Publications by authors named "Volker Brinkmann"

99Publications

FX11 limits growth and potentiates bactericidal activity of isoniazid through host-directed activity.

Authors:
Gopinath Krishnamoorthy Peggy Kaiser Ulrike Abu Abed January Weiner Pedro Moura-Alves Volker Brinkmann Stefan H E Kaufmann

Dis Model Mech 2020 03 30;13(3). Epub 2020 Mar 30.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin 10117, Germany

View Article and Find Full Text PDF
March 2020

Polarization of MTIP is a signature of gliding locomotion in Plasmodium ookinetes and sporozoites.

Authors:
Inga Siden-Kiamos Christian Goosmann Carlos A Buscaglia Volker Brinkmann Kai Matuschewski Georgina N Montagna

Mol Biochem Parasitol 2020 01 23;235:111247. Epub 2019 Dec 23.

Max Planck Institute for Infection Biology, 10117 Berlin, Germany; Instituto de Investigaciones Biotecnológicas 'Dr Rodolfo Ugalde' (IIBio), UNSAM-CONICET, 1650 San Martín, Buenos Aires, Argentina; Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, 049032, SP, Brazil.. Electronic address:

View Article and Find Full Text PDF
January 2020

Immunofluorescent Detection of NET Components in Paraffin-Embedded Tissue.

Authors:
Ulrike Abu-Abed Volker Brinkmann

Methods Mol Biol 2020 ;2087:415-424

Microscopy Core Facility, Max Planck Institute for Infection Biology, Berlin, Germany.

View Article and Find Full Text PDF
January 2021

Neutrophil extracellular traps drive inflammatory pathogenesis in malaria.

Authors:
Sebastian Lorenz Knackstedt Athina Georgiadou Falko Apel Ulrike Abu-Abed Christopher A Moxon Aubrey J Cunnington Bärbel Raupach Deirdre Cunningham Jean Langhorne Renate Krüger Valentina Barrera Simon P Harding Aase Berg Sam Patel Kari Otterdal Benjamin Mordmüller Evelin Schwarzer Volker Brinkmann Arturo Zychlinsky Borko Amulic

Sci Immunol 2019 10;4(40)

Max Planck Institute for Infection Biology, Department of Cellular Microbiology, Charitéplatz 1, 10117 Berlin, Germany.

View Article and Find Full Text PDF
October 2019

Immunofluorescence Labelling of Human and Murine Neutrophil Extracellular Traps in Paraffin-Embedded Tissue.

Authors:
Ulrike Abu Abed Volker Brinkmann

J Vis Exp 2019 09 10(151). Epub 2019 Sep 10.

Microscopy Core Facility, Max Planck Institute for Infection Biology;

View Article and Find Full Text PDF
September 2019

Isolated From Blood Cultures and Prosthetic Joint Infections Exhibits Excessive Genome Decay.

Authors:
Holger Brüggemann Anja Poehlein Elzbieta Brzuszkiewicz Carsten Scavenius Jan J Enghild Munir A Al-Zeer Volker Brinkmann Anders Jensen Bo Söderquist

Front Microbiol 2019 12;10:478. Epub 2019 Mar 12.

Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

View Article and Find Full Text PDF
March 2019

Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation.

Authors:
Mirjana Kessler Karen Hoffmann Kristin Fritsche Volker Brinkmann Hans-Joachim Mollenkopf Oliver Thieck Ana Rita Teixeira da Costa Elena I Braicu Jalid Sehouli Mandy Mangler Hilmar Berger Thomas F Meyer

Nat Commun 2019 03 18;10(1):1194. Epub 2019 Mar 18.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117, Berlin, Germany.

View Article and Find Full Text PDF
March 2019

Dnase1-deficient mice spontaneously develop a systemic lupus erythematosus-like disease.

Authors:
Elaine F Kenny Bärbel Raupach Ulrike Abu Abed Volker Brinkmann Arturo Zychlinsky

Eur J Immunol 2019 04 21;49(4):590-599. Epub 2019 Feb 21.

Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany.

View Article and Find Full Text PDF
April 2019

Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.

Authors:
Ludwig T Weckbach Ulrich Grabmaier Andreas Uhl Sebastian Gess Felicitas Boehm Annette Zehrer Robert Pick Melanie Salvermoser Thomas Czermak Joachim Pircher Noah Sorrelle Mary Migliorini Dudley K Strickland Karin Klingel Volker Brinkmann Ulrike Abu Abed Urs Eriksson Steffen Massberg Stefan Brunner Barbara Walzog

J Exp Med 2019 02 15;216(2):350-368. Epub 2019 Jan 15.

Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany

View Article and Find Full Text PDF
February 2019

Genomic features of the Helicobacter pylori strain PMSS1 and its virulence attributes as deduced from its in vivo colonisation patterns.

Authors:
Victoria Dyer Holger Brüggemann Meike Sörensen Anja A Kühl Kirstin Hoffman Volker Brinkmann Maria Del Mar Reines Stephanie Zimmerman Thomas F Meyer Manuel Koch

Mol Microbiol 2018 12 25;110(5):761-776. Epub 2018 Oct 25.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, 10117, Germany.

View Article and Find Full Text PDF
December 2018

Unbiased classification of mosquito blood cells by single-cell genomics and high-content imaging.

Authors:
Maiara S Severo Jonathan J M Landry Randall L Lindquist Christian Goosmann Volker Brinkmann Paul Collier Anja E Hauser Vladimir Benes Johan Henriksson Sarah A Teichmann Elena A Levashina

Proc Natl Acad Sci U S A 2018 08 23;115(32):E7568-E7577. Epub 2018 Jul 23.

Vector Biology Unit, Max Planck Institute for Infection Biology, 10117 Berlin, Germany;

View Article and Find Full Text PDF
August 2018

Neutrophil Extracellular Traps in the Second Decade.

Authors:
Volker Brinkmann

J Innate Immun 2018 15;10(5-6):414-421. Epub 2018 Jun 15.

View Article and Find Full Text PDF
October 2019

Pan-genome analysis of the genus Finegoldia identifies two distinct clades, strain-specific heterogeneity, and putative virulence factors.

