Vladimir Kren

Vladimir Kren

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Vladimir Kren

Vladimir Kren

Publications by authors named "Vladimir Kren"

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Dual SMO/BRAF Inhibition by Flavonolignans from .

Antioxidants (Basel) 2020 May 5;9(5). Epub 2020 May 5.

Department of QSAR and Molecular Modelling, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.

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http://dx.doi.org/10.3390/antiox9050384DOI Listing
May 2020

Multidrug Resistance Modulation Activity of Silybin Derivatives and Their Anti-inflammatory Potential.

Antioxidants (Basel) 2020 May 25;9(5). Epub 2020 May 25.

Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, CZ 166 28 Prague, Czech Republic.

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http://dx.doi.org/10.3390/antiox9050455DOI Listing
May 2020

Defying Multidrug Resistance! Modulation of Related Transporters by Flavonoids and Flavonolignans.

J Agric Food Chem 2020 Feb 3;68(7):1763-1779. Epub 2019 Apr 3.

Laboratory of Biotransformation , Institute of Microbiology, Czech Academy of Sciences , Vídeňská 1083 , CZ 142 20 Prague , Czech Republic.

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http://pubs.acs.org/doi/10.1021/acs.jafc.9b00694
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http://dx.doi.org/10.1021/acs.jafc.9b00694DOI Listing
February 2020

A novel enzymatic tool for transferring GalNAc moiety onto challenging acceptors.

Biochim Biophys Acta Proteins Proteom 2020 02 15;1868(2):140319. Epub 2019 Nov 15.

Institute of Microbiology, Czech Academy of Sciences, Vídeňská 1083, CZ-14220 Praha 4, Czech Republic; Department of Health Care Disciplines and Population Protection, Faculty of Biomedical Engineering, Czech Technical University in Prague, Nám. Sítná 3105, CZ-272 01 Kladno, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2019.140319DOI Listing
February 2020

High-Affinity -(2-Hydroxypropyl)methacrylamide Copolymers with Tailored -Acetyllactosamine Presentation Discriminate between Galectins.

Biomacromolecules 2020 Feb 23;21(2):641-652. Epub 2020 Jan 23.

Institute of Macromolecular Chemistry , Czech Academy of Sciences , Heyrovského náměstí 2 , CZ-162 06 Prague 6 , Czech Republic.

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http://dx.doi.org/10.1021/acs.biomac.9b01370DOI Listing
February 2020

Liquid chromatography-drift tube ion mobility-mass spectrometry as a new challenging tool for the separation and characterization of silymarin flavonolignans.

Anal Bioanal Chem 2020 Feb 9;412(4):819-832. Epub 2020 Jan 9.

Department of Food Analysis and Nutrition, University of Chemistry and Technology, Technická 3, 16628, Prague 6, Czech Republic.

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http://dx.doi.org/10.1007/s00216-019-02274-3DOI Listing
February 2020

response of human ovarian cancer cells to dietary bioflavonoid isoquercitrin.

J Environ Sci Health B 2019 4;54(9):752-757. Epub 2019 Jul 4.

Faculty of Biotechnology and Food Sciences , Slovak University of Agriculture in Nitra , Nitra , Slovak Republic.

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http://dx.doi.org/10.1080/03601234.2019.1633214DOI Listing
January 2020

Identification of UDP-glucuronosyltransferases involved in the metabolism of silymarin flavonolignans.

J Pharm Biomed Anal 2020 Jan 4;178:112972. Epub 2019 Nov 4.

Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, Olomouc 77515, Czech Republic.

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http://dx.doi.org/10.1016/j.jpba.2019.112972DOI Listing
January 2020

Biotransformation of Silymarin Flavonolignans by Human Fecal Microbiota.

Metabolites 2020 Jan 9;10(1). Epub 2020 Jan 9.

Laboratory of Biotransformation, Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, 14220 Prague, Czech Republic.

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http://dx.doi.org/10.3390/metabo10010029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023230PMC
January 2020

Rutinosidase from Aspergillus niger: crystal structure and insight into the enzymatic activity.

FEBS J 2020 Jan 13. Epub 2020 Jan 13.

Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic.

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http://dx.doi.org/10.1111/febs.15208DOI Listing
January 2020

Simple and Rapid HPLC Separation and Quantification of Flavonoid, Flavonolignans, and 2,3-Dehydroflavonolignans in Silymarin.

Foods 2020 Jan 21;9(2). Epub 2020 Jan 21.

Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ 142 20 Prague, Czech Republic.

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http://dx.doi.org/10.3390/foods9020116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073671PMC
January 2020

Potential of Mitochondria-Targeted Antioxidants to Prevent Oxidative Stress in Pancreatic -cells.

