Publications by authors named "Vincenzo D"

15 Publications

  • Page 1 of 1

Effects of surgical mandibular advancement on the upper airways of adult class II patients: A systematic review with meta-analysis.

J Oral Rehabil 2021 Mar 13;48(3):210-232. Epub 2021 Jan 13.

Department of Neurosciences, Reproductive Sciences and Oral Sciences, University of Naples Federico II, Naples, Italy.

Aim: To systematically review the effects of surgical mandibular advancement (SMA) regarding changes of the upper airways in adult patients with skeletal Class II malocclusion.

Materials And Methods: Five electronic databases were searched up to April 2020. Human studies focusing on the morphology and dimension of the upper airways after SMA were included. 'Quality assessment for Before-After (Pre-Post) Studies' was used to assess the risk of bias of the individual studies. Standard mean differences (SMD) with 95% confidence intervals (CI) were calculated for random effect model meta-analysis. The certainty of evidence was assessed using the GRADE tool.

Results: Twenty cohort studies of only treated patients without control group were eligible for qualitative synthesis, of which 17 were used for quantitative synthesis. Very low certainty of evidence indicated that SMA resulted in significant increase of the volume and of the smallest cross-sectional area (SMC) of the nasopharynx (volume SMD: 1.43, CI: 0.62, 2.24, P = .001, I  = 87.8%; SMC SMD: 1.53, CI: 0.59, 2.47, P = .001, I  = 90.5%) and oropharynx (volume SMD: 1.36, CI: 0.37,2.35, P = .007, I  = 92.1%; SMC SMD: 1.21, CI: 0.11,2.32, P = .032, I  = 93.1%). Significant augmentation of the distances between the posterior pharynx wall and the uvala (SMD: 0.73, CI: 0.46,0.98, P < .001, I  = 72.7%), the posterior border of the tongue (SMD: 0.52, CI: 0.21,0.84, P = .001; I : 60.5%), the gonion (SMD: 1.24, CI: 0.56,1.91, P < .001; I  = 88.8%) and the epiglottis (SMD: 0.40, CI: 0.06,0.74, P = .033; I  = 84.8%) were observed.

Conclusions: Weak evidence suggests enlargement of the upper airways of adult Class II subjects following SMA, with major increases in the oropharynx.
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http://dx.doi.org/10.1111/joor.13140DOI Listing
March 2021

Toll like receptor 7 expressed by malignant cells promotes tumor progression and metastasis through the recruitment of myeloid derived suppressor cells.

Oncoimmunology 2019;8(1):e1505174. Epub 2018 Oct 11.

Institut National de la Santé et de la Recherche Medicale (INSERM), UMRS1138, Centre de Recherche des Cordeliers, Paris, France.

In non-small cell lung carcinoma (NSCLC), stimulation of toll-like receptor 7 (TLR7), a receptor for single stranded RNA, is linked to tumor progression and resistance to anticancer chemotherapy. However, the mechanism of this effect has been elusive. Here, using a murine model of lung adenocarcinoma, we demonstrate a key role for TLR7 expressed by malignant (rather than by stromal and immune) cells, in the recruitment of myeloid derived suppressor cells (MDSCs), induced after TLR7 stimulation, resulting in accelerated tumor growth and metastasis. In adenocarcinoma patients, high TLR7 expression on malignant cells was associated with poor clinical outcome, as well as with a gene expression signature linked to aggressiveness and metastastic dissemination with high abundance of mRNA encoding intercellular adhesion molecule 1 (ICAM-1), cytokeratins 7 and 19 (KRT-7 and 19), syndecan 4 (SDC4), and p53. In addition, lung tumors expressing high levels of TLR7 have a phenotype of epithelial mesenchymal transition with high expression of vimentin and low abundance of E-cadherin. These data reveal a crucial role for cancer cell-intrinsic TLR7 expression in lung adenocarcinoma progression.
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http://dx.doi.org/10.1080/2162402X.2018.1505174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287801PMC
October 2018

Radiofrequency energy in the arthroscopic treatment of knee chondral lesions: a systematic review.

