Publications by authors named "Vladimir N Uversky"

100Publications

A Possible Path towards Rapid Development of Live-Attenuated SARS-CoV-2 Vaccines: Plunging into the Natural Pool.

Biomolecules 2020 10 14;10(10). Epub 2020 Oct 14.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

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http://dx.doi.org/10.3390/biom10101438DOI Listing
October 2020

Papain-like cysteine proteinase zone (PCP-zone) and PCP structural catalytic core (PCP-SCC) of enzymes with cysteine proteinase fold.

Int J Biol Macromol 2020 Oct 12. Epub 2020 Oct 12.

Structural Bioinformatics Laboratory, Faculty of Science and Engineering, Biochemistry, Åbo Akademi University, Turku 20520, Finland; Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Pushchino 142290, Russia.

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http://dx.doi.org/10.1016/j.ijbiomac.2020.10.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548629PMC
October 2020

DeepAdd: Protein function prediction from k-mer embedding and additional features.

Comput Biol Chem 2020 Sep 23;89:107379. Epub 2020 Sep 23.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd. MDC07, Tampa, FL, USA; USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd. MDC07, Tampa, FL, USA; Laboratory of New Methods in Biology, Institute for Biological Instrumentation, Russian Academy of Sciences, Institutskaya Str., 7, Pushchino, Moscow Region, 142290, Russia. Electronic address:

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http://dx.doi.org/10.1016/j.compbiolchem.2020.107379DOI Listing
September 2020

A Novel Strategy for the Development of Vaccines for SARS-CoV-2 (COVID-19) and Other Viruses Using AI and Viral Shell Disorder.

J Proteome Res 2020 Oct 2. Epub 2020 Oct 2.

Department of Molecular Medicine, USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida 33620, United States.

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http://dx.doi.org/10.1021/acs.jproteome.0c00672DOI Listing
October 2020

IDPology of the living cell: intrinsic disorder in the subcellular compartments of the human cell.

Cell Mol Life Sci 2020 Sep 30. Epub 2020 Sep 30.

Department of Computer Science, Virginia Commonwealth University, 401 West Main Street, Room E4225, Richmond, VA, 23284, USA.

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http://dx.doi.org/10.1007/s00018-020-03654-0DOI Listing
September 2020

Insulin fibrillation: toward strategies for attenuating the process.

Chem Commun (Camb) 2020 Sep;56(77):11354-11373

Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

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http://dx.doi.org/10.1039/d0cc05171cDOI Listing
September 2020

Household pets and SARS-CoV2 transmissibility in the light of the ACE2 intrinsic disorder status.

J Biomol Struct Dyn 2020 Sep 18:1-4. Epub 2020 Sep 18.

Biological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

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http://dx.doi.org/10.1080/07391102.2020.1821784DOI Listing
September 2020

Why COVID-19 Transmission Is More Efficient and Aggressive Than Viral Transmission in Previous Coronavirus Epidemics?

Biomolecules 2020 09 11;10(9). Epub 2020 Sep 11.

Biological Science Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.

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http://dx.doi.org/10.3390/biom10091312DOI Listing
September 2020

The Pathophysiological Significance of Fibulin-3.

Biomolecules 2020 Sep 8;10(9). Epub 2020 Sep 8.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford OX3 7LD, UK.

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http://dx.doi.org/10.3390/biom10091294DOI Listing
September 2020

Intrinsic Disorder in Human Proteins Encoded by Core Duplicon Gene Families.

J Phys Chem B 2020 Sep 3;124(37):8050-8070. Epub 2020 Sep 3.

Department of Molecular Medicine Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, Tampa, Florida 33612, United States.

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http://dx.doi.org/10.1021/acs.jpcb.0c07676DOI Listing
September 2020

The exquisite structural biophysics of the Golgi reassembly and stacking proteins.

Int J Biol Macromol 2020 Aug 29. Epub 2020 Aug 29.

Molecular Biophysics Laboratory, Physics Department, Ribeirão Preto School of Philosophy, Sciences and Literature, University of São Paulo, Ribeirão Preto, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2020.08.203DOI Listing
August 2020

Intrinsic disorder perspective of an interplay between the renin-angiotensin-aldosterone system and SARS-CoV-2.

