Publications by authors named "Vivek Chaturvedi"

45 Publications

Biomolecules of mushroom: a recipe of human wellness.

Crit Rev Biotechnol 2021 Aug 19:1-18. Epub 2021 Aug 19.

Department of Chemistry and Biochemistry, University of Maryland, Baltimore County (UMBC), Baltimore, MD, USA.

The Indian system of medicine - Ayurveda says "When diet is wrong, medicine is of no use. When diet is correct, medicine is of no use". In this context, mushroom constitutes one of the major resources for nutraceuticals. Biomolecules of mushrooms have attracted the attention of researchers around the globe due to their proven healthy attributes. They have a plenitude of health-giving properties and these range from immunomodulatory, antiviral, antibacterial, antifungal, antioxidant, anti-inflammatory, antitumor, anticancer, anti-HIV, antidiabetic, anticholesterolic to antiarthritic activities.Mushrooms contain both primary and secondary metabolites. The primary metabolites provide energy while the secondary metabolite exhibits medicinal properties. Hence, the mushroom can be a recipe for human wellness and will play a significant role in fighting COVID-19 pandemics and other infectious diseases.The key findings suggested in this paper refer to the exploration of health and the healing traits of biomolecules of mushrooms. This article reviews the current status of the medicinal attributes of mushrooms and their biomolecules in different diseases such as cardiovascular, diabetes, reproductive diseases, cancer, and neurodegenerative diseases. The global malnutrition-related morbidity and mortality among children under five and lactating women presents a frightening picture and also a black spot on the human face. Malnutrition is responsible for more ill-health than any other cause. Mushrooms as a rich source of bioactive compounds can be claimed as "Best from the Waste" since they grow on the most abundant organic wastes of the Earth, the lignocellulosic substrate, and 'Best of the Rest' because they are excellent nutraceutical resources.
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http://dx.doi.org/10.1080/07388551.2021.1964431DOI Listing
August 2021

Promising drug targets and associated therapeutic interventions in Parkinson's disease.

Neural Regen Res 2021 Sep;16(9):1730-1739

Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.

Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the availability of symptomatic treatments, response towards the health of PD patients remains scarce. To fulfil the medical needs of the PD patients, an efficacious and etiological treatment is required. In this review, we have compiled the information covering limitations of current therapeutic options in PD, novel drug targets for PD, and finally, the role of some critical beneficial natural products to control the progression of PD.
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http://dx.doi.org/10.4103/1673-5374.306066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328771PMC
September 2021

Two birds with one stone: oyster mushroom mediated bimetallic Au-Pt nanoparticles for agro-waste management and anticancer activity.

Environ Sci Pollut Res Int 2021 Mar 16;28(11):13761-13775. Epub 2020 Nov 16.

Centre of Biotechnology, Institute of Interdisciplinary Sciences (IIDS), University of Allahabad, Prayagraj, 211002, India.

Agriculture has the most significant contribution in fulfilling the basic human need, sustaining life, and strengthening the economy of any country. To feed the exploding population of the world, there has been a quantum jump in the production of agricultural commodities, which has led to the production of a substantial considerable quantity of agricultural and agro-industrial wastes. The bulks of these wastes are lignocellulosic in nature and consist of three main polymeric constituents, i.e., cellulose, hemicellulose, and lignin, which are recalcitrant. The primary significant portions of these remain unutilized and are burnt in the field, leading to severe environmental aggression and wastage of resource. Farmers across the globe, including India, burn these agricultural wastes in their thousands of acre land, which contribute to spoiling the air quality index (AQI). This is very harmful, especially to children, pregnant women, old adults, and for patients suffering from respiratory diseases. The current manuscript sets up an agro-waste management platform by using paddy straw as a substrate for the production of nutritionally and medically rich oyster mushroom, Pleurotus florida (Pf) and which is further used in the green synthesis of bimetallic (gold-platinum) Au-Pt nanoparticle. Yield performance and biological efficiency of Pf were calculated from the degraded paddy straw. The green synthesized Au-Pt NPs were structurally characterized by ultraviolet-visible (UV-Vis), X-ray diffraction (XRD), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), and zeta potential analysis. The prepared NPs showed a face-centered cubic crystal structure, icosahedral shape with a mean particle size of 16 nm. Furthermore, we examined the cytotoxic activity of Au-Pt NPs using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, intracellular reactive oxygen species (ROS) generation, and apoptosis by propidium iodide assay. We found that Au-Pt NPs exerted apoptotic activity on the human colon cancer cell line (HCT 116) in a dose-dependent manner from 12.5 to 200 μg/mL. Overall, our findings create a prototype and open a new door to synthesizing functional nanoparticle by using oyster mushroom as the substrate for paddy straw agro-waste management and the applicability of Pf in the synthesis of eco-friendly Au-Pt NPs. This is the first kind of approach that kills two birds with one stone.
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http://dx.doi.org/10.1007/s11356-020-11435-2DOI Listing
March 2021

in Parkinson's and in some other diseases: recent advancement and future prospective.