Oxid Med Cell Longev 2019 21;2019:1826303. Epub 2019 May 21.

Department of Mitochondrial Physiology, No. 75, Institute of Physiology of the Czech Academy of Sciences, Vídeňská 1083, Prague 14220, Czech Republic.

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http://dx.doi.org/10.1155/2019/1826303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556329PMC
December 2019

The flavonoid degrading fungus Acremonium sp. DSM 24697 produces two diglycosidases with different specificities.

Appl Microbiol Biotechnol 2019 Dec 8;103(23-24):9493-9504. Epub 2019 Nov 8.

Facultad de Ciencias Exactas y Naturales, Instituto de Ciencias de la Tierra y Ambientales de La Pampa (INCITAP), Universidad Nacional de La Pampa - Consejo Nacional de Investigaciones Científicas y Técnicas (UNLPam-CONICET), Av. Uruguay 151, 6300, Santa Rosa, La Pampa, Argentina.

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http://dx.doi.org/10.1007/s00253-019-10180-yDOI Listing
December 2019

Acceptor Specificity of β--Acetylhexosaminidase from : A Rational Explanation.

Int J Mol Sci 2019 Dec 7;20(24). Epub 2019 Dec 7.

Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ 14220 Prague 4, Czech Republic.

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http://dx.doi.org/10.3390/ijms20246181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940953PMC
December 2019

Redox properties of individual quercetin moieties.

Free Radic Biol Med 2019 11 2;143:240-251. Epub 2019 Aug 2.

Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, 775 15, Olomouc, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.08.001DOI Listing
November 2019

β-N-Acetylhexosaminidases-the wizards of glycosylation.

Appl Microbiol Biotechnol 2019 Oct 10;103(19):7869-7881. Epub 2019 Aug 10.

Laboratory of Biotransformation, Institute of Microbiology, Czech Academy of Sciences, Vídeňská 1083, CZ-14220, Praha 4, Czech Republic.

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http://dx.doi.org/10.1007/s00253-019-10065-0DOI Listing
October 2019

Identifying Efficient Toxin A Binders with a Multivalent Neo-Glycoprotein Glycan Library.

Bioconjug Chem 2019 09 9;30(9):2373-2383. Epub 2019 Sep 9.

Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering , RWTH Aachen University , Pauwelsstrasse 20 , 52074 Aachen , Germany.

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http://dx.doi.org/10.1021/acs.bioconjchem.9b00486DOI Listing
September 2019

Antioxidant, Anti-Inflammatory, and Multidrug Resistance Modulation Activity of Silychristin Derivatives.

Antioxidants (Basel) 2019 Aug 14;8(8). Epub 2019 Aug 14.

Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, CZ 166 28 Prague, Czech Republic.

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http://dx.doi.org/10.3390/antiox8080303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720199PMC
August 2019

Complex Evaluation of Antioxidant Capacity of Milk Thistle Dietary Supplements.

Antioxidants (Basel) 2019 Aug 18;8(8). Epub 2019 Aug 18.

Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague, Czech Republic.

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http://dx.doi.org/10.3390/antiox8080317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720444PMC
August 2019

Chemoenzymatic Synthesis and Radical Scavenging of Sulfated Hydroxytyrosol, Tyrosol, and Acetylated Derivatives.

J Agric Food Chem 2019 Jul 25;67(26):7281-7288. Epub 2019 Jun 25.

Institute of Microbiology , Czech Academy of Sciences , Vídeňská 1083 , Prague CZ 142 20 , Czech Republic.

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http://dx.doi.org/10.1021/acs.jafc.9b01065DOI Listing
July 2019

Preparation of Retinoyl-Flavonolignan Hybrids and Their Antioxidant Properties.

Antioxidants (Basel) 2019 Jul 23;8(7). Epub 2019 Jul 23.

Laboratory of Biotransformation, Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, 14220 Prague, Czech Republic.

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http://dx.doi.org/10.3390/antiox8070236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680806PMC
July 2019

Isolated Silymarin Flavonoids Increase Systemic and Hepatic Bilirubin Concentrations and Lower Lipoperoxidation in Mice.

Oxid Med Cell Longev 2019 12;2019:6026902. Epub 2019 Feb 12.

Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, Kateřinská 32, Praha 2 12000, Czech Republic.

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http://dx.doi.org/10.1155/2019/6026902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390243PMC
May 2019

Galectin-Carbohydrate Interactions in Biomedicine and Biotechnology.

Trends Biotechnol 2019 04 6;37(4):402-415. Epub 2018 Nov 6.

Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-14220 Prague 4, Czech Republic. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01677799183026
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http://dx.doi.org/10.1016/j.tibtech.2018.10.001DOI Listing
April 2019

Bioproduction of Quercetin and Rutinose Catalyzed by Rutinosidase: Novel Concept of "Solid State Biocatalysis".