Infect Genet Evol 2020 Aug 24;85:104510. Epub 2020 Aug 24.

Biological Science Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia; Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Pushchino, Moscow region 142290, Russia; Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Bruce B. Downs Blvd., MDC07, Tampa, FL 33612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.meegid.2020.104510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444473PMC
August 2020

On the roles of calcium and zinc ions in the formation of a catalytically active form of the metalloenzyme, l-alanyl-d-glutamate peptidase of the bacteriophage T5 (EndoT5).

Int J Biol Macromol 2020 Aug 22. Epub 2020 Aug 22.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA; Laboratory of New Methods in Biology, Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Pushchino, Moscow Region 142290, Russia. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2020.08.161DOI Listing
August 2020

Preface: Looking at the clouds through kaleidoscope.

Prog Mol Biol Transl Sci 2020 ;174:xiii-xx

Department of Molecular Medicine and Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, United States; The Laboratory of New Methods in Biology, Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Pushchino, Moscow Region, Russia. Electronic address:

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http://dx.doi.org/10.1016/S1877-1173(20)30132-0DOI Listing
January 2020

Disorder and cysteines in proteins: A design for orchestration of conformational see-saw and modulatory functions.

Prog Mol Biol Transl Sci 2020 27;174:331-373. Epub 2020 Jun 27.

Department of Chemistry and Biochemistry, School of Mathematics and Natural Sciences, University of Southern Mississippi, Hattiesburg, MS, United States; Center of Molecular and Cellular Biosciences, University of Southern Mississippi, Hattiesburg, MS, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.pmbts.2020.06.001DOI Listing
June 2020

Intrinsic disorder-based design of stable globular proteins.

Prog Mol Biol Transl Sci 2020 18;174:157-186. Epub 2020 Jun 18.

Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia. Electronic address:

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http://dx.doi.org/10.1016/bs.pmbts.2020.05.005DOI Listing
June 2020

Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis.

Prog Mol Biol Transl Sci 2020 2;174:1-78. Epub 2020 Apr 2.

School of Basic Sciences, Indian Institute of Technology, Mandi, Mandi, Himachal Pradesh, Mandi, India. Electronic address:

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http://dx.doi.org/10.1016/bs.pmbts.2020.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129803PMC
April 2020

Zooming into the Dark Side of Human Annexin-S100 Complexes: Dynamic Alliance of Flexible Partners.

Int J Mol Sci 2020 Aug 16;21(16). Epub 2020 Aug 16.

Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Pushchino, 142290 Moscow, Russia.

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http://dx.doi.org/10.3390/ijms21165879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461550PMC
August 2020

Biophysical characterization of intrinsically disordered human Golgi matrix protein GRASP65.

Int J Biol Macromol 2020 Nov 18;162:1982-1993. Epub 2020 Aug 18.

Department of Physics, Ribeirão Preto School of Philosophy, Science and Literature, University of Sao Paulo, Av. Bandeirantes 3900, 14040-901 Ribeirão Preto, SP, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2020.08.126DOI Listing
November 2020

On the origin of matrix mechanism in protocells and key problems of molecular biology.

J Biomol Struct Dyn 2020 Aug 21:1-12. Epub 2020 Aug 21.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

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http://dx.doi.org/10.1080/07391102.2020.1809523DOI Listing
August 2020

Shell Disorder Analysis Suggests That Pangolins Offered a Window for a Silent Spread of an Attenuated SARS-CoV-2 Precursor among Humans.

J Proteome Res 2020 Aug 27. Epub 2020 Aug 27.

Department of Molecular Medicine, USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida 33620, United States.

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http://dx.doi.org/10.1021/acs.jproteome.0c00460DOI Listing
August 2020

A multitude of signaling pathways associated with Alzheimer's disease and their roles in AD pathogenesis and therapy.

Med Res Rev 2020 Aug 11. Epub 2020 Aug 11.

School of Basic Sciences, Indian Institute of Technology Mandi, Kamand, Himachal Pradesh, India.

