Vladimir N Uversky

Vladimir N Uversky

UNVERIFIED PROFILE

Are you Vladimir N Uversky?   Register this Author

Register author
Vladimir N Uversky

Vladimir N Uversky

Publications by authors named "Vladimir N Uversky"

Are you Vladimir N Uversky?   Register this Author

100Publications

869Reads

7Profile Views

Molecular dynamics analysis of the effects of GTP, GDP and benzimidazole derivative on structural dynamics of a cell division protein FtsZ from .

J Biomol Struct Dyn 2019 Oct 11;37(16):4361-4373. Epub 2019 Jan 11.

School of Biotechnology, Shri Mata Vaishno Devi University (SMVDU) , Katra , India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07391102.2018.1548979DOI Listing
October 2019

Structural and functional analysis of "non-smelly" proteins.

Cell Mol Life Sci 2019 Sep 5. Epub 2019 Sep 5.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC07, Tampa, FL, 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-019-03292-1DOI Listing
September 2019

Supramolecular Fuzziness of Intracellular Liquid Droplets: Liquid-Liquid Phase Transitions, Membrane-Less Organelles, and Intrinsic Disorder.

Molecules 2019 Sep 7;24(18). Epub 2019 Sep 7.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd. MDC07, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules24183265DOI Listing
September 2019

Driving Forces of Liquid-Liquid Phase Separation in Biological Systems.

Biomolecules 2019 Sep 10;9(9). Epub 2019 Sep 10.

Department of Molecular Medicine and Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biom9090473DOI Listing
September 2019

Single-cell RNA-Seq: a next generation sequencing tool for a high-resolution view of the individual cell.

J Biomol Struct Dyn 2019 Sep 15:1-6. Epub 2019 Sep 15.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida , Tampa , FL , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07391102.2019.1659859DOI Listing
September 2019

Synergistic Killing of Pathogenic Escherichia coli Using Camel Lactoferrin from Different Saudi Camel Clans and Various Antibiotics.

Protein J 2019 Aug;38(4):479-496

Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, P.O. Box 80203, Jeddah, Saudi Arabia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10930-019-09828-5DOI Listing
August 2019

Stochasticity of Biological Soft Matter: Emerging Concepts in Intrinsically Disordered Proteins and Biological Phase Separation.

Trends Biochem Sci 2019 Aug 22;44(8):716-728. Epub 2019 Apr 22.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tibs.2019.03.005DOI Listing
August 2019

Ferroptosis - An iron- and disorder-dependent programmed cell death.

Int J Biol Macromol 2019 Aug 5;135:1052-1069. Epub 2019 Jun 5.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; Protein Research Group, Institute for Biological Instrumentation of the Russian Academy of Sciences, 142290 Pushchino, Moscow region, Russia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2019.05.221DOI Listing
August 2019

Multi-functionality of proteins involved in GPCR and G protein signaling: making sense of structure-function continuum with intrinsic disorder-based proteoforms.

Cell Mol Life Sci 2019 Aug 19. Epub 2019 Aug 19.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-019-03276-1DOI Listing
August 2019

Structure Determination by Single-Particle Cryo-Electron Microscopy: Only the Sky (and Intrinsic Disorder) is the Limit.

Int J Mol Sci 2019 Aug 27;20(17). Epub 2019 Aug 27.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20174186DOI Listing
August 2019

The roles of intrinsic disorder-based liquid-liquid phase transitions in the "Dr. Jekyll-Mr. Hyde" behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.

Autophagy 2017 17;13(12):2115-2162. Epub 2017 Dec 17.

a Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute , Morsani College of Medicine , University of South Florida , Tampa , FL , USA.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/15548627.2017.1
Publisher Site
http://dx.doi.org/10.1080/15548627.2017.1384889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788550PMC
July 2019

Can a retro-polypeptide fold into a globule?