Authors:
Holger Brüggemann Anders Jensen Seven Nazipi Hüsnü Aslan Rikke Louise Meyer Anja Poehlein Elzbieta Brzuszkiewicz Munir A Al-Zeer Volker Brinkmann Bo Söderquist

Sci Rep 2018 01 10;8(1):266. Epub 2018 Jan 10.

Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, 70185, Örebro, Sweden.

View Article and Find Full Text PDF
January 2018

Efficacy Testing of H56 cDNA Tattoo Immunization against Tuberculosis in a Mouse Model.

Authors:
Anouk C M Platteel Natalie E Nieuwenhuizen Teresa Domaszewska Stefanie Schürer Ulrike Zedler Volker Brinkmann Alice J A M Sijts Stefan H E Kaufmann

Front Immunol 2017 11;8:1744. Epub 2017 Dec 11.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

View Article and Find Full Text PDF
December 2017

The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.

Authors:
Gang Pei Hellen Buijze Haipeng Liu Pedro Moura-Alves Christian Goosmann Volker Brinkmann Hiroshi Kawabe Anca Dorhoi Stefan H E Kaufmann

Autophagy 2017 17;13(12):2041-2055. Epub 2017 Dec 17.

a Department of Immunology , Max Planck Institute for Infection Biology , Berlin , Germany.

View Article and Find Full Text PDF
July 2019

Prevalence of Flp Pili-Encoding Plasmids in Isolates Obtained from Prostatic Tissue.

Authors:
Sabina Davidsson Jessica Carlsson Paula Mölling Natyra Gashi Ove Andrén Swen-Olof Andersson Elzbieta Brzuszkiewicz Anja Poehlein Munir A Al-Zeer Volker Brinkmann Carsten Scavenius Seven Nazipi Bo Söderquist Holger Brüggemann

Front Microbiol 2017 16;8:2241. Epub 2017 Nov 16.

Department of Biomedicine, Aarhus University, Aarhus, Denmark.

View Article and Find Full Text PDF
November 2017

Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps.

Authors:
Borko Amulic Sebastian Lorenz Knackstedt Ulrike Abu Abed Nikolaus Deigendesch Christopher J Harbort Brian E Caffrey Volker Brinkmann Frank L Heppner Philip W Hinds Arturo Zychlinsky

Dev Cell 2017 11 2;43(4):449-462.e5. Epub 2017 Nov 2.

Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin 10117, Germany. Electronic address:

View Article and Find Full Text PDF
November 2017

Mycobacterium tuberculosis infection modulates adipose tissue biology.

Authors:
Macarena Beigier-Bompadre Georgina N Montagna Anja A Kühl Laura Lozza January Weiner Andreas Kupz Alexis Vogelzang Hans-Joachim Mollenkopf Delia Löwe Silke Bandermann Anca Dorhoi Volker Brinkmann Kai Matuschewski Stefan H E Kaufmann

PLoS Pathog 2017 Oct 17;13(10):e1006676. Epub 2017 Oct 17.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

View Article and Find Full Text PDF
October 2017

ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System.

Authors:
Stephanie Zimmermann Lennart Pfannkuch Munir A Al-Zeer Sina Bartfeld Manuel Koch Jianping Liu Cindy Rechner Meike Soerensen Olga Sokolova Alla Zamyatina Paul Kosma André P Mäurer Frithjof Glowinski Klaus-Peter Pleissner Monika Schmid Volker Brinkmann Alexander Karlas Michael Naumann Marion Rother Nikolaus Machuy Thomas F Meyer

Cell Rep 2017 Sep;20(10):2384-2395

Department of Molecular Biology, Max-Planck Institute for Infection Biology, 10117 Berlin, Germany; Steinbeis Innovation, Center for Systems Biomedicine, 14612 Berlin-Falkensee, Germany. Electronic address:

View Article and Find Full Text PDF
September 2017

Diverse stimuli engage different neutrophil extracellular trap pathways.

Authors:
Elaine F Kenny Alf Herzig Renate Krüger Aaron Muth Santanu Mondal Paul R Thompson Volker Brinkmann Horst von Bernuth Arturo Zychlinsky

Elife 2017 06 2;6. Epub 2017 Jun 2.

Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany.

View Article and Find Full Text PDF
June 2017

Optogenetic monitoring identifies phosphatidylthreonine-regulated calcium homeostasis in .

Authors:
Arunakar Kuchipudi Ruben D Arroyo-Olarte Friederike Hoffmann Volker Brinkmann Nishith Gupta

Microb Cell 2016 05 2;3(5):215-223. Epub 2016 May 2.

Humboldt University, Berlin, Germany.

View Article and Find Full Text PDF
May 2016

Immunodetection of NETs in Paraffin-Embedded Tissue.

Authors:
Volker Brinkmann Ulrike Abu Abed Christian Goosmann Arturo Zychlinsky

Front Immunol 2016 22;7:513. Epub 2016 Nov 22.

Department of Cellular Microbiology, Max Planck Institute for Infection Biology , Berlin , Germany.

View Article and Find Full Text PDF
November 2016

Comparative Plasmodium gene overexpression reveals distinct perturbation of sporozoite transmission by profilin.

Authors:
Yuko Sato Marion Hliscs Josefine Dunst Christian Goosmann Volker Brinkmann Georgina N Montagna Kai Matuschewski

Mol Biol Cell 2016 07 25;27(14):2234-44. Epub 2016 May 25.

Parasitology Unit, Max Planck Institute for Infection Biology, 10117 Berlin, Germany Institute of Biology, Humboldt University, 10117 Berlin, Germany.

View Article and Find Full Text PDF
July 2016

Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer's disease.

Authors:
Nurgul Aytan Ji-Kyung Choi Isabel Carreras Volker Brinkmann Neil W Kowall Bruce G Jenkins Alpaslan Dedeoglu

Sci Rep 2016 04 27;6:24939. Epub 2016 Apr 27.

Department of Veterans Affairs, VA Boston Healthcare System, Boston, MA 02130, USA.