3 Biotech 2020 Dec 10;10(12):522. Epub 2020 Nov 10.

Centre of Biotechnology, University of Allahabad, Prayagraj, 211002 India.

 (Mp) is an annual and perennial legume which belongs to the family Fabaceae having different types of therapeutic activity. Anti-oxidative, anti-inflammatory, anti-epileptic, anti-microbial, etc. are the example of some most common activities of Mp. It is widely utilized as a potent aphrodisiac. The anti-Parkinsonian activity of Mp was explored since the nineteenth century. The neuroprotective activity of Mp was shown by several researchers. Levodopa (L-DOPA) is the important constituents responsible for the anti-Parkinsonian activity of Mp. Apart from L-DOPA, several other important bioactive components like Ursolic acid (UA) and Betulinic acid (BA) also exhibit a similar neuroprotective activity. Parkinson's disease (PD) is mainly sporadic. A very small proportion shows the genetic nature of PD. The anti-Parkinsonian activity of Mp was explored in different toxin-induced PD models as like MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), Rotenone, Paraquat, 6-hydroxydopamine (6-OHDA) as suggested by several pieces of literature. Various parts of Mp's like seed, leaf, and stem exhibit potent neuroprotective attributes. Among different parts, seeds are widely utilized as anti-PD agents because of the higher percentage of L-DOPA. Besides anti-PD activity, Mp's neuroprotective potential was also explored in the ischemic model of stroke that also shows positive results. Recently, several clinical trials have been performed on the anti-PD activity of Mp on PD patients that show convincing results. Although, a small population-based study needs to be further validated in the broader population. Apart from anti-PD activity, Mp also shows its therapeutic activity in some other diseases like cancer, diabetes, skin infection, anemia, antihypertensive, etc. that are summarized in Table 1. In this review, we have discussed the anti-PD potential of Mp in the sporadic and genetic model along with some clinical trials that have performed on PD patients. Some other activity of Mp is also summarized in this review. There is a strong need to test the efficacy of Mp in some other neurodegenerative diseases along with PD. Following this, this review emphasizes the role of Mp in PD systematically through literature analysis available to date. [Table: see text].
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http://dx.doi.org/10.1007/s13205-020-02532-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655893PMC
December 2020

Rapid eco-friendly synthesis, characterization, and cytotoxic study of trimetallic stable nanomedicine: A potential material for biomedical applications.

Biochem Biophys Rep 2020 Dec 5;24:100812. Epub 2020 Oct 5.

Centre of Biotechnology, University of Allahabad, Prayagraj, 211002, India.

In the current scenario of the fight against cancer Integration of potential elements seems to be the best alternative since it overcomes the weaknesses of individuals and the combination of elements makes them formidable in the fight against the cancer war. Inspired by this objective and trusting our knowledge of paddy straw grown oyster mushroom, (Pf) mediated synthesis; a first-of-kind approach has been developed for the rapid synthesis of Au-Pt-Ag trimetallic nanoparticles (TMNPs). The developed method was successful, which was confirmed by Ultraviolet-Visible, X-ray diffraction, Transmission Electron Microscopy, Energy Dispersive Spectroscopy. Specifically, prepared TMNPs have been studied for their stability and size as a primary prerequisite for nanomedicine. Finally, the stable nanomedicine developed has been assessed for its performance against the highly metastatic breast cancer cell line (mda-mb-231). The performance was assessed using MTT assay and morphological readings, which were integrated with the cell viability data. We also determined the IC50 value, which was far superior to individual components and motivated us to postulate the possible breast cancer cell killing mechanism of TMNPs. The present study unlocks the new paths for the mushroom-mediated environmentally friendly, economic synthesis of trimetallic nanoparticles, which can be effectively used in cancer nanomedicine.
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http://dx.doi.org/10.1016/j.bbrep.2020.100812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551978PMC
December 2020

An overview of COVID-19 with an emphasis on computational approach for its preventive intervention.

3 Biotech 2020 Oct 16;10(10):435. Epub 2020 Sep 16.

Centre of Bioinformatics, University of Allahabad, Prayagraj, 211002 India.