J Biomol Struct Dyn 2019 Jul 2:1-5. Epub 2019 Jul 2.

c Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine , University of South Florida , Tampa , FL , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07391102.2019.1635045DOI Listing
July 2019

Experimental Insight into the Structural and Functional Roles of the 'Black' and 'Gray' Clusters in Recoverin, a Calcium Binding Protein with Four EF-Hand Motifs.

Molecules 2019 Jul 8;24(13). Epub 2019 Jul 8.

Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, 142290 Pushchino, Russia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules24132494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650976PMC
July 2019

An interplay of structure and intrinsic disorder in the functionality of peptidylarginine deiminases, a family of key autoimmunity-related enzymes.

Cell Mol Life Sci 2019 Jul 24. Epub 2019 Jul 24.

Biological Sciences Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-019-03237-8DOI Listing
July 2019

Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases.

Prog Mol Biol Transl Sci 2019 19;166:145-223. Epub 2019 Jul 19.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, United States; Laboratory of New Methods in Biology, Institute for Biological Instrumentation, Russian Academy of Sciences, Moscow, Russia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/bs.pmbts.2019.05.007DOI Listing
July 2019

Intrinsic Disorder, Protein-Protein Interactions, and Disease.

Adv Protein Chem Struct Biol 2018 24;110:85-121. Epub 2017 Jul 24.

USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, United States; Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, Russia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/bs.apcsb.2017.06.005DOI Listing
June 2019

Nanoparticle formulations in the diagnosis and therapy of Alzheimer's disease.

Int J Biol Macromol 2019 Jun 28;130:515-526. Epub 2019 Feb 28.

DISC, Interdisciplinary Biotechnology Unit, A.M.U., Aligarh 202002, India. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2019.02.156DOI Listing
June 2019

Effect of Cu and Zn ions on human serum albumin interaction with plasma unsaturated fatty acids.

Int J Biol Macromol 2019 Jun 14;131:505-509. Epub 2019 Mar 14.

Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center 'Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences', Institutskaya str., 7, Pushchino, Moscow region 142290, Russia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2019.03.085DOI Listing
June 2019

Analyzing the structural and functional roles of residues from the 'black' and 'gray' clusters of human S100P protein.

Cell Calcium 2019 Jun 28;80:46-55. Epub 2019 Mar 28.

Institute for Biological Instrumentation of the Russian Academy of Sciences, Pushchino, Moscow region, 142290, Russia; Department of Biomedical Engineering, Pushchino State Institute of Natural Sciences, Pushchino, Moscow region, 142290, Russia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ceca.2019.03.008DOI Listing
June 2019

Intrinsic Disorder-Based Emergence in Cellular Biology: Physiological and Pathological Liquid-Liquid Phase Transitions in Cells.

Polymers (Basel) 2019 Jun 4;11(6). Epub 2019 Jun 4.

Department of Molecular Medicine and Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/polym11060990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631845PMC
June 2019

Codon selection reduces GC content bias in nucleic acids encoding for intrinsically disordered proteins.

Cell Mol Life Sci 2019 Jun 7. Epub 2019 Jun 7.

Department of Computer Science, Virginia Commonwealth University, Richmond, VA, 23284, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-019-03166-6DOI Listing
June 2019

Analyzing aggregation propensities of clinically relevant PTEN mutants: a new culprit in pathogenesis of cancer and other PTENopathies.

J Biomol Struct Dyn 2019 Jun 22:1-14. Epub 2019 Jun 22.

a Department of Pathology and Cell Biology, Morsani College of Medicine , University of South Florida , Tampa , FL , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07391102.2019.1630005DOI Listing
June 2019

5-Aminolevulinate synthase catalysis: The catcher in heme biosynthesis.

Mol Genet Metab 2019 Jun 13. Epub 2019 Jun 13.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; Department of Global Health, College of Public Health, University of South Florida, Tampa, FL 33612, USA; Department of Chemistry, College of Arts and Sciences, University of South Florida, Tampa, FL 33612, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgme.2019.06.003DOI Listing
June 2019

Protein intrinsic disorder and structure-function continuum.

