Mr. Vishma Pratap Sur - MENDEL UNIVERSITY - PhD STUDENT

Mr. Vishma Pratap Sur

MENDEL UNIVERSITY

PhD STUDENT

BRNO, SOUTH MORAVIA | Czech Republic

Main Specialties: Biology, Biotechnology, Chemical Pathology, Infectious Disease, Ophthalmology

Additional Specialties: Molecular Biology, Biotechnology, Animal experiment, Computational Biology

ORCID logohttps://orcid.org/0000-0002-1175-7194

Mr. Vishma Pratap Sur - MENDEL UNIVERSITY - PhD STUDENT

Mr. Vishma Pratap Sur

Publications

21Publications

102Reads

4Profile Views

10PubMed Central Citations

Novel Ruthenium coordinate compound combined with Schiff base and benzimidazole as a potent antibacterial agent against VRSA and MRSA

Sur, V.P., Mazumdar, A., Kopel, P., & Moulick, A. (2019). Novel Ruthenium coordinate compound combined with Schiff base and benzimidazole as a potent antibacterial agent against VRSA and MRSA. MendelNet, 26, 654-658.

Proceedings of 26 International PhD Students Conference

The rise of antibiotic-resistant strains is an important public health problem and thus the development of an alternative to antibiotics is imminent. The Ruthenium–Schiff base with benzimidazole (RU–S2), a co-ordinate compound is novel and first of its kind to be synthesized in such combination. The aim of the experiment is based on the synthesis of RU–S2 and to study its antibacterial activity against the pathogenic resistant strains of Staphylococcus aureus like Vancomycin-resistant Staphylococcus aureus (VRSA) and Methicillin-resistant Staphylococcus aureus (MRSA). The antibacterial activity was studied using growth curve analysis based on turbidimetry which was confirmed by the fluorescence live/dead cell microscopic imaging of the bacteria after treatment with RU–S2. Lastly, the cytotoxicity test was performed by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against human normal and cancer epithelial cell lines to understand the toxic effects of RU-S2 at 160 µg/ml concentration. The concentration 160 µg/ml of RU–S2 was very effective against those resistant strains and also nontoxic in this concentration. Thus RU-S2 can be used as an efficient alternative to antibiotics that have promising antibacterial efficacy against the pathogenic strains with no toxicity and biocompatibility towards human cells.

https://mendelnet.cz/artkey/mnt-201901-0126_Novel-Ruthenium-coordinate-compound-combined-with-Schiff-base-and-benzimidazole-as-a-potent-antibacterial-agent.php?back=/magno/mnt/2019/mn1.php?secid=4

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November 2019
1 Read

Intracameral Use of Nepafenac: Safety and Efficacy Study.

Curr Eye Res 2018 05 4;43(5):630-638. Epub 2017 Dec 4.

a Dept of Veterinary Surgery & Radiology , West Bengal University of Animal & Fishery Sciences , Kolkata , India.

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http://dx.doi.org/10.1080/02713683.2017.1408129DOI Listing
May 2018
25 Reads
1 Citation
1.663 Impact Factor

Estrogen Modulates Corneal Nociception and Maintains Corneal Homeostasis in Rat Eye.

Cornea 2018 Apr;37(4):508-514

Department of Veterinary Surgery & Radiology, West Bengal University of Animal & Fishery Sciences, Kolkata, India.

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http://dx.doi.org/10.1097/ICO.0000000000001437DOI Listing
April 2018
4 Reads
1 Citation
2.360 Impact Factor

Intracameral Use of Nepafenac: Safety and Efficacy Study Intracameral Use of Nepafenac: Safety and Efficacy Study

