Vishva M Dixit

Vishva M Dixit

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Vishva M Dixit

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Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.

Nature 2019 Sep 11. Epub 2019 Sep 11.

Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41586-019-1548-xDOI Listing
September 2019

Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation.

Cell Rep 2019 May;27(9):2679-2689.e3

Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193060
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http://dx.doi.org/10.1016/j.celrep.2019.04.111DOI Listing
May 2019

TBK1 and IKKε restrain cell death.

Nat Cell Biol 2018 12;20(12):1330-1331

Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41556-018-0239-4DOI Listing
December 2018

Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity.

Structure 2018 05 26;26(5):767-777.e5. Epub 2018 Apr 26.

Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09692126183012
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http://dx.doi.org/10.1016/j.str.2018.04.002DOI Listing
May 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.

Cell 2017 Nov 12;171(4):918-933.e20. Epub 2017 Oct 12.

Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, USA; Howard Hughes Medical Institute, Berkeley, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669814PMC
November 2017

A new lead to NLRP3 inhibition.

J Exp Med 2017 11 23;214(11):3147-3149. Epub 2017 Oct 23.

VIB-UGent Center for Inflammation Research, VIB; and Department of Internal Medicine, Ghent University, Ghent, Belgium; Department of Physiological Chemistry, Genentech, South San Francisco, CA

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http://www.jem.org/lookup/doi/10.1084/jem.20171848
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http://dx.doi.org/10.1084/jem.20171848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678032PMC
November 2017

In Retrospect: The inflammasome turns 15.

Nature 2017 08;548(7669):534-535

Department of Physiological Chemistry, Genentech, South San Francisco, California 94080, USA.

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http://www.nature.com/doifinder/10.1038/548534a
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http://dx.doi.org/10.1038/548534aDOI Listing
August 2017

RIPK1 inhibits ZBP1-driven necroptosis during development.

Nature 2016 12 7;540(7631):129-133. Epub 2016 Nov 7.

Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1038/nature20559DOI Listing
December 2016

Inflammasomes: mechanism of assembly, regulation and signalling.

Nat Rev Immunol 2016 07 13;16(7):407-20. Epub 2016 Jun 13.

Genentech Inc., South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1038/nri.2016.58DOI Listing
July 2016

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes.

Proc Natl Acad Sci U S A 2016 07 23;113(28):7858-63. Epub 2016 Jun 23.

Department of Early Discovery Biochemistry, Genentech, Inc., South San Francisco, CA 94080;

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http://dx.doi.org/10.1073/pnas.1607769113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948338PMC
July 2016

NLRP3 recruitment by NLRC4 during Salmonella infection.

J Exp Med 2016 05 2;213(6):877-85. Epub 2016 May 2.

Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA 94080

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http://dx.doi.org/10.1084/jem.20132234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886354PMC
May 2016

Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity.

J Immunol 2016 Apr 2;196(8):3438-51. Epub 2016 Mar 2.

Department of Physiological Chemistry, Genentech, Inc., South San Francisco, CA 94080

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http://dx.doi.org/10.4049/jimmunol.1403165DOI Listing
April 2016

Drugging the undruggables: exploring the ubiquitin system for drug development.

Cell Res 2016 Apr 22;26(4):484-98. Epub 2016 Mar 22.

Department of Physiological Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1038/cr.2016.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822129PMC
April 2016

Structural Analysis and Optimization of Context-Independent Anti-Hypusine Antibodies.

J Mol Biol 2016 Feb 14;428(3):603-617. Epub 2016 Jan 14.

Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.01.006DOI Listing
February 2016

Ubiquitin in the activation and attenuation of innate antiviral immunity.

J Exp Med 2016 Jan 28;213(1):1-13. Epub 2015 Dec 28.

Department of Physiological Chemistry, Genentech, Inc., South San Francisco, CA 94080

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http://dx.doi.org/10.1084/jem.20151531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710203PMC
January 2016

β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.

Cell 2015 Dec 25;163(6):1457-67. Epub 2015 Nov 25.

Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674150147
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http://dx.doi.org/10.1016/j.cell.2015.10.076DOI Listing
December 2015

Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X.

J Exp Med 2014 Sep 8;211(10):1947-55. Epub 2014 Sep 8.