Prog Mol Biol Transl Sci 2019 8;166:1-17. Epub 2019 Jun 8.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, United States; Laboratory of New Methods in Biology, Institute for Biological Instrumentation, Russian Academy of Sciences, Moscow, Russia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/bs.pmbts.2019.05.003DOI Listing
June 2019

Disorder in Milk Proteins: Lactadherin Multifunctionality and Structure.

Curr Protein Pept Sci 2018 ;19(10):983-997

Department of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah, PO Box 80203, Jeddah 21589, Saudi Arabia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1389203719666180608091849DOI Listing
May 2019

Predicting Functions of Disordered Proteins with MoRFpred.

Methods Mol Biol 2019 ;1851:337-352

Department of Computer Science, Virginia Commonwealth University, Richmond, VA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-8736-8_19DOI Listing
May 2019

HIV Vaccine Mystery and Viral Shell Disorder.

Biomolecules 2019 05 8;9(5). Epub 2019 May 8.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biom9050178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572542PMC
May 2019

The Structural and Functional Diversity of Intrinsically Disordered Regions in Transmembrane Proteins.

J Membr Biol 2019 May 28. Epub 2019 May 28.

Molecular Biophysics Unit, Biological Sciences Division, Indian Institute of Science, Bangalore, Karnataka, 560012, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00232-019-00069-2DOI Listing
May 2019

Molecular docking of Aβ peptide and its Iowa DN mutant using small molecule inhibitors: Possible mechanisms of Aβ-peptide inhibition.

Int J Biol Macromol 2019 Apr 4;127:250-270. Epub 2019 Jan 4.

DISC, Interdisciplinary Biotechnology Unit, A.M.U., Aligarh 202002, India. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01418130183611
Publisher Site
http://dx.doi.org/10.1016/j.ijbiomac.2018.12.271DOI Listing
April 2019

Repeated repeat problems: Combinatorial effect of C9orf72-derived dipeptide repeat proteins.

Int J Biol Macromol 2019 Apr 9;127:136-145. Epub 2019 Jan 9.

Department of Molecular Medicine, College of Medicine, Byrd Alzheimer's Institute, University of South Florida, Tampa, FL 33612, USA; Institute for Biological Instrumentation of the Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2019.01.035DOI Listing
April 2019

Intrinsically Disordered Proteins in Chronic Diseases.

Biomolecules 2019 04 11;9(4). Epub 2019 Apr 11.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biom9040147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523076PMC
April 2019

Network mapping of the conformational heterogeneity of SOD1 by deploying statistical cluster analysis of FTIR spectra.

Cell Mol Life Sci 2019 Apr 22. Epub 2019 Apr 22.

Protein Folding and Dynamics Laboratory, Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, 700032, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-019-03108-2DOI Listing
April 2019

A multiparametric analysis of the synergistic impact of anti-Parkinson's drugs on the fibrillation of human serum albumin.

Biochim Biophys Acta Proteins Proteom 2019 03 9;1867(3):275-285. Epub 2018 Oct 9.

Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, U.P., India. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbapap.2018.10.003DOI Listing
March 2019

Effect of C-terminal His-tag and purification routine on the activity and structure of the metalloenzyme, l-alanyl-d-glutamate peptidase of the bacteriophage T5.

Int J Biol Macromol 2019 Mar 28;124:810-818. Epub 2018 Nov 28.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA; Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2018.11.219DOI Listing
March 2019

Folding of poly-amino acids and intrinsically disordered proteins in overcrowded milieu induced by pH change.

Int J Biol Macromol 2019 Mar 5;125:244-255. Epub 2018 Dec 5.