View Article and Find Full Text PDF
April 2016

Genetic characterization of an adapted pandemic 2009 H1N1 influenza virus that reveals improved replication rates in human lung epithelial cells.

Authors:
Xenia Wörmann Markus Lesch Robert-William Welke Konstantin Okonechnikov Mirshat Abdurishid Christian Sieben Andreas Geissner Volker Brinkmann Markus Kastner Andreas Karner Rong Zhu Peter Hinterdorfer Chakkumkal Anish Peter H Seeberger Andreas Herrmann Thomas F Meyer Alexander Karlas

Virology 2016 May 23;492:118-29. Epub 2016 Feb 23.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany; Steinbeis Innovation gGmbH, Center for Systems Biomedicine, Falkensee, Germany. Electronic address:

View Article and Find Full Text PDF
May 2016

The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids.

Authors:
Mirjana Kessler Karen Hoffmann Volker Brinkmann Oliver Thieck Susan Jackisch Benjamin Toelle Hilmar Berger Hans-Joachim Mollenkopf Mandy Mangler Jalid Sehouli Christina Fotopoulou Thomas F Meyer

Nat Commun 2015 Dec 8;6:8989. Epub 2015 Dec 8.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany.

View Article and Find Full Text PDF
December 2015

The Plasmodium berghei translocon of exported proteins reveals spatiotemporal dynamics of tubular extensions.

Authors:
Joachim M Matz Christian Goosmann Volker Brinkmann Josephine Grützke Alyssa Ingmundson Kai Matuschewski Taco W A Kooij

Sci Rep 2015 Jul 29;5:12532. Epub 2015 Jul 29.

1] Parasitology Unit, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany [2] Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands [3] Centre for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

View Article and Find Full Text PDF
July 2015

Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity.

Authors:
Ding Xu Joshua Olson Jason N Cole Xander M van Wijk Volker Brinkmann Arturo Zychlinsky Victor Nizet Jeffrey D Esko Yung-Chi Chang

Infect Immun 2015 Sep 6;83(9):3648-56. Epub 2015 Jul 6.

Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA Department of Pediatrics, University of California, San Diego, La Jolla, California, USA Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan

View Article and Find Full Text PDF
September 2015

A prospective randomized radiographic and dual-energy X-ray absorptiometric study of migration and bone remodeling after implantation of two modern short-stemmed femoral prostheses.

Authors:
Volker Brinkmann Florian Radetzki Karl Stefan Delank David Wohlrab Alexander Zeh

J Orthop Traumatol 2015 Sep 11;16(3):237-43. Epub 2015 Feb 11.

Department of Orthopaedics and Traumatology, Faculty of Medicine, Martin-Luther-University of Halle-Wittenberg, Ernst-Grube-Strasse 40, 06120, Halle/Saale, Germany.

View Article and Find Full Text PDF
September 2015

Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications.

Authors:
John Camm Timothy Hla Rajesh Bakshi Volker Brinkmann

Am Heart J 2014 Nov 11;168(5):632-44. Epub 2014 Jul 11.

Novartis Pharma AG, Basel, Switzerland.

View Article and Find Full Text PDF
November 2014

Chlamydia infection depends on a functional MDM2-p53 axis.

Authors:
Erik González Marion Rother Markus C Kerr Munir A Al-Zeer Mohammad Abu-Lubad Mirjana Kessler Volker Brinkmann Alexander Loewer Thomas F Meyer

Nat Commun 2014 Nov 13;5:5201. Epub 2014 Nov 13.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany.

View Article and Find Full Text PDF
November 2014

Chlamydia trachomatis remodels stable microtubules to coordinate Golgi stack recruitment to the chlamydial inclusion surface.

Authors:
Munir A Al-Zeer Hesham M Al-Younes Markus Kerr Mohammad Abu-Lubad Erik Gonzalez Volker Brinkmann Thomas F Meyer

Mol Microbiol 2014 Dec 3;94(6):1285-97. Epub 2014 Nov 3.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Charitèplatz 1, 10117, Berlin, Germany.

View Article and Find Full Text PDF
December 2014

Lung-residing myeloid-derived suppressors display dual functionality in murine pulmonary tuberculosis.

Authors:
Julia K Knaul Sabine Jörg Dagmar Oberbeck-Mueller Ellen Heinemann Lisa Scheuermann Volker Brinkmann Hans-Joachim Mollenkopf Vladimir Yeremeev Stefan H E Kaufmann Anca Dorhoi

Am J Respir Crit Care Med 2014 Nov;190(9):1053-66

1 Department of Immunology.

View Article and Find Full Text PDF
November 2014

AhR sensing of bacterial pigments regulates antibacterial defence.

Authors:
Pedro Moura-Alves Kellen Faé Erica Houthuys Anca Dorhoi Annika Kreuchwig Jens Furkert Nicola Barison Anne Diehl Antje Munder Patricia Constant Tatsiana Skrahina Ute Guhlich-Bornhof Marion Klemm Anne-Britta Koehler Silke Bandermann Christian Goosmann Hans-Joachim Mollenkopf Robert Hurwitz Volker Brinkmann Simon Fillatreau Mamadou Daffe Burkhard Tümmler Michael Kolbe Hartmut Oschkinat Gerd Krause Stefan H E Kaufmann

Nature 2014 Aug 13;512(7515):387-92. Epub 2014 Aug 13.

Max Planck Institute for Infection Biology, Department of Immunology, Charitéplatz 1, 10117 Berlin, Germany.

View Article and Find Full Text PDF
August 2014

Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics.

Authors:
Anca Dorhoi Vladimir Yeremeev Geraldine Nouailles January Weiner Sabine Jörg Ellen Heinemann Dagmar Oberbeck-Müller Julia K Knaul Alexis Vogelzang Stephen T Reece Karin Hahnke Hans-Joachim Mollenkopf Volker Brinkmann Stefan H E Kaufmann

Eur J Immunol 2014 Aug 24;44(8):2380-93. Epub 2014 Jun 24.

Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany.

View Article and Find Full Text PDF
August 2014

IcsA is a Shigella flexneri adhesin regulated by the type III secretion system and required for pathogenesis.