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http://dx.doi.org/10.1002/med.21719DOI Listing
August 2020

Loops linking secondary structure elements affect the stability of the molten globule intermediate state of apomyoglobin.

FEBS Lett 2020 Aug 8. Epub 2020 Aug 8.

Institute of Protein research RAS, Pushchino, Russia.

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http://dx.doi.org/10.1002/1873-3468.13905DOI Listing
August 2020

Drug Discovery Targeting the Disorder-To-Order Transition Regions through the Conformational Diversity Mimicking and Statistical Analysis.

Int J Mol Sci 2020 Jul 24;21(15). Epub 2020 Jul 24.

Department of Life Science and Research Institute for Natural Sciences, Hanyang University, Seoul 04763, Korea.

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http://dx.doi.org/10.3390/ijms21155248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432763PMC
July 2020

Understanding COVID-19 via comparative analysis of dark proteomes of SARS-CoV-2, human SARS and bat SARS-like coronaviruses.

Cell Mol Life Sci 2020 Jul 25. Epub 2020 Jul 25.

Department of Molecular Medicine, Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

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http://dx.doi.org/10.1007/s00018-020-03603-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382329PMC
July 2020

Analyzing IDPs in Interactomes.

Methods Mol Biol 2020 ;2141:895-945

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

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http://dx.doi.org/10.1007/978-1-0716-0524-0_46DOI Listing
January 2020

The latitude hypothesis, vitamin D, and SARS-Co-V2.

J Biomol Struct Dyn 2020 Jul 17:1-3. Epub 2020 Jul 17.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

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http://dx.doi.org/10.1080/07391102.2020.1794973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441773PMC
July 2020

On the potential role of exosomes in the COVID-19 reinfection/reactivation opportunity.

J Biomol Struct Dyn 2020 Jul 9:1-12. Epub 2020 Jul 9.

Biological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

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http://dx.doi.org/10.1080/07391102.2020.1790426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441802PMC
July 2020

Intrinsic disorder in protein sense-antisense recognition.

J Mol Recognit 2020 Oct 22;33(10):e2868. Epub 2020 Jun 22.

Laboratory of New Methods in Biology, Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Pushchino, Russia.

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http://dx.doi.org/10.1002/jmr.2868DOI Listing
October 2020

Japanese encephalitis virus - exploring the dark proteome and disorder-function paradigm.

FEBS J 2020 May 30. Epub 2020 May 30.

School of Basic Sciences, Indian Institute of Technology Mandi, India.

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http://dx.doi.org/10.1111/febs.15427DOI Listing
May 2020

Intrinsic Disorder in Tetratricopeptide Repeat Proteins.

Int J Mol Sci 2020 May 25;21(10). Epub 2020 May 25.

. Department of Molecular Medicine Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA.

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http://dx.doi.org/10.3390/ijms21103709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279152PMC
May 2020

Unstructured Biology of Proteins from Ubiquitin-Proteasome System: Roles in Cancer and Neurodegenerative Diseases.

Biomolecules 2020 May 21;10(5). Epub 2020 May 21.

School of Basic Sciences, Indian Institute of Technology Mandi, VPO Kamand, Himachal Pradesh 175005, India.

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http://dx.doi.org/10.3390/biom10050796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278180PMC
May 2020

Deciphering the structural intricacy in virulence effectors for proton-motive force mediated unfolding in type-III protein secretion.

Int J Biol Macromol 2020 Sep 11;159:18-33. Epub 2020 May 11.

Department of Structural Biology and Bioinformatics, CSIR-Indian Institute of Chemical Biology (CSIR-IICB), India; Academy of Scientific and Innovative Research (AcSIR), India. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2020.04.266DOI Listing
September 2020

Natural container for drug storage and delivery: chimeric GFP with embedded xenogenic peptide.

J Biomol Struct Dyn 2020 Jun 1:1-6. Epub 2020 Jun 1.

Institute of Protein research RAS, Pushchino, Russian Federation.

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http://dx.doi.org/10.1080/07391102.2020.1771423DOI Listing
June 2020

MMTR/Dmap1 Sets the Stage for Early Lineage Commitment of Embryonic Stem Cells by Crosstalk with PcG Proteins.