SARS-CoV-2, a novel , has attracted global attention because of its extremely high infection rate and large number of human deaths. It possesses a positive-sense, single-stranded RNA of ~ 30 kb nucleotides as its genetic material. It is responsible for COVID-19 which has been declared a pandemic by WHO. Having reported for the first time in Wuhan, China, the virus infected over 21.48 million people and caused over 0.77 million deaths till mid-august 2020. SARS-CoV-2 contains the spike protein site that gets activated by an enzyme furin which is found in the lung, liver, and small intestine of humans. It shows the potentiality of virus for attacking multiple organs and their failures. Due to the absence of vaccines, the cure is restricted to supportive care including repurposed drugs. In silico approaches may offer an alternative screening to optimize hits to lead stages. It can provide important related to drug resistance, their lineages and evolution. This approach may also help to find an effective vaccine against COVID-19. This review focuses on the in silico aspects of genomics, proteomics, pathogenesis, phylogenetic analysis and viral receptor binding analysis in .
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http://dx.doi.org/10.1007/s13205-020-02425-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493697PMC
October 2020

-Mediated Synthesis of Silver and Gold Nanoparticles Active against Colon Cancer Cell Lines: A New Era of Herbonanoceutics.

Molecules 2020 Jul 7;25(13). Epub 2020 Jul 7.

Centre of Biotechnology, University of Allahabad, Prayagraj 211002, India.

Herbal medicines are widely used worldwide and much appreciated because of their fewer side effects and the ability to fight diseases at the root cause. Active 'phyto' ingredients require a scientific approach and a mechanism to distribute components at the target site for better therapeutic results. Nanotechnology, on the other hand, has created new hope for cancer treatment but is still far from being proven in clinical settings. This article combines a unique approach to synthesis with the use of , followed by microwave irritation of silver and gold nanoparticles that ensures the capping of the active phyto ingredient and further enhances the effects of nanomedicine to fight colon cancer, thus opening a new era of what we call herbonanoceutics. The article also compares the characteristics and properties of silver (Au) and gold (Ag) nanoparticles synthesized by an in house developed novel microwave-assisted rapid green synthesis method. The as-prepared Ag NPs and Au NPs were compared using ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), and energy dispersive spectroscopy (EDS). Our comparative study revealed that both assemblies display face-centred cubic structures (FCCs) and are nanocrystalline in nature. The advantage of the approach was that the sizes of gold and silver were identical in range with a similar distribution pattern. This has helped us to study the activity against colon cancer cell line (HCT-116) without incoherence since size plays a key role in the application. More specifically, morphological changes, cell viability, the production of reactive oxygen species (ROS) and the fragmentation of DNA have been further reported to assess better the results obtained with the two metals. Our results suggest that the newly adopted synthesis method may ensure the dual benefits from phyto ingredients which further enhances the effectiveness of advanced nanomedicine.
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http://dx.doi.org/10.3390/molecules25133091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412267PMC
July 2020

Role of edible mushroom as a potent therapeutics for the diabetes and obesity.

3 Biotech 2019 Dec 14;9(12):450. Epub 2019 Nov 14.

1Centre of Biotechnology, Institute of Interdisciplinary Studies (IIDS), University of Allahabad, Prayagraj, 211002 India.

Diabetes and obesity are the most frequently found disease worldwide. Several factors are responsible for obesity, i.e., imbalance in energy expenditure, environmental factors, feeding habit, lifestyle, etc., which can also be responsible for type 2 diabetes mellitus. There are several synthetic drugs available to combat these diseases which have some side effects on sufferers. Therefore, people are shifting towards inexpensive, effective, widely available natural and herbal medicines. Edible mushrooms, which have been used from ancient time to cure these diseases, contain anti-oxidant, fibers, triterpenoids, alkaloid, and other phytochemicals. Comatin, β-glucan, Tremellastin, and Lentinan KS-2 are active chemicals of mushrooms which show great effect on diabetes mellitus and obesity by modulating either cellular function or biochemical pathways. Here, in this review, we have discussed the potential role of edible mushrooms and its biochemicals in control of diabetes and obesity. Using Bioinformatics, we can find the specific targets of theses biochemicals, so that these can be more effective.
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http://dx.doi.org/10.1007/s13205-019-1982-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856246PMC
December 2019

Reverse electrical and structural remodeling of the left atrium occurs early after pulmonary vein isolation for persistent atrial fibrillation.

J Interv Card Electrophysiol 2020 Jun 13;58(1):9-19. Epub 2019 Jun 13.

Institute of Cardiovascular Medicine and Science, Department of Cardiology, Liverpool Heart and Chest Hospital, Thomas Drive, Liverpool, L14 3PE, UK.