{Jha, 2018 #120}

Current Eye Research

Purpose: To test the intracameral safety of nepafenac and its efficacy in inhibiting prostaglandin synthesis during phacoemulsification surgery. Methods: The safety evaluation was conducted in normal eyes of rabbits, 0.1ml of 0.3% and 1% nepafenac was injected intracamerally. Extensive studies to detect adverse response ranged from a gross examination of eyes under slit lamp biomicroscope, fluorescein dye test, Schirmer tear test, test for corneal sensitivity, intraocular pressure measurement (IOP), specular microscopy, electroretinography(ERG), and histopathological examination of intraocular tissues. Efficacy of nepafenac was studied by intracameral injection of 0.1%, 0.3% nepafenac, nepafenac 0.3%+1% lignocaine, and 1% lignocaine alone, before phacoemulsification surgery and intraoperative mydriasis along with PGE2(ProstaglandinE2) secretion were recorded. Results: Single 0.1ml of 0.3% or 1% nepafenac did not significantly (p > 0.05) alter physiological parameters and histology of cornea, iris, and retina. Nepafenac 0.3% effectively inhibited PGE2 secretion. No significant (p > 0.05) prevention of miosis was recorded with 0.1% or 0.3% nepafenac. However, a combination of 0.3% nepafenac + 1% lignocaine and 1% lignocaine alone significantly (p < 0.05) arrested miosis during the intraoperative period. Conclusion: An intracameral concentration of up to 1% nepafenac does not adversely affect the rabbit eye. Nepafenac fails to prevent miosis but inhibits prostaglandin release during phacoemulsification surgery.

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December 2017
2 Reads

Pirfenidone inhibits post-traumatic proliferative vitreoretinopathy.

Eye (Lond) 2017 Sep 17;31(9):1317-1328. Epub 2017 Mar 17.

Department of Veterinary Surgery &Radiology, West Bengal University of Animal &Fishery Sciences, Kolkata, India.

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http://dx.doi.org/10.1038/eye.2017.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601446PMC
September 2017
3 Reads
1.900 Impact Factor

ADSBET2: Automated Determination of Salt-Bridge Energy-Terms version 2.

Bioinformation 2015 31;11(8):413-5. Epub 2015 Aug 31.

Department of Biotechnology, The University of Burdwan, Golapbag, Burdwan, 713104, West Bengal, India.

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http://dx.doi.org/10.6026/97320630011413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574125PMC
September 2015
18 Reads
2 Citations

ADSBET: AUTOMATED DETERMINATION OF SALT-BRIDGE ENERGY TERMS

INTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES

Salt-bridges are specific electrostatic interaction between groups of opposite charges. Net-interaction-energy (ΔΔGnet) of a salt-bridge is partitioned into bridge (ΔΔGbrd), desolvation (ΔΔGdsolv) and protein (ΔΔGprot) energy-terms of which estimation of the later two are possible only by computational means. Computation of salt-bridge energy-terms using Poison-Boltzmann-Equation (PBE) solver method employs highly involved process in that prior computation of energy-terms, one needs to determine protein-specific salt-bridges, input-parameters, hydrophobicisosteres-mutated charge-radius files. At this juncture, an efficient fully automated all-in-one-procedure that could analyze large dataset in a single run would be useful. To the best of our knowledge, such procedure is truly lacking in public domain. At this end, our fully automated procedure: ADSBET uses “APBS” method to compute component as well as net energy-terms for any numbers of salt-bridges in any numbers of structure files and redirect output in excel format. The output is not only useful for post run application of these energy terms but also helps to extract net energetic contribution of networked salt bridges. It works in UNIX like environment including CYGWIN. Overall, our ADSBET provides detailed energetic of salt-bridges from multiple crystal structures and find application in the field of computational structural biology. ADSBET is freely available at (http://sourceforge.net/projects/adsbet/).

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April 2015
6 Reads

SBION2: Analyses of Salt Bridges from Multiple Structure Files, Version 2.

Bioinformation 2015 30;11(1):39-42. Epub 2015 Jan 30.

Department of Biotechnology, The University of Burdwan, Golapbag, Burdwan, 713104.

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http://dx.doi.org/10.6026/97320630011039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349938PMC
March 2015
14 Reads
3 Citations

Top co-authors

Sunit Das
Sunit Das

Northwestern University

3
Arnab Nayek
Arnab Nayek

Authors equally contributed

3
Pratyay Seth
Pratyay Seth

The University of Burdwan

3
Shyamashree Banerjee
Shyamashree Banerjee

The University of Burdwan

3
Sarbani Hazra
Sarbani Hazra

West Bengal University of Animal and Fishery Sciences

2
Amal Kumar Bandyopadhyay
Amal Kumar Bandyopadhyay

The University of Burdwan

2
Vinod Kumar
Vinod Kumar

All India Institute of Medical Sciences

2
Aditya Konar
Aditya Konar

Indian Institute of Chemical Biology

2