Publications by authors named "Volker Brinkmann"

99Publications

FX11 limits growth and potentiates bactericidal activity of isoniazid through host-directed activity.

Dis Model Mech 2020 03 30;13(3). Epub 2020 Mar 30.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin 10117, Germany

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March 2020

Polarization of MTIP is a signature of gliding locomotion in Plasmodium ookinetes and sporozoites.

Mol Biochem Parasitol 2020 01 23;235:111247. Epub 2019 Dec 23.

Max Planck Institute for Infection Biology, 10117 Berlin, Germany; Instituto de Investigaciones Biotecnológicas 'Dr Rodolfo Ugalde' (IIBio), UNSAM-CONICET, 1650 San Martín, Buenos Aires, Argentina; Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, 049032, SP, Brazil.. Electronic address:

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January 2020

Immunofluorescent Detection of NET Components in Paraffin-Embedded Tissue.

Methods Mol Biol 2020 ;2087:415-424

Microscopy Core Facility, Max Planck Institute for Infection Biology, Berlin, Germany.

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January 2021

Immunofluorescence Labelling of Human and Murine Neutrophil Extracellular Traps in Paraffin-Embedded Tissue.

J Vis Exp 2019 09 10(151). Epub 2019 Sep 10.

Microscopy Core Facility, Max Planck Institute for Infection Biology;

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September 2019

Isolated From Blood Cultures and Prosthetic Joint Infections Exhibits Excessive Genome Decay.

Front Microbiol 2019 12;10:478. Epub 2019 Mar 12.

Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

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March 2019

Dnase1-deficient mice spontaneously develop a systemic lupus erythematosus-like disease.

Eur J Immunol 2019 04 21;49(4):590-599. Epub 2019 Feb 21.

Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany.

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April 2019

Neutrophil Extracellular Traps in the Second Decade.

Authors:
Volker Brinkmann

J Innate Immun 2018 15;10(5-6):414-421. Epub 2018 Jun 15.

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October 2019

Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps.

Dev Cell 2017 11 2;43(4):449-462.e5. Epub 2017 Nov 2.

Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin 10117, Germany. Electronic address:

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November 2017

Diverse stimuli engage different neutrophil extracellular trap pathways.

Elife 2017 06 2;6. Epub 2017 Jun 2.

Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany.

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June 2017

Immunodetection of NETs in Paraffin-Embedded Tissue.

Front Immunol 2016 22;7:513. Epub 2016 Nov 22.

Department of Cellular Microbiology, Max Planck Institute for Infection Biology , Berlin , Germany.

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November 2016

Comparative Plasmodium gene overexpression reveals distinct perturbation of sporozoite transmission by profilin.

Mol Biol Cell 2016 07 25;27(14):2234-44. Epub 2016 May 25.

Parasitology Unit, Max Planck Institute for Infection Biology, 10117 Berlin, Germany Institute of Biology, Humboldt University, 10117 Berlin, Germany.

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July 2016

Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer's disease.

Sci Rep 2016 04 27;6:24939. Epub 2016 Apr 27.

Department of Veterans Affairs, VA Boston Healthcare System, Boston, MA 02130, USA.

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April 2016

The Plasmodium berghei translocon of exported proteins reveals spatiotemporal dynamics of tubular extensions.

Sci Rep 2015 Jul 29;5:12532. Epub 2015 Jul 29.

1] Parasitology Unit, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany [2] Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands [3] Centre for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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July 2015

Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity.

Infect Immun 2015 Sep 6;83(9):3648-56. Epub 2015 Jul 6.

Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA Department of Pediatrics, University of California, San Diego, La Jolla, California, USA Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan

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September 2015

A prospective randomized radiographic and dual-energy X-ray absorptiometric study of migration and bone remodeling after implantation of two modern short-stemmed femoral prostheses.

J Orthop Traumatol 2015 Sep 11;16(3):237-43. Epub 2015 Feb 11.

Department of Orthopaedics and Traumatology, Faculty of Medicine, Martin-Luther-University of Halle-Wittenberg, Ernst-Grube-Strasse 40, 06120, Halle/Saale, Germany.

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September 2015

Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications.

Am Heart J 2014 Nov 11;168(5):632-44. Epub 2014 Jul 11.

Novartis Pharma AG, Basel, Switzerland.

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November 2014

Chlamydia infection depends on a functional MDM2-p53 axis.

Nat Commun 2014 Nov 13;5:5201. Epub 2014 Nov 13.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany.

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November 2014

Chlamydia trachomatis remodels stable microtubules to coordinate Golgi stack recruitment to the chlamydial inclusion surface.

Mol Microbiol 2014 Dec 3;94(6):1285-97. Epub 2014 Nov 3.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Charitèplatz 1, 10117, Berlin, Germany.

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December 2014

IcsA is a Shigella flexneri adhesin regulated by the type III secretion system and required for pathogenesis.

Cell Host Microbe 2014 Apr;15(4):435-45

Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin 13353, Germany. Electronic address:

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April 2014

Second generation S1P pathway modulators: research strategies and clinical developments.