Institute of Cytology of the Russian Academy of Sciences, Laboratory of Structural Dynamics, Stability and Folding of Proteins, Tikhoretsky av. 4, St. Petersburg, Russia; Peter the Great St. Petersburg Polytechnic University, Department of Biophysics, Polytechnicheskaya av. 29, St. Petersburg, Russia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2018.12.038DOI Listing
March 2019

On the Need to Develop Guidelines for Characterizing and Reporting Intrinsic Disorder in Proteins.

Proteomics 2019 Mar 1;19(6):e1800415. Epub 2019 Mar 1.

Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201800415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571172PMC
March 2019

Torches, Candles, Lamps, Lanterns, Flashlights, Spotlights, Night Vision Goggles… You Need Them All to See in Darkness.

Proteomics 2019 Mar;19(6):e1900085

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201900085DOI Listing
March 2019

Disorder in milk proteins: adipophilin and TIP47, important constituents of the milk fat globule membrane.

J Biomol Struct Dyn 2019 Mar 21:1-16. Epub 2019 Mar 21.

a Biological Sciences Department, Faculty of Sciences , King Abdulaziz University , Jeddah , Saudi Arabia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07391102.2019.1592027DOI Listing
March 2019

Bioinformatics characterisation of the (mutated) proteins related to Andersen-Tawil syndrome.

Math Biosci Eng 2019 03;16(4):2532-2548

Department of Biochemistry, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", México City, México.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3934/mbe.2019127DOI Listing
March 2019

Structural disorder in the proteome and interactome of Alkhurma virus (ALKV).

Cell Mol Life Sci 2019 Feb 15;76(3):577-608. Epub 2018 Nov 15.

Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, P.O. Box 80203, Jeddah, Saudi Arabia.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00018-018-2968-8
Publisher Site
http://dx.doi.org/10.1007/s00018-018-2968-8DOI Listing
February 2019

Alanine Scanning Effects on the Biochemical and Biophysical Properties of Intrinsically Disordered Proteins: A Case Study of the Histidine to Alanine Mutations in Amyloid-β.

J Chem Inf Model 2019 Feb 7;59(2):871-884. Epub 2019 Feb 7.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine , University of South Florida , Tampa , Florida 33612 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jcim.8b00926DOI Listing
February 2019

Bacteriostatic and Bactericidal Activities of Camel Lactoferrins Against Salmonella enterica Serovar Typhi.

Probiotics Antimicrob Proteins 2019 Feb 5. Epub 2019 Feb 5.

Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, P.O. Box 80203, Jeddah, Saudi Arabia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12602-019-9520-5DOI Listing
February 2019

Effects of sodium chloride and sodium perchlorate on properties and partition behavior of solutes in aqueous dextran-polyethylene glycol and polyethylene glycol-sodium sulfate two-phase systems.

J Chromatogr A 2019 Jan 12;1583:28-38. Epub 2018 Nov 12.

IBB-Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chroma.2018.11.015DOI Listing
January 2019

Effects of his-tags on physical properties of parvalbumins.

Cell Calcium 2019 Jan 16;77:1-7. Epub 2018 Nov 16.

Institute for Biological Instrumentation of the Russian Academy of Sciences, Pushchino, Moscow region, 142290, Russia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ceca.2018.11.006DOI Listing
January 2019

In silico evaluation of the resistance of the T790M variant of epidermal growth factor receptor kinase to cancer drug Erlotinib.

J Biomol Struct Dyn 2018 Dec 11;36(16):4209-4219. Epub 2017 Dec 11.

a Department of Biotechnology , Shri Mata Vaishno Devi University (SMVDU) , Kakryal , Katra 182320 , Jammu and Kashmir , India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07391102.2017.1411293DOI Listing
December 2018

Not all AMLETs are made equal: complexes of cow and camel α-lactalbumin with oleic acid show different structure and stability.

J Biomol Struct Dyn 2018 12 2;36(16):4405-4412. Epub 2018 Jan 2.

a Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute , Morsani College of Medicine, University of South Florida , Tampa 33612 , FL , USA.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/07391102.2017.1
Publisher Site
http://dx.doi.org/10.1080/07391102.2017.1417163DOI Listing
December 2018

Arrestins: structural disorder creates rich functionality.

