Publications by authors named "Volker M Lauschke"

69Publications

Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier.

Br J Cancer 2020 Sep 25. Epub 2020 Sep 25.

Department of Physiology and Pharmacology, Karolinska Institutet, 17177, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41416-020-01084-0DOI Listing
September 2020

High glucose-induced oxidative stress accelerates myogenesis by altering SUMO reactions.

Exp Cell Res 2020 Oct 19;395(2):112234. Epub 2020 Aug 19.

Precision Medicine Research Center, School of Pharmacy, Binzhou Medical University, Laishan District, Guanhai Road 346, Yantai, Shandong Province, 264003, China; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, SE, 17177, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2020.112234DOI Listing
October 2020

A 3D Cell Culture Model Identifies Wnt/-Catenin Mediated Inhibition of p53 as a Critical Step during Human Hepatocyte Regeneration.

Adv Sci (Weinh) 2020 Aug 23;7(15):2000248. Epub 2020 Jun 23.

Department of Physiology and Pharmacology Karolinska Institutet Stockholm 171 77 Sweden.

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http://dx.doi.org/10.1002/advs.202000248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404138PMC
August 2020

The Past, Present and Future of Intestinal In Vitro Cell Systems for Drug Absorption Studies.

J Pharm Sci 2020 Jul 3. Epub 2020 Jul 3.

Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2020.07.001DOI Listing
July 2020

Can CYP Inhibition Overcome Chemotherapy Resistance?

Trends Pharmacol Sci 2020 Aug 19;41(8):503-506. Epub 2020 Jun 19.

Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2020.05.007DOI Listing
August 2020

Global Frequencies of Clinically Important HLA Alleles and Their Implications For the Cost-Effectiveness of Preemptive Pharmacogenetic Testing.

Clin Pharmacol Ther 2020 Jun 14. Epub 2020 Jun 14.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/cpt.1944DOI Listing
June 2020

Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain.

Cell Rep 2020 Jun;31(9):107699

Department of Women's and Children's Health, Karolinska Institutet, 171 64 Stockholm, Sweden; Henan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital and Institute of Neuroscience, Zhengzhou University, Zhengzhou 4500 52, China; Pediatric Oncology, Karolinska University Hospital, 171 64 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.107699DOI Listing
June 2020

Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three-Dimensional Spheroid Cultures of Primary Human Hepatocytes.

Clin Pharmacol Ther 2020 Oct 22;108(4):844-855. Epub 2020 May 22.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/cpt.1860DOI Listing
October 2020

Ethnogeographic and inter-individual variability of human ABC transporters.

Hum Genet 2020 May 23;139(5):623-646. Epub 2020 Mar 23.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, 17177, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00439-020-02150-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170817PMC
May 2020

Emerging strategies to bridge the gap between pharmacogenomic research and its clinical implementation.

NPJ Genom Med 2020 5;5. Epub 2020 Mar 5.

Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41525-020-0119-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057970PMC
March 2020

In Vitro Functional Characterization and in Silico Prediction of Rare Genetic Variation in the Bile Acid and Drug Transporter, Na-Taurocholate Cotransporting Polypeptide (NTCP, ).

Mol Pharm 2020 04 10;17(4):1170-1181. Epub 2020 Mar 10.

Department of Physiology & Pharmacology, Western University, Medical Sciences Building, Rm 216, N6A 5C1 London, Ontario, Canada.

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b01200DOI Listing
April 2020

Germline variant burden in multidrug resistance transporters is a therapy-specific predictor of survival in breast cancer patients.

Int J Cancer 2020 05 17;146(9):2475-2487. Epub 2020 Feb 17.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ijc.32898DOI Listing
May 2020

Genetic and Epigenetic Biomarkers of Immune Checkpoint Blockade Response.

J Clin Med 2020 Jan 20;9(1). Epub 2020 Jan 20.

Group of Pharmacoepigenetics, Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.3390/jcm9010286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019273PMC
January 2020

Expression of SUMO enzymes is fiber type dependent in skeletal muscles and is dysregulated in muscle disuse.

FASEB J 2020 02 13;34(2):2269-2286. Epub 2019 Dec 13.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1096/fj.201901913RDOI Listing
February 2020

Pharmacogenomic network analysis of the gene-drug interaction landscape underlying drug disposition.

Comput Struct Biotechnol J 2020 5;18:52-58. Epub 2019 Dec 5.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 171 77, Sweden.

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http://dx.doi.org/10.1016/j.csbj.2019.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921140PMC
December 2019

The genetic landscape of the human solute carrier (SLC) transporter superfamily.