Department of Physiological Chemistry, Department of Pathology, Department of Immunology, Department of Bioinformatics and Computational Biology, Genentech, Inc., South San Francisco, CA 94080

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http://dx.doi.org/10.1084/jem.20140860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172213PMC
September 2014

Mechanisms and functions of inflammasomes.

Cell 2014 May;157(5):1013-22

Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674140047
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http://dx.doi.org/10.1016/j.cell.2014.04.007DOI Listing
May 2014

Is SIRT2 required for necroptosis?

Nature 2014 Feb;506(7489):E4-6

1] The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia [2] Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1038/nature13024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005920PMC
February 2014

An interview with Vishva M. Dixit.

Authors:
Vishva M Dixit

Trends Pharmacol Sci 2013 Nov 21;34(11):596-8. Epub 2013 Oct 21.

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http://dx.doi.org/10.1016/j.tips.2013.09.005DOI Listing
November 2013

Inflammasomes and their roles in health and disease.

Annu Rev Cell Dev Biol 2012 10;28:137-61. Epub 2012 Sep 10.

Department of Biochemistry, Ghent University, Ghent 9000, Belgium.

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http://www.annualreviews.org/doi/10.1146/annurev-cellbio-101
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http://dx.doi.org/10.1146/annurev-cellbio-101011-155745DOI Listing
March 2013

Phosphorylation of NLRC4 is critical for inflammasome activation.

Nature 2012 Oct 12;490(7421):539-42. Epub 2012 Aug 12.

Department of Physiological Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1038/nature11429DOI Listing
October 2012

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.

Nature 2012 Oct 15;490(7419):288-91. Epub 2012 Aug 15.

Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, California 94305, USA.

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http://dx.doi.org/10.1038/nature11419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470772PMC
October 2012

Using linkage-specific monoclonal antibodies to analyze cellular ubiquitylation.

Methods Mol Biol 2012 ;832:185-96

Physiological Chemistry Department, Genentech, Inc., South San Francisco, CA, USA.

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http://dx.doi.org/10.1007/978-1-61779-474-2_13DOI Listing
July 2012

Engineering and structural characterization of a linear polyubiquitin-specific antibody.

J Mol Biol 2012 May 29;418(3-4):134-44. Epub 2011 Dec 29.

Department of Antibody Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.jmb.2011.12.053DOI Listing
May 2012

Signaling in innate immunity and inflammation.

Cold Spring Harb Perspect Biol 2012 Mar 1;4(3). Epub 2012 Mar 1.

Department of Physiological Chemistry, Genentech, Inc., South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1101/cshperspect.a006049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282411PMC
March 2012

Regulation of NF-κB by deubiquitinases.

Immunol Rev 2012 Mar;246(1):107-24

Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2012.01100.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540820PMC
March 2012

Phosphorylation-dependent activity of the deubiquitinase DUBA.

Nat Struct Mol Biol 2012 Jan 15;19(2):171-5. Epub 2012 Jan 15.

Department of Early Discovery Biochemistry, Genentech, South San Francisco, California, USA.

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http://dx.doi.org/10.1038/nsmb.2206DOI Listing
January 2012

Non-canonical inflammasome activation targets caspase-11.

Nature 2011 Oct 16;479(7371):117-21. Epub 2011 Oct 16.

Department of Physiological Chemistry, Genentech Inc., South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1038/nature10558DOI Listing
October 2011

Cross talk between ubiquitination and demethylation.

Mol Cell Biol 2011 Sep 1;31(18):3682-3. Epub 2011 Aug 1.

Department of Physiological Chemistry, Genentech, Inc, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1128/MCB.06001-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165723PMC
September 2011

USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma.

Cell 2011 Sep;146(6):918-30

Department of Physiological Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.cell.2011.07.040DOI Listing
September 2011

A20 edits ubiquitin and autoimmune paradigms.

Nat Genet 2011 Aug 29;43(9):822-3. Epub 2011 Aug 29.

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http://www.nature.com/articles/ng.916
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http://dx.doi.org/10.1038/ng.916DOI Listing
August 2011

Modulation of inflammasome pathways by bacterial and viral pathogens.

J Immunol 2011 Jul;187(2):597-602

Department of Biochemistry, Ghent University, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.4049/jimmunol.1100229DOI Listing
July 2011

Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation.