Protein Cell 2018 12 16;9(12):986-1003. Epub 2018 Feb 16.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13238-017-0501-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251804PMC
December 2018

Correction to: Variability of Some Milk-Associated Genes and Proteins in Several Breeds of Saudi Arabian Camels.

Protein J 2018 12;37(6):622

Biological Sciences Department, Faculty of Sciences, King Abdulaziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10930-018-9788-4DOI Listing
December 2018

On the relationship between the conserved 'black' and 'gray' structural clusters and intrinsic disorder in parvalbumins.

Int J Biol Macromol 2018 Dec 30;120(Pt A):1055-1062. Epub 2018 Aug 30.

Institute for Biological Instrumentation of the Russian Academy of Sciences, Pushchino, Moscow region 142290, Russia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2018.08.183DOI Listing
December 2018

Intrinsically Disordered Proteins and the Janus Challenge.

Biomolecules 2018 12 18;8(4). Epub 2018 Dec 18.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://www.mdpi.com/2218-273X/8/4/179
Publisher Site
http://dx.doi.org/10.3390/biom8040179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315817PMC
December 2018

Intrinsically disordered proteins in crowded milieu: when chaos prevails within the cellular gumbo.

Cell Mol Life Sci 2018 Nov 31;75(21):3907-3929. Epub 2018 Jul 31.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-018-2894-9DOI Listing
November 2018

Born This Way: Using Intrinsic Disorder to Map the Connections between SLITRKs, TSHR, and Male Sexual Orientation.

Proteomics 2018 11 6;18(21-22):e1800307. Epub 2018 Sep 6.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201800307DOI Listing
November 2018

Flexibility of the Sec13/31 cage is influenced by the Sec31 C-terminal disordered domain.

J Struct Biol 2018 11 30;204(2):250-260. Epub 2018 Aug 30.

Institute of Molecular Biophysics, 91 Chieftan Way, Florida State University, Tallahassee, FL 32306, USA; Department of Chemistry and Biochemistry, 95 Chieftain Way, Florida State University, Tallahassee, FL 32306, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10478477183024
Publisher Site
http://dx.doi.org/10.1016/j.jsb.2018.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188663PMC
November 2018

Comprehensive analysis of the roles of 'black' and 'gray' clusters in structure and function of rat β-parvalbumin.

Cell Calcium 2018 11 27;75:64-78. Epub 2018 Aug 27.

Institute for Biological Instrumentation of the Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia; Department of Biomedical Engineering, Pushchino State Institute of Natural Sciences, Pushchino, Moscow Region, 142290, Russia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ceca.2018.08.005DOI Listing
November 2018

Taxonomic Landscape of the Dark Proteomes: Whole-Proteome Scale Interplay Between Structural Darkness, Intrinsic Disorder, and Crystallization Propensity.

Proteomics 2018 11 8;18(21-22):e1800243. Epub 2018 Oct 8.

Department of Computer Science, Virginia Commonwealth University, Richmond, VA, 23284, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201800243DOI Listing
November 2018

Intrinsically Disordered Proteins: The Dark Horse of the Dark Proteome.

Proteomics 2018 11 24;18(21-22):e1800061. Epub 2018 Oct 24.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201800061DOI Listing
November 2018

Effect of an Intrinsically Disordered Plant Stress Protein on the Properties of Water.

Biophys J 2018 11 22;115(9):1696-1706. Epub 2018 Sep 22.

Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00063495183106
Publisher Site
http://dx.doi.org/10.1016/j.bpj.2018.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224673PMC
November 2018

Bringing Darkness to Light: Intrinsic Disorder as a Means to Dig into the Dark Proteome.