Hum Genet 2019 Dec 2;138(11-12):1359-1377. Epub 2019 Nov 2.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, 171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00439-019-02081-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874521PMC
December 2019

One non-believer: Response to "Obviously Nine Believers: Actionable Germline Genetic Variants for Pre-emptive Pharmacogenetic Testing".

Basic Clin Pharmacol Toxicol 2019 Oct 31. Epub 2019 Oct 31.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/bcpt.13336DOI Listing
October 2019

Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury.

Front Pharmacol 2019 24;10:1093. Epub 2019 Sep 24.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fphar.2019.01093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769037PMC
September 2019

CYP3A5 is unlikely to mediate anticancer drug resistance in hepatocellular carcinoma.

Pharmacogenomics 2019 10;20(15):1085-1092

Department of Physiology & Pharmacology, Karolinska Institutet, Biomedicum 5B, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.2217/pgs-2019-0094DOI Listing
October 2019

Organotypic and Microphysiological Models of Liver, Gut, and Kidney for Studies of Drug Metabolism, Pharmacokinetics, and Toxicity.

Chem Res Toxicol 2020 01 17;33(1):38-60. Epub 2019 Oct 17.

Department of Physiology and Pharmacology , Karolinska Institutet , SE-171 77 Stockholm , Sweden.

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http://dx.doi.org/10.1021/acs.chemrestox.9b00245DOI Listing
January 2020

Frequencies of clinically important CYP2C19 and CYP2D6 alleles are graded across Europe.

Eur J Hum Genet 2020 01 29;28(1):88-94. Epub 2019 Jul 29.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41431-019-0480-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906321PMC
January 2020

3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications.

Biotechnol J 2019 Jul 20;14(7):e1800347. Epub 2019 May 20.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Biomedicum 5B, Karolinska Institutet, SE-171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1002/biot.201800347DOI Listing
July 2019

Prediction of drug response and adverse drug reactions: From twin studies to Next Generation Sequencing.

Eur J Pharm Sci 2019 Mar 23;130:65-77. Epub 2019 Jan 23.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2019.01.024DOI Listing
March 2019

Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity.

Pharmacol Ther 2019 05 22;197:122-152. Epub 2019 Jan 22.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Biomedicum 5B, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01637258193000
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http://dx.doi.org/10.1016/j.pharmthera.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527860PMC
May 2019

Computational Methods for the Pharmacogenetic Interpretation of Next Generation Sequencing Data.

Front Pharmacol 2018 4;9:1437. Epub 2018 Dec 4.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fphar.2018.01437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288784PMC
December 2018

Genetic variability and population diversity of the human SLCO (OATP) transporter family.

Pharmacol Res 2019 01 22;139:550-559. Epub 2018 Oct 22.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183119
Publisher Site
http://dx.doi.org/10.1016/j.phrs.2018.10.017DOI Listing
January 2019

Human hepatic 3D spheroids as a model for steatosis and insulin resistance.

Sci Rep 2018 09 24;8(1):14297. Epub 2018 Sep 24.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-17177, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41598-018-32722-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155201PMC
September 2018

An optimized prediction framework to assess the functional impact of pharmacogenetic variants.

Pharmacogenomics J 2019 04 12;19(2):115-126. Epub 2018 Sep 12.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41397-018-0044-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462826PMC
April 2019

Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk.

J Lipid Res 2018 10 3;59(10):1987-2000. Epub 2018 Aug 3.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.1194/jlr.P086710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168301PMC
October 2018

Current Statistical Metrics Are Pragmatic Measures to Compare the Predictive Quality of Preclinical Assays.

Toxicol Sci 2018 09;165(1):4-5

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1093/toxsci/kfy160DOI Listing
September 2018

Human liver spheroids in chemically defined conditions for studies of gene-drug, drug-drug and disease-drug interactions.

Pharmacogenomics 2018 09 25;19(14):1133-1138. Epub 2018 Jul 25.

Department of Physiology & Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.2217/pgs-2018-0096DOI Listing
September 2018

Functional characterization of CYP2D7 gene variants.

Pharmacogenomics 2018 08 24;19(12):931-936. Epub 2018 Jul 24.

Department of Physiology & Pharmacology, Karolinska Institutet, 17165 Stockholm, Sweden.

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http://dx.doi.org/10.2217/pgs-2018-0065DOI Listing
August 2018

Calcium Signaling in Liver Injury and Regeneration.

Front Med (Lausanne) 2018 4;5:192. Epub 2018 Jul 4.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fmed.2018.00192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039545PMC
July 2018

Comprehensive overview of the pharmacogenetic diversity in Ashkenazi Jews.

J Med Genet 2018 09 3;55(9):617-627. Epub 2018 Jul 3.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1136/jmedgenet-2018-105429DOI Listing
September 2018

Integrating rare genetic variants into pharmacogenetic drug response predictions.