Purpose: Adverse left atrial (LA) remodeling is known to be associated with persistent atrial fibrillation (PeAF). The time course and pattern of reversal of LA remodeling following catheter ablation is poorly understood. We aimed to evaluate LA chamber volumes and dimensions, LA conduction velocities, and LA bipolar voltages at baseline and at 2 months after catheter ablation for PeAF.

Methods: Twenty-three patients with PeAF underwent detailed LA mapping during fixed rate atrial pacing using the CARTO3 navigation system prior to undergoing pulmonary vein isolation. All patients returned for protocol-mandated repeat electrophysiology study at 2 months, irrespective of symptoms or arrhythmia recurrence, during which all measurements were repeated using an identical mapping protocol. Patients then underwent daily ECG monitoring for 12 months.

Results: Nineteen out of twenty-three (83.6%) patients had durable PVI of all veins at repeat electrophysiology study, while 4 (17.4%) patients had late reconnection of a single vein each. In the blinded offline analysis, LA volume at follow-up was significantly lower as compared with baseline (55 ± 14 mL/m vs. 65 ± 15 mL/m, P < 0.001). LA conduction velocities were significantly greater at 2 months (0.90 ± 0.13 m/s vs. 0.78 ± 0.13 m/s, P = 0.01). There was non-uniform regional LA voltage evolution, with a significant increase in bipolar voltages observed on the LA posterior wall (2.18 ± 0.85 mV vs. 1.83 ± 0.49 mV, P = 0.04), but not elsewhere. Individual variables of remodeling were not associated with AF recurrence.

Conclusion: Significant structural and electrical reverse remodeling of the LA can be seen as early as 2 months following successful catheter ablation for PeAF.
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http://dx.doi.org/10.1007/s10840-019-00576-1DOI Listing
June 2020

Lipid Bilayer-like Mixed Self-Assembled Monolayers with Strong Mobility and Clustering-Dependent Lectin Affinity.

Langmuir 2019 06 4;35(24):8174-8181. Epub 2019 Jun 4.

Department of Biomedical Sciences and Biofilms-Research Center for Biointerfaces (BRCB), Faculty of Health and Society , Malmö University , 205 06 Malmö , Sweden.

Glycans at the surface of cellular membranes modulate biological activity via multivalent association with extracellular messengers. The lack of tuneable simplified models mimicking this dynamic environment complicates basic studies of these phenomena. We here present a series of mixed reversible self-assembled monolayers (rSAMs) that addresses this deficiency. Mixed rSAMs were prepared in water by simple immersion of a negatively charged surface in a mixture of sialic acid- and hydroxy-terminated benzamidine amphiphiles. Surface compositions derived from infrared reflection-absorption spectroscopy (IRAS) and film thickness information (atomic force microscopy, ellipsometry) suggest the latter to be statistically incorporated in the monolayer. These surfaces' affinity for the lectin hemagglutinin revealed a strong dependence of the affinity on the presentation, density, and mobility of the sialic acid ligands. Hence, a spacer length of 4 ethylene glycol and a surface density of 15% resulted in a dissociation constant K of 1.3 × 10 M, on par with the best di- or tri-saccharide-based binders reported to date, whereas a density of 20% demonstrated complete resistance to hemagglutinin binding. These results correlated with ligand mobility measured by fluorescence recovery after photobleaching which showed a dramatic drop in the same interval. The results have a direct bearing on biological cell surface multivalent recognition involving lipid bilayers and may guide the design of model surfaces and sensors for both fundamental and applied studies.
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http://dx.doi.org/10.1021/acs.langmuir.9b01452DOI Listing
June 2019

Molecular mechanistic insight of hepatitis B virus mediated hepatocellular carcinoma.

Microb Pathog 2019 Mar 3;128:184-194. Epub 2019 Jan 3.

Centre of Biotechnology, University of Allahabad, Prayagraj, 211002, India. Electronic address:

Hepatocellular carcinoma (HCC) is a cancer which occurs in liver and severity of this cancer makes it the sixth most prevalent cancer and second leading cause of death among all cancers. The load of hepatitis-B virus (HBV) in serum is one of the important risk factors for the HCC. Several other factors also contribute to the HBV associated malignant hepatoma (HCC) i.e. HBV mutation, integration and condition of the host. Transformation of the liver to HBV-associated HCC usually accompanies long-run symptoms i.e. inflammation and cirrhosis of the liver and infective agent load could be a vigorous prognosticator for each incidence and progression of this carcinoma. One of the prominent factors i.e. HBV X supermolecule (HBx) interferes with many signal pathways that are related to the proliferation and apoptosis of hepatic cells. Besides, HBx C-terminal truncation is also responsible for HCC. Longtime HBV infection causes risk of HCC; thus most of the study related to HBV (85%) is limited to HBV endemic regions. In this review, we have outlined the molecular mechanisms that come from other than HBV endemic places which can be innovative approaches to treat HCC.
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http://dx.doi.org/10.1016/j.micpath.2019.01.004DOI Listing
March 2019

Cancer Nanotechnology: A New Revolution for Cancer Diagnosis and Therapy.