Authors:
Anna Brotcke Zumsteg Christian Goosmann Volker Brinkmann Renato Morona Arturo Zychlinsky

Cell Host Microbe 2014 Apr;15(4):435-45

Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin 13353, Germany. Electronic address:

View Article and Find Full Text PDF
April 2014

The spatiotemporal dynamics and membranous features of the Plasmodium liver stage tubovesicular network.

Authors:
Josephine Grützke Kerstin Rindte Christian Goosmann Olivier Silvie Carolin Rauch Dagmar Heuer Maik J Lehmann Ann-Kristin Mueller Volker Brinkmann Kai Matuschewski Alyssa Ingmundson

Traffic 2014 Apr 13;15(4):362-82. Epub 2014 Feb 13.

Max Planck Institute for Infection Biology, Charitéplatz 1, 10117, Berlin, Germany.

View Article and Find Full Text PDF
April 2014

Second generation S1P pathway modulators: research strategies and clinical developments.

Authors:
Marc Bigaud Danilo Guerini Andreas Billich Frederic Bassilana Volker Brinkmann

Biochim Biophys Acta 2014 May 12;1841(5):745-58. Epub 2013 Nov 12.

Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland. Electronic address:

View Article and Find Full Text PDF
May 2014

Comparative genomics reveals distinct host-interacting traits of three major human-associated propionibacteria.

Authors:
Tim N Mak Monika Schmid Elzbieta Brzuszkiewicz Guanghong Zeng Rikke Meyer Karen S Sfanos Volker Brinkmann Thomas F Meyer Holger Brüggemann

BMC Genomics 2013 Sep 22;14:640. Epub 2013 Sep 22.

Department of Biomedicine, Aarhus University, Aarhus, Denmark.

View Article and Find Full Text PDF
September 2013

Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours.

Authors:
Peter Wend Liang Fang Qionghua Zhu Jörg H Schipper Christoph Loddenkemper Frauke Kosel Volker Brinkmann Klaus Eckert Simone Hindersin Jane D Holland Stephan Lehr Michael Kahn Ulrike Ziebold Walter Birchmeier

EMBO J 2013 Jul 4;32(14):1977-89. Epub 2013 Jun 4.

Max-Delbrueck Center for Molecular Medicine, Berlin, Germany.

View Article and Find Full Text PDF
July 2013

A proposed role for neutrophil extracellular traps in cancer immunoediting.

Authors:
Sivan Berger-Achituv Volker Brinkmann Ulrike Abu Abed Lars I Kühn Jonathan Ben-Ezra Ronit Elhasid Arturo Zychlinsky

Front Immunol 2013 6;4:48. Epub 2013 Mar 6.

Research Laboratory for Pediatric Hemato-Oncology, Department of Pediatric Hemato-Oncology, Dana Children's Hospital, Tel Aviv Sourasky Medical Center Tel Aviv, Israel.

View Article and Find Full Text PDF
March 2013

Homing frequency of human T cells inferred from peripheral blood depletion kinetics after sphingosine-1-phosphate receptor blockade.

Authors:
Matthias Mehling Volker Brinkmann Anne-Valerie Burgener Patrick Gubser Andrew D Luster Ludwig Kappos Christoph Hess

J Allergy Clin Immunol 2013 May 21;131(5):1440-3.e7. Epub 2013 Feb 21.

View Article and Find Full Text PDF
May 2013

Automatic quantification of in vitro NET formation.

Authors:
Volker Brinkmann Christian Goosmann Lars I Kühn Arturo Zychlinsky

Front Immunol 2012 9;3:413. Epub 2013 Jan 9.

Microscopy Core Facility, Max Planck Institute for Infection Biology Berlin, Germany.

View Article and Find Full Text PDF
January 2013

A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis.

Authors:
Jean Quancard Birgit Bollbuck Philipp Janser Daniela Angst Frédéric Berst Peter Buehlmayer Markus Streiff Christian Beerli Volker Brinkmann Danilo Guerini Paul A Smith Timothy J Seabrook Martin Traebert Klaus Seuwen René Hersperger Christian Bruns Frédéric Bassilana Marc Bigaud

Chem Biol 2012 Sep;19(9):1142-51

Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland.

View Article and Find Full Text PDF
September 2012

Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development.

Authors:
Bongnam Jung Hideru Obinata Sylvain Galvani Karen Mendelson Bi-sen Ding Athanasia Skoura Bernd Kinzel Volker Brinkmann Shahin Rafii Todd Evans Timothy Hla

Dev Cell 2012 Sep;23(3):600-10

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

View Article and Find Full Text PDF
September 2012

Neutrophil extracellular traps: is immunity the second function of chromatin?

Authors:
Volker Brinkmann Arturo Zychlinsky

J Cell Biol 2012 Sep;198(5):773-83

Microscopy Core Facility, Max Planck Institute for Infection Biology, 10117 Berlin, Germany.

View Article and Find Full Text PDF
September 2012

T cells become licensed in the lung to enter the central nervous system.

Authors:
Francesca Odoardi Christopher Sie Kristina Streyl Vijay K Ulaganathan Christian Schläger Dmitri Lodygin Klaus Heckelsmiller Wilfried Nietfeld Joachim Ellwart Wolfgang E F Klinkert Claudio Lottaz Mikhail Nosov Volker Brinkmann Rainer Spang Hans Lehrach Martin Vingron Hartmut Wekerle Cassandra Flügel-Koch Alexander Flügel

Nature 2012 Aug;488(7413):675-9

Institute for Multiple Sclerosis Research, Department of Neuroimmunology, Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen, 37073 Göttingen, Germany.

View Article and Find Full Text PDF
August 2012

Propionibacterium acnes host cell tropism contributes to vimentin-mediated invasion and induction of inflammation.

Authors:
Tim N Mak Natalie Fischer Britta Laube Volker Brinkmann Matteo M E Metruccio Karen S Sfanos Hans-Joachim Mollenkopf Thomas F Meyer Holger Brüggemann

Cell Microbiol 2012 Nov 22;14(11):1720-33. Epub 2012 Jul 22.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany.

