Virginia M Lee

Virginia M Lee

UNVERIFIED PROFILE

Are you Virginia M Lee?   Register this Author

Register author
Virginia M Lee

Virginia M Lee

Publications by authors named "Virginia M Lee"

Are you Virginia M Lee?   Register this Author

85Publications

3781Reads

36Profile Views

TREM2 function impedes tau seeding in neuritic plaques.

Nat Neurosci 2019 Aug 24;22(8):1217-1222. Epub 2019 Jun 24.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41593-019-0433-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660358PMC
August 2019

Humanization of the entire murine gene provides a murine model of pathological human tau propagation.

J Biol Chem 2019 Aug 4;294(34):12754-12765. Epub 2019 Jul 4.

Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-city, Saitama 351-0198, Japan

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA119.009487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709628PMC
August 2019

Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis.

Nat Neurosci 2019 Aug 25;22(8):1248-1257. Epub 2019 Jul 25.

Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41593-019-0457-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662627PMC
August 2019

LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice.

Acta Neuropathol Commun 2019 Feb 26;7(1):28. Epub 2019 Feb 26.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, 3600 Spruce St, 3rd Floor Maloney, Philadelphia, PA, 19104-4283, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40478-019-0679-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391792PMC
February 2019

Mechanisms of Cell-to-Cell Transmission of Pathological Tau: A Review.

JAMA Neurol 2019 Jan;76(1):101-108

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaneurol.2018.2505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382549PMC
January 2019

Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology.

Alzheimers Dement 2019 01 12;15(1):55-64. Epub 2018 Oct 12.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333489PMC
January 2019

The use of mouse models to study cell-to-cell transmission of pathological tau.

Methods Cell Biol 2017 14;141:287-305. Epub 2017 Jul 14.

Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/bs.mcb.2017.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733800PMC
June 2018

Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity.

Acta Neuropathol 2018 06 3;135(6):855-875. Epub 2018 Mar 3.

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Philadelphia, PA, 19104-4283, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-018-1829-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955788PMC
June 2018

LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.

Acta Neuropathol Commun 2018 05 31;6(1):45. Epub 2018 May 31.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, 3600 Spruce St, 3rd Floor Maloney, Philadelphia, PA, 19104-4283, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40478-018-0550-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984465PMC
May 2018

Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases.

Brain Pathol 2018 03 19;28(2):274-283. Epub 2017 Jan 19.

Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology & Laboratory Medicine, Philadelphia, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bpa.12482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484758PMC
March 2018

Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies.

J Neuropathol Exp Neurol 2018 03;77(3):216-228

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
https://academic.oup.com/jnen/article/77/3/216/4839220
Publisher Site
http://dx.doi.org/10.1093/jnen/nly010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251598PMC
March 2018

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain.

J Neurosci 2017 11 20;37(47):11406-11423. Epub 2017 Oct 20.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.1230-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700423PMC
November 2017

Protein astrogliopathies in human neurodegenerative diseases and aging.

Brain Pathol 2017 Sep;27(5):675-690

Center for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bpa.12536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578412PMC
September 2017

Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain.

Proc Natl Acad Sci U S A 2017 09 12;114(39):E8284-E8293. Epub 2017 Sep 12.

Wallenberg Neuroscience Center, Neurobiology Division, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1710442114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625925PMC
September 2017

Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members.

PLoS One 2016 21;11(12):e0168913. Epub 2016 Dec 21.

Department of Neurology, UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168913PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176320PMC
July 2017

Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies.

J Neurosci 2017 06 18;37(24):5870-5884. Epub 2017 May 18.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.2705-16.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473205PMC
June 2017

Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice.

J Exp Med 2016 11 17;213(12):2635-2654. Epub 2016 Oct 17.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20160833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110027PMC
November 2016

Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy.

Acta Neuropathol Commun 2016 Sep 29;4(1):106. Epub 2016 Sep 29.

Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, 3600 Spruce St., Maloney 3, Philadelphia, PA, 19104, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043530PMC
http://dx.doi.org/10.1186/s40478-016-0378-4DOI Listing
September 2016

The Dynamics and Turnover of Tau Aggregates in Cultured Cells: INSIGHTS INTO THERAPIES FOR TAUOPATHIES.

J Biol Chem 2016 Jun 18;291(25):13175-93. Epub 2016 Apr 18.

From the Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M115.712083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933232PMC
June 2016

An acetylation switch controls TDP-43 function and aggregation propensity.

Nat Commun 2015 Jan 5;6:5845. Epub 2015 Jan 5.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, 3600 Spruce Street, 3rd Fl Maloney Building, Philadelphia Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms6845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407365PMC
January 2015

In vivo measurement of glutamate loss is associated with synapse loss in a mouse model of tauopathy.