Int J Mol Sci 2019 Mar 5;20(5). Epub 2019 Mar 5.

Institute of Microbiology of the Czech Academy of Sciences, Laboratory of Biotransformation, Vídeňská 1083, CZ 14220 Prague 4, Czech Republic.

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http://dx.doi.org/10.3390/ijms20051112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429052PMC
March 2019

Selective β-N-acetylhexosaminidase from Aspergillus versicolor-a tool for producing bioactive carbohydrates.

Appl Microbiol Biotechnol 2019 Feb 2;103(4):1737-1753. Epub 2019 Jan 2.

Laboratory of Biotransformation, Institute of Microbiology, Czech Academy of Sciences, Vídeňská 1083, CZ-14220, Prague 4, Czech Republic.

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http://dx.doi.org/10.1007/s00253-018-9534-zDOI Listing
February 2019

In vitro and in silico studies of the membrane permeability of natural flavonoids from Silybum marianum (L.) Gaertn. and their derivatives.

Phytomedicine 2019 Feb 5;53:79-85. Epub 2018 Sep 5.

Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 105, 1113 Sofia, Bulgaria. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2018.09.001DOI Listing
February 2019

The β--Acetylhexosaminidase in the Synthesis of Bioactive Glycans: Protein and Reaction Engineering.

Molecules 2019 Feb 8;24(3). Epub 2019 Feb 8.

Laboratory of Biotransformation, Institute of Microbiology, Czech Academy of Sciences, Vídeňská 1083, CZ-14220 Praha 4, Czech Republic.

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http://dx.doi.org/10.3390/molecules24030599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384963PMC
February 2019

Enzyme-mediated transglycosylation of rutinose (6-O-α-l-rhamnosyl-d-glucose) to phenolic compounds by a diglycosidase from Acremonium sp. DSM 24697.

Biotechnol Appl Biochem 2019 Jan 23;66(1):53-59. Epub 2018 Oct 23.

INCITAP (CONICET-UNLPam) National Scientific and Technical Research Council, Department of Chemistry, Faculty of Natural Sciences, National University of La Pampa (UNLPam), Santa Rosa, La Pampa, Argentina.

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http://dx.doi.org/10.1002/bab.1695DOI Listing
January 2019

Interaction of isolated silymarin flavonolignans with iron and copper.

J Inorg Biochem 2018 12 13;189:115-123. Epub 2018 Sep 13.

Laboratory of Biotransformation, Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic.

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http://dx.doi.org/10.1016/j.jinorgbio.2018.09.006DOI Listing
December 2018

KnowVolution Campaign of an Aryl Sulfotransferase Increases Activity toward Cellobiose.

Chemistry 2018 Nov 24;24(64):17117-17124. Epub 2018 Oct 24.

DWI-Leibniz Institute for Interactive Materials, Forckenbeckstraße 50, 52056, Aachen, Germany.

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http://dx.doi.org/10.1002/chem.201803729DOI Listing
November 2018

Crystal structure of native α-L-rhamnosidase from Aspergillus terreus.

Acta Crystallogr D Struct Biol 2018 Nov 29;74(Pt 11):1078-1084. Epub 2018 Oct 29.

Structural Biology, Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, 16610 Prague 6, Czech Republic.

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http://dx.doi.org/10.1107/S2059798318013049DOI Listing
November 2018

Biocatalytic production of mandelic acid and analogues: a review and comparison with chemical processes.

Appl Microbiol Biotechnol 2018 May 10;102(9):3893-3900. Epub 2018 Mar 10.

Laboratory of Biotransformation, Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-142 20, Prague, Czech Republic.

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http://dx.doi.org/10.1007/s00253-018-8894-8DOI Listing
May 2018

Metabolism of flavonolignans in human hepatocytes.

J Pharm Biomed Anal 2018 Apr 31;152:94-101. Epub 2018 Jan 31.

Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, Olomouc 77515, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2018.01.048DOI Listing
April 2018

Single-Gene Congenic Strain Reveals the Effect of on Dexamethasone-Induced Insulin Resistance.

Front Endocrinol (Lausanne) 2018 20;9:185. Epub 2018 Apr 20.

The First Faculty of Medicine, Institute of Biology and Medical Genetics, Charles University, The General Teaching Hospital, Prague, Czechia.

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http://journal.frontiersin.org/article/10.3389/fendo.2018.00
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http://dx.doi.org/10.3389/fendo.2018.00185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919955PMC
April 2018

Poly-N-Acetyllactosamine Neo-Glycoproteins as Nanomolar Ligands of Human Galectin-3: Binding Kinetics and Modeling.