View Article and Find Full Text PDF
November 2012

B cell-specific S1PR1 deficiency blocks prion dissemination between secondary lymphoid organs.

Authors:
Simon W F Mok Richard L Proia Volker Brinkmann Neil A Mabbott

J Immunol 2012 May 13;188(10):5032-40. Epub 2012 Apr 13.

The Roslin Institute and Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Midlothian EH25 9RG, United Kingdom.

View Article and Find Full Text PDF
May 2012

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo.

Authors:
Marie-Luise von Brühl Konstantin Stark Alexander Steinhart Sue Chandraratne Ildiko Konrad Michael Lorenz Alexander Khandoga Anca Tirniceriu Raffaele Coletti Maria Köllnberger Robert A Byrne Iina Laitinen Axel Walch Alexander Brill Susanne Pfeiler Davit Manukyan Siegmund Braun Philipp Lange Julia Riegger Jerry Ware Annekathrin Eckart Selgai Haidari Martina Rudelius Christian Schulz Katrin Echtler Volker Brinkmann Markus Schwaiger Klaus T Preissner Denisa D Wagner Nigel Mackman Bernd Engelmann Steffen Massberg

J Exp Med 2012 Apr 26;209(4):819-35. Epub 2012 Mar 26.

Deutsches Herzzentrum and I. Medizinische Klinik, Technische Universität München (TUM), 80333 Munich, Germany.

View Article and Find Full Text PDF
April 2012

The exported Plasmodium berghei protein IBIS1 delineates membranous structures in infected red blood cells.

Authors:
Alyssa Ingmundson Carolin Nahar Volker Brinkmann Maik J Lehmann Kai Matuschewski

Mol Microbiol 2012 Mar 21;83(6):1229-43. Epub 2012 Feb 21.

Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany.

View Article and Find Full Text PDF
March 2012

Critical role for heat shock protein 20 (HSP20) in migration of malarial sporozoites.

Authors:
Georgina N Montagna Carlos A Buscaglia Sylvia Münter Christian Goosmann Friedrich Frischknecht Volker Brinkmann Kai Matuschewski

J Biol Chem 2012 Jan 2;287(4):2410-22. Epub 2011 Dec 2.

Max Planck Institute for Infection Biology, 10117 Berlin, Germany.

View Article and Find Full Text PDF
January 2012

Therapeutic dosing of fingolimod (FTY720) prevents cell infiltration, rapidly suppresses ocular inflammation, and maintains the blood-ocular barrier.

Authors:
David A Copland Jian Liu Lauren P Schewitz-Bowers Volker Brinkmann Karen Anderson Lindsay B Nicholson Andrew D Dick

Am J Pathol 2012 Feb 24;180(2):672-81. Epub 2011 Nov 24.

Unit of Ophthalmology, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom.

View Article and Find Full Text PDF
February 2012

Optimal deconvolution of transcriptional profiling data using quadratic programming with application to complex clinical blood samples.

Authors:
Ting Gong Nicole Hartmann Isaac S Kohane Volker Brinkmann Frank Staedtler Martin Letzkus Sandrine Bongiovanni Joseph D Szustakowski

PLoS One 2011 16;6(11):e27156. Epub 2011 Nov 16.

Biomarker Development, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America.

View Article and Find Full Text PDF
March 2012

A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya).

Authors:
Jerold Chun Volker Brinkmann

Discov Med 2011 Sep;12(64):213-28

Department of Molecular Biology and Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California 92037, USA.

View Article and Find Full Text PDF
September 2011

Autophagy-independent function of MAP-LC3 during intracellular propagation of Chlamydia trachomatis.

Authors:
Hesham M Al-Younes Munir A Al-Zeer Hany Khalil Joscha Gussmann Alexander Karlas Nikolaus Machuy Volker Brinkmann Peter R Braun Thomas F Meyer

Autophagy 2011 Aug 1;7(8):814-28. Epub 2011 Aug 1.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany.

View Article and Find Full Text PDF
August 2011

Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation.

Authors:
Timothy Hla Volker Brinkmann

Neurology 2011 Feb;76(8 Suppl 3):S3-8

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Cornell University, New York, NY 10065, USA.

View Article and Find Full Text PDF
February 2011

Impact of sphingosine 1-phosphate modulation on immune outcomes.

Authors:
Daniel D Pinschewer Volker Brinkmann Doron Merkler

Neurology 2011 Feb;76(8 Suppl 3):S15-9

Department of Pathology and Immunology, University of Geneva, Geneva.

View Article and Find Full Text PDF
February 2011

Fingolimod provides long-term protection in rodent models of cerebral ischemia.

Authors:
Ying Wei Muge Yemisci Hyung-Hwan Kim Lai Ming Yung Hwa Kyoung Shin Seo-Kyoung Hwang Shuzhen Guo Tao Qin Nafiseh Alsharif Volker Brinkmann James K Liao Eng H Lo Christian Waeber

Ann Neurol 2011 Jan 12;69(1):119-29. Epub 2010 Nov 12.

Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.

View Article and Find Full Text PDF
January 2011

Angiogenesis is present in experimental autoimmune encephalomyelitis and pro-angiogenic factors are increased in multiple sclerosis lesions.

Authors:
Timothy J Seabrook Amanda Littlewood-Evans Volker Brinkmann Bernadette Pöllinger Christian Schnell Peter C Hiestand

J Neuroinflammation 2010 Dec 22;7:95. Epub 2010 Dec 22.

Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland.

View Article and Find Full Text PDF
December 2010

Helicobacter pylori HP0518 affects flagellin glycosylation to alter bacterial motility.

Authors:
Hiroshi Asakura Yuri Churin Bianca Bauer Jan Peter Boettcher Sina Bartfeld Noritaka Hashii Nana Kawasaki Hans J Mollenkopf Peter R Jungblut Volker Brinkmann Thomas F Meyer

Mol Microbiol 2010 Dec 30;78(5):1130-44. Epub 2010 Sep 30.

Department of Molecular Biology and Core Facilities for Genomics, Max Planck Institute for Infection Biology, Cháriteplatz 1, Campus Chárite, 10117 Berlin, Germany.

