Viola Oorschot

Viola Oorschot

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Viola Oorschot

Publications by authors named "Viola Oorschot"

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Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation.

J Cell Biol 2016 Dec 18;215(6):857-874. Epub 2016 Nov 18.

Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria 3800, Australia

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http://dx.doi.org/10.1083/jcb.201607039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166504PMC
December 2016

FLNC myofibrillar myopathy results from impaired autophagy and protein insufficiency.

Hum Mol Genet 2016 06 11;25(11):2131-2142. Epub 2016 Mar 11.

School of Biological Sciences,

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http://dx.doi.org/10.1093/hmg/ddw080DOI Listing
June 2016

Cathepsin D and its newly identified transport receptor SEZ6L2 can modulate neurite outgrowth.

J Cell Sci 2016 Feb 23;129(3):557-68. Epub 2015 Dec 23.

URPhyM-Laboratoire de Chimie Physiologique, University of Namur, 61 rue de Bruxelles, Namur 5000, Belgium

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http://dx.doi.org/10.1242/jcs.179374DOI Listing
February 2016

Vps33B is required for delivery of endocytosed cargo to lysosomes.

Traffic 2015 Dec 21;16(12):1288-305. Epub 2015 Oct 21.

Department of Cell Biology and Institute of Biomembranes, Center for Molecular Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands.

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http://doi.wiley.com/10.1111/tra.12334
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http://dx.doi.org/10.1111/tra.12334DOI Listing
December 2015

Immuno correlative light and electron microscopy on Tokuyasu cryosections.

Methods Cell Biol 2014 ;124:241-58

Monash Micro Imaging, Monash University, Melbourne, Victoria, Australia; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/B978-0-12-801075-4.00011-2DOI Listing
June 2015

Lysosomal capturing of cytoplasmic injected nanoparticles by autophagy: an additional barrier to non viral gene delivery.

J Control Release 2014 Dec 11;195:29-36. Epub 2014 Aug 11.

Lab General Biochemistry & Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.08.002DOI Listing
December 2014

Zebrafish models of BAG3 myofibrillar myopathy suggest a toxic gain of function leading to BAG3 insufficiency.

Acta Neuropathol 2014 Dec 2;128(6):821-33. Epub 2014 Oct 2.

School of Biological Sciences, Monash University, Melbourne, VIC, 3800, Australia.

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http://dx.doi.org/10.1007/s00401-014-1344-5DOI Listing
December 2014

Apoptosis-linked gene-2 (ALG-2)/Sec31 interactions regulate endoplasmic reticulum (ER)-to-Golgi transport: a potential effector pathway for luminal calcium.

J Biol Chem 2014 Aug 8;289(34):23609-28. Epub 2014 Jul 8.

From the Division of Biological Sciences and Center for Structural and Functional Neuroscience, University of Montana, Missoula, Montana 59812-4824 and

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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.561829
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http://dx.doi.org/10.1074/jbc.M114.561829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156086PMC
August 2014

Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance.

Mol Cancer Ther 2013 Oct 6;12(10):2018-30. Epub 2013 Aug 6.

Corresponding Author: Marja Jäättelä, Cell Death and Metabolism, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, DK-2100, Denmark.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-13
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http://dx.doi.org/10.1158/1535-7163.MCT-13-0084DOI Listing
October 2013

hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins.

Nat Commun 2013 ;4:1361

Department of Cell Biology, University Medical Centre Utrecht, AZU Room H02.313, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands.

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http://dx.doi.org/10.1038/ncomms2360DOI Listing
June 2013

Different characteristics and nucleotide binding properties of inosine monophosphate dehydrogenase (IMPDH) isoforms.

PLoS One 2012 7;7(12):e51096. Epub 2012 Dec 7.

Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051096PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517587PMC
May 2013

The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).

J Biol Chem 2013 Apr 5;288(16):11532-45. Epub 2013 Feb 5.

Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

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http://dx.doi.org/10.1074/jbc.M112.438481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630886PMC
April 2013

The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion.

Traffic 2013 Feb 12;14(2):219-32. Epub 2012 Dec 12.

Department of Cell Biology, University Medical Center Utrecht, Heidelberglaan 100, 3584, CX Utrecht, The Netherlands.

