Vladimir Razinkov

Vladimir Razinkov

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Vladimir Razinkov

Vladimir Razinkov

Publications by authors named "Vladimir Razinkov"

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How Well Do Low- and High-Concentration Protein Interactions Predict Solution Viscosities of Monoclonal Antibodies?

J Pharm Sci 2019 Jan 12;108(1):142-154. Epub 2018 Jul 12.

Department of Chemical & Biomolecular Engineering, University of Delaware, Newark, Delaware 19716. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2018.07.007DOI Listing
January 2019

Biophysical characterization and molecular simulation of electrostatically driven self-association of a single-chain antibody.

Protein Sci 2018 07 3;27(7):1275-1285. Epub 2018 May 3.

Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, 19716.

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http://dx.doi.org/10.1002/pro.3415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032362PMC
July 2018

High-Throughput Screening and Analysis of Charge Variants of Monoclonal Antibodies in Multiple Formulations.

SLAS Discov 2017 Sep 1;22(8):1044-1052. Epub 2017 Jun 1.

1 Drug Product Technologies, Amgen Inc., Thousand Oaks, CA, USA.

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http://dx.doi.org/10.1177/2472555217711666DOI Listing
September 2017

Reply to "Comment on 'Osmolyte Effects on Monoclonal Antibody Stability and Concentration-Dependent Protein Interactions with Water and Common Osmolytes'".

J Phys Chem B 2016 11 19;120(43):11333-11334. Epub 2016 Oct 19.

Department of Chemical and Biomolecular Engineering, University of Delaware , Newark, Delaware 19716, United States.

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http://dx.doi.org/10.1021/acs.jpcb.6b06832DOI Listing
November 2016

Identifying protein aggregation mechanisms and quantifying aggregation rates from combined monomer depletion and continuous scattering.

Anal Biochem 2016 10 7;511:80-91. Epub 2016 Aug 7.

Department of Chemical & Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2016.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004974PMC
October 2016

Osmolyte Effects on Monoclonal Antibody Stability and Concentration-Dependent Protein Interactions with Water and Common Osmolytes.

J Phys Chem B 2016 Apr 23;120(13):3318-30. Epub 2016 Mar 23.

Department of Chemical and Biomolecular Engineering, University of Delaware , Newark, Delaware 19716, United States.

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http://dx.doi.org/10.1021/acs.jpcb.6b00621DOI Listing
April 2016

Acetate- and Citrate-Specific Ion Effects on Unfolding and Temperature-Dependent Aggregation Rates of Anti-Streptavidin IgG1.

J Pharm Sci 2016 Mar 3;105(3):1066-73. Epub 2016 Feb 3.

Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware 19716. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2015.12.017DOI Listing
March 2016

Structural Changes and Aggregation Mechanisms for Anti-Streptavidin IgG1 at Elevated Concentration.

J Phys Chem B 2015 Dec 25;119(49):15150-63. Epub 2015 Nov 25.

Department of Chemical and Biomolecular Engineering, University of Delaware , Newark, Delaware 19716, United States.

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http://dx.doi.org/10.1021/acs.jpcb.5b08748DOI Listing
December 2015

Specific-ion effects on the aggregation mechanisms and protein-protein interactions for anti-streptavidin immunoglobulin gamma-1.

J Phys Chem B 2015 May 27;119(18):5793-804. Epub 2015 Apr 27.

†Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware 19716, United States.

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http://dx.doi.org/10.1021/acs.jpcb.5b01881DOI Listing
May 2015

Accelerated formulation development of monoclonal antibodies (mAbs) and mAb-based modalities: review of methods and tools.

J Biomol Screen 2015 Apr 9;20(4):468-83. Epub 2015 Jan 9.

Drug Product Development, Amgen Inc., Seattle, WA, USA.

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http://dx.doi.org/10.1177/1087057114565593DOI Listing
April 2015

High-throughput screening and stability optimization of anti-streptavidin IgG1 and IgG2 formulations.

J Biomol Screen 2014 Oct 14;19(9):1290-301. Epub 2014 Jul 14.

Process & Product Development, Amgen, Inc., Seattle, WA, USA

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http://dx.doi.org/10.1177/1087057114542431DOI Listing
October 2014

Methods of high throughput biophysical characterization in biopharmaceutical development.

Curr Drug Discov Technol 2013 Mar;10(1):59-70

Amgen Inc., 1201 Amgen Court West, Seattle, WA 98119, USA.

