Vinod Bhakuni

Vinod Bhakuni

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Vinod Bhakuni

Vinod Bhakuni

Publications by authors named "Vinod Bhakuni"

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Novel protein-protein interactions between Entamoeba histolyticad-phosphoglycerate dehydrogenase and phosphoserine aminotransferase.

Biochimie 2012 Aug 24;94(8):1676-86. Epub 2012 Feb 24.

Division of Molecular and Structural Biology, CSIR-Central Drug Research Institute, MG Marg, Lucknow 226001, India.

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http://linkinghub.elsevier.com/retrieve/pii/S030090841200087
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http://dx.doi.org/10.1016/j.biochi.2012.02.028DOI Listing
August 2012

Role of conserved active site tryptophan-101 in functional activity and stability of phosphoserine aminotransferase from an enteric human parasite.

Amino Acids 2012 Jul 29;43(1):483-91. Epub 2011 Oct 29.

Division of Molecular and Structural Biology, CSIR-Central Drug Research Institute, Lucknow, 226001, India.

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http://dx.doi.org/10.1007/s00726-011-1105-xDOI Listing
July 2012

Glu-108 is essential for subunit assembly and dimer stability of D-phosphoglycerate dehydrogenase from Entamoeba histolytica.

Mol Biochem Parasitol 2012 Feb 23;181(2):117-24. Epub 2011 Oct 23.

Division of Molecular and Structural Biology, CSIR-Central Drug Research Institute, Lucknow 226001, India.

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http://linkinghub.elsevier.com/retrieve/pii/S016668511100246
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http://dx.doi.org/10.1016/j.molbiopara.2011.10.008DOI Listing
February 2012

Comparative analysis of malate synthase G from Mycobacterium tuberculosis and E. coli: role of ionic interaction in modulation of structural and functional properties.

Int J Biol Macromol 2011 Dec 12;49(5):917-22. Epub 2011 Aug 12.

Molecular and Structural Biology Division, Central Drug Research Institute, Lucknow 226001, India.

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http://dx.doi.org/10.1016/j.ijbiomac.2011.08.008DOI Listing
December 2011

Biophysical characterization of Entamoeba histolytica phosphoserine aminotransferase (EhPSAT): role of cofactor and domains in stability and subunit assembly.

Eur Biophys J 2011 May 16;40(5):599-610. Epub 2010 Dec 16.

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow, India.

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http://dx.doi.org/10.1007/s00249-010-0654-3DOI Listing
May 2011

Maximizing the native concentration and shelf life of protein: a multiobjective optimization to reduce aggregation.

Appl Microbiol Biotechnol 2011 Jan 27;89(1):99-108. Epub 2010 Aug 27.

Department of Biotechnology, Integral University, Lucknow 226021, India.

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http://link.springer.com/10.1007/s00253-010-2835-5
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http://dx.doi.org/10.1007/s00253-010-2835-5DOI Listing
January 2011

A functionally active dimer of mycobacterium tuberculosis malate synthase G.

Eur Biophys J 2010 Oct 21;39(11):1557-62. Epub 2010 Mar 21.

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226 001, India.

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http://dx.doi.org/10.1007/s00249-010-0598-7DOI Listing
October 2010

Alkaline pH-dependent differential unfolding characteristics of mesophilic and thermophilic homologs of dimeric serine hydroxymethyltransferase.

Biochim Biophys Acta 2010 Jun 10;1804(6):1294-300. Epub 2010 Feb 10.

Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Delhi 110 054, India.

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http://dx.doi.org/10.1016/j.bbapap.2010.01.023DOI Listing
June 2010

Conformational stability and energetics of Plasmodium falciparum glutaredoxin.

Biochimie 2010 Mar 17;92(3):284-91. Epub 2009 Dec 17.

Department of Biochemistry, North-Eastern Hill University, Shillong, India.

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http://dx.doi.org/10.1016/j.biochi.2009.12.003DOI Listing
March 2010

Entamoeba histolytica Phosphoserine aminotransferase (EhPSAT): insights into the structure-function relationship.

BMC Res Notes 2010 Mar 3;3:52. Epub 2010 Mar 3.