Curr Drug Metab 2019 ;20(6):416-429

Centre of Biotechnology, University of Allahabad, Allahabad-211002, India.

Background: Nanotechnology is gaining significant attention worldwide for cancer treatment. Nanobiotechnology encourages the combination of diagnostics with therapeutics, which is a vital component of a customized way to deal with the malignancy. Nanoparticles are being used as Nanomedicine which participates in diagnosis and treatment of various diseases including cancer. The unique characteristic of Nanomedicine i.e. their high surface to volume ratio enables them to tie, absorb, and convey small biomolecule like DNA, RNA, drugs, proteins, and other molecules to targeted site and thus enhances the efficacy of therapeutic agents.

Objective: The objective of the present article is to provide an insight of several aspect of nanotechnology in cancer therapeutics such as various nanomaterials as drug vehicle, drug release strategies and role of nanotechnology in cancer therapy.

Methods: We performed an extensive search on bibliographic database for research article on nanotechnology and cancer therapeutics and further compiled the necessary information from various articles into the present article.

Results: Cancer nanotechnology confers a unique technology against cancer through early diagnosis, prevention, personalized therapy by utilizing nanoparticles and quantum dots.Nano-biotechnology plays an important role in the discovery of cancer biomarkers. Quantum dots, gold nanoparticles, magnetic nanoparticles, carbon nanotubes, gold nanowires etc. have been developed as a carrier of biomolecules that can detect cancer biomarkers. Nanoparticle assisted cancer detection and monitoring involves biomolecules like proteins, antibody fragments, DNA fragments, and RNA fragments as the base of cancer biomarkers.

Conclusion: This review highlights various approaches of cancer nanotechnology in the advancement of cancer therapy.
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http://dx.doi.org/10.2174/1389200219666180918111528DOI Listing
January 2020

Medicinal mushroom: boon for therapeutic applications.

3 Biotech 2018 Aug 23;8(8):334. Epub 2018 Jul 23.

1Centre of Biotechnology, Institute of Interdisciplinary Sciences (IIDS), University of Allahabad, Allahabad, 211002 India.

Medicinal mushrooms are higher fungi with additional nutraceutical attributes having low fat content and a trans-isomer of unsaturated fatty acids along with high fibre content, triterpenes, phenolic compounds, sterols, eritadenine and chitosan. They are considered as the unmatched source of healthy foods and drugs. They have outstanding attractive taste, aroma and nutritional value, so are considered as functional food, which means they are beneficial to the body not only in terms of nutrition but also for improved health. Medicinal mushrooms and their extract have a large number of bioactive components called secondary metabolites. The presence of polysaccharide β-glucans or polysaccharide-protein complexes content in mushroom extract have great therapeutic applications in human health as they possess many properties such as anti-diabetic, anti-cancerous, anti-obesity, immunomodulatory, hypocholesteremia, hepatoprotective nature along with anti-aging. The present review focuses on the comprehensive account of the medicinal properties of various medicinal mushrooms. This will further help the researchers to understand the metabolites and find other metabolites as well from the mushrooms which can be used for the potential development of the drugs to treat various life-threatening diseases.
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http://dx.doi.org/10.1007/s13205-018-1358-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056353PMC
August 2018

Accuracy of left atrial bipolar voltages obtained by ConfiDENSE multielectrode mapping in patients with persistent atrial fibrillation.

J Cardiovasc Electrophysiol 2018 06 6;29(6):881-888. Epub 2018 Apr 6.

Institute of Cardiovascular Medicine and Science, Department of Cardiology, Liverpool Heart and Chest Hospital, Thomas Drive, Liverpool, L14 3PE, UK.

Introduction: The ConfiDENSE™ module (Carto3 v4) allows rapid annotation of endocardial electrograms acquired by multielectrode (ME) mapping. However, its accuracy in assessing atrial voltages is unknown.