Biochim Biophys Acta 2014 May 12;1841(5):745-58. Epub 2013 Nov 12.

Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland. Electronic address:

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May 2014

A proposed role for neutrophil extracellular traps in cancer immunoediting.

Front Immunol 2013 6;4:48. Epub 2013 Mar 6.

Research Laboratory for Pediatric Hemato-Oncology, Department of Pediatric Hemato-Oncology, Dana Children's Hospital, Tel Aviv Sourasky Medical Center Tel Aviv, Israel.

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March 2013

Automatic quantification of in vitro NET formation.

Front Immunol 2012 9;3:413. Epub 2013 Jan 9.

Microscopy Core Facility, Max Planck Institute for Infection Biology Berlin, Germany.

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January 2013

Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development.

Dev Cell 2012 Sep;23(3):600-10

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

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September 2012

Neutrophil extracellular traps: is immunity the second function of chromatin?

J Cell Biol 2012 Sep;198(5):773-83

Microscopy Core Facility, Max Planck Institute for Infection Biology, 10117 Berlin, Germany.

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September 2012

B cell-specific S1PR1 deficiency blocks prion dissemination between secondary lymphoid organs.

J Immunol 2012 May 13;188(10):5032-40. Epub 2012 Apr 13.

The Roslin Institute and Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Midlothian EH25 9RG, United Kingdom.

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May 2012

The exported Plasmodium berghei protein IBIS1 delineates membranous structures in infected red blood cells.

Mol Microbiol 2012 Mar 21;83(6):1229-43. Epub 2012 Feb 21.

Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany.

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March 2012

Optimal deconvolution of transcriptional profiling data using quadratic programming with application to complex clinical blood samples.

PLoS One 2011 16;6(11):e27156. Epub 2011 Nov 16.

Biomarker Development, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America.

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March 2012

A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya).

Discov Med 2011 Sep;12(64):213-28

Department of Molecular Biology and Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California 92037, USA.

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September 2011

Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation.

Neurology 2011 Feb;76(8 Suppl 3):S3-8

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Cornell University, New York, NY 10065, USA.

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February 2011

Impact of sphingosine 1-phosphate modulation on immune outcomes.

Neurology 2011 Feb;76(8 Suppl 3):S15-9

Department of Pathology and Immunology, University of Geneva, Geneva.

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February 2011

Angiogenesis is present in experimental autoimmune encephalomyelitis and pro-angiogenic factors are increased in multiple sclerosis lesions.

J Neuroinflammation 2010 Dec 22;7:95. Epub 2010 Dec 22.

Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland.

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December 2010

Helicobacter pylori HP0518 affects flagellin glycosylation to alter bacterial motility.

Mol Microbiol 2010 Dec 30;78(5):1130-44. Epub 2010 Sep 30.

Department of Molecular Biology and Core Facilities for Genomics, Max Planck Institute for Infection Biology, Cháriteplatz 1, Campus Chárite, 10117 Berlin, Germany.

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December 2010

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.

Nat Rev Drug Discov 2010 Nov 29;9(11):883-97. Epub 2010 Oct 29.

Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Campus Forum 1, WSJ-386, CH-4056 Basel, Switzerland.

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November 2010

Prevalence of Propionibacterium acnes in diseased prostates and its inflammatory and transforming activity on prostate epithelial cells.

Int J Med Microbiol 2011 Jan 12;301(1):69-78. Epub 2010 Oct 12.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Charitéplatz 1, D-10117 Berlin, Germany.

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January 2011

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis.

Proc Natl Acad Sci U S A 2010 May 3;107(21):9813-8. Epub 2010 May 3.

Department of Cellular Microbiology and Microscopy Core Facility, Max-Planck Institute for Infection Biology, Berlin 10117, Germany.

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May 2010

The adaptor molecule CARD9 is essential for tuberculosis control.

J Exp Med 2010 Apr 29;207(4):777-92. Epub 2010 Mar 29.

Max Planck Institute for Infection Biology, Department of Immunology, 10117 Berlin, Germany.

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April 2010

Neutrophil extracellular traps: how to generate and visualize them.

J Vis Exp 2010 Feb 24(36). Epub 2010 Feb 24.

Core Facility Microscopy, Max Planck Institute for Infection Biology.

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February 2010

Alpha-GalCer ameliorates listeriosis by accelerating infiltration of Gr-1+ cells into the liver.

Eur J Immunol 2010 May;40(5):1328-41

Laboratory of Immunology, Department of Laboratory Sciences, Gunma University School of Health Sciences, Maebashi, Gunma, Japan.

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May 2010

Rab6 and Rab11 regulate Chlamydia trachomatis development and golgin-84-dependent Golgi fragmentation.

PLoS Pathog 2009 Oct 9;5(10):e1000615. Epub 2009 Oct 9.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany.

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October 2009

FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system.

Authors:
Volker Brinkmann

Br J Pharmacol 2009 Nov 8;158(5):1173-82. Epub 2009 Oct 8.

Autoimmunity, Transplantation & Inflammation, Novartis Institutes for BioMedical Research, Basel, Switzerland.