Int J Mol Sci 2018 Jan 26;19(2). Epub 2018 Jan 26.

Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, 14220 Prague, Czech Republic.

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http://www.mdpi.com/1422-0067/19/2/372
Publisher Site
http://dx.doi.org/10.3390/ijms19020372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855594PMC
January 2018

Tailored Multivalent Neo-Glycoproteins: Synthesis, Evaluation, and Application of a Library of Galectin-3-Binding Glycan Ligands.

Bioconjug Chem 2017 11 18;28(11):2832-2840. Epub 2017 Oct 18.

Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University , Pauwelsstrasse 20, 52074 Aachen, Germany.

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http://dx.doi.org/10.1021/acs.bioconjchem.7b00520DOI Listing
November 2017

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

Authors:
Javier Egea Isabel Fabregat Yves M Frapart Pietro Ghezzi Agnes Görlach Thomas Kietzmann Kateryna Kubaichuk Ulla G Knaus Manuela G Lopez Gloria Olaso-Gonzalez Andreas Petry Rainer Schulz Jose Vina Paul Winyard Kahina Abbas Opeyemi S Ademowo Catarina B Afonso Ioanna Andreadou Haike Antelmann Fernando Antunes Mutay Aslan Markus M Bachschmid Rui M Barbosa Vsevolod Belousov Carsten Berndt David Bernlohr Esther Bertrán Alberto Bindoli Serge P Bottari Paula M Brito Guia Carrara Ana I Casas Afroditi Chatzi Niki Chondrogianni Marcus Conrad Marcus S Cooke João G Costa Antonio Cuadrado Pham My-Chan Dang Barbara De Smet Bilge Debelec-Butuner Irundika H K Dias Joe Dan Dunn Amanda J Edson Mariam El Assar Jamel El-Benna Péter Ferdinandy Ana S Fernandes Kari E Fladmark Ulrich Förstermann Rashid Giniatullin Zoltán Giricz Anikó Görbe Helen Griffiths Vaclav Hampl Alina Hanf Jan Herget Pablo Hernansanz-Agustín Melanie Hillion Jingjing Huang Serap Ilikay Pidder Jansen-Dürr Vincent Jaquet Jaap A Joles Balaraman Kalyanaraman Danylo Kaminskyy Mahsa Karbaschi Marina Kleanthous Lars-Oliver Klotz Bato Korac Kemal Sami Korkmaz Rafal Koziel Damir Kračun Karl-Heinz Krause Vladimír Křen Thomas Krieg João Laranjinha Antigone Lazou Huige Li Antonio Martínez-Ruiz Reiko Matsui Gethin J McBean Stuart P Meredith Joris Messens Verónica Miguel Yuliya Mikhed Irina Milisav Lidija Milković Antonio Miranda-Vizuete Miloš Mojović María Monsalve Pierre-Alexis Mouthuy John Mulvey Thomas Münzel Vladimir Muzykantov Isabel T N Nguyen Matthias Oelze Nuno G Oliveira Carlos M Palmeira Nikoletta Papaevgeniou Aleksandra Pavićević Brandán Pedre Fabienne Peyrot Marios Phylactides Gratiela G Pircalabioru Andrew R Pitt Henrik E Poulsen Ignacio Prieto Maria Pia Rigobello Natalia Robledinos-Antón Leocadio Rodríguez-Mañas Anabela P Rolo Francis Rousset Tatjana Ruskovska Nuno Saraiva Shlomo Sasson Katrin Schröder Khrystyna Semen Tamara Seredenina Anastasia Shakirzyanova Geoffrey L Smith Thierry Soldati Bebiana C Sousa Corinne M Spickett Ana Stancic Marie José Stasia Holger Steinbrenner Višnja Stepanić Sebastian Steven Kostas Tokatlidis Erkan Tuncay Belma Turan Fulvio Ursini Jan Vacek Olga Vajnerova Kateřina Valentová Frank Van Breusegem Lokman Varisli Elizabeth A Veal A Suha Yalçın Olha Yelisyeyeva Neven Žarković Martina Zatloukalová Jacek Zielonka Rhian M Touyz Andreas Papapetropoulos Tilman Grune Santiago Lamas Harald H H W Schmidt Fabio Di Lisa Andreas Daiber

Redox Biol 2017 10 18;13:94-162. Epub 2017 May 18.

Molecular Cardiology, Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany; DZHK (German Centre for Cardiovascular Research), partner site Rhine-Main, Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458069PMC
October 2017

Quercetin and its analogues: optical and acido-basic properties.

Phys Chem Chem Phys 2017 Oct;19(39):26870-26879

Department of Biophysics, Centre of the Region Haná for Biotechnological and Agricultural Research, Palacký University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic.

