Virginia M-Y Lee

Virginia M-Y Lee

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Virginia M-Y Lee

Virginia M-Y Lee

Publications by authors named "Virginia M-Y Lee"

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The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates.

Mol Neurobiol 2020 Sep 23;57(9):3803-3813. Epub 2020 Jun 23.

Department of Radiology, University of Pennsylvania, Vagelos Laboratories, 1012, 231 S. 34th Street, Philadelphia, PA, 19104-6323, USA.

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http://dx.doi.org/10.1007/s12035-020-01988-1DOI Listing
September 2020

Defining and predicting transdiagnostic categories of neurodegenerative disease.

Nat Biomed Eng 2020 Aug 3. Epub 2020 Aug 3.

Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41551-020-0593-yDOI Listing
August 2020

Neuroimmune interactions in Alzheimer's disease-New frontier with old challenges?

Prog Mol Biol Transl Sci 2019 24;168:183-201. Epub 2019 Oct 24.

Department of Pathology and Laboratory Medicine, AD Center Core (ADCC), Center for Neurodegenerative Disease Research, University of Pennsylvania (PENN), School of Medicine, Philadelphia, PA, United States.

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http://dx.doi.org/10.1016/bs.pmbts.2019.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939624PMC
July 2020

Thorn-shaped astrocytes in the depth of cortical sulci in Western Pacific ALS/Parkinsonism-Dementia complex.

Acta Neuropathol 2020 Jul 13. Epub 2020 Jul 13.

Center for Neurodegenerative Disease Research (CNDR), Institute On Aging and Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3600 Spruce Street, 3 Maloney Building, Philadelphia, PA, 19104-4283, USA.

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http://dx.doi.org/10.1007/s00401-020-02192-0DOI Listing
July 2020

Cell-to-Cell Transmission of Tau and α-Synuclein.

Trends Mol Med 2020 May 1. Epub 2020 May 1.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-2676, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2020.03.012DOI Listing
May 2020

Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer's disease.

Brain 2020 May;143(5):1572-1587

Department of Neurosurgery, Penn Center for Brain Injury and Repair, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1093/brain/awaa071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241956PMC
May 2020

Protein transmission in neurodegenerative disease.

Nat Rev Neurol 2020 04 23;16(4):199-212. Epub 2020 Mar 23.

The Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41582-020-0333-7DOI Listing
April 2020

Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia.

Front Aging Neurosci 2020 14;12:80. Epub 2020 Apr 14.

Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

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http://dx.doi.org/10.3389/fnagi.2020.00080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171590PMC
April 2020

Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease.

Neurobiol Dis 2020 03 16;136:104712. Epub 2019 Dec 16.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.104712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026836PMC
March 2020

Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult.

Neuron 2020 03 30;105(5):822-836.e7. Epub 2019 Dec 30.

Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.neuron.2019.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060125PMC
March 2020

Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.

J Biol Chem 2020 Mar 7;295(12):4001-4013. Epub 2020 Feb 7.

Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

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http://dx.doi.org/10.1074/jbc.RA119.010532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086036PMC
March 2020

Synthesis and characterization of high affinity fluorogenic α-synuclein probes.

Chem Commun (Camb) 2020 Mar;56(24):3567-3570

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1039/c9cc09849fDOI Listing
March 2020

Human tau pathology transmits glial tau aggregates in the absence of neuronal tau.

J Exp Med 2020 Feb;217(2)

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia PA.

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http://dx.doi.org/10.1084/jem.20190783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041709PMC
February 2020

Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology.

Neuron 2020 01 20;105(2):260-275.e6. Epub 2019 Nov 20.

The Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981053PMC
January 2020

Transmission of tauopathy strains is independent of their isoform composition.

Nat Commun 2020 01 7;11(1). Epub 2020 Jan 7.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1038/s41467-019-13787-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946697PMC
January 2020

Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease.

Acta Neuropathol Commun 2019 11 16;7(1):183. Epub 2019 Nov 16.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, 3600 Spruce St, 3rd Floor Maloney, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1186/s40478-019-0836-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858668PMC
November 2019

Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples.

Acta Neuropathol 2019 10 26;138(4):613-630. Epub 2019 Jul 26.

Department of Pathology and Laboratory Medicine, AD Center Core (ADCC), Center for Neurodegenerative Disease Research, University of Pennsylvania (PENN) School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s00401-019-02048-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939638PMC
October 2019

Slow Progressive Accumulation of Oligodendroglial Alpha-Synuclein (α-Syn) Pathology in Synthetic α-Syn Fibril-Induced Mouse Models of Synucleinopathy.