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November 2009

Restoration of NET formation by gene therapy in CGD controls aspergillosis.

Blood 2009 Sep 18;114(13):2619-22. Epub 2009 Jun 18.

Division of Immunology/Haematology/BMT, University Children's Hospital Zurich, Zurich, Switzerland.

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September 2009

Identifying activated T cells in reconstituted RAG deficient mice using retrovirally transduced Pax5 deficient pro-B cells.

PLoS One 2009 2;4(4):e5115. Epub 2009 Apr 2.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

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July 2009

Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection.

PLoS Pathog 2009 Mar 20;5(3):e1000348. Epub 2009 Mar 20.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany.

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March 2009

Mouse neutrophil extracellular traps in microbial infections.

J Innate Immun 2009 26;1(3):181-93. Epub 2009 Feb 26.

Department for Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany.

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July 2010

Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction.

Nature 2009 Feb 7;457(7230):731-5. Epub 2008 Dec 7.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany.

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February 2009

Infection at the cellular level.

Methods Cell Biol 2008 ;88:477-96

Max-Planck-Institut für Infektionsbiologie, Charitéplatz 1, 10117 Berlin, Germany.

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August 2008

Transgenic, fluorescent Leishmania mexicana allow direct analysis of the proteome of intracellular amastigotes.

Mol Cell Proteomics 2008 Sep 12;7(9):1688-701. Epub 2008 May 12.

Institute of Immunology and Infection Research, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom.

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September 2008

Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.

Cancer Lett 2008 Aug 18;266(2):203-8. Epub 2008 Apr 18.

Division of Cellular Biochemistry and Center for Biomedical Genetics, The Netherlands Cancer Institute, 1066 Amsterdam, The Netherlands.

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August 2008

Delay of phagosome maturation by a mycobacterial lipid is reversed by nitric oxide.

Cell Microbiol 2008 Jul 21;10(7):1530-45. Epub 2008 Mar 21.

Department of Immunology, Max Planck Institute for Infection Biology, D-10117 Berlin, Germany.

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July 2008

Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure.

Int Immunol 2008 May 14;20(5):633-44. Epub 2008 Mar 14.

Department of Autoimmunity and Transplantation, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland.

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May 2008

Role of interleukin-12 in determining differential kinetics of invariant natural killer T cells in response to differential burden of Listeria monocytogenes.

Microbes Infect 2008 Mar 3;10(3):224-32. Epub 2007 Dec 3.

Laboratory of Immunology, Department of Laboratory Sciences, Gunma University School of Health Sciences, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.

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March 2008

Long-term effects of natural amino acids on infection with Chlamydia trachomatis.

Microb Pathog 2008 May 14;44(5):438-47. Epub 2007 Dec 14.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Chariteplatz 1, D-10117 Berlin, Germany.

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May 2008

A small non-coding RNA of the invasion gene island (SPI-1) represses outer membrane protein synthesis from the Salmonella core genome.

Mol Microbiol 2007 Dec 29;66(5):1174-91. Epub 2007 Oct 29.

Max Planck Institute for Infection Biology, Charitéplatz 1, D-10117 Berlin, Germany.

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December 2007

A small non-coding RNA of the invasion gene island (SPI-1) represses outer membrane protein synthesis from the Salmonella core genome.

Mol Microbiol 2007 Dec 29;66(5):1174-91. Epub 2007 Oct 29.

Max Planck Institute for Infection Biology, Charitéplatz 1, D-10117 Berlin, Germany.

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December 2007

Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD).

Blood 2007 Nov 2;110(9):3480-8. Epub 2007 Jul 2.

Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Cancer Center, 420 Delaware Street SE, Minneapolis, MN 55455, USA.

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November 2007

Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology.

Authors:
Volker Brinkmann

Pharmacol Ther 2007 Jul 22;115(1):84-105. Epub 2007 May 22.

Autoimmunity and Transplantation, Novartis Institutes for BioMedical Research, Lichtstrasse 35, CH-4002 Basel, Switzerland.

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July 2007

FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis.

Expert Opin Investig Drugs 2007 Mar;16(3):283-9

Novartis Institutes for BioMedical Research, Autoimmunity & Transplantation, Brunner Strasse 59, A-1235 Vienna, Austria.

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March 2007

FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice.

Circulation 2007 Jan 22;115(4):501-8. Epub 2007 Jan 22.

Institut für Klinische Chemie und Laboratoriumsmedizin, Westfälische Wilhelms-Universität Münster, Albert Schweizer Str 33, D-48129 Münster, Germany.

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January 2007

The Helicobacter pylori CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin.

Cell Microbiol 2007 May 9;9(5):1148-61. Epub 2007 Jan 9.

Department of Molecular Biology, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany.

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May 2007

Novel cell death program leads to neutrophil extracellular traps.

J Cell Biol 2007 Jan 8;176(2):231-41. Epub 2007 Jan 8.

Department for Cellular Microbiology, Max-Planck Institute for Infection Biology, 10117 Berlin, Germany.

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January 2007