Division of Molecular and Structural Biology, Central Drug Research Institute, Chattar Manzil Palace, Council of scientific and industrial research (CSIR), Lucknow 226001, India.

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http://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0
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http://dx.doi.org/10.1186/1756-0500-3-52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850911PMC
March 2010

Structural, functional and unfolding characteristics of glutathione S-transferase of Plasmodium vivax.

Arch Biochem Biophys 2009 Jul 23;487(2):115-22. Epub 2009 May 23.

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226 001, India.

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http://dx.doi.org/10.1016/j.abb.2009.05.011DOI Listing
July 2009

Guanidine hydrochloride- and urea-induced unfolding of Toxoplasma gondii ferredoxin-NADP+ reductase: stabilization of a functionally inactive holo-intermediate.

J Biochem 2009 Jun 23;145(6):721-31. Epub 2009 Feb 23.

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226 001, India.

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https://academic.oup.com/jb/article-lookup/doi/10.1093/jb/mv
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http://dx.doi.org/10.1093/jb/mvp029DOI Listing
June 2009

Self-assembly of bacteriophage-associated hyaluronate lyase (HYLP2) into an enzymatically active fibrillar film.

J Biol Chem 2009 Feb 10;284(8):5240-9. Epub 2008 Oct 10.

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226001, India.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M806730200
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http://dx.doi.org/10.1074/jbc.M806730200DOI Listing
February 2009

Evidence for inhibitory interaction of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) with Streptococcus pneumoniae hyaluronidase.

J Biol Chem 2009 Feb 11;284(6):3897-905. Epub 2008 Nov 11.

Computational Biology Laboratory, National Institute for Plant Genome Research, Aruna Asaf Ali Marg, New Delhi 110067, India.

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http://dx.doi.org/10.1074/jbc.M804246200DOI Listing
February 2009

Characterization of pyridoxal 5'- phosphate-binding domain and folding intermediate of Bacillus subtilis serine hydroxymethyltransferase: an autonomous folding domain.

J Biochem 2008 Sep 15;144(3):295-303. Epub 2008 May 15.

Division of Biocybernetics, Institute of Nuclear Medicine and Allied Sciences, Delhi 110 054, India.

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http://dx.doi.org/10.1093/jb/mvn067DOI Listing
September 2008

Mycobacterium tuberculosis isocitrate lyase (MtbIcl): role of divalent cations in modulation of functional and structural properties.

Proteins 2008 Aug;72(3):892-900

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow, India.

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http://doi.wiley.com/10.1002/prot.21984
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http://dx.doi.org/10.1002/prot.21984DOI Listing
August 2008

Toxoplasma gondii ferredoxin-NADP+ reductase: Role of ionic interactions in stabilization of native conformation and structural cooperativity.

Proteins 2008 Jun;71(4):1879-88

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow-226 001, India.

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http://doi.wiley.com/10.1002/prot.21872
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http://dx.doi.org/10.1002/prot.21872DOI Listing
June 2008

Structural and stability characteristics of a monothiol glutaredoxin: glutaredoxin-like protein 1 from Plasmodium falciparum.

Biochim Biophys Acta 2008 Jun 11;1784(6):946-52. Epub 2008 Apr 11.

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow, India.

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http://linkinghub.elsevier.com/retrieve/pii/S157096390800106
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http://dx.doi.org/10.1016/j.bbapap.2008.03.012DOI Listing
June 2008

Glutathione mediated regulation of oligomeric structure and functional activity of Plasmodium falciparum glutathione S-transferase.

BMC Struct Biol 2007 Oct 17;7:67. Epub 2007 Oct 17.

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226001, India.

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http://bmcstructbiol.biomedcentral.com/articles/10.1186/1472
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http://dx.doi.org/10.1186/1472-6807-7-67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2110890PMC
October 2007

Cloning and structural analysis of Mycobacterium leprae serine hydroxymethyltransferase.

Protein Expr Purif 2007 Sep 29;55(1):189-97. Epub 2007 Apr 29.

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226001, India.

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http://dx.doi.org/10.1016/j.pep.2007.04.017DOI Listing
September 2007

Cation induced differential effect on structural and functional properties of Mycobacterium tuberculosis alpha-isopropylmalate synthase.