Proteomics 2018 11;18(21-22):e1800352

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201800352DOI Listing
November 2018

The solvent side of proteinaceous membrane-less organelles in light of aqueous two-phase systems.

Int J Biol Macromol 2018 Oct 14;117:1224-1251. Epub 2018 Jun 14.

Department of Molecular Medicine, College of Medicine, Byrd Alzheimer's Institute, University of South Florida, Tampa, FL 33612, USA; Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow region 142290, Russia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijbiomac.2018.06.030DOI Listing
October 2018

Potential functions of LEA proteins from the brine shrimp Artemia franciscana - anhydrobiosis meets bioinformatics.

J Biomol Struct Dyn 2018 Sep 23;36(12):3291-3309. Epub 2017 Oct 23.

a Department of Biology , University of Louisville , Louisville 40292 , KY , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07391102.2017.1387177DOI Listing
September 2018

On the Regularities of the Polar Profiles of Proteins Related to Ebola Virus Infection and their Functional Domains.

Cell Biochem Biophys 2018 Sep 6;76(3):411-431. Epub 2018 Mar 6.

Department of Mathematics, Faculty of Sciences, Universidad Nacional Autonoma de México, Av. Universidad 3000, México City, 04510, Mexico.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12013-018-0839-4DOI Listing
September 2018

Functionally Aberrant Mutant KCNQ1 With Intermediate Heterozygous and Homozygous Phenotypes.

Can J Cardiol 2018 09 30;34(9):1174-1184. Epub 2018 Jun 30.

Departments of Medicine and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Cardiovascular Sciences, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cjca.2018.06.015DOI Listing
September 2018

Stabilizing proteins to prevent conformational changes required for amyloid fibril formation.

J Cell Biochem 2018 Sep 22. Epub 2018 Sep 22.

Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcb.27576DOI Listing
September 2018

Molecular Recognition Features in Zika Virus Proteome.

J Mol Biol 2018 08 7;430(16):2372-2388. Epub 2017 Nov 7.

School of Basic Sciences, Indian Institute of Technology Mandi, Himachal Pradesh 175005, India; BioX Center, Indian Institute of Technology Mandi, Himachal Pradesh, 175005, India. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2017.10.018DOI Listing
August 2018

A Statistical Approach to Detect Intrinsically Disordered Proteins Associated with Uterine Leiomyoma.

Protein Pept Lett 2018 ;25(5):483-491

Department of Computer Science and Engineering, Jadavpur University, Kolkata - 700032, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/0929866525666180326114325DOI Listing
August 2018

Dissection of the deep-blue autofluorescence changes accompanying amyloid fibrillation.

Arch Biochem Biophys 2018 08 24;651:13-20. Epub 2018 May 24.

Faculty of Physics, M.V. Lomonosov Moscow State University, Leninskie Gory, Moscow, 119991, Russia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abb.2018.05.019DOI Listing
August 2018

Chemical modifications of insulin: Finding a compromise between stability and pharmaceutical performance.

Int J Pharm 2018 Aug 8;547(1-2):450-468. Epub 2018 Jun 8.

Protein Chemistry Laboratory (PCL), Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2018.06.023DOI Listing
August 2018

Variability of Some Milk-Associated Genes and Proteins in Several Breeds of Saudi Arabian Camels.

Protein J 2018 08;37(4):333-352

Biology Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10930-018-9782-xDOI Listing
August 2018

Recombinant Fusion Protein Joining E Protein Domain III of Tick-Borne Encephalitis Virus and HSP70 of as an Antigen for the TI-Complexes.

Biomolecules 2018 08 25;8(3). Epub 2018 Aug 25.

Department of Biochemistry, Microbiology and Biotechnology, Far Eastern Federal University, Sukhanov St., 8, Vladivostok 690091, Russia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biom8030082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164642PMC
August 2018

Structure-Function Relationships in the Oligomeric NADPH-Dependent Assimilatory Sulfite Reductase.