J Neuropathol Exp Neurol 2019 10;78(10):877-890

Laboratory Medicine, Department of Pathology, School of Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1093/jnen/nlz070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934438PMC
October 2019

Genetic predictors of survival in behavioral variant frontotemporal degeneration.

Neurology 2019 10 19;93(18):e1707-e1714. Epub 2019 Sep 19.

From the Department of Biostatistics, Epidemiology, and Informatics (C.C., S.X.X.), Department of Neurology (C.T.M., D.J.I., M.G., L.M.M.), Penn Frontotemporal Degeneration Center (C.T.M., D.J.I., M.G., L.M.M.), Translational Neuropathology Research Laboratory (E.B.L.), Department of Pathology and Laboratory Medicine (V.M.V.D., E.B.L., J.Q.T., V.M.-Y.L.), and Center for Neurodegenerative Disease Research (V.M.V.D., E.S., E.B.L., J.Q.T., V.M.-Y.L.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1212/WNL.0000000000008387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946477PMC
October 2019

α-Synuclein pathology in Parkinson's disease and related α-synucleinopathies.

Neurosci Lett 2019 09 3;709:134316. Epub 2019 Jun 3.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104 USA. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2019.134316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014913PMC
September 2019

TREM2 function impedes tau seeding in neuritic plaques.

Nat Neurosci 2019 08 24;22(8):1217-1222. Epub 2019 Jun 24.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1038/s41593-019-0433-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660358PMC
August 2019

Humanization of the entire murine gene provides a murine model of pathological human tau propagation.

J Biol Chem 2019 08 4;294(34):12754-12765. Epub 2019 Jul 4.

Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-city, Saitama 351-0198, Japan

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http://dx.doi.org/10.1074/jbc.RA119.009487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709628PMC
August 2019

Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis.

Nat Neurosci 2019 08 25;22(8):1248-1257. Epub 2019 Jul 25.

Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41593-019-0457-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662627PMC
August 2019

Transmission of α-synuclein seeds in neurodegenerative disease: recent developments.

Lab Invest 2019 07 13;99(7):971-981. Epub 2019 Feb 13.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1038/s41374-019-0195-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609465PMC
July 2019

Stereotaxic Targeting of Alpha-Synuclein Pathology in Mouse Brain Using Preformed Fibrils.

Methods Mol Biol 2019 ;1948:45-57

Center for Neurodegenerative Disease Research, Institute on Aging, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-1-4939-9124-2_5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463287PMC
July 2019

α-Synuclein (αSyn) Preformed Fibrils Induce Endogenous αSyn Aggregation, Compromise Synaptic Activity and Enhance Synapse Loss in Cultured Excitatory Hippocampal Neurons.

J Neurosci 2019 06 29;39(26):5080-5094. Epub 2019 Apr 29.

Departments of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research,

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http://dx.doi.org/10.1523/JNEUROSCI.0060-19.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595958PMC
June 2019

eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS.

Acta Neuropathol Commun 2019 04 25;7(1):62. Epub 2019 Apr 25.

Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1186/s40478-019-0711-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485101PMC
April 2019

Detection of Alzheimer's disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau).

Acta Neuropathol Commun 2019 03 4;7(1):34. Epub 2019 Mar 4.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, 3600 Spruce St. 3 Maloney, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1186/s40478-019-0687-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399892PMC
March 2019

A "Clickable" Photoconvertible Small Fluorescent Molecule as a Minimalist Probe for Tracking Individual Biomolecule Complexes.

J Am Chem Soc 2019 02 28;141(5):1893-1897. Epub 2019 Jan 28.

Department of Chemistry , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.

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http://pubs.acs.org/doi/10.1021/jacs.8b13094
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http://dx.doi.org/10.1021/jacs.8b13094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732186PMC
February 2019

LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice.

Acta Neuropathol Commun 2019 02 26;7(1):28. Epub 2019 Feb 26.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, 3600 Spruce St, 3rd Floor Maloney, Philadelphia, PA, 19104-4283, USA.

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http://dx.doi.org/10.1186/s40478-019-0679-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391792PMC
February 2019

Mechanisms of Cell-to-Cell Transmission of Pathological Tau: A Review.

JAMA Neurol 2019 01;76(1):101-108

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia.

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http://dx.doi.org/10.1001/jamaneurol.2018.2505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382549PMC
January 2019

Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology.

Alzheimers Dement 2019 01 12;15(1):55-64. Epub 2018 Oct 12.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

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http://dx.doi.org/10.1016/j.jalz.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333489PMC
January 2019

Converging Patterns of α-Synuclein Pathology in Multiple System Atrophy.

J Neuropathol Exp Neurol 2018 11;77(11):1005-1016

Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1093/jnen/nly080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181179PMC
November 2018

A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model.