View Article and Find Full Text PDF
December 2010

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.

Authors:
Volker Brinkmann Andreas Billich Thomas Baumruker Peter Heining Robert Schmouder Gordon Francis Shreeram Aradhye Pascale Burtin

Nat Rev Drug Discov 2010 Nov 29;9(11):883-97. Epub 2010 Oct 29.

Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Campus Forum 1, WSJ-386, CH-4056 Basel, Switzerland.

View Article and Find Full Text PDF
November 2010

Prevalence of Propionibacterium acnes in diseased prostates and its inflammatory and transforming activity on prostate epithelial cells.

Authors:
Lina Fassi Fehri Tim N Mak Britta Laube Volker Brinkmann Lesley A Ogilvie Hans Mollenkopf Michael Lein Timo Schmidt Thomas F Meyer Holger Brüggemann

Int J Med Microbiol 2011 Jan 12;301(1):69-78. Epub 2010 Oct 12.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Charitéplatz 1, D-10117 Berlin, Germany.

View Article and Find Full Text PDF
January 2011

Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements.

Authors:
Jan Peter Boettcher Marieluise Kirchner Yuri Churin Alexis Kaushansky Malvika Pompaiah Hans Thorn Volker Brinkmann Gavin Macbeath Thomas F Meyer

PLoS Biol 2010 Aug 24;8(8). Epub 2010 Aug 24.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany.

View Article and Find Full Text PDF
August 2010

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases.

Authors:
Steffen Massberg Lenka Grahl Marie-Luise von Bruehl Davit Manukyan Susanne Pfeiler Christian Goosmann Volker Brinkmann Michael Lorenz Kiril Bidzhekov Avinash B Khandagale Ildiko Konrad Elisabeth Kennerknecht Katja Reges Stefan Holdenrieder Siegmund Braun Christoph Reinhardt Michael Spannagl Klaus T Preissner Bernd Engelmann

Nat Med 2010 Aug 1;16(8):887-96. Epub 2010 Aug 1.

Deutsches Herzzentrum, Technische Universität, Munich, Germany.

View Article and Find Full Text PDF
August 2010

A key role for lung-resident memory lymphocytes in protective immune responses after BCG vaccination.

Authors:
Lisa M Connor Marina C Harvie Fenella J Rich Kylie M Quinn Volker Brinkmann Graham Le Gros Joanna R Kirman

Eur J Immunol 2010 Sep;40(9):2482-92

Malaghan Institute of Medical Research, Wellington, New Zealand.

View Article and Find Full Text PDF
September 2010

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis.

Authors:
Abdul Hakkim Barbara G Fürnrohr Kerstin Amann Britta Laube Ulrike Abu Abed Volker Brinkmann Martin Herrmann Reinhard E Voll Arturo Zychlinsky

Proc Natl Acad Sci U S A 2010 May 3;107(21):9813-8. Epub 2010 May 3.

Department of Cellular Microbiology and Microscopy Core Facility, Max-Planck Institute for Infection Biology, Berlin 10117, Germany.

View Article and Find Full Text PDF
May 2010

The adaptor molecule CARD9 is essential for tuberculosis control.

Authors:
Anca Dorhoi Christiane Desel Vladimir Yeremeev Lydia Pradl Volker Brinkmann Hans-Joachim Mollenkopf Karin Hanke Olaf Gross Jürgen Ruland Stefan H E Kaufmann

J Exp Med 2010 Apr 29;207(4):777-92. Epub 2010 Mar 29.

Max Planck Institute for Infection Biology, Department of Immunology, 10117 Berlin, Germany.

View Article and Find Full Text PDF
April 2010

Neutrophil extracellular traps: how to generate and visualize them.

Authors:
Volker Brinkmann Britta Laube Ulrike Abu Abed Christian Goosmann Arturo Zychlinsky

J Vis Exp 2010 Feb 24(36). Epub 2010 Feb 24.

Core Facility Microscopy, Max Planck Institute for Infection Biology.

View Article and Find Full Text PDF
February 2010

Alpha-GalCer ameliorates listeriosis by accelerating infiltration of Gr-1+ cells into the liver.

Authors:
Masashi Emoto Yoshiko Emoto Izumi Yoshizawa Eiji Kita Takamitsu Shimizu Robert Hurwitz Volker Brinkmann Stefan H E Kaufmann

Eur J Immunol 2010 May;40(5):1328-41

Laboratory of Immunology, Department of Laboratory Sciences, Gunma University School of Health Sciences, Maebashi, Gunma, Japan.

View Article and Find Full Text PDF
May 2010

Dynamic T cell migration program provides resident memory within intestinal epithelium.

Authors:
David Masopust Daniel Choo Vaiva Vezys E John Wherry Jaikumar Duraiswamy Rama Akondy Jun Wang Kerry A Casey Daniel L Barber Kim S Kawamura Kathryn A Fraser Richard J Webby Volker Brinkmann Eugene C Butcher Kenneth A Newell Rafi Ahmed

J Exp Med 2010 Mar 15;207(3):553-64. Epub 2010 Feb 15.

Department of Microbiology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.

View Article and Find Full Text PDF
March 2010

Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans.

Authors:
Constantin F Urban David Ermert Monika Schmid Ulrike Abu-Abed Christian Goosmann Wolfgang Nacken Volker Brinkmann Peter R Jungblut Arturo Zychlinsky

PLoS Pathog 2009 Oct 30;5(10):e1000639. Epub 2009 Oct 30.

Department for Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany.

View Article and Find Full Text PDF
October 2009

Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis.

Authors:
Vera Kozjak-Pavlovic Elke A Dian-Lothrop Michael Meinecke Oliver Kepp Katharina Ross Krishnaraj Rajalingam Anke Harsman Eva Hauf Volker Brinkmann Dirk Günther Ines Herrmann Robert Hurwitz Joachim Rassow Richard Wagner Thomas Rudel

PLoS Pathog 2009 Oct 23;5(10):e1000629. Epub 2009 Oct 23.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany.