Methods And Results: Two ConfiDENSE™ left atrial voltage maps were created during continuous pacing in 20 patients undergoing catheter ablation for persistent AF using a ME lasso catheter and a contact force (CF) sensing ablation catheter. The automated tissue proximity indicator (TPI) filter was then applied to the ME map to yield a TPI map. Reference maps (RM) were created offline by a blinded observer by manually assessing all points against fidelity criteria. Bipolar voltages and proportion of low voltage points (< 0.5 mV) derived from the ME, CF, and TPI maps were compared with those derived from the RM. Note that 853 ± 365 points, 252 ± 184 points, and 144 ± 73 were collected for ME, TPI, and CF maps, respectively, and 429 ± 153 points were included in the RM. Voltages with CF and TPI maps were similar to those with RM (1.57 ± 0.47 mV vs. 1.63 ± 0.31 mV, P = 0.57 and 1.50 ± 0.38 mV vs. 1.63 ± 0.31 mV, P = 0.07, respectively), whereas ME maps showed a significantly lower mean voltage (1.00 ± 0.22 mV, P < 0.001). As compared to RM maps (17 ± 8%), low voltage points were significantly overestimated by the ME maps (50 ± 9% (P < 0.001) and TPI maps (28 ± 13% (P < 0.001), but not by the CF maps (22 ± 14%, P = 0.17).

Conclusion: Application of the TPI filter to ConfiDENSE maps significantly increases the quality of the voltage data, conserving a reasonable point density, but still overestimates low voltage points as compared to CF-sensing maps or maps reviewed manually.
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http://dx.doi.org/10.1111/jce.13472DOI Listing
June 2018

Prospective use of Ablation Index targets improves clinical outcomes following ablation for atrial fibrillation.

J Cardiovasc Electrophysiol 2017 Sep 26;28(9):1037-1047. Epub 2017 Jul 26.

Institute of Cardiovascular Medicine and Science, Department of Cardiology, Liverpool Heart and Chest Hospital, Liverpool, UK.

Aims: Late recovery of ablated tissue leading to reconnection of pulmonary veins remains common following radiofrequency catheter ablation for AF. Ablation Index (AI), a novel ablation quality marker, incorporates contact force (CF), time, and power in a weighted formula. We hypothesized that prospective use of our previously published derived AI targets would result in better outcomes when compared to CF-guided ablation.

Methods: Eighty-nine consecutive drug-refractory AF patients (49% paroxysmal) underwent AI-guided ablation (AI-group). AI targets were 550 for anterior/roof and 400 for posterior/inferior left atrial segments. Procedural and clinical outcomes of these patients were compared to 89 propensity-matched controls who underwent CF-guided ablation (CF-group). All 178 procedures were otherwise similar, and both groups were followed-up for 12 months. The last 25 patients from each group underwent analysis of all VisiTags™ for ablation duration, CF, Force-Time Integral, and impedance drop.

Results: First-pass pulmonary vein isolation (PVI) was more frequent in AI-group than in CF-group (173 [97%] vs. 149 [84%] circles, P < 0.001), and acute PV reconnection was lower (11 [6%] vs. 24 [13%] circles, P = 0.02). Mean PVI ablation time was similar (AI-group: 42 ± 9 vs. CF-group: 45 ± 14 minutes, P = 0.14). Median impedance drop for AI-group was significantly higher than in CF-group (13.7 [9-19] Ω vs. 8.8 [5.2-13] Ω, P < 0.001). Two major complications occurred in CF-group and none in AI-group. Atrial tachyarrhythmia recurrence was significantly lower in AI-group (15 of 89 [17%]) than in CF-group (33 of 89 [37%], P = 0.002).

Conclusion: AI-guided ablation is associated with significant improvements in the incidence of acute PV reconnection and atrial tachyarrhythmia recurrence rate compared to CF-guided ablation, potentially due to creation of better quality lesions as suggested by greater impedance drop.
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http://dx.doi.org/10.1111/jce.13281DOI Listing
September 2017

Bipolar voltage analysis with multi-electrode mapping.

J Cardiovasc Electrophysiol 2017 11 1;28(11):E3. Epub 2017 Sep 1.

Liverpool Heart and Chest Hospital, Liverpool, United Kingdom.

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http://dx.doi.org/10.1111/jce.13238DOI Listing
November 2017

Grip strength and mortality.

Authors:
Vivek Chaturvedi

Natl Med J India 2015 Nov-Dec;28(6):287-9

Department of Cardiology G.B. Pant Hospital New Delhi,

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July 2016

Current research on the relevance of electrocardiography in cardiac resynchronization therapy.

Authors:
Vivek Chaturvedi

Indian Pacing Electrophysiol J 2015 Mar-Apr;15(2):145-7. Epub 2015 Oct 19.

Department of Cardiology, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, Room 124, Academic Block, First Floor, New Delhi 110002, India.

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http://dx.doi.org/10.1016/j.ipej.2015.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750123PMC
March 2016

Subvalvular disease in patients undergoing balloon mitral valvotomy: a strong base is not always good.

Indian Heart J 2015 Sep-Oct;67(5):416-8. Epub 2015 Aug 17.