Br Med Bull 2016 Mar 9;117(1):149-56. Epub 2016 Feb 9.

Department of Orthopaedic and Trauma Surgery, Campus Biomedico University of Rome, Via Alvaro del Portillo 200, Rome, Italy.

Introduction: Cartilage debridement is one of the recommended procedures for the management of chondral defects. Radiofrequency probes allow to debride the cartilage, but may induce subchondral bone necrosis.

Sources Of Data: Medline, Cochrane and Google Scholar were searched to identify studies on arthroscopic debridement of the articular cartilage of the knee using radiofrequency chondroplasty. The methodological quality of the studies was assessed using the Coleman methodology score (CMS).

Areas Of Agreement: Monopolar and bipolar radiofrequency devices provide significantly better clinical outcomes, especially for patients with high-grade chondral lesions, compared with mechanical shaver only. Despite the original concerns regarding subchondral bone necrosis, low complication rates are reported.

Areas Of Controversy: Heterogeneity in terms of type of device does not allow sound comparison of the published results. There is lack of evidence on the long-term effects of radiofrequency chondroplasty.

Growing Points: Study methodology should be improved: the average Coleman methodology score was 56.2 out of 100.

Research: More comparative, well-designed and larger cohort trials are needed to ascertain whether radiofrequency chondroplasty offers long-term benefits over other simpler and more economical alternatives.
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http://dx.doi.org/10.1093/bmb/ldw004DOI Listing
March 2016

Hemiarthroplasty in a patient affected by osteonecrosis of the first metatarsal head following chevron osteotomy: a case report.

Foot (Edinb) 2010 Mar 29;20(1):32-4. Epub 2009 Oct 29.

Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 200, Rome, Italy.

Osteonecrosis of the first metatarsal head after distal metatarsal osteotomy is a rare condition. Latter stages with complete destruction of the metatarsophalangeal joint often required arthrodesis in order to relieve pain and improve function. We present a case of a 50-years old woman who developed osteonecrosis of the first metatarsal head after distal chevron osteotomy which was successfully treated with hemiarthroplasty of the proximal phalanx. Although longer follow-up and larger number of patients is needed to draw valid conclusions, the current result is encouraging and can be suggested in similar cases.
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http://dx.doi.org/10.1016/j.foot.2009.09.001DOI Listing
March 2010

[Observation Unit].

Recenti Prog Med 2009 May;100(5):259-60

Observation Unit is an extention of Emergency Department for evaluation and stabilization of patients beyond the traditional 2- to 3-hour limit. A benefit of this continued patient management is better definition of the patient's problem, with resulting reduction in costs and inappropriate dispositions. The ultimate goal is to improve the quality of medical care for patients through extended evaluation and treatment while reducing inappropriate admissions and health care costs.
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May 2009

[Retroperitoneal ganglioneuroma: a case report].

Recenti Prog Med 2008 Nov;99(11):559-60

U.O. di Pronto Soccorso, Ospedale Civile V. Cosentino, Cariati.

The ganglioneuroma is a benign neuroblastic tumor and derives from immature cells of the sympathetic nerve system. The ganglioneuroma is a very rare disease and effects newborns and infants more often than adolescents and adults. The benign tumors are relatively difficult to diagnose since they usually are asymptomatic. We report a case of a 14-year-old boy coming to us with persistent asthenia. In the Department of Emergency an abdominal ultrasonography incidentally revealed abdominal mass near his left kidney. The computed tomography revealed dis-homogeneous abdominal mass. In another hospital, subsequently, a complete surgical resection and histopathologic examination established the diagnosis of ganglioneuroma.
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November 2008

Diagnosis and treatment of refractory asthma.

Eur Rev Med Pharmacol Sci 2008 Sep-Oct;12(5):315-20

Emergency Department, V Cosentino Hospital, Cariati Marina, Cosenza, Italy.