BMC Struct Biol 2007 Jun 19;7:39. Epub 2007 Jun 19.

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow, India.

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http://bmcstructbiol.biomedcentral.com/articles/10.1186/1472
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http://dx.doi.org/10.1186/1472-6807-7-39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1919377PMC
June 2007

Role of ionic interactions and linker in the domain interaction and modulation of functional activity of hyaluronate lyases.

Biochem Biophys Res Commun 2007 Feb 12;353(2):286-92. Epub 2006 Dec 12.

Molecular and Structural Biology Division, Central Drug Research Institute, Lucknow 226 001, India.

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http://dx.doi.org/10.1016/j.bbrc.2006.12.014DOI Listing
February 2007

Insights into the mechanism of action of hyaluronate lyase: role of C-terminal domain and Ca2+ in the functional regulation of enzyme.

J Biol Chem 2006 Sep 19;281(38):28336-44. Epub 2006 Jul 19.

Central Drug Research Institute, Lucknow 226 001, India.

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http://dx.doi.org/10.1074/jbc.M601165200DOI Listing
September 2006

Unusual structural features of the bacteriophage-associated hyaluronate lyase (hylp2).

J Biol Chem 2006 Mar 16;281(11):7143-50. Epub 2006 Jan 16.

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226 001, India.

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http://dx.doi.org/10.1074/jbc.M510991200DOI Listing
March 2006

Resistance reversal action of ketoconazole against mefloquine resistance of Plasmodium yoelii nigeriensis.

Exp Parasitol 2004 Jul-Aug;107(3-4):115-9

Division of Parasitology, Central Drug Research Institute, Chattat Manzil, PO Box No. 173, Lucknow 226 001, India.

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http://linkinghub.elsevier.com/retrieve/pii/S001448940400099
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http://dx.doi.org/10.1016/j.exppara.2004.06.001DOI Listing
October 2004

Unusual structural, functional, and stability properties of serine hydroxymethyltransferase from Mycobacterium tuberculosis.

J Biol Chem 2003 Oct 11;278(42):40793-805. Epub 2003 Aug 11.

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226 001, India.

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http://dx.doi.org/10.1074/jbc.M306192200DOI Listing
October 2003

Streptococcus pneumoniae hyaluronate lyase contains two non-cooperative independent folding/unfolding structural domains: characterization of functional domain and inhibitors of enzyme.

J Biol Chem 2003 Jul 27;278(28):25509-16. Epub 2003 Apr 27.

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226 001, India.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M301894200
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http://dx.doi.org/10.1074/jbc.M301894200DOI Listing
July 2003

Alkaline treatment has contrasting effects on the structure of deglycosylated and glycosylated forms of glucose oxidase.

Arch Biochem Biophys 2003 May;413(2):221-8

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226001, India.

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May 2003

Unique holoenzyme dimers of the tetrameric enzyme Escherichia coli methylenetetrahydrofolate reductase: characterization of structural features associated with modulation of the enzyme's function.

Biochemistry 2003 Apr;42(13):3921-8

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226 001, India.

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http://dx.doi.org/10.1021/bi0340200DOI Listing
April 2003

Different unfolding pathways for mesophilic and thermophilic homologues of serine hydroxymethyltransferase.

Biochemistry 2002 Oct;41(40):12115-23

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226 001, India.

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October 2002

Divalent cation induced changes in structural properties of the dimeric enzyme glucose oxidase: dual effect of dimer stabilization and dissociation with loss of cooperative interactions in enzyme monomer.

Biochemistry 2002 Jun;41(22):7142-9

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226 001, India.

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June 2002

Guanidinium chloride- and urea-induced unfolding of the dimeric enzyme glucose oxidase.

Biochemistry 2002 Mar;41(11):3819-27

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226 001, India.

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March 2002

Unique oligomeric intermediates of bovine liver catalase.

Protein Sci 2002 Jan;11(1):46-57

Molecular and Structural Biology Division, Central Drug Research Institute, Lucknow 226 001, India.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2368769PMC
http://dx.doi.org/10.1110/ps.20102DOI Listing
January 2002