Associate Professor of Cardiology, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India.

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http://dx.doi.org/10.1016/j.ihj.2015.07.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593844PMC
August 2016

Ostial atresia of left circumflex coronary artery arising from non-coronary sinus: a combination of rare anomalies.

Cardiovasc Interv Ther 2016 Oct 25;31(4):284-7. Epub 2015 Aug 25.

Department of Cardiology and Radiology, GB Pant Hospital and Associated Maulana Azad Medical College, Room 125, Academic Block, First Floor Dept of Cardiology, New Delhi, 110002, India.

Atresia of the left coronary artery ostium and right coronary artery ostium is a rare anatomic variant of the coronary circulation. Atresia of the left circumflex artery and its origin of from the non-coronary sinus have never been described. We report this unusual combination of rare anomalies for the first time.
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http://dx.doi.org/10.1007/s12928-015-0350-4DOI Listing
October 2016

Primary percutaneous coronary intervention in an anomalous single coronary trunk arising anomalously from ascending aorta.

Cardiovasc Interv Ther 2016 Jul 3;31(3):250-3. Epub 2015 Jul 3.

Department of Cardiology, G.B. Pant Hospital and Associated Maulana Azad Medical College, New Delhi, 110002, India.

A 45-year-old male patient presented with acute anterior wall myocardial infarction. Angiography revealed a single coronary trunk arising from the ascending aorta above the coronary sinuses and giving rise to right coronary artery, left circumflex artery and critical stenosis in the left anterior descending artery. This report also highlights the feasibility of performing percutaneous coronary intervention (PCI) in this rare anomaly and discusses the important technical considerations to be kept in mind while attempting such a case. This is the first report of such an anomalous origin of a single coronary trunk arising from ascending aorta.
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http://dx.doi.org/10.1007/s12928-015-0343-3DOI Listing
July 2016

Are western guidelines good enough for Indians? My name is Borat.

Indian Heart J 2015 Mar-Apr;67(2):85-9. Epub 2015 May 14.

Associate Professor, Department of Cardiology, GB Pant Hospital, New Delhi, India.

Physicians in an attempt to give their patients the best possible care need to be updated on the evolving body of scientific research, trials, case reports, and combine this evidence with their own clinical experience keeping in mind each individual patient's circumstances and preferences. To address this felt need, guidelines are systematically developed statements designed to help clinicians make management decisions. While a multitude of guidelines are available from developed world they might not exactly fit into developing world context. Thus a host of fresh guidelines might be required to fill this void or the existing guidelines modified (supplemented, altered or deleted) to be relevant to this part of the world.
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http://dx.doi.org/10.1016/j.ihj.2015.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475859PMC
December 2016

Scleral depressed vitreous shaving, 360 laser, and perfluoropropane (C3 F8) for retinal detachment.

Indian J Ophthalmol 2014 Jul;62(7):804-8

Department of Ophthalmology, Rush University Medical Center, Chicago; Illinois Retina Associates, Harvey, Illinois, USA.

Unlabelled: Purpose : To review the characteristics and outcomes of patients who underwent pars plana vitrectomy (PPV) with scleral depressed vitreous shaving, 360 degree peripheral endolaser, and 14% C3F8 gas for rhegmatogenous retinal detachment (RRD). Materials and Methods : A retrospective review of a consecutive series of patients who underwent primary repair of RRD by PPV with scleral depressed vitreous shaving, 360 degree peripheral endolaser, and 14% perfluoropropane (C 3 F 8 ) was conducted. Patients with less than 3 months follow-up, previous retinal surgery, and higher than grade B proliferative vitreoretinopathy were excluded. Results : Ninety-one eyes were included in the study. The mean age was 60.1 years. The mean follow-up was 13.7 months. The macula was detached in 63% (58/91) of the eyes. The reattachment rate after one surgical procedure was 95% (86/91) while overall reattachment rate was 100%. There was no statistically significant difference between reattachment rates of superior, nasal/temporal, or inferior RRDs. The mean final best corrected visual acuity (BCVA) was 20/40. Of all the patients, 66% of patients with macula-off RRDs had a final BCVA of 20/40 or better.

Conclusions: PPV with scleral depressed vitreous shaving, 360 degree peripheral endolaser, and 14% C 3 F 8 leads to successful anatomical reattachment with visual improvement in patients with primary RRD.
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http://dx.doi.org/10.4103/0301-4738.138621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152652PMC
July 2014

Intermittent Right Ventricular Outflow Tract Capture due to Chronic Right Atrial Lead Dislodgement.

Indian Pacing Electrophysiol J 2014 Jul 15;14(4):217-22. Epub 2014 Jul 15.