Asthma is an inflammatory disorder of the airway associated with airflow obstruction and bronchial hyperresponsiveness that varies in severity across the spectrum of the disease. Asthma affects 5-7% of the population of North America and Europe, and the prevalence is increasing. Most patients with asthma are easily diagnosed, responding to standard treatment with a short-acting inhaled beta2-agonists for symptom control, and to long-term therapy to including inhaled glucocorticosteroids to control airway inflammation. However a subgroup of patients with asthma (likely approximately 10%) have more troublesome disease reflected by high medication requirements to maintain good disease control or persistent symptoms, asthma exacerbations, or airflow obstruction despite high medication use. A term to describe this subgroup of asthmatic patients is "Refractory Asthma". Patients with difficult to control asthma require a rigorous and systematic approach to their diagnosis and treatment. It is critical to make a diagnosis of asthma and to exclude other airways diseases and to identify whether there are any correctable factors that may contribute to their poor control. Another poor adherence to therapy is common reason for a poor response. Treatment involves optimizing corticosteroid inhaled therapy, assesing additional controllers, such as inhaled beta2-agonist, leukotriene inhibitors, anti-immunoglobulins (Ig), oral corticosteroids and sustained-release theophylline.
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December 2008

[Acute asthma and coma in Emergency Department: a case report].

Recenti Prog Med 2008 Jan;99(1):33

U.O. di Pronto Soccorso, Ospedale Civile V. Cosentino, Cariati, Cosenza.

Acute asthma is a common medical emergency. The goals of therapy are therefore to remove hypoxaemia, improve airflow limitation and prevent death. We describe the case of a 51-year-old woman with asthma admitted to Emergency Department after complaining acute respiratory failure and coma. The improvement of respiratory failure, after administration of high concentration of oxygen, beta-2 agonist and corticosteroids, wasn't associated at improvement of consciousness. The deterioration of blood gases dont justified coma. Having a suspicion the patient takes some benzodiazepines, we administered flumazenil and the patient improved adequately.
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January 2008

Regional variation in shea butter lipid and triterpene composition in four African countries.

J Agric Food Chem 2005 Sep;53(19):7473-9

Istituto Sperimentale per la Elaiotecnica, Città Sant'Angelo (PE), Italy.

The triacylglycerol, fatty acid, and polycyclic triterpene compositions of shea butter were determined for 150 samples from the sub-Saharan countries of Mali, Burkina Faso, Nigeria, and Uganda. The compositional profiles showed high variability in all three classes of compounds. Shea butter is made up mainly of four triglycerides (TAG) differing in carbon number (CN) by two, starting from CN 50 to CN 56. The greatest source of variation was in the CN 54 TAG. Shea butter is characterized by 16 saturated and unsaturated fatty acids in greatly varying proportion, the major ones being the even homologues in the range of C(16)-C(20). Oleic acid is dominant in Ugandan provenances, whereas stearic acid is dominant in West African shea butter. Acetyl and cinnamyl polycyclic triterpene means for countries ranged from 3.69 to 12.57%, with the highest values found in Nigerian provenances. Statistical comparisons of fat composition show that the geographic distance between shea populations is reflected in the degree of separation of their chemical profiles.
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http://dx.doi.org/10.1021/jf0509759DOI Listing
September 2005

Panic disorder in menopause: a case control study.

Maturitas 2004 Jun;48(2):147-54

Psychiatry Section, Department of Neurosciences, University of Siena, Italy.

Objective: The course of panic disorder (PD) is often influenced by the different phases of the female reproductive cycle. The aim of this study is to assess PD in the climacteric stage and single out possible correlations between symptoms of PD and clinical and demographic variables in order to identify possible risk factors.

Method: Forty-five women between 40 and 60 years of age was assessed through the SCL-90, the SCID, a "Climacteric Symptoms Questionnaire" (CSQ) devised to evaluate psychological symptoms typically associated with menopause, the Kupperman Index for the analysis of climacteric symptoms, and plasma level of allopregnanolone (ALLO).