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http://dx.doi.org/10.1039/c7cp03845cDOI Listing
October 2017

The silymarin composition… and why does it matter???

Food Res Int 2017 10 12;100(Pt 3):339-353. Epub 2017 Jul 12.

Laboratory of Biotransformation, Institute of Microbiology, Czech Academy of Sciences, Vídeňská 1083, CZ14220 Prague, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.foodres.2017.07.017DOI Listing
October 2017

The Stoichiometry of Isoquercitrin Complex with Iron or Copper Is Highly Dependent on Experimental Conditions.

Nutrients 2017 Oct 30;9(11). Epub 2017 Oct 30.

Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.

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http://dx.doi.org/10.3390/nu9111193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707665PMC
October 2017

Oxidation of Natural Bioactive Flavonolignan 2,3-Dehydrosilybin: An Electrochemical and Spectral Study.

J Phys Chem B 2017 07 11;121(28):6841-6846. Epub 2017 Jul 11.

Institute of Microbiology, Czech Academy of Sciences , Vídeňská 1083, 142 20 Prague 4, Czech Republic.

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http://dx.doi.org/10.1021/acs.jpcb.7b04651DOI Listing
July 2017

Downregulation of Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat.

Hypertension 2017 06 10;69(6):1084-1091. Epub 2017 Apr 10.

From the Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic (F.L., O.Š., V.K., M.P.); Institute of Physiology (V.L., V.Z., P.M., J.Š., M.Š., M.P.) and Institute of Molecular Genetics (H.S.), Czech Academy of Sciences, Prague, Czech Republic; Institute for Experimental Medicine, Prague, Czech Republic (J.T., V.Š., L.K.); Department of Genetics, Cell Biology, and Development and Center for Genome Engineering, University of Minnesota, Minneapolis (C.G.S., D.F.V.); Max-Delbrück-Center for Molecular Medicine in the Hemholtz Society, Berlin, Germany (Z.I.); and Department of Molecular Medicine "Sapienza" University of Rome, Italy (M.M.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08798DOI Listing
June 2017

Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells.

Fitoterapia 2017 Jun 24;119:115-120. Epub 2017 Apr 24.

Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, Olomouc 77515, Czech Republic; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, Olomouc 77515, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2017.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476199PMC
June 2017

A Sustainable One-Pot, Two-Enzyme Synthesis of Naturally Occurring Arylalkyl Glucosides.

ChemSusChem 2017 05 22;10(9):2040-2045. Epub 2017 Mar 22.

Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche, Via Mario Bianco 9, Milano, 20131, Italy.

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http://dx.doi.org/10.1002/cssc.201700136DOI Listing
May 2017

Synthesis and Antiradical Activity of Isoquercitrin Esters with Aromatic Acids and Their Homologues.

Int J Mol Sci 2017 May 17;18(5). Epub 2017 May 17.

Laboratory of Biotransformation, Institute of Microbiology, Czech Academy of Sciences, Vídeňská 1083, CZ-142 20 Prague, Czech Republic.

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http://dx.doi.org/10.3390/ijms18051074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454983PMC
May 2017

2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound.

Free Radic Biol Med 2017 02 28;103:256-267. Epub 2016 Dec 28.

Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., Athens 11635, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.12.042DOI Listing
February 2017

Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.

Eur J Med Chem 2017 Feb 26;127:263-274. Epub 2016 Dec 26.

Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, Olomouc, 775 15, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.12.051DOI Listing
February 2017

Protective effect of isoquercitrin against acute dextran sulfate sodium-induced rat colitis depends on the severity of tissue damage.

Pharmacol Rep 2016 Dec 19;68(6):1197-1204. Epub 2016 Sep 19.

Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic.

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http://dx.doi.org/10.1016/j.pharep.2016.07.007DOI Listing
December 2016

Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells.

Chem Biol Interact 2016 Dec 21;260:58-66. Epub 2016 Oct 21.

Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, Olomouc 77515, Czech Republic; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, Olomouc 77515, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2016.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148792PMC
December 2016

Silychristin: Skeletal Alterations and Biological Activities.

J Nat Prod 2016 Dec 22;79(12):3086-3092. Epub 2016 Nov 22.

Institute of Microbiology, Laboratory of Biotransformation, Czech Academy of Sciences , Vídeňská 1083, CZ 142 20 Prague, Czech Republic.

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http://dx.doi.org/10.1021/acs.jnatprod.6b00750DOI Listing
December 2016

Heterozygous connexin 50 mutation affects metabolic syndrome attributes in spontaneously hypertensive rat.

Lipids Health Dis 2016 Nov 21;15(1):199. Epub 2016 Nov 21.

Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Albertov 4, 128 00, Prague 2, Czech Republic.