Mol Neurodegener 2018 11 7;13(1):59. Epub 2018 Nov 7.

Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, 3600 Spruce St, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1186/s13024-018-0291-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223064PMC
November 2018

Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo.

Nat Commun 2018 10 11;9(1):4220. Epub 2018 Oct 11.

Center for Neurodegenerative Disease Research (CNDR), Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://www.nature.com/articles/s41467-018-06548-9
Publisher Site
http://dx.doi.org/10.1038/s41467-018-06548-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181940PMC
October 2018

Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study.

Acta Neuropathol 2018 09 18;136(3):377-388. Epub 2018 Jun 18.

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Institute on Aging, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s00401-018-1872-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534149PMC
September 2018

Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines.

Bioorg Med Chem Lett 2018 07 5;28(12):2180-2183. Epub 2018 May 5.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993642PMC
July 2018

The use of mouse models to study cell-to-cell transmission of pathological tau.

Methods Cell Biol 2017 14;141:287-305. Epub 2017 Jul 14.

Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mcb.2017.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733800PMC
June 2018

Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease.

J Neurochem 2018 06 10;145(6):489-503. Epub 2018 Jun 10.

Center for Neurodegenerative Disease Research and Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/jnc.14330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030437PMC
June 2018

Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity.

Acta Neuropathol 2018 06 3;135(6):855-875. Epub 2018 Mar 3.

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Philadelphia, PA, 19104-4283, USA.

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http://dx.doi.org/10.1007/s00401-018-1829-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955788PMC
June 2018

Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain.

Acta Neuropathol Commun 2018 06 11;6(1):50. Epub 2018 Jun 11.

Center for Neurodegenerative Disease Research (CNDR), Institute on Aging and Department of Pathology & Laboratory Medicine, Perelman School of Medicine (PSOM) at the University of Pennsylvania, HUP Maloney 3rd Floor, 36th and Spruce Street, Philadelphia, PA, 19104 - 4283, USA.

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http://dx.doi.org/10.1186/s40478-018-0552-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996526PMC
June 2018

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies.

Nature 2018 05 9;557(7706):558-563. Epub 2018 May 9.

The Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41586-018-0104-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970994PMC
May 2018

LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.

Acta Neuropathol Commun 2018 05 31;6(1):45. Epub 2018 May 31.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, 3600 Spruce St, 3rd Floor Maloney, Philadelphia, PA, 19104-4283, USA.

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http://dx.doi.org/10.1186/s40478-018-0550-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984465PMC
May 2018

Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies.

J Neuropathol Exp Neurol 2018 03;77(3):216-228

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

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https://academic.oup.com/jnen/article/77/3/216/4839220
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http://dx.doi.org/10.1093/jnen/nly010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251598PMC
March 2018

Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy.

Nat Neurosci 2018 03 20;21(3):329-340. Epub 2018 Feb 20.

Center for Neurodegenerative Disease Research (CNDR), Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://www.nature.com/articles/s41593-018-0083-7
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http://dx.doi.org/10.1038/s41593-018-0083-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857237PMC
March 2018

Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies.

Neurobiol Dis 2018 Jan 24;109(Pt B):209-218. Epub 2017 Jul 24.

The Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2017.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735026PMC
January 2018

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation.

Nat Med 2018 01 4;24(1):29-38. Epub 2017 Dec 4.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/nm.4443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760353PMC
January 2018

Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.

Acta Neuropathol 2018 01 5;135(1):65-83. Epub 2017 Dec 5.

Center for Neurodegenerative Science, Van Andel Research Institute, 333 Bostwick Avenue N.E., Grand Rapids, MI, 49503, USA.

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http://dx.doi.org/10.1007/s00401-017-1792-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756266PMC
January 2018

GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils.

J Neurosci 2017 11 6;37(47):11485-11494. Epub 2017 Oct 6.

Department of Pathology and Laboratory Medicine and Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104

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http://dx.doi.org/10.1523/JNEUROSCI.2393-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700428PMC
November 2017

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain.

J Neurosci 2017 11 20;37(47):11406-11423. Epub 2017 Oct 20.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104

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http://dx.doi.org/10.1523/JNEUROSCI.1230-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700423PMC
November 2017

Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs.

Neurobiol Dis 2017 Sep 22;105:328-335. Epub 2016 Dec 22.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, United States.

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http://dx.doi.org/10.1016/j.nbd.2016.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481496PMC
September 2017

Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration.

Acta Neuropathol Commun 2017 09 6;5(1):68. Epub 2017 Sep 6.

Center for Neurodegenerative Disease Research and Institute on Aging, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1186/s40478-017-0471-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586052PMC
September 2017

Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain.