Hum Genomics 2018 05 25;12(1):26. Epub 2018 May 25.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s40246-018-0157-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968569PMC
May 2018

Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions.

Toxicol Sci 2018 06;163(2):655-665

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm SE-171 77, Sweden.

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http://dx.doi.org/10.1093/toxsci/kfy058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974779PMC
June 2018

Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation.

Cell 2018 02;172(5):1079-1090.e12

Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany, European Molecular Biology Laboratory, 69117 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847172PMC
February 2018

How to Consider Rare Genetic Variants in Personalized Drug Therapy.

Clin Pharmacol Ther 2018 05 5;103(5):745-748. Epub 2018 Jan 5.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/cpt.976DOI Listing
May 2018

Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics.

Genet Med 2018 06 26;20(6):622-629. Epub 2017 Oct 26.

Hereditary Endocrine Cancer Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1038/gim.2017.156DOI Listing
June 2018

Pharmacogenomic Biomarkers for Improved Drug Therapy-Recent Progress and Future Developments.

AAPS J 2017 11 27;20(1). Epub 2017 Nov 27.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1208/s12248-017-0161-xDOI Listing
November 2017

Pharmacoepigenetics and Toxicoepigenetics: Novel Mechanistic Insights and Therapeutic Opportunities.

Annu Rev Pharmacol Toxicol 2018 01 13;58:161-185. Epub 2017 Oct 13.

Pharmacogenetics Section, Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden; email:

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http://dx.doi.org/10.1146/annurev-pharmtox-010617-053021DOI Listing
January 2018

Dysregulation of miR-223 constitutes a promising biomarker that informs about clinical outcomes of acute liver failure.

Clin Sci (Lond) 2017 Aug 19;131(15):2059-2062. Epub 2017 Jul 19.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-17177 Stockholm, Sweden

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http://dx.doi.org/10.1042/CS20171129DOI Listing
August 2017

Pitfalls and Opportunities for Epigenomic Analyses Focused on Disease Diagnosis, Prognosis, and Therapy.

Trends Pharmacol Sci 2017 09 15;38(9):765-770. Epub 2017 Jun 15.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2017.05.007DOI Listing
September 2017

Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell-Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury.

Drug Metab Dispos 2017 04 30;45(4):419-429. Epub 2017 Jan 30.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (C.C.B., V.M.L., S.U.V., T.B.A., M.I.-S.); Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Mölndal, Sweden (H.P., T.B.A.); and CXR Biosciences Ltd., Dundee, United Kingdom (R.D.).

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http://dx.doi.org/10.1124/dmd.116.074369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363699PMC
April 2017

The role of microRNAs in liver injury at the crossroad between hepatic cell death and regeneration.

Biochem Biophys Res Commun 2017 01 24;482(3):399-407. Epub 2016 Oct 24.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2016.10.084DOI Listing
January 2017

The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity.

Int J Mol Sci 2016 Oct 12;17(10). Epub 2016 Oct 12.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-17177 Stockholm, Sweden.

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http://dx.doi.org/10.3390/ijms17101714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085745PMC
October 2016

Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates.

Chem Res Toxicol 2016 12 23;29(12):1936-1955. Epub 2016 Sep 23.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet , SE-17177 Stockholm, Sweden.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00150DOI Listing
December 2016

Requirements for comprehensive pharmacogenetic genotyping platforms.

Pharmacogenomics 2016 06 1;17(8):917-24. Epub 2016 Jun 1.

Section of Pharmacogenetics, Department of Physiology & Pharmacology, Karolinska Institutet, SE-17177 Stockholm, Sweden.

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http://dx.doi.org/10.2217/pgs-2016-0023DOI Listing
June 2016

Rare genetic variants in cellular transporters, metabolic enzymes, and nuclear receptors can be important determinants of interindividual differences in drug response.

Genet Med 2017 01 21;19(1):20-29. Epub 2016 Apr 21.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/gim.2016.33DOI Listing
January 2017

Precision Medicine and Rare Genetic Variants.

Trends Pharmacol Sci 2016 Feb 17;37(2):85-86. Epub 2015 Dec 17.

Karolinska Institutet, Department of Physiology and Pharmacology, Section of Pharmacogenetics, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2015.10.006DOI Listing
February 2016

Genetic variation in the human cytochrome P450 supergene family.

Pharmacogenet Genomics 2015 Dec;25(12):584-94

aKobe University Hospital, Kobe, Japan bSection of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1097/FPC.0000000000000172DOI Listing
December 2015

Scaling of embryonic patterning based on phase-gradient encoding.

Nature 2013 Jan 19;493(7430):101-5. Epub 2012 Dec 19.

Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature11804DOI Listing
January 2013