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http://dx.doi.org/10.1186/s12944-016-0376-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117636PMC
November 2016

"Non-Taxifolin" Derived Flavonolignans: Phytochemistry and Biology.

Curr Pharm Des 2015 ;21(38):5489-500

Laboratory of Biotransformation, Institute of Microbiology, Czech Academy of Sciences, Vídenská 1083, CZ 142 20 Prague, Czech Republic.

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http://dx.doi.org/10.2174/1381612821666151002112720DOI Listing
September 2016

Splicing mutation in Sbf1 causes nonsyndromic male infertility in the rat.

Reproduction 2016 09 22;152(3):215-23. Epub 2016 Jun 22.

Institute of Biology and Medical GeneticsFirst Faculty of Medicine, Charles University in Prague, Prague 2, Czech Republic Institute of PhysiologyCzech Academy of Sciences, Prague 4, Czech Republic.

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http://dx.doi.org/10.1530/REP-16-0042DOI Listing
September 2016

Isolation of a Genomic Region Affecting Most Components of Metabolic Syndrome in a Chromosome-16 Congenic Rat Model.

PLoS One 2016 31;11(3):e0152708. Epub 2016 Mar 31.

Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and the General Teaching Hospital, Prague, Czech Republic.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816345PMC
August 2016

Expression of human β-N-acetylhexosaminidase B in yeast eases the search for selective inhibitors.

Enzyme Microb Technol 2016 Jul 9;89:1-6. Epub 2016 Mar 9.

Laboratory of Biotransformation, Institute of Microbiology, Czech Academy of Sciences, Vídeňská 1083, CZ 14220 Praha 4, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.enzmictec.2016.03.003DOI Listing
July 2016

Isoquercitrin Esters with Mono- or Dicarboxylic Acids: Enzymatic Preparation and Properties.

Int J Mol Sci 2016 Jun 7;17(6). Epub 2016 Jun 7.

Laboratory of Biotransformation, Institute of Microbiology, Czech Academy of Sciences, Vídeňská 1083, CZ-142 20 Prague, Czech Republic.

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http://dx.doi.org/10.3390/ijms17060899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926433PMC
June 2016

Unconventional application of the Mitsunobu reaction: Selective flavonolignan dehydration yielding hydnocarpins.

Beilstein J Org Chem 2016 8;12:662-9. Epub 2016 Apr 8.

Pharmazeutische und Medizinische Chemie, Institut für Pharmazie und Lebensmittelchemie, Julius-Maximilians-Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany.

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http://dx.doi.org/10.3762/bjoc.12.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901995PMC
June 2016

Bacteria as source of diglycosidase activity: Actinoplanes missouriensis produces 6-O-α-L-rhamnosyl-β-D-glucosidase active on flavonoids.

Appl Microbiol Biotechnol 2016 Apr 9;100(7):3061-70. Epub 2015 Nov 9.

INCITAP - CONICET (National Scientific and Technical Research Council. Department of Chemistry, Faculty of Natural Sciences, National University of La Pampa (UNLPam), Av. Uruguay 151, (6300), Santa Rosa, La Pampa, Argentina.

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http://link.springer.com/10.1007/s00253-015-7088-x
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http://dx.doi.org/10.1007/s00253-015-7088-xDOI Listing
April 2016

(Anti)mutagenic and immunomodulatory properties of quercetin glycosides.

J Sci Food Agric 2016 Mar 29;96(5):1492-9. Epub 2015 May 29.

Institute of Microbiology, Czech Academy of Sciences, Vídeňská 1083, CZ-142 20, Prague 4, Czech Republic.

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http://dx.doi.org/10.1002/jsfa.7251DOI Listing
March 2016

Silibinin and its 2,3-dehydro-derivative inhibit basal cell carcinoma growth via suppression of mitogenic signaling and transcription factors activation.

Mol Carcinog 2016 Jan 9;55(1):3-14. Epub 2014 Dec 9.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado.

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http://dx.doi.org/10.1002/mc.22253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461565PMC
January 2016

Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity.

Free Radic Biol Med 2016 Jan 12;90:114-25. Epub 2015 Nov 12.

Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, 775 15 Olomouc, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.11.014DOI Listing
January 2016

Upscale of recombinant α-L-rhamnosidase production by Pichia pastoris Mut(S) strain.

Front Microbiol 2015 19;6:1140. Epub 2015 Oct 19.

Department of Biochemical Technology, Slovak University of Technology Bratislava, Slovakia.

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http://dx.doi.org/10.3389/fmicb.2015.01140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611059PMC
November 2015

Enzymatic Glycosylation of Phenolic Antioxidants: Phosphorylase-Mediated Synthesis and Characterization.