Biochemistry 2018 07 4;57(26):3764-3772. Epub 2018 Jun 4.

Translational Science Laboratory, College of Medicine , Florida State University , Tallahassee , Florida 32306 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biochem.8b00446DOI Listing
July 2018

Functions of short lifetime biological structures at large: the case of intrinsically disordered proteins.

Brief Funct Genomics 2018 Jul 3. Epub 2018 Jul 3.

Department of Molecular Medicine, USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA and Laboratory of New Methods in Biology, Institute for Biological Instrumentation, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bfgp/ely023DOI Listing
July 2018

Mbd2-CP2c loop drives adult-type globin gene expression and definitive erythropoiesis.

Nucleic Acids Res 2018 06;46(10):4933-4949

Department of Life Science and Research Institute of Natural Sciences, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gky193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007553PMC
June 2018

The Use of Human, Bovine, and Camel Milk Albumins in Anticancer Complexes with Oleic Acid.

Protein J 2018 06;37(3):203-215

Therapeutic and Protective Proteins Laboratory, Protein Research Department, Genetic Engineering and Biotechnology Research Institute, City for Scientific Research and Technology Applications (SRTA-City), New Borg EL-Arab, 21934, Alexandria, Egypt.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10930-018-9770-1DOI Listing
June 2018

Anti-Correlation between the Dynamics of the Active Site Loop and C-Terminal Tail in Relation to the Homodimer Asymmetry of the Mouse Erythroid 5-Aminolevulinate Synthase.

Int J Mol Sci 2018 06 28;19(7). Epub 2018 Jun 28.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms19071899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073955PMC
June 2018

In Aqua Veritas: The Indispensable yet Mostly Ignored Role of Water in Phase Separation and Membrane-less Organelles.

Biochemistry 2018 05 19;57(17):2437-2451. Epub 2018 Jan 19.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine , University of South Florida , Tampa , Florida 33612 , United States.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.biochem.7b01215
Publisher Site
http://dx.doi.org/10.1021/acs.biochem.7b01215DOI Listing
May 2018

Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease.

Hum Mol Genet 2018 05;27(9):1514-1532

Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddy059DOI Listing
May 2018

Intrinsic Disorder and Posttranslational Modifications: The Darker Side of the Biological Dark Matter.

Front Genet 2018 4;9:158. Epub 2018 May 4.

Department of Molecular Medicine, USF Health Byrd Alzheimer's Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fgene.2018.00158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945825PMC
May 2018

Deciphering the dark proteome of Chikungunya virus.

Sci Rep 2018 04 11;8(1):5822. Epub 2018 Apr 11.

School of Basic Sciences, Indian Institute of Technology Mandi, Himachal Pradesh, 175005, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-23969-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895634PMC
April 2018

Intrinsically Disordered Proteome of Human Membrane-Less Organelles.

Proteomics 2018 03 21;18(5-6):e1700193. Epub 2017 Dec 21.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201700193DOI Listing
March 2018

Conserved Functional Dynamics: I Like to Move It, Move It!

Structure 2018 03;26(3):371-373

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; Institute for Biological Instrumentation, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2018.02.010DOI Listing
March 2018

Prediction of Disordered Regions and Their Roles in the Anti-Pathogenic and Immunomodulatory Functions of Butyrophilins.

Molecules 2018 Feb 4;23(2). Epub 2018 Feb 4.

Department of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah, PO Box 80203, Jeddah 21589, Saudi Arabia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules23020328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017450PMC
February 2018

Structural Impact of Phosphorylation and Dielectric Constant Variation on Synaptotagmin's IDR.

Biophys J 2018 02;114(3):550-561

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bpj.2017.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985037PMC
February 2018

Insights into the Molecular Mechanisms of Alzheimer's and Parkinson's Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology.

Int J Mol Sci 2018 Jan 24;19(2). Epub 2018 Jan 24.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms19020336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855558PMC
January 2018

Functional Analysis of Human Hub Proteins and Their Interactors Involved in the Intrinsic Disorder-Enriched Interactions.

