Vladimir Lazar

Vladimir Lazar

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Vladimir Lazar

Vladimir Lazar

Publications by authors named "Vladimir Lazar"

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Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA.

Cancer Immunol Res 2019 Jul 4;7(7):1120-1134. Epub 2019 Jun 4.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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http://dx.doi.org/10.1158/2326-6066.CIR-19-0023DOI Listing
July 2019

Genetic alterations in sporadic triple negative breast cancer.

Breast 2018 Apr 5;38:30-38. Epub 2017 Dec 5.

Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Cluj, Romania; Department of Functional Genomics and Experimental Pathology, The Oncology Institute "Prof. Dr. I Chiricuta", Cluj-Napoca, Cluj, Romania; MEDFUTURE Research Center for Advanced Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09609776173077
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http://dx.doi.org/10.1016/j.breast.2017.11.006DOI Listing
April 2018

Association of Biomarker-Based Treatment Strategies With Response Rates and Progression-Free Survival in Refractory Malignant Neoplasms: A Meta-analysis.

JAMA Oncol 2016 Nov;2(11):1452-1459

Center for Personalized Cancer Therapy, Division of Hematology and Oncology, University of California, San Diego3Worldwide Innovative Network for Personalized Cancer Therapy, Villejuif, France.

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http://dx.doi.org/10.1001/jamaoncol.2016.2129DOI Listing
November 2016

Novel insight into triple-negative breast cancers, the emerging role of angiogenesis, and antiangiogenic therapy.

Expert Rev Mol Med 2016 11 7;18:e18. Epub 2016 Nov 7.

Research Centre for Functional Genomics,Biomedicine and Translational Medicine,Iuliu Hatieganu University of Medicine and Pharmacy,Cluj-Napoca,Romania.

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http://dx.doi.org/10.1017/erm.2016.17DOI Listing
November 2016

DUX4-induced constitutive DNA damage and oxidative stress contribute to aberrant differentiation of myoblasts from FSHD patients.

Free Radic Biol Med 2016 10 9;99:244-258. Epub 2016 Aug 9.

UMR 8126, Univ. Paris-Sud, CNRS, Institut de Cancérologie Gustave-Roussy, F-94805 Villejuif, France; Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, 119991 Moscow, Russia. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.08.007DOI Listing
October 2016

Identifying and Assessing Interesting Subgroups in a Heterogeneous Population.

Biomed Res Int 2015 3;2015:462549. Epub 2015 Aug 3.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.

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http://dx.doi.org/10.1155/2015/462549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539210PMC
May 2016

Impact of Precision Medicine in Diverse Cancers: A Meta-Analysis of Phase II Clinical Trials.

J Clin Oncol 2015 Nov 24;33(32):3817-25. Epub 2015 Aug 24.

Maria Schwaederle, Melissa Zhao, and Razelle Kurzrock, Center for Personalized Cancer Therapy, University of California, San Diego, Moores Cancer Center, La Jolla, CA; J. Jack Lee and John Mendelsohn, The University of Texas MD Anderson Cancer Center, Houston, TX; Richard L. Schilsky, American Society of Clinical Oncology, Alexandria, VA; Alexander M. Eggermont and Vladimir Lazar, Institut Gustave Roussy, University Paris-Sud; and Alexander M. Eggermont, Richard L. Schilsky, John Mendelsohn, Vladimir Lazar, and Razelle Kurzrock, Worldwide Innovative Network in Personalized Cancer Medicine, Villejuif, France.

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http://jco.ascopubs.org/content/33/32/3817.full.pdf
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.61.5997
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http://dx.doi.org/10.1200/JCO.2015.61.5997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737863PMC
November 2015

Impact of a Biomarker-Based Strategy on Oncology Drug Development: A Meta-analysis of Clinical Trials Leading to FDA Approval.

J Natl Cancer Inst 2015 Nov 15;107(11). Epub 2015 Sep 15.

Department of Clinical Medicine, Hemocentro da Unicamp, University of Campinas, Sao Paulo, Brazil (DLFJ); Department of Clinical Oncology, Hospital Sirio Libanes, Sao Paulo, Brazil (DLFJ); Center for Personalized Cancer Therapy and Division of Hematology and Oncology, University of California, San Diego, CA (MS, RK); Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX (CW, JJL); Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center, Houston, TX (DSH); Department of Functional Genomics, Institut Gustave Roussy, University Paris-Sud, Villejuif, France (AME, VL); Worldwide Innovative Network in Personalized Cancer Medicine, Villejuif, France (AME, RLS, JM, VL, RK); American Society of Clinical Oncology, Alexandria, VA (RLS); The University of Texas MD Anderson Cancer Center, Houston, TX (JM).

