Viviana Gradinaru

Viviana Gradinaru

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Viviana Gradinaru

Viviana Gradinaru

Publications by authors named "Viviana Gradinaru"

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Publisher Correction: Tissue clearing and its applications in neuroscience.

Nat Rev Neurosci 2020 Mar 9. Epub 2020 Mar 9.

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.

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http://dx.doi.org/10.1038/s41583-020-0291-5DOI Listing
March 2020

Tissue clearing and its applications in neuroscience.

Nat Rev Neurosci 2020 Feb;21(2):61-79

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.

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http://dx.doi.org/10.1038/s41583-019-0250-1DOI Listing
February 2020

Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators.

Nat Protoc 2019 12 15;14(12):3471-3505. Epub 2019 Nov 15.

Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, USA.

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http://dx.doi.org/10.1038/s41596-019-0239-2DOI Listing
December 2019

Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics.

Nat Methods 2019 11 14;16(11):1176-1184. Epub 2019 Oct 14.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

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http://dx.doi.org/10.1038/s41592-019-0583-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858556PMC
November 2019

The Serotonergic Raphe Promote Sleep in Zebrafish and Mice.

Neuron 2019 08 24;103(4):686-701.e8. Epub 2019 Jun 24.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.05.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706304PMC
August 2019

TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice.

Cell Rep 2019 04;27(2):549-560.e6

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.12.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485958PMC
April 2019

Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies.

Nat Commun 2019 04 26;10(1):1944. Epub 2019 Apr 26.

Cardiac Arrhythmia Center and Neurocardiology Research Program of Excellence, David Geffen School of Medicine, University of California - Los Angeles (UCLA), Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1038/s41467-019-09770-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486614PMC
April 2019

Systemic AAV vectors for widespread and targeted gene delivery in rodents.

Nat Protoc 2019 02;14(2):379-414

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

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http://dx.doi.org/10.1038/s41596-018-0097-3DOI Listing
February 2019

Two-Photon Microscopy with a Double-Wavelength Metasurface Objective Lens.

Nano Lett 2018 08 23;18(8):4943-4948. Epub 2018 Jul 23.

T. J. Watson Laboratory of Applied Physics and Kavli Nanoscience Institute , California Institute of Technology , 1200 East California Boulevard , Pasadena , California 91125 , United States.

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http://dx.doi.org/10.1021/acs.nanolett.8b01737DOI Listing
August 2018

Viral Strategies for Targeting the Central and Peripheral Nervous Systems.

Annu Rev Neurosci 2018 07 25;41:323-348. Epub 2018 Apr 25.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA; email:

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http://dx.doi.org/10.1146/annurev-neuro-080317-062048DOI Listing
July 2018

The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress.

Cell 2018 05;173(5):1265-1279.e19

Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA; Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA; Tianqiao and Chrissy Chen Institute for Neuroscience, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.03.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967263PMC
May 2018

Hydrogel-Tissue Chemistry: Principles and Applications.

Annu Rev Biophys 2018 05;47:355-376

Department of Bioengineering, Stanford University, Stanford, California 94305, USA; email:

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http://dx.doi.org/10.1146/annurev-biophys-070317-032905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359929PMC
May 2018

Dopaminergic dysfunction in neurodevelopmental disorders: recent advances and synergistic technologies to aid basic research.

Curr Opin Neurobiol 2018 02 30;48:17-29. Epub 2017 Aug 30.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09594388173016
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http://dx.doi.org/10.1016/j.conb.2017.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825239PMC
February 2018

Deep tissue optical focusing and optogenetic modulation with time-reversed ultrasonically encoded light.

Sci Adv 2017 12 8;3(12):eaao5520. Epub 2017 Dec 8.

Department of Electrical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1126/sciadv.aao5520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722648PMC
December 2017

The Jellyfish Cassiopea Exhibits a Sleep-like State.

Curr Biol 2017 Oct 21;27(19):2984-2990.e3. Epub 2017 Sep 21.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09609822173102
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http://dx.doi.org/10.1016/j.cub.2017.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653286PMC
October 2017

Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization.

PLoS Comput Biol 2017 Oct 23;13(10):e1005786. Epub 2017 Oct 23.

Division of Biology and Biological Engineering; California Institute of Technology; Pasadena, California; United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695628PMC
October 2017

Overriding sleep.

Science 2017 Oct;358(6362):457

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http://dx.doi.org/10.1126/science.aap9535DOI Listing
October 2017

Q&A: How can advances in tissue clearing and optogenetics contribute to our understanding of normal and diseased biology?

BMC Biol 2017 09 25;15(1):87. Epub 2017 Sep 25.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.

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http://dx.doi.org/10.1186/s12915-017-0421-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613628PMC
September 2017

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems.

Nat Neurosci 2017 Aug 26;20(8):1172-1179. Epub 2017 Jun 26.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.

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http://dx.doi.org/10.1038/nn.4593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529245PMC
August 2017

Dorsal Raphe Dopamine Neurons Modulate Arousal and Promote Wakefulness by Salient Stimuli.

Neuron 2017 Jun 8;94(6):1205-1219.e8. Epub 2017 Jun 8.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.05.020DOI Listing
June 2017

Global Representations of Goal-Directed Behavior in Distinct Cell Types of Mouse Neocortex.