Cells 2020 May 11;9(5). Epub 2020 May 11.

Department of Life Science and Research Institute for Natural Sciences, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.

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http://dx.doi.org/10.3390/cells9051190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290897PMC
May 2020

In Vitro N-Terminal Acetylation of Bacterially Expressed Parvalbumins by N-Terminal Acetyltransferases from Escherichia coli.

Appl Biochem Biotechnol 2020 May 11. Epub 2020 May 11.

Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Pushchino, Moscow Region, 142290, Russia.

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http://dx.doi.org/10.1007/s12010-020-03324-8DOI Listing
May 2020

Serum albumin-mediated strategy for the effective targeting of SARS-CoV-2.

Med Hypotheses 2020 Apr 24;140:109790. Epub 2020 Apr 24.

School of Basic Sciences, Indian Institute of Technology Mandi, Mandi, Himachal Pradesh 175005, India; BioX Center, Indian Institute of Technology Mandi, Himachal Pradesh 175005, India. Electronic address:

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http://dx.doi.org/10.1016/j.mehy.2020.109790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195355PMC
April 2020

Dancing with Trojan horses: an interplay between the extracellular vesicles and viruses.

J Biomol Struct Dyn 2020 Apr 30:1-27. Epub 2020 Apr 30.

Biological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

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http://dx.doi.org/10.1080/07391102.2020.1756409DOI Listing
April 2020

Shell disorder analysis predicts greater resilience of the SARS-CoV-2 (COVID-19) outside the body and in body fluids.

Microb Pathog 2020 Jul 31;144:104177. Epub 2020 Mar 31.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA; Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow region, Russia.

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http://dx.doi.org/10.1016/j.micpath.2020.104177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118597PMC
July 2020

Folding and structural polymorphism of p53 C-terminal domain: One peptide with many conformations.

Arch Biochem Biophys 2020 05 14;684:108342. Epub 2020 Mar 14.

School of Basic Sciences, Indian Institute of Technology Mandi, VPO Kamand, Himachal Pradesh, 175005, India. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2020.108342DOI Listing
May 2020

NBCZone: Universal three-dimensional construction of eleven amino acids near the catalytic nucleophile and base in the superfamily of (chymo)trypsin-like serine fold proteases.

Int J Biol Macromol 2020 Jun 6;153:399-411. Epub 2020 Mar 6.

Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, 20520 Turku, Finland; Pharmaceutical Sciences Laboratory, Pharmacy, Faculty of Science and Engineering, Åbo Akademi University, 20520 Turku, Finland.

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http://dx.doi.org/10.1016/j.ijbiomac.2020.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124590PMC
June 2020

Mouse S100G protein exhibits properties characteristic of a calcium sensor.

Cell Calcium 2020 05 24;87:102185. Epub 2020 Feb 24.

Institute for Biological Instrumentation of the Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia.

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http://dx.doi.org/10.1016/j.ceca.2020.102185DOI Listing
May 2020

Rigidity of the Outer Shell Predicted by a Protein Intrinsic Disorder Model Sheds Light on the COVID-19 (Wuhan-2019-nCoV) Infectivity.

Biomolecules 2020 02 19;10(2). Epub 2020 Feb 19.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

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http://dx.doi.org/10.3390/biom10020331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072294PMC
February 2020

New technologies to analyse protein function: an intrinsic disorder perspective.

F1000Res 2020 10;9. Epub 2020 Feb 10.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, 33620, USA.

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http://dx.doi.org/10.12688/f1000research.20867.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014577PMC
February 2020

Structural facets of POU2F1 in light of the functional annotations and sequence-structure patterns.

J Biomol Struct Dyn 2020 Mar 2:1-13. Epub 2020 Mar 2.

Computer Science and Engineering, Jadavpur University, Kolkata, West Bengal, India.

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http://dx.doi.org/10.1080/07391102.2020.1733092DOI Listing
March 2020

Nipah shell disorder, modes of infection, and virulence.