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http://jnci.oxfordjournals.org/content/107/11/djv253.full.pd
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http://jnci.oxfordjournals.org/content/108/3/djv430.full.pdf
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http://jnci.oxfordjournals.org/lookup/doi/10.1093/jnci/djv25
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http://dx.doi.org/10.1093/jnci/djv253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857149PMC
November 2015

Chk1 as a new therapeutic target in triple-negative breast cancer.

Breast 2014 Jun 15;23(3):250-8. Epub 2014 Mar 15.

Institut National de la Santé et de la Recherche Médicale (INSERM) UMR981, Villejuif F-94800, France.

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http://dx.doi.org/10.1016/j.breast.2014.02.004DOI Listing
June 2014

BMP7 expression correlates with secondary drug resistance in mantle cell lymphoma.

PLoS One 2013 12;8(9):e73993. Epub 2013 Sep 12.

Institut de Recherche Intégrée en cancérologie à Villejuif (IRCIV), Institut de cancérologie Gustave Roussy, Villejuif, France ; Institut National de la Santé et de la Recherche Médicale (INSERM) U1009, Université Paris Sud, Institut de cancérologie Gustave Roussy, Villejuif, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073993PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771972PMC
May 2014

Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes.

J Cell Mol Med 2014 Feb 17;18(2):208-17. Epub 2013 Dec 17.

UMR8126, Université Paris-Sud 11, CNRS, Institut de cancérologie Gustave Roussy, Villejuif, France; INSERM U1046, Université Montpellier I, Montpellier, France.

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http://dx.doi.org/10.1111/jcmm.12182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930408PMC
February 2014

Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers.

Clin Breast Cancer 2013 Oct 3;13(5):401-8. Epub 2013 Jul 3.

INSERM U981 "Identification of molecular predictors and new targets for cancer treatment", Gustave Roussy Cancer Institute, Villejuif, France.

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http://dx.doi.org/10.1016/j.clbc.2013.02.001DOI Listing
October 2013

Quantitative proteomics profiling of primary lung adenocarcinoma tumors reveals functional perturbations in tumor metabolism.

J Proteome Res 2013 Sep 13;12(9):3934-43. Epub 2013 Aug 13.

Cancer Proteomics Mass Spectrometry, Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1021/pr4002096DOI Listing
September 2013

Loss of microRNA-200a and c, and microRNA-203 expression at the invasive front of primary cutaneous melanoma is associated with increased thickness and disease progression.

Virchows Arch 2012 Oct 6;461(4):441-8. Epub 2012 Sep 6.

Lady Davis Institute for Medical Research, Jewish General Hospital, LDI-E447, 3755 Cote Ste-Catherine, Montreal, QC, Canada H3T 1E2.

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http://dx.doi.org/10.1007/s00428-012-1309-9DOI Listing
October 2012

Network enrichment analysis: extension of gene-set enrichment analysis to gene networks.

BMC Bioinformatics 2012 Sep 11;13:226. Epub 2012 Sep 11.

School of Biotechnology, Royal Institute of Technology, Stockholm, Sweden.

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http://dx.doi.org/10.1186/1471-2105-13-226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505158PMC
September 2012

WIN Consortium--challenges and advances.

Nat Rev Clin Oncol 2011 Mar;8(3):133-4

The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/nrclinonc.2010.230DOI Listing
March 2011

Implications of personalized medicine--perspective from a cancer center.

Nat Rev Clin Oncol 2011 03;8(3):177-83

Department of Medical Oncology and INSERM U981, Institut Gustave Roussy, 39 Rue Camilles Desmoulins, Villejuif 94805, France.

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http://www.nature.com/articles/nrclinonc.2010.222
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http://dx.doi.org/10.1038/nrclinonc.2010.222DOI Listing
March 2011

Amplification of fibroblast growth factor receptor-1 in breast cancer and the effects of brivanib alaninate.

Breast Cancer Res Treat 2010 Oct 19;123(3):747-55. Epub 2009 Dec 19.

Department of Breast Medical Oncology, Unit 1354, The University of Texas M. D. Anderson Cancer Center, P.O. Box 301439, Houston, TX 77230-1439, USA.

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http://dx.doi.org/10.1007/s10549-009-0677-6DOI Listing
October 2010

Cancer-related forecast biomarkers: a topic in focus of the Worldwide Innovative Network in Personalized Cancer Medicine (WIN).

Bioanalysis 2010 May;2(5):851-3

Clinical Research Unit, Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Germany.

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http://dx.doi.org/10.4155/bio.10.47DOI Listing
May 2010

Exonic expression profiling of breast cancer and benign lesions: a retrospective analysis.

Lancet Oncol 2009 Apr 25;10(4):381-90. Epub 2009 Feb 25.