J Agric Food Chem 2015 Nov 11;63(46):10131-9. Epub 2015 Nov 11.

Centre for Industrial Biotechnology and Biocatalysis, Department of Biochemical and Microbial Technology, Faculty of Biosciences Engineering, Ghent University , Coupure Links 653, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.1021/acs.jafc.5b04380DOI Listing
November 2015

Genomic determinants of triglyceride and cholesterol distribution into lipoprotein fractions in the rat.

PLoS One 2014 8;9(10):e109983. Epub 2014 Oct 8.

Institute of Biology and Medical Genetics, the First Faculty of Medicine, Charles University and the General Teaching Hospital, Prague, Czech Republic; Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190321PMC
October 2015

Sulfation modulates the cell uptake, antiradical activity and biological effects of flavonoids in vitro: An examination of quercetin, isoquercitrin and taxifolin.

Bioorg Med Chem 2015 Sep 29;23(17):5402-9. Epub 2015 Jul 29.

Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, Olomouc 77515, Czech Republic; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, Olomouc 77515, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.07.055DOI Listing
September 2015

Regioselective alcoholysis of silychristin acetates catalyzed by lipases.

Int J Mol Sci 2015 May 26;16(6):11983-95. Epub 2015 May 26.

Laboratory of Biotransformation, Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ 142 20 Prague, Czech Republic.

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http://dx.doi.org/10.3390/ijms160611983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490424PMC
May 2015

Computational study of β-N-acetylhexosaminidase from Talaromyces flavus, a glycosidase with high substrate flexibility.

BMC Bioinformatics 2015 Jan 28;16:28. Epub 2015 Jan 28.

Laboratory of Biotransformation, Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, 14220, Praha 4, Czech Republic.

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http://dx.doi.org/10.1186/s12859-015-0465-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384365PMC
January 2015

Protein engineering study of β-mannosidase to set up a potential chemically efficient biocatalyst.

Glycobiology 2014 Dec 21;24(12):1301-11. Epub 2014 Jul 21.

National Centre for Biomolecular Research, Faculty of Science Central European Institute of Technology, Masaryk University, Kamenice 5/A4, Brno 62500, Czech Republic Department of Biochemistry, Faculty of Science, Masaryk University, Kamenice 5/A5, Brno 62500, Czech Republic

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http://dx.doi.org/10.1093/glycob/cwu074DOI Listing
December 2014

Pharmacogenomic analysis of retinoic-acid induced dyslipidemia in congenic rat model.

Lipids Health Dis 2014 Nov 17;13:172. Epub 2014 Nov 17.

Institute of Biology and Medical Genetics, the First Faculty of Medicine, Charles University and the General Teaching Hospital, Albertov 4, 12800 Prague, Czech Republic.

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http://lipidworld.biomedcentral.com/articles/10.1186/1476-51
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http://dx.doi.org/10.1186/1476-511X-13-172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247747PMC
November 2014

Inhibition of microbial β-N-acetylhexosaminidases by 4-deoxy- and galacto-analogues of NAG-thiazoline.

Bioorg Med Chem Lett 2014 Nov 2;24(22):5321-3. Epub 2014 Oct 2.

Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ 14220 Praha 4, Czech Republic.

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http://dx.doi.org/10.1016/j.bmcl.2014.09.066DOI Listing
November 2014

Access to bifunctionalized biomolecular platforms using oxime ligation.

Carbohydr Res 2014 Jul 9;393:9-14. Epub 2014 May 9.

Département de Chimie Moléculaire, UMR CNRS 5250 & ICMG FR 2607, Université Joseph Fourier, BP53, 38041 Grenoble Cedex 9, France; Institut Universitaire de France, 103 boulevard Saint-Michel, 75005 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.carres.2014.04.020DOI Listing
July 2014

cis-trans Isomerization of silybins A and B.

Beilstein J Org Chem 2014 8;10:1047-1063. Epub 2014 May 8.

Institute of Microbiology, v.v.i. AS CR, Vídeňská 1083, Prague 4, CZ-14220, Czech Republic.

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http://dx.doi.org/10.3762/bjoc.10.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077359PMC
July 2014

Isoquercitrin: pharmacology, toxicology, and metabolism.

Food Chem Toxicol 2014 Jun 27;68:267-82. Epub 2014 Mar 27.

Laboratory of Biotransformation, Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, Prague 4 CZ-142 20, Czech Republic.

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http://dx.doi.org/10.1016/j.fct.2014.03.018DOI Listing
June 2014

Chemo-enzymatic synthesis of silybin and 2,3-dehydrosilybin dimers.

Molecules 2014 Apr 2;19(4):4115-34. Epub 2014 Apr 2.

Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ-142 20 Prague 4, Czech Republic.