Neuron 2017 May;94(4):891-907.e6

Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723385PMC
May 2017

Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow.

Sci Transl Med 2017 04;9(387)

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1126/scitranslmed.aah6518DOI Listing
April 2017

Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore.

Cell Chem Biol 2017 Mar 2;24(3):415-425. Epub 2017 Mar 2.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA; Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456173003
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http://dx.doi.org/10.1016/j.chembiol.2017.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357175PMC
March 2017

Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins.

Proc Natl Acad Sci U S A 2017 03 10;114(13):E2624-E2633. Epub 2017 Mar 10.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125;

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http://dx.doi.org/10.1073/pnas.1700269114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380088PMC
March 2017

Exposing the Three-Dimensional Biogeography and Metabolic States of Pathogens in Cystic Fibrosis Sputum via Hydrogel Embedding, Clearing, and rRNA Labeling.

mBio 2016 Sep 27;7(5). Epub 2016 Sep 27.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, California, USA Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California, USA

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040109PMC
http://dx.doi.org/10.1128/mBio.00796-16DOI Listing
September 2016

Single-molecule RNA detection at depth by hybridization chain reaction and tissue hydrogel embedding and clearing.

Development 2016 08 24;143(15):2862-7. Epub 2016 Jun 24.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA

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http://dx.doi.org/10.1242/dev.138560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004914PMC
August 2016

Extracting structural and functional features of widely distributed biological circuits with single cell resolution via tissue clearing and delivery vectors.

Curr Opin Biotechnol 2016 08 6;40:193-207. Epub 2016 Jul 6.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09581669163006
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http://dx.doi.org/10.1016/j.copbio.2016.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975678PMC
August 2016

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain.

Nat Biotechnol 2016 Feb 1;34(2):204-9. Epub 2016 Feb 1.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088052PMC
http://dx.doi.org/10.1038/nbt.3440DOI Listing
February 2016

Neuroscience: Fluorescent boost for voltage sensors.

Nature 2016 Jan;529(7587):469-70

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1038/529469aDOI Listing
January 2016

Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo.

Chem Biol 2015 Aug 23;22(8):1108-21. Epub 2015 Jul 23.

Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard MC 156-29, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2015.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546540PMC
August 2015

Directed evolution of a far-red fluorescent rhodopsin.

Proc Natl Acad Sci U S A 2014 Sep 25;111(36):13034-9. Epub 2014 Aug 25.

Divisions of Chemistry and Chemical Engineering and Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125; and

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http://dx.doi.org/10.1073/pnas.1413987111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246972PMC
September 2014

Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons.

Nat Commun 2014 Sep 15;5:4894. Epub 2014 Sep 15.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1038/ncomms5894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166526PMC
September 2014

Single-cell phenotyping within transparent intact tissue through whole-body clearing.

Cell 2014 Aug 31;158(4):945-958. Epub 2014 Jul 31.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153367PMC
August 2014

Bioelectronic medicines: a research roadmap.

Nat Rev Drug Discov 2014 06;13(6):399-400

Bioelectronics R&D, GlaxoSmithKline, Stevenage, Hertfordshire SG1 2NY, UK.

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http://dx.doi.org/10.1038/nrd4351DOI Listing
June 2014

Optogenetic delay of status epilepticus onset in an in vivo rodent epilepsy model.

PLoS One 2013 24;8(4):e62013. Epub 2013 Apr 24.

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062013PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634849PMC
December 2013

Leptin regulates the reward value of nutrient.

Nat Neurosci 2011 Nov 13;14(12):1562-8. Epub 2011 Nov 13.

Laboratory of Molecular Genetics, Rockefeller University, New York, New York, USA.

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http://dx.doi.org/10.1038/nn.2977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238286PMC
November 2011

Dynamics of retrieval strategies for remote memories.

Cell 2011 Oct 20;147(3):678-89. Epub 2011 Oct 20.

Department of Bioengineering, Howard Hughes Medical Institute, CNC Program, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.cell.2011.09.033DOI Listing
October 2011

Global and local fMRI signals driven by neurons defined optogenetically by type and wiring.

Nature 2010 Jun;465(7299):788-92

Department of Electrical Engineering, Psychiatry and Biobehavioral Sciences, Bioengineering, and Radiology, University of California, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1038/nature09108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177305PMC
June 2010

Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures.

Nat Protoc 2010 Mar 18;5(3):439-56. Epub 2010 Feb 18.

Department of Bioengineering, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1038/nprot.2009.226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503465PMC
March 2010

Optical deconstruction of parkinsonian neural circuitry.

Science 2009 Apr 19;324(5925):354-9. Epub 2009 Mar 19.

Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1167093
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http://dx.doi.org/10.1126/science.1167093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744370PMC
April 2009

eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications.

Brain Cell Biol 2008 Aug 2;36(1-4):129-39. Epub 2008 Aug 2.

Department of Bioengineering, Stanford University, W083 Clark Center, 318 Campus Drive West, Stanford, CA, USA.

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http://dx.doi.org/10.1007/s11068-008-9027-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588488PMC
August 2008

Controlling neuronal activity.

Am J Psychiatry 2008 May;165(5):562

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http://dx.doi.org/10.1176/appi.ajp.2008.08030444DOI Listing
May 2008