Neuroimage 2014 Nov 5;101:185-92. Epub 2014 Jul 5.

Center for Magnetic Resonance and Optical Imaging (CMROI), Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroimage.2014.06.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303593PMC
November 2014

Poly-A binding protein-1 localization to a subset of TDP-43 inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72.

J Neuropathol Exp Neurol 2014 Sep;73(9):837-45

From the Department of Biology, University of Pennsylvania (LM, NMB); Translational Neuropathology Research Laboratory, Stellar Chance Laboratories (EBL); and Department of Pathology and Laboratory Medicine, Perelman School of Medicine (VML, JQT, VMVD, EBL), Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/NEN.0000000000000102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149258PMC
September 2014

Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration.

Cell Rep 2014 Jun 12;7(6):2054-65. Epub 2014 Jun 12.

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute of Aging, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2014.05.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410967PMC
June 2014

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.

Acta Neuropathol 2014 Mar 19;127(3):407-18. Epub 2014 Jan 19.

Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-013-1239-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003885PMC
March 2014

Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins.

Acta Neuropathol Commun 2014 Mar 31;2:33. Epub 2014 Mar 31.

Center for Neurodegenerative Disease Research & Institute on Aging, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-4283, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/2051-5960-2-33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023626PMC
March 2014

Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases.

Nat Med 2014 Feb;20(2):130-8

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.3457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011661PMC
February 2014

Amyotrophic lateral sclerosis--a model of corticofugal axonal spread.

Nat Rev Neurol 2013 12 12;9(12):708-14. Epub 2013 Nov 12.

Clinical Neuroanatomy Section, Department of Neurology, Centre for Biomedical Research, University of Ulm, Helmholtzstrasse 8/1, 89081 Ulm, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrneurol.2013.221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943211PMC
December 2013

Therapeutic strategies for tau mediated neurodegeneration.

J Neurol Neurosurg Psychiatry 2013 Jul 20;84(7):784-95. Epub 2012 Oct 20.

Department of Neurology, Chiba East National Hospital, 673 Nitona, Chuo Ward, Chiba, Chiba 260-8712, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jnnp-2012-303144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912572PMC
July 2013

Distinct α-synuclein strains differentially promote tau inclusions in neurons.

Cell 2013 Jul;154(1):103-17

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2013.05.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820001PMC
July 2013

The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease.

Acta Neuropathol Commun 2013 Jul 6;1:31. Epub 2013 Jul 6.

Department of Pathology and Laboratory Medicine, 3630 Hamilton Walk, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/2051-5960-1-31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893579PMC
July 2013

The microtubule-associated tau protein has intrinsic acetyltransferase activity.

Nat Struct Mol Biol 2013 Jun 28;20(6):756-62. Epub 2013 Apr 28.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.2555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827724PMC
June 2013

Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy.

J Biol Chem 2013 May 26;288(21):15194-210. Epub 2013 Mar 26.

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M113.457408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663539PMC
May 2013

Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau.

FEBS Lett 2013 Mar 5;587(6):717-23. Epub 2013 Feb 5.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2013.01.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678381PMC
March 2013

Vascular disease and dementias: paradigm shifts to drive research in new directions.

Alzheimers Dement 2013 Jan 22;9(1):76-92. Epub 2012 Nov 22.

Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2012.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640817PMC
January 2013

Cardiovascular risk factors, cortisol, and amyloid-β deposition in Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement 2012 Nov;8(6):483-9

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2011.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668456PMC
November 2012

Distinct TDP-43 pathology in ALS patients with ataxin 2 intermediate-length polyQ expansions.

Acta Neuropathol 2012 Aug 21;124(2):221-30. Epub 2012 Apr 21.

Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, M322 Alway Building, Stanford, CA 94305, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-012-0985-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543833PMC
August 2012

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.

Hum Mol Genet 2012 Aug 3;21(15):3500-12. Epub 2012 May 3.

Department of Neurology, University of California, Los Angeles, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/dds161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392107PMC
August 2012

Improved protocol for measurement of plasma β-amyloid in longitudinal evaluation of Alzheimer's Disease Neuroimaging Initiative study patients.

Alzheimers Dement 2012 Jul;8(4):250-60

Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2012.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732031PMC
July 2012

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice.

J Exp Med 2012 May 16;209(5):975-86. Epub 2012 Apr 16.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20112457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348112PMC
May 2012

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking.

EMBO J 2012 Mar 23;31(5):1241-52. Epub 2011 Dec 23.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/emboj.2011.471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297986PMC
March 2012

Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis.

Acta Neuropathol 2012 Mar 1;123(3):395-407. Epub 2012 Jan 1.

Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-011-0932-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595560PMC
March 2012

Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.