Microb Pathog 2020 Apr 12;141:103976. Epub 2020 Jan 12.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA; Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow region, Russia. Electronic address:

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http://dx.doi.org/10.1016/j.micpath.2020.103976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126952PMC
April 2020

Nucleation-dependent amyloid fibrillation of human GRASP55 in aqueous solution.

Eur Biophys J 2020 Mar 8;49(2):133-143. Epub 2020 Jan 8.

Department of Physics, Ribeirão Preto School of Philosophy, Science and Literature, University of Sao Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, 14040-901, Brazil.

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http://dx.doi.org/10.1007/s00249-019-01419-7DOI Listing
March 2020

Granulins modulate liquid-liquid phase separation and aggregation of the prion-like C-terminal domain of the neurodegeneration-associated protein TDP-43.

J Biol Chem 2020 02 6;295(8):2506-2519. Epub 2020 Jan 6.

Department of Chemistry and Biochemistry, School of Mathematics and Natural Sciences, University of Southern Mississippi, Hattiesburg, Mississippi 39406

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http://dx.doi.org/10.1074/jbc.RA119.011501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039568PMC
February 2020

Intrinsic Disorder-Based Design of Stable Globular Proteins.

Biomolecules 2019 12 30;10(1). Epub 2019 Dec 30.

Institute of Protein Research, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia.

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http://dx.doi.org/10.3390/biom10010064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022990PMC
December 2019

The dark side of Alzheimer's disease: unstructured biology of proteins from the amyloid cascade signaling pathway.

Cell Mol Life Sci 2020 Oct 2;77(20):4163-4208. Epub 2020 Jan 2.

School of Basic Sciences, Indian Institute of Technology Mandi, Mandi, India.

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http://dx.doi.org/10.1007/s00018-019-03414-9DOI Listing
October 2020

Life in Phases: Intra- and Inter- Molecular Phase Transitions in Protein Solutions.

Biomolecules 2019 12 8;9(12). Epub 2019 Dec 8.

Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow, Russia.

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http://dx.doi.org/10.3390/biom9120842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995567PMC
December 2019

Evolutionary Analyses of Sequence and Structure Space Unravel the Structural Facets of SOD1.

Biomolecules 2019 12 4;9(12). Epub 2019 Dec 4.

Protein Folding and Dynamics Group, Structural Biology and Bio-informatics Division, CSIR-Indian Institute of Chemical Biology,4 Raja S.C.Mullick Road, Kolkata 700032, India.

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http://dx.doi.org/10.3390/biom9120826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995586PMC
December 2019

Many-to-one binding by intrinsically disordered protein regions.

Pac Symp Biocomput 2020 ;25:159-170

Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 410 W. 10th St, HS5000, Indianapolis, IN46202, USA,

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January 2020

Characterization of an Extensive Interface on Vitronectin for Binding to Plasminogen Activator Inhibitor-1: Adoption of Structure in an Intrinsically Disordered Region.

Biochemistry 2019 12 16;58(51):5117-5134. Epub 2019 Dec 16.

Department of Biological Sciences , Louisiana State University , Baton Rouge , Louisiana 70803 , United States.

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http://dx.doi.org/10.1021/acs.biochem.9b00605DOI Listing
December 2019

Comprehensive analysis of the molecular docking of small molecule inhibitors to the Aβ peptide and its Osaka-mutant: insights into the molecular mechanisms of Aβ-peptide inhibition.

J Biomol Struct Dyn 2020 Sep 9;38(15):4536-4566. Epub 2019 Dec 9.

Protein Research Group, Institute for Biological Instrumentation of the Russian Academy of Sciences, Pushchino, Russia.

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http://dx.doi.org/10.1080/07391102.2019.1697367DOI Listing
September 2020

Expanding the understanding of the heterogeneous nature of melanoma with bioinformatics and disorder-based proteomics.

Int J Biol Macromol 2020 May 16;150:1281-1293. Epub 2019 Nov 16.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; Protein Research Group, Institute for Biological Instrumentation of the Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2019.10.139DOI Listing
May 2020

Chemical complementarity between immune receptor CDR3s and IDH1 mutants correlates with increased survival for lower grade glioma.