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http://dx.doi.org/10.1111/tra.12027DOI Listing
February 2013

R-SNARE ykt6 resides in membrane-associated protease-resistant protein particles and modulates cell cycle progression when over-expressed.

Biol Cell 2012 Jul 29;104(7):397-417. Epub 2012 May 29.

Division of Biological Sciences and Centre for Structural and Functional Neuroscience, The University of Montana, Missoula, MT 59812, USA.

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http://dx.doi.org/10.1111/boc.201100048DOI Listing
July 2012

Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport.

Biol Open 2012 Jun 9;1(6):607-14. Epub 2012 May 9.

Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht , 3584 CX Utrecht , The Netherlands.

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http://dx.doi.org/10.1242/bio.2012778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509441PMC
June 2012

Disruption of the Man-6-P targeting pathway in mice impairs osteoclast secretory lysosome biogenesis.

Traffic 2011 Jul 5;12(7):912-24. Epub 2011 May 5.

Department of Cell Biology, University Medical Center, Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

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http://doi.wiley.com/10.1111/j.1600-0854.2011.01203.x
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http://dx.doi.org/10.1111/j.1600-0854.2011.01203.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115509PMC
July 2011

Vacuolization of mucolipidosis type II mouse exocrine gland cells represents accumulation of autolysosomes.

Mol Biol Cell 2011 Apr 16;22(8):1135-47. Epub 2011 Feb 16.

Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1091/mbc.E10-07-0584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078071PMC
April 2011

Modern approaches for ultrastructural analysis of the zebrafish embryo.

Methods Cell Biol 2010 ;96:425-42

Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane, 4072 Queensland, Australia.

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http://dx.doi.org/10.1016/S0091-679X(10)96018-4DOI Listing
January 2011

Spatial regulation of Golgi phosphatidylinositol-4-phosphate is required for enzyme localization and glycosylation fidelity.

Traffic 2010 Sep 21;11(9):1180-90. Epub 2010 Jun 21.

Division of Nephrology & Hypertension, Department of Medicine Oregon Health & Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1111/j.1600-0854.2010.01092.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921771PMC
September 2010

Termination of autophagy and reformation of lysosomes regulated by mTOR.

Nature 2010 Jun 6;465(7300):942-6. Epub 2010 Jun 6.

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nature09076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920749PMC
June 2010

mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles.

Mol Biol Cell 2009 Oct 5;20(19):4205-15. Epub 2009 Aug 5.

Department of Cell Biology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06519, USA.

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http://dx.doi.org/10.1091/mbc.e09-05-0387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754934PMC
October 2009

Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1.

Proc Natl Acad Sci U S A 2009 Oct 17;106(40):17019-24. Epub 2009 Sep 17.

Cellular Protein Chemistry and Biomolecular Mass Spectrometry, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands.

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http://dx.doi.org/10.1073/pnas.0903036106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761347PMC
October 2009

Intracellular activation of vasopressin V2 receptor mutants in nephrogenic diabetes insipidus by nonpeptide agonists.

Proc Natl Acad Sci U S A 2009 Jul 8;106(29):12195-200. Epub 2009 Jul 8.

Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500HB Nijmegen, The Netherlands.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0900130106
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http://dx.doi.org/10.1073/pnas.0900130106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715499PMC
July 2009

Correlative light-electron microscopy (CLEM) combining live-cell imaging and immunolabeling of ultrathin cryosections.

Nat Methods 2008 Nov;5(11):973-80

Cell Microscopy Center, Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

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http://www.nature.com/articles/nmeth.1263
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http://dx.doi.org/10.1038/nmeth.1263DOI Listing
November 2008

Cripto localizes Nodal at the limiting membrane of early endosomes.

Sci Signal 2008 Nov 11;1(45):ra13. Epub 2008 Nov 11.

Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland.

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http://dx.doi.org/10.1126/scisignal.1165027DOI Listing
November 2008

Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation.

EMBO J 2008 Oct 4;27(19):2580-91. Epub 2008 Sep 4.

Ecole Polytechnique Fédérale de Lausanne (EPFL), Swiss Institute for Experimental Cancer Research (ISREC), Epalinges, Switzerland.