J Immunol 2011 Jun 20;186(11):6553-61. Epub 2011 Apr 20.

Physiological Chemistry Department, Genentech, Inc, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.4049/jimmunol.1100478DOI Listing
June 2011

Immunology: In command of commensals.

Nature 2011 Jun;474(7349):42-3

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http://dx.doi.org/10.1038/474042aDOI Listing
June 2011

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death.

Nat Rev Mol Cell Biol 2011 Jun 23;12(7):439-52. Epub 2011 Jun 23.

Department of Early Discovery Biochemistry, Genentech Inc., South San Francisco, California 94080, USA.

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http://www.nature.com/articles/nrm3143
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http://dx.doi.org/10.1038/nrm3143DOI Listing
June 2011

Modulation of K11-linkage formation by variable loop residues within UbcH5A.

J Mol Biol 2011 May 10;408(3):420-31. Epub 2011 Mar 10.

Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.jmb.2011.03.011DOI Listing
May 2011

COP1 is a tumour suppressor that causes degradation of ETS transcription factors.

Nature 2011 May 15;474(7351):403-6. Epub 2011 May 15.

Department of Physiological Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1038/nature10005DOI Listing
May 2011

Mitochondrial reactive oxygen species drive proinflammatory cytokine production.

J Exp Med 2011 Mar 28;208(3):417-20. Epub 2011 Feb 28.

Genentech, Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1084/jem.20110367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058577PMC
March 2011

Deubiquitinases in the regulation of NF-κB signaling.

Cell Res 2011 Jan 30;21(1):22-39. Epub 2010 Nov 30.

Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, 1550 NW 10 Avenue, Miami, FL 33136, USA.

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http://dx.doi.org/10.1038/cr.2010.166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075605PMC
January 2011

Unleashing cell death: the Fas-FADD complex.

Nat Struct Mol Biol 2010 Nov;17(11):1289-90

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http://dx.doi.org/10.1038/nsmb1110-1289DOI Listing
November 2010

Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling.

Mol Cell 2010 Nov;40(4):548-57

Department of Structural Biology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.10.009DOI Listing
November 2010

Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia.

J Immunol 2010 Oct 27;185(7):4385-92. Epub 2010 Aug 27.

Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.4049/jimmunol.1000803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428148PMC
October 2010

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella.

J Exp Med 2010 Aug 5;207(8):1745-55. Epub 2010 Jul 5.

Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1084/jem.20100257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916133PMC
August 2010

K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody.

Mol Cell 2010 Aug 22;39(3):477-84. Epub 2010 Jul 22.

Department of Antibody Engineering, Genentech, Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.07.001DOI Listing
August 2010

Modulation of inflammasome activity for the treatment of auto-inflammatory disorders.

J Clin Immunol 2010 Jul 1;30(4):485-90. Epub 2010 Apr 1.

Genentech, Inc, South San Francisco, CA, USA.

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http://dx.doi.org/10.1007/s10875-010-9383-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900592PMC
July 2010

Manipulation of host cell death pathways during microbial infections.

Cell Host Microbe 2010 Jul;8(1):44-54

Department of Biochemistry, Ghent University, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.1016/j.chom.2010.06.007DOI Listing
July 2010

Signalling lessons from death receptors: the importance of cleavage.

Authors:
Vishva M Dixit

Nat Cell Biol 2010 May;12(5):415

Genentech, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1038/ncb0510-415DOI Listing
May 2010

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.

Proc Natl Acad Sci U S A 2010 May 10;107(21):9771-6. Epub 2010 May 10.

Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1073/pnas.1003738107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906881PMC
May 2010

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.

Nat Cell Biol 2010 Apr 14;12(4):400-6. Epub 2010 Mar 14.

Department of Physiological Chemistry, 1 DNA Way, South San Francisco, California, 94080, USA.

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http://dx.doi.org/10.1038/ncb2041DOI Listing
April 2010

Signaling to NF-kappaB: regulation by ubiquitination.

Cold Spring Harb Perspect Biol 2010 Mar;2(3):a003350

Department of Protein Engineering, Genentech, Inc., South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1101/cshperspect.a003350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829959PMC
March 2010

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.