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March 2013

Aggregation of anti-streptavidin immunoglobulin gamma-1 involves Fab unfolding and competing growth pathways mediated by pH and salt concentration.

Biophys Chem 2013 Feb 26;172:26-36. Epub 2012 Dec 26.

Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA.

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http://dx.doi.org/10.1016/j.bpc.2012.12.004DOI Listing
February 2013

Native-state solubility and transfer free energy as predictive tools for selecting excipients to include in protein formulation development studies.

J Pharm Sci 2012 Aug 30;101(8):2720-32. Epub 2012 May 30.

Department of Drug Product Development, Amgen Inc., Seattle, Washington 98119-3105, USA.

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http://dx.doi.org/10.1002/jps.23219DOI Listing
August 2012

High-throughput assessment of thermal and colloidal stability parameters for monoclonal antibody formulations.

J Pharm Sci 2011 Dec 24;100(12):5126-41. Epub 2011 Jul 24.

Process & Product Development, Amgen Inc., Seattle, Washington 98119, USA.

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http://dx.doi.org/10.1002/jps.22712DOI Listing
December 2011

Improved particle counting and size distribution determination of aggregated virus populations by asymmetric flow field-flow fractionation and multiangle light scattering techniques.

Biotechnol Prog 2011 Mar-Apr;27(2):547-54. Epub 2011 Feb 7.

Department of Analytical Biochemistry, MedImmune, One MedImmune Way, Gaithersburg, MD 20878, USA.

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http://dx.doi.org/10.1002/btpr.499DOI Listing
September 2011

Effect of sugar molecules on the viscosity of high concentration monoclonal antibody solutions.

Pharm Res 2011 Jul 15;28(7):1552-60. Epub 2011 May 15.

Formulation and Analytical Resources, Amgen, Inc., Seattle, Washington, USA.

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http://dx.doi.org/10.1007/s11095-011-0388-7DOI Listing
July 2011

Acid-induced aggregation of human monoclonal IgG1 and IgG2: molecular mechanism and the effect of solution composition.

Biochemistry 2010 Nov;49(43):9328-38

Process and Product Development, Amgen Inc., Seattle, WA 98119, USA.

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http://dx.doi.org/10.1021/bi100841uDOI Listing
November 2010

Detection of IgG aggregation by a high throughput method based on extrinsic fluorescence.

J Pharm Sci 2010 Jun;99(6):2598-608

Formulation and Analytical Resources, AW2/D3152, Amgen, Inc., 1201 Amgen Court West, Seattle, Washington, USA.

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http://dx.doi.org/10.1002/jps.22036DOI Listing
June 2010

High throughput thermostability screening of monoclonal antibody formulations.

J Pharm Sci 2010 Apr;99(4):1707-20

Formulation and Analytical Resources, Amgen Inc., Seattle, Washington, USA.

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http://dx.doi.org/10.1002/jps.21955DOI Listing
April 2010

High-throughput dynamic light scattering method for measuring viscosity of concentrated protein solutions.

Anal Biochem 2010 Apr 6;399(1):141-3. Epub 2009 Dec 6.

Formulation and Analytical Resources, Amgen Inc., Seattle, WA 98119, USA.

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http://dx.doi.org/10.1016/j.ab.2009.12.003DOI Listing
April 2010

Structural and thermodynamic effects of ANS binding to human interleukin-1 receptor antagonist.

Protein Sci 2008 Apr 27;17(4):652-63. Epub 2008 Feb 27.

Department of Pharmaceutics, Amgen Inc., Seattle, Washington 98119-3105, USA.

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http://dx.doi.org/10.1110/ps.073332408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271160PMC
April 2008

Biophysical characterization of the interactions of HTI-286 with tubulin heterodimer and microtubules.

Biochemistry 2003 Nov;42(46):13484-95

Biophysics/Enzymology, Screening Sciences, Oncology Research, and Chemical Sciences, Wyeth Research, Pearl River, New York 10965, USA.

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http://dx.doi.org/10.1021/bi035530xDOI Listing
November 2003

Effects of membrane potential and sphingolipid structures on fusion of Semliki Forest virus.

J Virol 2002 Dec;76(24):12691-702

Department of Molecular Biophysics and Physiology, Rush Medical College, 1653 W. Congress Parkway, Chicago, IL 60612, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136663PMC
December 2002

RSV entry inhibitors block F-protein mediated fusion with model membranes.

Antiviral Res 2002 Jul;55(1):189-200

Department of Biological Chemistry, Wyeth Research, Pearl River, NY 10965, USA.

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July 2002