Department of Cardiology, GB Pant Hospital, New Delhi, India.

A 58 year old male, known case of type 2 diabetes and hypertension, had undergone implantation of a dual chamber pacemaker(DDDR) in 2007 for complaints of recurrent syncope and trifascicular block with a normal ejection fraction andnormal coronaries. His post implantation parameters were normal at that time.He now presented to our pacemaker clinic where his ECG done showed two types o fpaced complexes. The first few complexes were consistent with atrial sensed right ventricular apical pacing with left superior axis. Later complexes showed loss of atrial sensing with pacing from right ventricular outflow tract(inferior axis) with subtle oscillation in it's axis. On application of magnet, two pacemaker spikes were visible withinterspike interval of 120 ms and paced complexes with inferior axis starting from the first spike suggesting that the atrial lead was responsible for RVOT depolarization. On interrogation of the pacemaker, atrial EGM showed sensed activity from atrium followed by large sensed ventricular complex. Fluoroscopy confirmed that the atrial lead was dislodged and was intermittently prolapsing into the RVOT. Since the patient was asymptomatic, he refused any intervention and subsequentlyhis atrial lead was switched off by telemetry. The above case signifies that asymptomatic lead dislodgement is no talways manifested as loss of capture and even subtle variation of the axis o fthe paced complexes can provide us with a clue that can be confirmed by telemetry of the pacemaker and fluoroscopy.
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http://dx.doi.org/10.1016/s0972-6292(16)30779-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100087PMC
July 2014

Rapid guiding catheter swapping for management of rupture during percutaneous venoplasty for idiopathic occlusion of superior vena cava.

Cardiovasc Interv Ther 2015 Apr 24;30(2):171-5. Epub 2014 May 24.

Department of Cardiology, G.B. Pant Hospital, New Delhi, India,

Treatment for superior vena cava syndrome (SVCS) by percutaneous interventions has become established as a definitive therapy. However, there is a significant risk of rupture during SVC intervention. We describe an uncommon case that developed SVC rupture during percutaneous intervention for idiopathic SVCS. This was managed successfully with pericardiocentesis and rapid implantation of covered stent in SVC by rapid guiding catheter swapping technique. This, however, led to inadvertent obstruction of left innominate vein which was successfully treated by kissing balloon inflation. At 18-month follow-up, he is asymptomatic with a well apposed patent stent-graft in the SVC.
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http://dx.doi.org/10.1007/s12928-014-0269-1DOI Listing
April 2015

Double orifice mitral valve in rheumatic heart disease.

Echocardiography 2014 12;31(1):E27-9. Epub 2013 Sep 12.

Department of Cardiology, GB Pant Hospital, Delhi, India.

A 55-year-old female, presented to our outpatient department with complaints of dyspnea on exertion, NYHA grade II for 7 years, which had progressed to NYHA Grade III in the past 6 months. An echocardiogram done showed severe mitral stenosis with mitral valve fused in the middle to create an appearance of 2 separate valves (complete bridge type) with 2 separate turbulent jets of flow across these valves. No other congenital anomaly was seen. Due to presence of severe subvalvular disease, she was sent for elective mitral valve replacement. This case demonstrates that a careful analysis of the subvalvular apparatus of the mitral valve is needed before making a decision for definitive treatment of this condition.
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http://dx.doi.org/10.1111/echo.12381DOI Listing
August 2014

Pseudo-aneurysm of mitral aortic intervalvular fibrosa: two case reports.

Indian Heart J 2013 Jan-Feb;65(1):100-3. Epub 2012 Dec 26.

Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.

The fibrous body between the mitral and aortic valve, known as mitral-aortic intervalvular fibrosa (MAIVF) is prone to infection and injury resulting in pseudo-aneurysm formation. Because of its relative rarity, we are far from making any conclusion regarding the natural history and appropriate therapeutic strategy for this condition. We report two cases of this condition with two different and rare etiologies with strikingly different natural courses, providing insight into the natural course and timing of surgery in this rare entity.
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http://dx.doi.org/10.1016/j.ihj.2012.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860995PMC
December 2013

Indigenous telemedicine.

Indian Pacing Electrophysiol J 2012 May 20;12(3):131-2. Epub 2012 May 20.

Department of Cardiology, G.B. Pant Hospital, New Delhi, India.

We are describing a simple and innovative way of documenting tachycardia. This patient came with video recording of neck pulsation done with the help of mobile phone camera. No other documentation of this tachycardia was available as patient was living in a remote area away from even basic health facilities.
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http://dx.doi.org/10.1016/s0972-6292(16)30504-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356593PMC
May 2012
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