Nature 2010 Jan 20;463(7277):103-7. Epub 2009 Dec 20.

Department of Physiological Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1038/nature08646DOI Listing
January 2010

The inflammasomes.

PLoS Pathog 2009 Dec 24;5(12):e1000510. Epub 2009 Dec 24.

Department of Physiological Chemistry, Genentech, South San Francisco, California, USA.

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https://dx.plos.org/10.1371/journal.ppat.1000510
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http://dx.doi.org/10.1371/journal.ppat.1000510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791419PMC
December 2009

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome.

J Cell Biol 2009 Oct;187(1):61-70

Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1083/jcb.200903124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762099PMC
October 2009

Masking MALT1: the paracaspase's potential for cancer therapy.

J Exp Med 2009 Oct 19;206(11):2309-12. Epub 2009 Oct 19.

Department of Protein Engineering, Genentech, Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1084/jem.20092160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768848PMC
October 2009

IL-33 raises alarm.

Immunity 2009 Jul;31(1):5-7

Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S107476130900284
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http://dx.doi.org/10.1016/j.immuni.2009.06.011DOI Listing
July 2009

Inflammasomes: guardians of cytosolic sanctity.

Immunol Rev 2009 Jan;227(1):95-105

Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA.

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http://doi.wiley.com/10.1111/j.1600-065X.2008.00730.x
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http://dx.doi.org/10.1111/j.1600-065X.2008.00730.xDOI Listing
January 2009

GPS navigation of the protein-stability landscape.

Nat Biotechnol 2009 Jan;27(1):46-8

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http://dx.doi.org/10.1038/nbt0109-46DOI Listing
January 2009

Ubiquitin-mediated regulation of TNFR1 signaling.

Cytokine Growth Factor Rev 2008 Jun-Aug;19(3-4):313-24. Epub 2008 Jun 2.

Department of Protein Engineering, Genentech, Inc., 1 DNA Way, M/S 40, South San Francisco, CA 94080, United States.

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http://dx.doi.org/10.1016/j.cytogfr.2008.04.014DOI Listing
September 2008

DUBA: a deubiquitinase that regulates type I interferon production.

Science 2007 Dec 8;318(5856):1628-32. Epub 2007 Nov 8.

Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1126/science.1145918DOI Listing
December 2007

Targeted mass spectrometric strategy for global mapping of ubiquitination on proteins.

Rapid Commun Mass Spectrom 2007 ;21(20):3357-64

Applied Biosystems, Foster City, CA 94404, USA.

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http://dx.doi.org/10.1002/rcm.3227DOI Listing
November 2007

The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.

J Biol Chem 2006 Sep 4;281(39):29022-9. Epub 2006 Aug 4.

Departments of Protein Engineering and Physiological Chemistry, Genentech, Inc., South San Francisco, California 94110, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M605116200
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September 2006

ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage.

Science 2006 Aug;313(5790):1122-6

Department of Physiological Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1126/science.1127335DOI Listing
August 2006

Cryopyrin activates the inflammasome in response to toxins and ATP.

Nature 2006 Mar 11;440(7081):228-32. Epub 2006 Jan 11.

Molecular Oncology Department, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1038/nature04515DOI Listing
March 2006

Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-kappa B activation.

J Exp Med 2005 Nov;202(10):1327-32

Molecular Oncology Department, Genentech, Inc., San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1084/jem.20051194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212976PMC
November 2005

Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis.

J Exp Med 2005 Oct;202(8):1043-9

Molecular Oncology Department, Genentech Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1084/jem.20050977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213215PMC
October 2005

Unraveling TACIt functions.

Nat Genet 2005 Aug;37(8):793-4

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http://dx.doi.org/10.1038/ng0805-793DOI Listing
August 2005

Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A.

J Cell Biol 2005 Aug;170(5):745-55

Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada.

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http://dx.doi.org/10.1083/jcb.200502113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171356PMC
August 2005

Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity.

Cancer Cell 2005 May;7(5):425-31

Molecular Oncology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1016/j.ccr.2005.04.012DOI Listing
May 2005

COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas.

Cancer Res 2004 Oct;64(20):7226-30

Department of Molecular Oncology, Genentech, Inc., South San Francisco, California, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2601DOI Listing
October 2004