Publications by authors named "Vladimir Filaj"

5 Publications

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Ectopic Thyroid Papillary Carcinoma with Cervical Lymph Node Metastasis as the Initial Presentation, Accompanied by Benign Thyroid Gland.

Med Arch 2021 Apr;75(2):154-157

University of Medicine, Tirana University, Albania.

Background: Ectopic thyroid papillary carcinoma presenting as bilateral neck lymph nodes metastasis is very rare. Ectopic thyroid tissue may appear in any location along the trajectory of the thyroglossal duct from the foramen cecum to the mediastinum. It is subject to malignant transformation and is classically accompanied by a similar transformation of the native thyroid gland. Similar to that of the native thyroid gland, the most common malignancy found is Papillary thyroid carcinoma. Unusual cases in which ectopic thyroid carcinoma presents with normal native tissue support an alternative hypothesis that ectopic thyroid tissue may develop malignancies independently from the native thyroid gland.

Objective: We present an extremely rare case of a 30-year-old woman previously diagnosed with Hashimoto's thyroiditis, presenting with a palpable mass in the lateral neck suspicious for malignancy.

Results: After several examinations and surgical removal of the mass, histopathologic evaluation of the continuous sections of the thyroid, demonstrated metastatic disease from papillary carcinoma of the thyroid. Total thyroidectomy and biopsy revealed benign thyroid tissue without any foci of microcarcinoma. A hypothesis of ectopic thyroid tissue and its malignant transformation was made.

Conclusion: By presenting this case, our goal is to highlight and make the physicians aware of the possibility of developing primary carcinoma of the ectopic thyroid tissue, without an active tumor of the thyroid gland.
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April 2021

Our experience in the treatment of hemangioma with intense pulsed light laser: A 10 year study in Albania.

Dermatol Ther 2021 05 17;34(3):e14880. Epub 2021 Mar 17.

Service of Pediatric Oncohematology, University Hospital Center "Mother Theressa", Tirana, Albania.

Laser treatment brought an innovation in the treatment of hemangiomas and vascular anomalies. The range of superficial vascular lesions that can be treated with laser continues to expand. In our country laser device date relatively late, since then these technologies have facilitated the treatment of many skin condition. The goal of laser therapy is to maximize vascular destruction while minimizing injury to surrounding healthy epidermis and dermal tissues. We present our experience with IPL as a first line therapy in the treatment of superficial hemangiomas. After institutional review, board approval we analyzed the medical records of 202 patients diagnosed with hemangioma and treated with the IPL laser during January 2009 to January 2019. The performed procedure consists of using impulses of light with wave length that varies from 590 to 595 nm, duration 1.5 ms, and fluency by 11 to 12 J/cm . For each patient, four PDL sessions have been performed. We aim to evidence the efficacy and the good safety profile of (IPL) laser but with small adverse events that this treatment represent. The importance of proper patient selection, use of appropriate equipment settings, skin cooling mechanisms, and other safety measures minimize the occurrence of adverse events due to IPL treatment.
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May 2021

Undesirable Outcomes from Liposuction of the Calves and Ankles, what to Avoid?

Med Arch 2020 Oct;74(5):396-398

Department of Pathology, Genius Lab, Tirana, Albania.

Introduction: Liposuction, is amongst the most popular cosmetic surgical procedures worldwide and is pretty safe with a very low incidence of major complications in the hands of skilled plastic surgeons. As a matter of fact, a faultless liposuction of the calves and ankles is near the top of the list in providing a high satisfaction rate.

Aim: We present a case of 38-year old female with severe complication from liposuction of the thighs, calves and ankles with dimples and contour irregularity.

Results: The results were very bad aesthetically with over correction liposuction of the calves and a lot of contour surface irregularity, asymmetry, dimples and grooves. We recommended her several procedures of autologous fat grafting in the calves, to improve the contour irregularities, and the patient agreed to it.