View Article and Find Full Text PDF
October 2009

Rab6 and Rab11 regulate Chlamydia trachomatis development and golgin-84-dependent Golgi fragmentation.

Authors:
Anette Rejman Lipinski Julia Heymann Charlotte Meissner Alexander Karlas Volker Brinkmann Thomas F Meyer Dagmar Heuer

PLoS Pathog 2009 Oct 9;5(10):e1000615. Epub 2009 Oct 9.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany.

View Article and Find Full Text PDF
October 2009

FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system.

Authors:
Volker Brinkmann

Br J Pharmacol 2009 Nov 8;158(5):1173-82. Epub 2009 Oct 8.

Autoimmunity, Transplantation & Inflammation, Novartis Institutes for BioMedical Research, Basel, Switzerland.

View Article and Find Full Text PDF
November 2009

Restoration of NET formation by gene therapy in CGD controls aspergillosis.

Authors:
Matteo Bianchi Abdul Hakkim Volker Brinkmann Ulrich Siler Reinhard A Seger Arturo Zychlinsky Janine Reichenbach

Blood 2009 Sep 18;114(13):2619-22. Epub 2009 Jun 18.

Division of Immunology/Haematology/BMT, University Children's Hospital Zurich, Zurich, Switzerland.

View Article and Find Full Text PDF
September 2009

The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.

Authors:
Jean-Pierre Evenou Jürgen Wagner Gerhard Zenke Volker Brinkmann Kathrin Wagner Jiri Kovarik Karl A Welzenbach Gabriele Weitz-Schmidt Christine Guntermann Harry Towbin Sylvain Cottens Sandra Kaminski Thomas Letschka Christina Lutz-Nicoladoni Thomas Gruber Natascha Hermann-Kleiter Nikolaus Thuille Gottfried Baier

J Pharmacol Exp Ther 2009 Sep 2;330(3):792-801. Epub 2009 Jun 2.

Novartis Institute for BioMedical Research, WSJ-386.5.27, CH-4002 Basel, Switzerland.

View Article and Find Full Text PDF
September 2009

Netting neutrophils in autoimmune small-vessel vasculitis.

Authors:
Kai Kessenbrock Markus Krumbholz Ulf Schönermarck Walter Back Wolfgang L Gross Zena Werb Hermann-Josef Gröne Volker Brinkmann Dieter E Jenne

Nat Med 2009 Jun;15(6):623-5

Department of Neuroimmunology,Max-Planck-Institute of Neurobiology, Martinsried, Germany.

View Article and Find Full Text PDF
June 2009

Identifying activated T cells in reconstituted RAG deficient mice using retrovirally transduced Pax5 deficient pro-B cells.

Authors:
Nadesan Gajendran Dominique Vanhecke Volker Brinkmann Stefan H E Kaufmann

PLoS One 2009 2;4(4):e5115. Epub 2009 Apr 2.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

View Article and Find Full Text PDF
July 2009

Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection.

Authors:
Oliver Kepp Kathleen Gottschalk Yuri Churin Krishnaraj Rajalingam Volker Brinkmann Nikolaus Machuy Guido Kroemer Thomas Rudel

PLoS Pathog 2009 Mar 20;5(3):e1000348. Epub 2009 Mar 20.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany.

View Article and Find Full Text PDF
March 2009

Mouse neutrophil extracellular traps in microbial infections.

Authors:
David Ermert Constantin F Urban Britta Laube Christian Goosmann Arturo Zychlinsky Volker Brinkmann

J Innate Immun 2009 26;1(3):181-93. Epub 2009 Feb 26.

Department for Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany.

View Article and Find Full Text PDF
July 2010

Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction.

Authors:
Dagmar Heuer Anette Rejman Lipinski Nikolaus Machuy Alexander Karlas Andrea Wehrens Frank Siedler Volker Brinkmann Thomas F Meyer

Nature 2009 Feb 7;457(7230):731-5. Epub 2008 Dec 7.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany.

View Article and Find Full Text PDF
February 2009

Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice.

Authors:
Christoph Lippuner Daniel Paape Athina Paterou Janko Brand Melville Richardson Andrew J Smith Kirstin Hoffmann Volker Brinkmann Clare Blackburn Toni Aebischer

FASEB J 2009 Feb 16;23(2):483-91. Epub 2008 Oct 16.

Department of Molecular Biology, Max-Planck-Institute for Infection Biology, Berlin, Germany.

View Article and Find Full Text PDF
February 2009

Sphingosine 1-phosphate receptor agonism impairs skin dendritic cell migration and homing to secondary lymphoid tissue: association with prolonged allograft survival.

Authors:
Yuk Yuen Lan Daisuke Tokita Zhiliang Wang Hao Chen Wang Jianghua Zhan Volker Brinkmann Angus W Thomson

Transpl Immunol 2008 Nov 9;20(1-2):88-94. Epub 2008 Aug 9.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

View Article and Find Full Text PDF
November 2008

Infection at the cellular level.

Authors:
Christian Goosmann Ulrike Abu Abed Volker Brinkmann

Methods Cell Biol 2008 ;88:477-96

Max-Planck-Institut für Infektionsbiologie, Charitéplatz 1, 10117 Berlin, Germany.

View Article and Find Full Text PDF
August 2008

Transgenic, fluorescent Leishmania mexicana allow direct analysis of the proteome of intracellular amastigotes.

Authors:
Daniel Paape Christoph Lippuner Monika Schmid Renate Ackermann Martin E Barrios-Llerena Ursula Zimny-Arndt Volker Brinkmann Benjamin Arndt Klaus Peter Pleissner Peter R Jungblut Toni Aebischer

Mol Cell Proteomics 2008 Sep 12;7(9):1688-701. Epub 2008 May 12.

Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom.

View Article and Find Full Text PDF
September 2008

Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.

Authors:
Laurens A van Meeteren Volker Brinkmann Jean Sébastien Saulnier-Blache Kevin R Lynch Wouter H Moolenaar

Cancer Lett 2008 Aug 18;266(2):203-8. Epub 2008 Apr 18.

Division of Cellular Biochemistry and Center for Biomedical Genetics, The Netherlands Cancer Institute, 1066 Amsterdam, The Netherlands.

