graeme Stewart David Hafler Stephen L Hauser Alastair Compston Gil McVean Philip De Jager Stephen J Sawcer Jacob L McCauley

Nat Genet 2013 Nov 29;45(11):1353-60. Epub 2013 Sep 29.

1] John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA. [2].

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http://dx.doi.org/10.1038/ng.2770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832895PMC
November 2013

The role of CD8+ T cells and their local interaction with CD4+ T cells in myelin oligodendrocyte glycoprotein35-55-induced experimental autoimmune encephalomyelitis.

J Immunol 2013 Nov 11;191(10):4960-8. Epub 2013 Oct 11.

Department of Neurology, Focus Program Translational Neurosciences, Rhine Main Neuroscience Network, Johannes Gutenberg University Mainz, 55131 Mainz, Germany;

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http://dx.doi.org/10.4049/jimmunol.1300822DOI Listing
November 2013

Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis.

Brain 2013 Apr 20;136(Pt 4):1048-66. Epub 2013 Mar 20.

Focus Program Translational Neuroscience, Rhine Main Neuroscience Network, University Medical Centre of the Johannes Gutenberg-University of Mainz, 55131 Mainz, Germany.

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http://dx.doi.org/10.1093/brain/awt023DOI Listing
April 2013

Two-photon imaging of immune cells in neural tissue.

Cold Spring Harb Protoc 2013 Mar 1;2013(3). Epub 2013 Mar 1.

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http://dx.doi.org/10.1101/pdb.prot073528DOI Listing
March 2013

Neurodegeneration in multiple sclerosis: novel treatment strategies.

Expert Rev Neurother 2012 Sep;12(9):1061-76; quiz 1077

Focus Program Translational Neuroscience, Rhine Main Neuroscience Network, Department of Neurology, University Medical Center Mainz, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany.

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http://dx.doi.org/10.1586/ern.12.59DOI Listing
September 2012

Neurodegeneration in autoimmune CNS inflammation.

Exp Neurol 2010 Sep 1;225(1):9-17. Epub 2009 Dec 1.

Cecilie Vogt Klinik, Charité - University Hospital Berlin, Germany.

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http://dx.doi.org/10.1016/j.expneurol.2009.11.019DOI Listing
September 2010

Multiple sclerosis - candidate mechanisms underlying CNS atrophy.

Trends Neurosci 2010 Apr 12;33(4):202-10. Epub 2010 Feb 12.

Department of Neurology, University Medicine Mainz, Johannes Gutenberg University Mainz, Germany.

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http://dx.doi.org/10.1016/j.tins.2010.01.002DOI Listing
April 2010

Differential immune cell dynamics in the CNS cause CD4+ T cell compartmentalization.

Brain 2009 May 29;132(Pt 5):1247-58. Epub 2009 Jan 29.

Cecilie Vogt Clinic for Neurology in the HKBB, Charité - University Medicine Berlin and Max Delbrueck Centre for Molecular Medicine, Charitéplatz 1, 10117 Berlin, Germany.

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http://dx.doi.org/10.1093/brain/awn354DOI Listing
May 2009

New insights into adaptive immunity in chronic neuroinflammation.

Adv Immunol 2007 ;96:1-40

Cecilie-Vogt-Clinic for Molecular Neurology, Charité-Universitaetsmedizin Berlin, 10117 Berlin, Germany.

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http://dx.doi.org/10.1016/S0065-2776(07)96001-0DOI Listing
January 2008