Breast Cancer Unit, Department of Medical Oncology, Institut Gustave Roussy France, Villejuif, France.

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http://dx.doi.org/10.1016/S1470-2045(09)70024-5DOI Listing
April 2009

FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase.

J Immunol 2008 Sep;181(5):2980-9

Institut Cochin, Université Paris Descartes, Centre National de la Recherche Scientifique (Unité Mixte de Recherche 8104), Equipe labellisée par la Ligue Nationale contre le Cancer, Paris, France.

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http://dx.doi.org/10.4049/jimmunol.181.5.2980DOI Listing
September 2008

Preprocalcitonin signal peptide generates a cytotoxic T lymphocyte-defined tumor epitope processed by a proteasome-independent pathway.

Proc Natl Acad Sci U S A 2008 Jul 14;105(29):10119-24. Epub 2008 Jul 14.

Institut National de la Santé et de la Recherche Médicale, Unité 753, Laboratoire Immunologie des Tumeurs Humaines, Villejuif, France.

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http://dx.doi.org/10.1073/pnas.0802753105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481335PMC
July 2008

TWIST microdeletion identified by array CGH in a patient presenting Saethre-Chotzen phenotype and a complex rearrangement involving chromosomes 2 and 7.

Eur J Med Genet 2008 Mar-Apr;51(2):156-64. Epub 2007 Dec 24.

Hospices Civils de Lyon, Service de Cytogénétique Constitutionnelle - Centre de Biologie et de Pathologie Est, 59 Boulevard Pinel, Bron 69677 Cedex, France.

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http://dx.doi.org/10.1016/j.ejmg.2007.12.003DOI Listing
June 2008

Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis.

J Exp Med 2007 Mar 26;204(3):559-70. Epub 2007 Feb 26.

Institut National de la Santé et de la Recherche Médicale (INSERM) U753 and 2Unité de génomique fonctionnelle, Institut Fédératif de Recherche (IFR)-54, Institut Gustave Roussy, Villejuif Cedex 94805, France.

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http://dx.doi.org/10.1084/jem.20061524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137907PMC
March 2007

The THAP-zinc finger protein THAP1 regulates endothelial cell proliferation through modulation of pRB/E2F cell-cycle target genes.

Blood 2007 Jan 26;109(2):584-94. Epub 2006 Sep 26.

Laboratoire de Biologie Vasculaire, Equipe labellisée La Ligue 2006, Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique Unité mixte de recherche, Toulouse, France.

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http://dx.doi.org/10.1182/blood-2006-03-012013DOI Listing
January 2007

Microarray-based identification of tenascin C and tenascin XB, genes possibly involved in tumorigenesis associated with neurofibromatosis type 1.

Clin Cancer Res 2007 Jan 3;13(2 Pt 1):398-407. Epub 2007 Jan 3.

Laboratoire de Génétique Moléculaire-Institut National de la Sante et de la Recherche Medicale U745, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris V, 4 avenue de l'Observatoire, Paris, France.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-06-0182DOI Listing
January 2007

Expression and possible role of hPTTG1/securin in cutaneous malignant melanoma.

Mod Pathol 2006 Sep 23;19(9):1170-80. Epub 2006 Jun 23.

Department of Morphology and Molecular Pathology, University Hospitals, Katholieke Universiteit Leuven (KUL), Leuven, Belgium.

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http://dx.doi.org/10.1038/modpathol.3800627DOI Listing
September 2006

Epstein-Barr virus nuclear antigen 2 induces interleukin-18 receptor expression in B cells.

Blood 2005 Feb 21;105(4):1632-9. Epub 2004 Oct 21.

Institut National de la Santé et de la Recherche Médicale (INSERM) U255, Centre de Recherche Biomédicale des Cordeliers, Paris, France.

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http://dx.doi.org/10.1182/blood-2004-08-3196DOI Listing
February 2005

Irofulven cytotoxicity depends on transcription-coupled nucleotide excision repair and is correlated with XPG expression in solid tumor cells.

Clin Cancer Res 2004 Aug;10(16):5604-13

Group of Biology and Pharmacogenetics of Human Tumors, Centre National de la Recherche Scientifique, UMR 8113, Institut Gustave-Roussy, Villejuif, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-0442DOI Listing
August 2004

Epigenetic regulation of an IAP retrotransposon in the aging mouse: progressive demethylation and de-silencing of the element by its repetitive induction.

Nucleic Acids Res 2002 Jun;30(11):2365-73

Unité des Rétrovirus Endogènes et Eléments Rétroïdes des Eucaryotes Supérieurs, UMR 1573 CNRS, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC117196PMC
http://dx.doi.org/10.1093/nar/30.11.2365DOI Listing
June 2002