View Article and Find Full Text PDF
August 2008

Delay of phagosome maturation by a mycobacterial lipid is reversed by nitric oxide.

Authors:
Sofia Axelrod Hartmut Oschkinat Jana Enders Brigitte Schlegel Volker Brinkmann Stefan H E Kaufmann Albert Haas Ulrich E Schaible

Cell Microbiol 2008 Jul 21;10(7):1530-45. Epub 2008 Mar 21.

Department of Immunology, Max Planck Institute for Infection Biology, D-10117 Berlin, Germany.

View Article and Find Full Text PDF
July 2008

Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure.

Authors:
Barbara Metzler Patrick Gfeller Grazyna Wieczorek Jianping Li Barbara Nuesslein-Hildesheim Andreas Katopodis Matthias Mueller Volker Brinkmann

Int Immunol 2008 May 14;20(5):633-44. Epub 2008 Mar 14.

Department of Autoimmunity and Transplantation, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.

View Article and Find Full Text PDF
May 2008

Role of interleukin-12 in determining differential kinetics of invariant natural killer T cells in response to differential burden of Listeria monocytogenes.

Authors:
Yoshiko Emoto Izumi Yoshizawa Robert Hurwitz Volker Brinkmann Stefan H E Kaufmann Masashi Emoto

Microbes Infect 2008 Mar 3;10(3):224-32. Epub 2007 Dec 3.

Laboratory of Immunology, Department of Laboratory Sciences, Gunma University School of Health Sciences, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.

View Article and Find Full Text PDF
March 2008

Long-term effects of natural amino acids on infection with Chlamydia trachomatis.

Authors:
Joscha Gussmann Hesham M Al-Younes Peter R Braun Volker Brinkmann Thomas F Meyer

Microb Pathog 2008 May 14;44(5):438-47. Epub 2007 Dec 14.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Chariteplatz 1, D-10117 Berlin, Germany.

View Article and Find Full Text PDF
May 2008

Requirement of secondary lymphoid tissues for the induction of primary and secondary T cell responses against Listeria monocytogenes.

Authors:
Mischo Kursar Nathalie Jänner Klaus Pfeffer Volker Brinkmann Stefan H E Kaufmann Hans-Willi Mittrücker

Eur J Immunol 2008 Jan;38(1):127-38

Max-Planck-Institute for Infection Biology, Department of Immunology, Berlin, Germany.

View Article and Find Full Text PDF
January 2008

A small non-coding RNA of the invasion gene island (SPI-1) represses outer membrane protein synthesis from the Salmonella core genome.

Authors:
Verena Pfeiffer Alexandra Sittka Raju Tomer Karsten Tedin Volker Brinkmann Jörg Vogel

Mol Microbiol 2007 Dec 29;66(5):1174-91. Epub 2007 Oct 29.

Max Planck Institute for Infection Biology, Charitéplatz 1, D-10117 Berlin, Germany.

View Article and Find Full Text PDF
December 2007

A small non-coding RNA of the invasion gene island (SPI-1) represses outer membrane protein synthesis from the Salmonella core genome.

Authors:
Verena Pfeiffer Alexandra Sittka Raju Tomer Karsten Tedin Volker Brinkmann Jörg Vogel

Mol Microbiol 2007 Dec 29;66(5):1174-91. Epub 2007 Oct 29.

Max Planck Institute for Infection Biology, Charitéplatz 1, D-10117 Berlin, Germany.

View Article and Find Full Text PDF
December 2007

Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD).

Authors:
Patricia A Taylor Michael J Ehrhardt Christopher J Lees Jakub Tolar Brenda J Weigel Angela Panoskaltsis-Mortari Jonathan S Serody Volker Brinkmann Bruce R Blazar

Blood 2007 Nov 2;110(9):3480-8. Epub 2007 Jul 2.

Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Cancer Center, 420 Delaware Street SE, Minneapolis, MN 55455, USA.

View Article and Find Full Text PDF
November 2007

Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology.

Authors:
Volker Brinkmann

Pharmacol Ther 2007 Jul 22;115(1):84-105. Epub 2007 May 22.

Autoimmunity and Transplantation, Novartis Institutes for BioMedical Research, Lichtstrasse 35, CH-4002 Basel, Switzerland.

View Article and Find Full Text PDF
July 2007

FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis.

Authors:
Thomas Baumruker Andreas Billich Volker Brinkmann

Expert Opin Investig Drugs 2007 Mar;16(3):283-9

Novartis Institutes for BioMedical Research, Autoimmunity & Transplantation, Brunner Strasse 59, A-1235 Vienna, Austria.

View Article and Find Full Text PDF
March 2007

FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice.

Authors:
Jerzy-Roch Nofer Martine Bot Martin Brodde Paul J Taylor Paul Salm Volker Brinkmann Theo van Berkel Gerd Assmann Erik A L Biessen

Circulation 2007 Jan 22;115(4):501-8. Epub 2007 Jan 22.

Institut für Klinische Chemie und Laboratoriumsmedizin, Westfälische Wilhelms-Universität Münster, Albert Schweizer Str 33, D-48129 Münster, Germany.

View Article and Find Full Text PDF
January 2007

The Helicobacter pylori CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin.

Authors:
Stefan Moese Matthias Selbach Volker Brinkmann Alexander Karlas Beatrice Haimovich Steffen Backert Thomas F Meyer

Cell Microbiol 2007 May 9;9(5):1148-61. Epub 2007 Jan 9.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany.

View Article and Find Full Text PDF
May 2007

Novel cell death program leads to neutrophil extracellular traps.

Authors:
Tobias A Fuchs Ulrike Abed Christian Goosmann Robert Hurwitz Ilka Schulze Volker Wahn Yvette Weinrauch Volker Brinkmann Arturo Zychlinsky

J Cell Biol 2007 Jan 8;176(2):231-41. Epub 2007 Jan 8.

Department for Cellular Microbiology, Max-Planck Institute for Infection Biology, 10117 Berlin, Germany.

View Article and Find Full Text PDF
January 2007