Results: PD results in eight patients (18%). This group does not differ from the controls as far as socio-demographic data is concerned, but exhibits significantly higher values in the Kupperman Index, the SCL-90 total, and the CSQ. The plasma levels of ALLO correlate significantly inversely with the total of CSQ and, in any case, negatively with the other variables analysed.

Conclusions: PD may arise and worsen with menopause, in correlation with greater severity of the climacteric syndrome in its physical and psychological symptoms.
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http://dx.doi.org/10.1016/j.maturitas.2003.08.003DOI Listing
June 2004

Hypertension in obese subjects: distinct hypertensive subgroup.

J Hum Hypertens 1990 Feb;4(1):37-41

Istituto di Clinica Medica, Universitá di Palermo, Policlinico P. Giaccone, Italy.

Obesity and hypertension are two closely associated conditions and obesity probably predisposes to hypertension. In this investigation we evaluated central, systemic haemodynamic and intravascular volume characteristics of 51 established hypertensive obese subjects subgrouped for degree of obesity. Subgrouping according to body mass index (BMI) was as follows: lean hypertensives, 17 subjects (BMI 23.00 +/- 0.45 Kg/m2); moderately obese, 19 subjects (BMI 26.92 +/- 0.30 Kg/m2); severely obese, 15 subjects (BMI 32.78 +/- 0.45 Kg/m2). Obese hypertensives were characterised by significantly increased cardiac output and total plasma volume (P less than 0.05) and by decreased total peripheral resistance (not significantly) and left ventricular ejection fraction (P less than 0.01). These changes appear to be related to the degree of obesity. Significant correlation coefficients between body mass index and cardiac output, total blood volume, total peripheral resistance and ejection fraction were also observed. In conclusion, established hypertension in the severely obese patient appears to be a separate haemodynamic entity.
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February 1990

[Behavior of thyroid hormones and TSH in chronic active hepatitis].

Boll Soc Ital Biol Sper 1984 Oct;60(10):1863-9

The authors studied total and free circulating thyroid hormones, rT3, TBG and TSH behaviour on chronic liver disease in 11 subjects with cirrhosis of the liver with ascites(C.E.) and in 6 subjects with chronic active hepatitis (E.C.A.) in comparison with 15 healthy and euthyroid controls. Serum T3,FT3,T4 and FT4 levels were decreased significantly and serum rT3 values increased significantly both in the subjects with C.E. and in patients with E.C.A. Moreover no significantly changes of TSH and TBG levels has been found in 3 groups studied. These data suggest that the alteration of circulating thyroid hormones in chronic liver disease, may represent a compensatory way of reducing the patient's metabolic requirements.
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October 1984

Behaviour of serum T3, rT3, TT4, FT4 and TSH levels after exercise on a bicycle ergometer in healthy euthyroid male young subjects.

Boll Soc Ital Biol Sper 1984 Apr;60(4):753-9

In order to know thyroid function during physical activity, just studied by several authors without univocal findings, we have submitted 10 young subjects, non athletes, aged 22-25 years (mean age 23, 6 +/- 1, 43) to a biologically maximal exercise on a bicycle ergometer. We have also examined the change of TSH serum levels during exercise. Our data show an evident increase of T4 (18, 60% at 10'), p less than 0.025, an increment of FT4 (28, 49 soon after the strain), and no relevant change of T3 and rT3 serum levels. Moreover TSH values show a reduction at 30' (-26, 15%) in comparison with the basal level. Our findings confirm the known increment of T4 and FT4 serum level after physical activity. It can be due, more than an hemoconcentration supported by others, to a real rise of thyroid incretion as in our opinion TSH levels reduction suggests. Concluding we think that the increase of T4 and decrease of TSH could be due to a direct influence of the physical activity on the system interested in their production.
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April 1984

[Case of encephalopathy with cerebral arteritis following influenza].

Authors:
D A Vincenzo

Acta Neurol (Napoli) 1975 Sep-Oct;30(5):477-82

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August 1976
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