Oncogene 2020 Feb 18;39(8):1773-1783. Epub 2019 Nov 18.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.

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http://dx.doi.org/10.1038/s41388-019-1101-2DOI Listing
February 2020

Understanding the penetrance of intrinsic protein disorder in rotavirus proteome.

Int J Biol Macromol 2020 Feb 15;144:892-908. Epub 2019 Nov 15.

Indian Institute of Technology Mandi, VPO Kamand, Himachal Pradesh 175005, India; BioX Center, Indian Institute of Technology Mandi, Himachal Pradesh, India. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2019.09.166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112477PMC
February 2020

Folding perspectives of an intrinsically disordered transactivation domain and its single mutation breaking the folding propensity.

Int J Biol Macromol 2020 Jul 13;155:1359-1372. Epub 2019 Nov 13.

School of Basic Sciences, Indian Institute of Technology Mandi, Himachal Pradesh 175005, India; BioX Centre, Indian Institute of Technology Mandi, VPO Kamand, 175005, India. Electronic address:

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July 2020

Zika and Flavivirus Shell Disorder: Virulence and Fetal Morbidity.

Biomolecules 2019 11 6;9(11). Epub 2019 Nov 6.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

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http://dx.doi.org/10.3390/biom9110710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920988PMC
November 2019

Targeting the NTPase site of Zika virus NS3 helicase for inhibitor discovery.

J Biomol Struct Dyn 2020 Oct 14;38(16):4827-4837. Epub 2019 Nov 14.

School of Basic Sciences, Indian Institute of Technology Mandi, Mandi, India.

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http://dx.doi.org/10.1080/07391102.2019.1689851DOI Listing
October 2020

Development of a MEL Cell-Derived Allograft Mouse Model for Cancer Research.

Cancers (Basel) 2019 Nov 1;11(11). Epub 2019 Nov 1.

Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.

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http://dx.doi.org/10.3390/cancers11111707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895914PMC
November 2019

Biophysical Elucidation of Amyloid Fibrillation Inhibition and Prevention of Secondary Nucleation by Cholic Acid: An Unexplored Function of Cholic Acid.

ACS Chem Neurosci 2019 11 29;10(11):4704-4715. Epub 2019 Oct 29.

Interdisciplinary Biotechnology Unit , Aligarh Muslim University , Aligarh 202002 , India.

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http://dx.doi.org/10.1021/acschemneuro.9b00482DOI Listing
November 2019

Intrinsic Disorder of the BAF Complex: Roles in Chromatin Remodeling and Disease Development.

Int J Mol Sci 2019 Oct 23;20(21). Epub 2019 Oct 23.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd. MDC07, Tampa, FL 33612, USA.

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http://dx.doi.org/10.3390/ijms20215260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862534PMC
October 2019

Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease.

Front Pharmacol 2019 18;10:1047. Epub 2019 Sep 18.

Department of Molecular Medicine, USF Byrd Institute, University of South Florida, Tampa, FL, United States.

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http://dx.doi.org/10.3389/fphar.2019.01047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759932PMC
September 2019

Modulating Insulin Fibrillation Using Engineered B-Chains with Mutated C-Termini.

Biophys J 2019 11 23;117(9):1626-1641. Epub 2019 Sep 23.

Department of Molecular Medicine and Byrd Alzheimer's Center and Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida; Laboratory of New Methods in Biology, Institute for Biological Instrumentation of the Russian Academy of Sciences, Pushchino, Moscow Oblast, Russia.

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http://dx.doi.org/10.1016/j.bpj.2019.09.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838759PMC
November 2019

Single-cell RNA-Seq: a next generation sequencing tool for a high-resolution view of the individual cell.

J Biomol Struct Dyn 2020 Aug 15;38(12):3730-3735. Epub 2019 Sep 15.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

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http://dx.doi.org/10.1080/07391102.2019.1659859DOI Listing
August 2020

Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases.