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http://dx.doi.org/10.3390/molecules19044115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271273PMC
April 2014

Expression, characterization and homology modeling of a novel eukaryotic GH84 β-N-acetylglucosaminidase from Penicillium chrysogenum.

Protein Expr Purif 2014 Mar 14;95:204-10. Epub 2014 Jan 14.

Laboratory of Biotransformation, Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, 14220 Praha 4, Czech Republic.

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http://dx.doi.org/10.1016/j.pep.2014.01.002DOI Listing
March 2014

Inhibition of GlcNAc-processing glycosidases by C-6-azido-NAG-thiazoline and its derivatives.

Molecules 2014 Mar 20;19(3):3471-88. Epub 2014 Mar 20.

Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, 14220 Praha 4, Czech Republic.

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http://dx.doi.org/10.3390/molecules19033471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271965PMC
March 2014

Enzymatic preparation of silybin phase II metabolites: sulfation using aryl sulfotransferase from rat liver.

Appl Microbiol Biotechnol 2013 Dec 14;97(24):10391-8. Epub 2013 Mar 14.

Institute of Microbiology, Laboratory of Biotransformation, Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ 14220, Prague, Czech Republic.

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http://dx.doi.org/10.1007/s00253-013-4794-0DOI Listing
December 2013

LC-MS metabolic study on quercetin and taxifolin galloyl esters using human hepatocytes as toxicity and biotransformation in vitro cell model.

J Pharm Biomed Anal 2013 Dec 14;86:135-42. Epub 2013 Aug 14.

Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, CZ 775 15 Olomouc, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2013.07.045DOI Listing
December 2013

Biotransformation of silybin and its congeners.

Curr Drug Metab 2013 Dec;14(10):1009-21

Institute of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Hnevotínská 3, CZ-775 15 Olomouc, Czech Republic.

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http://dx.doi.org/10.2174/1389200214666131118234507DOI Listing
December 2013

Chemoenzymatic synthesis of α-L-rhamnosides using recombinant α-L-rhamnosidase from Aspergillus terreus.

Bioresour Technol 2013 Nov 23;147:640-644. Epub 2013 Aug 23.

Laboratory of Biotransformation, Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ 142 20 Prague, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.biortech.2013.08.083DOI Listing
November 2013

Antioxidant, metal-binding and DNA-damaging properties of flavonolignans: a joint experimental and computational highlight based on 7-O-galloylsilybin.

Chem Biol Interact 2013 Oct 18;205(3):173-80. Epub 2013 Jul 18.

Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, 775 15 Olomouc, Czech Republic.

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http://dx.doi.org/10.1016/j.cbi.2013.07.006DOI Listing
October 2013

Anti-cancer efficacy of silybin derivatives -- a structure-activity relationship.

PLoS One 2013 28;8(3):e60074. Epub 2013 Mar 28.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060074PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610875PMC
September 2013

Enzymatic glycosylation of multivalent scaffolds.

Chem Soc Rev 2013 Jun;42(11):4774-97

Institute of Microbiology, Center for Biocatalysis and Biotransformation, Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ 142 20, Prague 4, Czech Republic.

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http://dx.doi.org/10.1039/c2cs35395dDOI Listing
June 2013

Differential effects of 5-HT3 receptor antagonist on lipid profile in spontaneously hypertensive rat and chromosome 8 congenic strain.

Neuro Endocrinol Lett 2012 ;33 Suppl 2:43-9

Institute of Biology and Medical Genetics, Charles University, Prague, Czech Republic.

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April 2013

Erratum to: Purification and characterization of a nitrilase from Aspergillus niger K10.

Appl Microbiol Biotechnol 2013 Apr;97(8):3745-6

Institute of Microbiology, Centre of Biocatalysis and Biotransformation, Academy of Sciences of the Czech Republic, Vídeňská 1083, 14220, Prague, Czech Republic.

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http://dx.doi.org/10.1007/s00253-013-4743-yDOI Listing
April 2013

A novel semisynthetic flavonoid 7-O-galloyltaxifolin upregulates heme oxygenase-1 in RAW264.7 cells via MAPK/Nrf2 pathway.

J Med Chem 2013 Feb 18;56(3):856-66. Epub 2013 Jan 18.

Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, Olomouc 77515, Czech Republic.

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http://dx.doi.org/10.1021/jm3013344DOI Listing
February 2013

Chemo-enzymatic modification of poly-N-acetyllactosamine (LacNAc) oligomers and N,N-diacetyllactosamine (LacDiNAc) based on galactose oxidase treatment.

Beilstein J Org Chem 2012 9;8:712-25. Epub 2012 May 9.

Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Worringer Weg 1, Aachen, 52074, Germany.

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http://dx.doi.org/10.3762/bjoc.8.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388858PMC
September 2012