Authors:
Trygve E Bakken J Cooper Roddey Srdjan Djurovic Natacha Akshoomoff David G Amaral Cinnamon S Bloss B J Casey Linda Chang Thomas M Ernst Jeffrey R Gruen Terry L Jernigan Walter E Kaufmann Tal Kenet David N Kennedy Joshua M Kuperman Sarah S Murray Elizabeth R Sowell Lars M Rimol Morten Mattingsdal Ingrid Melle Ingrid Agartz Ole A Andreassen Nicholas J Schork Anders M Dale Michael Weiner Paul Aisen Ronald Petersen Clifford R Jack William Jagust John Q Trojanowki Arthur W Toga Laurel Beckett Robert C Green Andrew J Saykin John Morris Enchi Liu Tom Montine Anthony Gamst Ronald G Thomas Michael Donohue Sarah Walter Devon Gessert Tamie Sather Danielle Harvey John Kornak Anders Dale Matthew Bernstein Joel Felmlee Nick Fox Paul Thompson Norbert Schuff Gene Alexander Charles DeCarli Dan Bandy Robert A Koeppe Norm Foster Eric M Reiman Kewei Chen Chet Mathis Nigel J Cairns Lisa Taylor-Reinwald J Q Trojanowki Les Shaw Virginia M Y Lee Magdalena Korecka Karen Crawford Scott Neu Tatiana M Foroud Steven Potkin Li Shen Zaven Kachaturian Richard Frank Peter J Snyder Susan Molchan Jeffrey Kaye Joseph Quinn Betty Lind Sara Dolen Lon S Schneider Sonia Pawluczyk Bryan M Spann James Brewer Helen Vanderswag Judith L Heidebrink Joanne L Lord Kris Johnson Rachelle S Doody Javier Villanueva-Meyer Munir Chowdhury Yaakov Stern Lawrence S Honig Karen L Bell John C Morris Beau Ances Maria Carroll Sue Leon Mark A Mintun Stacy Schneider Daniel Marson Randall Griffith David Clark Hillel Grossman Effie Mitsis Aliza Romirowsky Leyla deToledo-Morrell Raj C Shah Ranjan Duara Daniel Varon Peggy Roberts Marilyn Albert Chiadi Onyike Stephanie Kielb Henry Rusinek Mony J de Leon Lidia Glodzik Susan De Santi P Murali Doraiswamy Jeffrey R Petrella R Edward Coleman Steven E Arnold Jason H Karlawish David Wolk Charles D Smith Greg Jicha Peter Hardy Oscar L Lopez MaryAnn Oakley Donna M Simpson Anton P Porsteinsson Bonnie S Goldstein Kim Martin Kelly M Makino M Saleem Ismail Connie Brand Ruth A Mulnard Gaby Thai Catherine Mc-Adams-Ortiz Kyle Womack Dana Mathews Mary Quiceno Ramon Diaz-Arrastia Richard King Myron Weiner Kristen Martin-Cook Michael DeVous Allan I Levey James J Lah Janet S Cellar Jeffrey M Burns Heather S Anderson Russell H Swerdlow Liana Apostolova Po H Lu George Bartzokis Daniel H S Silverman Neill R Graff-Radford Francine Parfitt Heather Johnson Martin R Farlow Ann Marie Hake Brandy R Matthews Scott Herring Christopher H van Dyck Richard E Carson Martha G MacAvoy Howard Chertkow Howard Bergman Chris Hosein Sandra Black Bojana Stefanovic Curtis Caldwell Ging-Yuek Robin Hsiung Howard Feldman Benita Mudge Michele Assaly Andrew Kertesz John Rogers Dick Trost Charles Bernick Donna Munic Diana Kerwin Marek-Marsel Mesulam Kristina Lipowski Chuang-Kuo Wu Nancy Johnson Carl Sadowsky Walter Martinez Teresa Villena Raymond Scott Turner Kathleen Johnson Brigid Reynolds Reisa A Sperling Keith A Johnson Gad Marshall Meghan Frey Jerome Yesavage Joy L Taylor Barton Lane Allyson Rosen Jared Tinklenberg Marwan Sabbagh Christine Belden Sandra Jacobson Neil Kowall Ronald Killiany Andrew E Budson Alexander Norbash Patricia Lynn Johnson Thomas O Obisesan Saba Wolday Salome K Bwayo Alan Lerner Leon Hudson Paula Ogrocki Evan Fletcher Owen Carmichael John Olichney Smita Kittur Michael Borrie T-Y Lee Rob Bartha Sterling Johnson Sanjay Asthana Cynthia M Carlsson Steven G Potkin Adrian Preda Dana Nguyen Pierre Tariot Adam Fleisher Stephanie Reeder Vernice Bates Horacio Capote Michelle Rainka Douglas W Scharre Maria Kataki Earl A Zimmerman Dzintra Celmins Alice D Brown Godfrey D Pearlson Karen Blank Karen Anderson Robert B Santulli Eben S Schwartz Kaycee M Sink Jeff D Williamson Pradeep Garg Franklin Watkins Brian R Ott Henry Querfurth Geoffrey Tremont Stephen Salloway Paul Malloy Stephen Correia Howard J Rosen Bruce L Miller Jacobo Mintzer Crystal Flynn Longmire Kenneth Spicer Elizabether Finger Irina Rachinsky Dick Drost Terry Jernigan Connor McCabe Ellen Grant Thomas Ernst Josh Kuperman Yoon Chung Sarah Murray Cinnamon Bloss Burcu Darst Lexi Pritchett Ashley Saito David Amaral Mishaela DiNino Bella Eyngorina Elizabeth Sowell Suzanne Houston Lindsay Soderberg Walter Kaufmann Peter van Zijl Hilda Rizzo-Busack Mohsin Javid Natasha Mehta Erika Ruberry Alisa Powers Bruce Rosen Nitzah Gebhard Holly Manigan Jean Frazier David Kennedy Lauren Yakutis Michael Hill Jeffrey Gruen Joan Bosson-Heenan Heatherly Carlson