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http://dx.doi.org/10.1038/emboj.2008.174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567404PMC
October 2008

The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions.

Cell Signal 2008 Sep 23;20(9):1608-15. Epub 2008 May 23.

Department of Physiological Chemistry, Centre for Biomedical Genetics and Cancer Genomics Centre, Utrecht, The Netherlands.

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http://groups.mcr.umcutrecht.nl/bos/UserFiles/File/Dube_2008
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http://linkinghub.elsevier.com/retrieve/pii/S089865680800145
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http://dx.doi.org/10.1016/j.cellsig.2008.05.006DOI Listing
September 2008

Rescue of a nephrogenic diabetes insipidus-causing vasopressin V2 receptor mutant by cell-penetrating peptides.

J Biol Chem 2007 Jul 8;282(28):20676-85. Epub 2007 May 8.

Leibniz-Institut für Molekulare Pharmakologie, Robert-Rössle-Strasse 10, 13125 Berlin, Germany.

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http://dx.doi.org/10.1074/jbc.M611530200DOI Listing
July 2007

Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel.

Proc Natl Acad Sci U S A 2006 Nov 13;103(48):18344-9. Epub 2006 Nov 13.

Department of Physiology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1073/pnas.0604073103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838753PMC
November 2006

A viral protein that blocks Arf1-mediated COP-I assembly by inhibiting the guanine nucleotide exchange factor GBF1.

Dev Cell 2006 Aug;11(2):191-201

Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.devcel.2006.06.005DOI Listing
August 2006

Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.

Traffic 2006 Mar;7(3):354-64

Cell Microscopy Center, Department of Cell Biology, University Medical Center and Institute for Biomembranes, 3584 CX Utrecht, the Netherlands.

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http://dx.doi.org/10.1111/j.1600-0854.2006.00388.xDOI Listing
March 2006

Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport.

J Cell Sci 2005 Oct;118(Pt 19):4527-39

Henry Wellcome Integrated Signalling Laboratories, Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK.

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http://dx.doi.org/10.1242/jcs.02568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904489PMC
October 2005

Sorting nexin 17 facilitates LRP recycling in the early endosome.

EMBO J 2005 Aug 28;24(16):2851-61. Epub 2005 Jul 28.

Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1038/sj.emboj.7600756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1187941PMC
August 2005

Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides.

Curr Biol 2004 Oct;14(20):1791-800

Henry Wellcome Integrated Signalling Laboratories, Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S096098220400750
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http://dx.doi.org/10.1016/j.cub.2004.09.077DOI Listing
October 2004

Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes.

Traffic 2003 Aug;4(8):553-65

Department of Cell Biology, University Medical Center and Institute for Biomembranes, Center for Biomedical Genetics, Utrecht University, 3584 CX Utrecht, The Netherlands.

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August 2003

Rab4 function in membrane recycling from early endosomes depends on a membrane to cytoplasm cycle.

J Biol Chem 2002 Aug 29;277(35):32029-35. Epub 2002 May 29.

Department of Cell Biology, University Medical Center Utrecht and Institute of Biomembranes, Utrecht 3584 CX, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M203064200DOI Listing
August 2002

A novel flat-embedding method to prepare ultrathin cryosections from cultured cells in their in situ orientation.

J Histochem Cytochem 2002 Aug;50(8):1067-80

Department of Cell Biology and Institute for Biomembranes, University Medical Center, Utrecht, The Netherlands.

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http://dx.doi.org/10.1177/002215540205000809DOI Listing
August 2002

Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes.

Mol Biol Cell 2002 Apr;13(4):1313-28

Department of Cell Biology, University Medical Center Utrecht and Institute of Biomembranes, 3584 CX Utrecht, The Netherlands.

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http://dx.doi.org/10.1091/mbc.01-10-0525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC102271PMC
April 2002

Immunoelectron microscopic localization of cholesterol using biotinylated and non-cytolytic perfringolysin O.

J Histochem Cytochem 2002 Jan;50(1):43-55

Department of Cell Biology, University Medical Center Utrecht and Center for Biomedical Genetics, Utrecht, The Netherlands.

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http://dx.doi.org/10.1177/002215540205000105DOI Listing
January 2002