Int J Mol Sci 2017 Dec 19;18(12). Epub 2017 Dec 19.

Department of Computer Science, Virginia Commonwealth University, Richmond, VA 23284, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms18122761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751360PMC
December 2017

In search for globally disordered apo-parvalbumins: Case of parvalbumin β-1 from coho salmon.

Cell Calcium 2017 11 7;67:53-64. Epub 2017 Sep 7.

Institute for Biological Instrumentation of the Russian Academy of Sciences, Pushchino, Moscow region, 142290, Russia; Pushchino State Institute of Natural Sciences, Pushchino, Moscow region, 142290, Russia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ceca.2017.08.011DOI Listing
November 2017

Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions.

Molecules 2017 11 24;22(12). Epub 2017 Nov 24.

Department of Molecular Medicine, College of Medicine, Byrd Alzheimer’s Institute, University of South Florida, Tampa, FL 33612, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules22122027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149999PMC
November 2017

Divergent Anticancer Activity of Free and Formulated Camel Milk α-Lactalbumin.

Cancer Invest 2017 Oct 26;35(9):610-623. Epub 2017 Sep 26.

a Department of Biological Sciences, Faculty of Sciences , King Abdulaziz University , Jeddah , Saudi Arabia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07357907.2017.1373783DOI Listing
October 2017

Paradoxes and wonders of intrinsic disorder: Stability of instability.

Intrinsically Disord Proteins 2017 16;5(1):e1327757. Epub 2017 Oct 16.

Department of Molecular Medicine and USF Health Byrd Alzheimer Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/21690707.2017.1
Publisher Site
http://dx.doi.org/10.1080/21690707.2017.1327757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149434PMC
October 2017

Flexibility of the "rigid" classics or rugged bottom of the folding funnels of myoglobin, lysozyme, RNase A, chymotrypsin, cytochrome , and carboxypeptidase A1.

Intrinsically Disord Proteins 2017 16;5(1):e1355205. Epub 2017 Oct 16.

Department of Molecular Medicine, USF Health Byrd Alzheimer Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/21690707.2017.1
Publisher Site
http://dx.doi.org/10.1080/21690707.2017.1355205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149440PMC
October 2017

How accurate are your simulations? Effects of confined aqueous volume and AMBER FF99SB and CHARMM22/CMAP force field parameters on structural ensembles of intrinsically disordered proteins: Amyloid-β in water.

Intrinsically Disord Proteins 2017 30;5(1):e1377813. Epub 2017 Oct 30.

Department of Molecular Medicine, USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21690707.2017.1377813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149486PMC
October 2017

Osmolyte-Like Stabilizing Effects of Low GdnHCl Concentrations on d-Glucose/d-Galactose-Binding Protein.

Int J Mol Sci 2017 Sep 19;18(9). Epub 2017 Sep 19.

Institute of Cytology of the Russian Academy of Sciences, Laboratory of Structural Dynamics, Stability and Folding of Proteins, Tikhoretsky av. 4, 194064 St. Petersburg, Russia.

View Article

Download full-text PDF

Source
http://www.mdpi.com/1422-0067/18/9/2008
Publisher Site
http://dx.doi.org/10.3390/ijms18092008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618657PMC
September 2017

A Comprehensive Survey of the Roles of Highly Disordered Proteins in Type 2 Diabetes.

Int J Mol Sci 2017 Sep 21;18(10). Epub 2017 Sep 21.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd. MDC07, Tampa, FL 33620, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms18102010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666700PMC
September 2017

Real Time Monitoring of Children, and Adults with Mental Disabilities Using a Low-Cost Non-Invasive Electronic Device.

Micromachines (Basel) 2017 Sep 28;8(10). Epub 2017 Sep 28.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33647, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/mi8100292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190192PMC
September 2017