Prog Mol Biol Transl Sci 2019 19;166:145-223. Epub 2019 Jul 19.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, United States; Laboratory of New Methods in Biology, Institute for Biological Instrumentation, Russian Academy of Sciences, Moscow, Russia. Electronic address:

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http://dx.doi.org/10.1016/bs.pmbts.2019.05.007DOI Listing
April 2020

Protein intrinsic disorder and structure-function continuum.

Prog Mol Biol Transl Sci 2019 8;166:1-17. Epub 2019 Jun 8.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, United States; Laboratory of New Methods in Biology, Institute for Biological Instrumentation, Russian Academy of Sciences, Moscow, Russia. Electronic address:

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http://dx.doi.org/10.1016/bs.pmbts.2019.05.003DOI Listing
April 2020

Driving Forces of Liquid-Liquid Phase Separation in Biological Systems.

Biomolecules 2019 09 10;9(9). Epub 2019 Sep 10.

Department of Molecular Medicine and Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

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http://dx.doi.org/10.3390/biom9090473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770153PMC
September 2019

Supramolecular Fuzziness of Intracellular Liquid Droplets: Liquid-Liquid Phase Transitions, Membrane-Less Organelles, and Intrinsic Disorder.

Molecules 2019 Sep 7;24(18). Epub 2019 Sep 7.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd. MDC07, Tampa, FL 33612, USA.

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http://dx.doi.org/10.3390/molecules24183265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767272PMC
September 2019

Structural and functional analysis of "non-smelly" proteins.

Cell Mol Life Sci 2020 Jun 5;77(12):2423-2440. Epub 2019 Sep 5.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC07, Tampa, FL, 33612, USA.

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June 2020

Structure Determination by Single-Particle Cryo-Electron Microscopy: Only the Sky (and Intrinsic Disorder) is the Limit.

Int J Mol Sci 2019 Aug 27;20(17). Epub 2019 Aug 27.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

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http://dx.doi.org/10.3390/ijms20174186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747279PMC
August 2019

Multi-functionality of proteins involved in GPCR and G protein signaling: making sense of structure-function continuum with intrinsic disorder-based proteoforms.

Cell Mol Life Sci 2019 Nov 19;76(22):4461-4492. Epub 2019 Aug 19.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

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http://dx.doi.org/10.1007/s00018-019-03276-1DOI Listing
November 2019

5-Aminolevulinate synthase catalysis: The catcher in heme biosynthesis.

Mol Genet Metab 2019 11 13;128(3):178-189. Epub 2019 Jun 13.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; Department of Global Health, College of Public Health, University of South Florida, Tampa, FL 33612, USA; Department of Chemistry, College of Arts and Sciences, University of South Florida, Tampa, FL 33612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2019.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908770PMC
November 2019

An interplay of structure and intrinsic disorder in the functionality of peptidylarginine deiminases, a family of key autoimmunity-related enzymes.

Cell Mol Life Sci 2019 Dec 24;76(23):4635-4662. Epub 2019 Jul 24.

Biological Sciences Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia.

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http://dx.doi.org/10.1007/s00018-019-03237-8DOI Listing
December 2019

Experimental Insight into the Structural and Functional Roles of the 'Black' and 'Gray' Clusters in Recoverin, a Calcium Binding Protein with Four EF-Hand Motifs.

Molecules 2019 Jul 8;24(13). Epub 2019 Jul 8.

Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, 142290 Pushchino, Russia.

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http://dx.doi.org/10.3390/molecules24132494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650976PMC
July 2019

Analyzing aggregation propensities of clinically relevant PTEN mutants: a new culprit in pathogenesis of cancer and other PTENopathies.

J Biomol Struct Dyn 2020 May 22;38(8):2253-2266. Epub 2019 Jun 22.

Department of Pathology and Cell Biology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

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http://dx.doi.org/10.1080/07391102.2019.1630005DOI Listing
May 2020

Can a retro-polypeptide fold into a globule?

J Biomol Struct Dyn 2020 Jun 2;38(9):2763-2767. Epub 2019 Jul 2.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

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http://dx.doi.org/10.1080/07391102.2019.1635045DOI Listing
June 2020

Ferroptosis - An iron- and disorder-dependent programmed cell death.