Conclusion: The surgeon should be very cautious in examining the patient in details to see if liposuction of the calves and ankles is the proper procedure to address their interest. Several times it is required to combine different refinement techniques to achieve patients' aesthetic requests and enhance their appearance.
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October 2020

Epidemiological trends of severe burns, 2009-2019: A study in the service of burns in Albania.

Burns 2021 Jun 8;47(4):930-943. Epub 2020 Oct 8.

Department of Surgery, Service of Burns and Plastic Surgery, University Hospital Center "Mother Teresa", Tirana, Albania; Department of Surgery, Service of Burns and Plastic Surgery, Service of Anesthesiology, University Hospital Center "Mother Teresa", Tirana, Albania; Department of Biomedical and Experimental Courses, Field of science: Pharmacology, Faculty of Medicine, University of Medicine, Tirana, Albania. Electronic address:

Introduction: Statistical and epidemiological data taken throughout decades show trends of the pathology of burns and its treatment. The aim of this study is to analyze the summarized epidemiological and clinical data of severe burn patients during the period 2009-2019 in order to acquire an accurate and recent picture of this pathology. This can create a basis for improving community health outcomes.

Material And Method: The study retrospectively analyzes the data of severe burn patients admitted in the Intensive Care Unit (ICU) of the Service of Burns and Plastic Surgery of the University Hospital Center in Tirana, Albania, from 2009 to 2019. SPSS 23 software is used for the conduction of the Descriptive and Inferential Statistics. Statistical significance is defined as p<0.05.

Results: Incidence rate of burn admissions which need ICU treatment in our data was 5.2 patients/100,000population/year. The mean age of our population was 24.9±25.5 years. The most frequent causes of burns in all patients were scalds (49.6%) followed by flame (39.5%), electrical (5.1%), chemical (5%) and with unknown cause (0.7%). Death rate from fire and burns for the period 2009-2019 was 0.3 patients per 100,000population/year. Overall mortality was 6.8%. The ABSI, Baux and R Baux scoring system remain accurate and valuable tools in the prediction of burn patient mortality. A probability of death chart for our service has been developed based on age and BSA (%) burned which needs to validate in the future.

Conclusions: Etiology of burns have changed toward an increase in proportion of flame burns especially in adults and elderly population. Survival following severe burns has improved over the past 11 years even in patients with three risk factors (age ≥60, BSA (%) burned ≥40% and presence of inhalation burn). LA 50 for all patients was 80%. LOS/BSA (%) ratio is a more valuable indicator than LOS alone. Improvement in the treatment of severe burns is a combination of preventive health care, appropriate treatment protocols and improvements in equipment and infrastructure.
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June 2021

Treatment of vascular soft tissue malformations: A retrospective study of 90 patients from Albania.

Dermatol Ther 2020 11 26;33(6):e14006. Epub 2020 Jul 26.

Central Michigan University, Saginaw, Michigan, USA.

Vascular malformations (Vascular Malformation) of soft tissue are a consequence of abnormal development of vascular elements during embryogenesis. They are named after the vessel responsible. Their presence at birth raises the hypothesis of an intrauterine etiology of Vascular Malformation, but the influence of other factors may play an important role in their appearance, localization, and size. The literature suggests that treatment of Vascular Malformation is rarely surgical. Surgery is applied in cases of voluminous malformations and in cases of possible hemorrhagic complications. Meanwhile, patient outcomes have improved with new discoveries in laser technology for the treatment of Vascular Malformation, especially those of capillaries and the results are, in most of the cases, quite satisfactory and without significant complications. After institutional review board approval, we collected and analyzed the medical records of 90 patients diagnosed with Vascular Malformation, between January 2015 and December 2019 at the service of Burns and Plastic Surgery, "Mother Teresa" University Hospital Center of Tirana, Albania and from another private clinic in Tirana. Data were collected from the medical records on patient's charts. The aim of this study is to analyze different treatment modalities and the outcomes achieved for each group.
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November 2020