Experienced in interdisciplinary approach through clinicians and laboratory staff, to the metabolic and genetic aspects of various diseases. My past research articles has been focused in reporting the approach to rare endocrinology related diseases.
Primary Affiliation: Institute of Medicine - Kathmandu , Nepal
EJIFCC. 2018 Jul 11;29(2):152-155. eCollection 2018 Jul.
Immunoassays are widely used for quantification of serum analytes however they are subjected to interference by endogenous antibodies. The laboratory procedures used to identify these endogenous antibodies is the demonstration of response to dilution or use of nonimmunoglobulin protein to block the interfering antibodies or the use of an alternate immunoassay. We report a clinical-diagnostic situation where serum vitamin B12 determination was interfered in an immunoassay due to excess of endogenous antibodies from monoclonal gammopathy that resulted in excess of analyte concentration. Reporting of such cases may be beneficial when assaying sera of multiple myeloma to avoid false results and in addition to avoid costs due to unnecessary repeat testing and further delay reporting of results. Key words: endogenous antibody, monoclonal gammopathy, immunoassay
Int Med Case Rep J 2017 16;10:275-278. Epub 2017 Aug 16.
Manmohan Cardiothoracic vascular and transplant Center, Institute of Medicine (IOM), Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal.
J Clin Diagn Res 2017 Jul 1;11(7):OC12-OC14. Epub 2017 Jul 1.
Resident Doctor, Department of Biochemistry, Institute of Medicine, Kathmandu, Nepal.
J Med Case Rep 2017 Jun 23;11(1):168. Epub 2017 Jun 23.
Department of Biochemistry, Institute of Medicine (IOM), Kathmandu, Nepal.
Int J Gen Med 2017 16;10:145-149. Epub 2017 May 16.
Department of Anesthesia, Institute of Medicine, TUTH, Kathmandu, Nepal.