Int J Biol Macromol 2019 Aug 5;135:1052-1069. Epub 2019 Jun 5.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; Protein Research Group, Institute for Biological Instrumentation of the Russian Academy of Sciences, 142290 Pushchino, Moscow region, Russia. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2019.05.221DOI Listing
August 2019

Codon selection reduces GC content bias in nucleic acids encoding for intrinsically disordered proteins.

Cell Mol Life Sci 2020 Jan 7;77(1):149-160. Epub 2019 Jun 7.

Department of Computer Science, Virginia Commonwealth University, Richmond, VA, 23284, USA.

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http://dx.doi.org/10.1007/s00018-019-03166-6DOI Listing
January 2020

Intrinsic Disorder-Based Emergence in Cellular Biology: Physiological and Pathological Liquid-Liquid Phase Transitions in Cells.

Polymers (Basel) 2019 Jun 4;11(6). Epub 2019 Jun 4.

Department of Molecular Medicine and Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

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http://dx.doi.org/10.3390/polym11060990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631845PMC
June 2019

The Structural and Functional Diversity of Intrinsically Disordered Regions in Transmembrane Proteins.

J Membr Biol 2019 10 28;252(4-5):273-292. Epub 2019 May 28.

Molecular Biophysics Unit, Biological Sciences Division, Indian Institute of Science, Bangalore, Karnataka, 560012, India.

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http://dx.doi.org/10.1007/s00232-019-00069-2DOI Listing
October 2019

Bioinformatics characterisation of the (mutated) proteins related to Andersen-Tawil syndrome.

Math Biosci Eng 2019 03;16(4):2532-2548

Department of Biochemistry, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", México City, México.

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http://dx.doi.org/10.3934/mbe.2019127DOI Listing
March 2019

HIV Vaccine Mystery and Viral Shell Disorder.

Biomolecules 2019 05 8;9(5). Epub 2019 May 8.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

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http://dx.doi.org/10.3390/biom9050178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572542PMC
May 2019

Stochasticity of Biological Soft Matter: Emerging Concepts in Intrinsically Disordered Proteins and Biological Phase Separation.

Trends Biochem Sci 2019 08 22;44(8):716-728. Epub 2019 Apr 22.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2019.03.005DOI Listing
August 2019

Network mapping of the conformational heterogeneity of SOD1 by deploying statistical cluster analysis of FTIR spectra.

Cell Mol Life Sci 2019 Oct 22;76(20):4145-4154. Epub 2019 Apr 22.

Protein Folding and Dynamics Laboratory, Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, 700032, India.

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http://link.springer.com/10.1007/s00018-019-03108-2
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October 2019

Intrinsically Disordered Proteins in Chronic Diseases.

Biomolecules 2019 04 11;9(4). Epub 2019 Apr 11.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

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http://dx.doi.org/10.3390/biom9040147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523076PMC
April 2019

Synergistic Killing of Pathogenic Escherichia coli Using Camel Lactoferrin from Different Saudi Camel Clans and Various Antibiotics.

Protein J 2019 08;38(4):479-496

Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, P.O. Box 80203, Jeddah, Saudi Arabia.

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http://dx.doi.org/10.1007/s10930-019-09828-5DOI Listing
August 2019

Analyzing the structural and functional roles of residues from the 'black' and 'gray' clusters of human S100P protein.

Cell Calcium 2019 06 28;80:46-55. Epub 2019 Mar 28.

Institute for Biological Instrumentation of the Russian Academy of Sciences, Pushchino, Moscow region, 142290, Russia; Department of Biomedical Engineering, Pushchino State Institute of Natural Sciences, Pushchino, Moscow region, 142290, Russia.

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http://dx.doi.org/10.1016/j.ceca.2019.03.008DOI Listing
June 2019

Sequential and Asynchronous Strengthening of the Influence of Temperature on the Endo- and Exocytosis of Insulin in the Isolated Vertebrata Hepatocytes: Summing up Previous Studies.

Curr Protein Pept Sci 2020 ;21(1):22-35

Department of Molecular Medicine and Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States.

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http://dx.doi.org/10.2174/1389203720666190325101804DOI Listing
January 2020