Proc Natl Acad Sci U S A 2012 Mar 16;109(10):3985-90. Epub 2012 Feb 16.

Medical Scientist Training Program, University of California at San Diego, La Jolla, CA 92093, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1105829109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309762PMC
March 2012

TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies.

Trends Mol Med 2011 Nov 23;17(11):659-67. Epub 2011 Jul 23.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14714914110010
Publisher Site
http://dx.doi.org/10.1016/j.molmed.2011.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202652PMC
November 2011

The acetylation of tau inhibits its function and promotes pathological tau aggregation.

Nat Commun 2011 ;2:252

Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms1255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120096PMC
August 2011

Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis.

Acta Neuropathol 2011 Mar 23;121(3):373-80. Epub 2010 Nov 23.

Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-010-0782-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095217PMC
March 2011

Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.

Acta Neuropathol 2010 Apr 3;119(4):409-19. Epub 2010 Mar 3.

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-010-0659-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880609PMC
April 2010

A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease.

J Biol Chem 2005 Jun 19;280(24):22670-8. Epub 2005 Apr 19.

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M501508200DOI Listing
June 2005

Molecular identification of AMY, an Alzheimer disease amyloid-associated protein.

J Neuropathol Exp Neurol 2003 Nov;62(11):1108-17

Department of Neurotec, Karolinska Institutet, Huddinge, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnen/62.11.1108DOI Listing
November 2003

NADPH oxidase activity in preeclampsia with immortalized lymphoblasts used as models.

Hypertension 2003 Apr 10;41(4):925-31. Epub 2003 Mar 10.

University of Leicester, Division of Medicine and Therapeutics, Level 4, Clinical Sciences Bldg, Leicester Royal Infirmary, Leicester, England.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/01.HYP.0000062021.68464.9DDOI Listing
April 2003

Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury.

J Neuropathol Exp Neurol 2003 Apr;62(4):368-80

Department of Pathobiology, Center for Comparative Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnen/62.4.368DOI Listing
April 2003

Neutrophil activation and production of reactive oxygen species in pre-eclampsia.

J Hypertens 2003 Feb;21(2):395-402

University of Leicester, The Division of Medicien and Therapeutics, Leicester Royal Infirmary, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/00004872-200302000-00032DOI Listing
February 2003

Radioiodinated styrylbenzene derivatives as potential SPECT imaging agents for amyloid plaque detection in Alzheimer's disease.

J Mol Neurosci 2002 Aug-Oct;19(1-2):7-10

Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12031-002-0003-9DOI Listing
January 2003

Neutrophil intracellular pH and Na+/H+ exchanger activity in pre-eclampsia.

Metabolism 2003 Jan;52(1):87-93

Department of Medicine, Leicester Royal Infirmary, Leicester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/meta.2003.50008DOI Listing
January 2003

Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses.

Neurotoxicology 2002 Oct;23(4-5):457-60

Department of Pathology, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

View Article

Download full-text PDF

Source
October 2002

The role of tau in Alzheimer's disease.

Med Clin North Am 2002 May;86(3):615-27

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Maloney Building, 3rd Floor, HUP, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0025-7125(02)00002-0DOI Listing
May 2002

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease.

Science 2002 Feb 20;295(5556):865-8. Epub 2001 Dec 20.

Department of Neuroscience, University of Pennsylvania and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1067389DOI Listing
February 2002

Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease.

Ann Neurol 2002 Feb;51(2):182-9

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
February 2002

Brain degeneration linked to "fatal attractions" of proteins in Alzheimer's disease and related disorders.

J Alzheimers Dis 2001 Feb;3(1):117-119

The Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
February 2001