Vladi V Heredia

Vladi V Heredia

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Vladi V Heredia

Vladi V Heredia

Publications by authors named "Vladi V Heredia"

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7Publications

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Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations.

J Biol Chem 2006 Dec 2;281(52):40201-7. Epub 2006 Nov 2.

Department of Biochemical Pharmacology, La Jolla Laboratories, Pfizer Global Research and Development, San Diego, California 92121, USA.

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http://dx.doi.org/10.1074/jbc.M607987200DOI Listing
December 2006

Glucose-induced conformational changes in glucokinase mediate allosteric regulation: transient kinetic analysis.

Biochemistry 2006 Jun;45(24):7553-62

Biochemical Pharmacology, La Jolla Laboratory, Pfizer Global Research and Development, San Diego, California 92121, USA.

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http://dx.doi.org/10.1021/bi060253qDOI Listing
June 2006

Dissection of the physiological interconversion of 5alpha-DHT and 3alpha-diol by rat 3alpha-HSD via transient kinetics shows that the chemical step is rate-determining: effect of mutating cofactor and substrate-binding pocket residues on catalysis.

Biochemistry 2004 Sep;43(38):12028-37

Department of Biochemistry & Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6084, USA.

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http://dx.doi.org/10.1021/bi0489762DOI Listing
September 2004

Alanine scanning mutagenesis of the testosterone binding site of rat 3 alpha-hydroxysteroid dehydrogenase demonstrates contact residues influence the rate-determining step.

Biochemistry 2004 May;43(19):5832-41

Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6084, USA.

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http://dx.doi.org/10.1021/bi0499563DOI Listing
May 2004

Structure-function relationships in 3alpha-hydroxysteroid dehydrogenases: a comparison of the rat and human isoforms.

J Steroid Biochem Mol Biol 2003 Jun;85(2-5):247-55

Department of Pharmacology, School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/s0960-0760(03)00236-xDOI Listing
June 2003

Steroid-binding site residues dictate optimal substrate positioning in rat 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD or AKR1C9).

Chem Biol Interact 2003 Feb;143-144:393-400

Departments Biochemistry and Biophysics, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/s0009-2797(02)00176-xDOI Listing
February 2003

The aldo-keto reductase superfamily homepage.

Chem Biol Interact 2003 Feb;143-144:621-31

Protein Function Discovery Facility, Queen's University, Ont., K7L 3N6, Kingston, Canada.

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http://dx.doi.org/10.1016/s0009-2797(02)00193-xDOI Listing
February 2003