Proc Natl Acad Sci U S A 2017 09 12;114(39):E8284-E8293. Epub 2017 Sep 12.

Wallenberg Neuroscience Center, Neurobiology Division, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden;

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http://dx.doi.org/10.1073/pnas.1710442114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625925PMC
September 2017

Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.

J Biol Chem 2017 08 13;292(32):13482-13497. Epub 2017 Jun 13.

From the Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, and

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http://dx.doi.org/10.1074/jbc.M117.780296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555207PMC
August 2017

Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members.

PLoS One 2016 21;11(12):e0168913. Epub 2016 Dec 21.

Department of Neurology, UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168913PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176320PMC
July 2017

Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies.

J Neurosci 2017 06 18;37(24):5870-5884. Epub 2017 May 18.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, and

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http://dx.doi.org/10.1523/JNEUROSCI.2705-16.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473205PMC
June 2017

Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases.

J Med Chem 2017 06 8;60(12):5120-5145. Epub 2017 Jun 8.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483893PMC
June 2017

Non-Naturally Occurring Small Molecule Microtubule-Stabilizing Agents: A Potential Tactic for CNS-Directed Therapies.

ACS Chem Neurosci 2017 01 29;8(1):5-7. Epub 2016 Nov 29.

Department of Chemistry, School of Arts and Sciences, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.

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http://dx.doi.org/10.1021/acschemneuro.6b00384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292930PMC
January 2017

Multimodal evaluation demonstrates in vivo F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration.

Acta Neuropathol 2016 12 4;132(6):935-937. Epub 2016 Nov 4.

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 3 West Gates, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s00401-016-1640-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154298PMC
December 2016

Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice.

J Exp Med 2016 11 17;213(12):2635-2654. Epub 2016 Oct 17.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104

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http://dx.doi.org/10.1084/jem.20160833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110027PMC
November 2016

Therapeutic strategies for the treatment of tauopathies: Hopes and challenges.

Alzheimers Dement 2016 10;12(10):1051-1065

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Institute on Aging, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2016.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116305PMC
October 2016

Cognitive reserve in frontotemporal degeneration: Neuroanatomic and neuropsychological evidence.

Neurology 2016 Oct 28;87(17):1813-1819. Epub 2016 Sep 28.

From the Department of Neurology, Penn Frontotemporal Degeneration Center (K.P., L.M., C.O., K.T., K.F., D.I., M.G., C.T.M.), and Department of Pathology & Laboratory Medicine, Center for Neurodegenerative Disease Research (V.V.D., E.B.L., J.Q.T., V.M.-Y.L., D.I.), University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1212/WNL.0000000000003250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089523PMC
October 2016

Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity.

Cell Rep 2016 09;16(12):3373-3387

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104-4283 USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087609PMC
http://dx.doi.org/10.1016/j.celrep.2016.08.053DOI Listing
September 2016

Progression of motor neuron disease is accelerated and the ability to recover is compromised with advanced age in rNLS8 mice.

Acta Neuropathol Commun 2016 Sep 29;4(1):105. Epub 2016 Sep 29.

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research (CNDR), Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Maloney Building, 3rd Floor 3600 Spruce Street, Philadelphia, PA, 19104-2676, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043606PMC
http://dx.doi.org/10.1186/s40478-016-0377-5DOI Listing
September 2016

Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy.

Acta Neuropathol Commun 2016 Sep 29;4(1):106. Epub 2016 Sep 29.

Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, 3600 Spruce St., Maloney 3, Philadelphia, PA, 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043530PMC
http://dx.doi.org/10.1186/s40478-016-0378-4DOI Listing
September 2016

Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis.

Neuron 2016 07 16;91(1):41-55. Epub 2016 Jun 16.

Department of Pathology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA; Pathology Service 113B, VA Medical Center, San Francisco, CA 94121, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938715PMC
July 2016

Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy.

J Neurosci 2016 07;36(29):7707-17

Center for Neurodegenerative Disease Research, Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

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http://dx.doi.org/10.1523/JNEUROSCI.1457-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705561PMC
July 2016

The Dynamics and Turnover of Tau Aggregates in Cultured Cells: INSIGHTS INTO THERAPIES FOR TAUOPATHIES.

J Biol Chem 2016 Jun 18;291(25):13175-93. Epub 2016 Apr 18.

From the Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 and

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http://dx.doi.org/10.1074/jbc.M115.712083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933232PMC
June 2016

Correction: Comparison of strategies for non-perturbing labeling of α-synuclein to study amyloidogenesis.

Org Biomol Chem 2016 06 12;14(21):4957. Epub 2016 May 12.

Department of Chemistry, University of Pennsylvania, 213 South 34th Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1039/c6ob90070dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553073PMC
June 2016