Publications

Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells.
J Immunol 2017 Oct 6;199(8):2631-2638. Epub 2017 Sep 6.
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom.


Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1.
Nat Immunol 2017 Jul 15;18(7):762-770. Epub 2017 May 15.
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.



Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells.
Cancer Res 2016 Nov 20;76(21):6193-6204. Epub 2016 Sep 20.
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a.
J Exp Med 2016 Oct 26;213(11):2399-2412. Epub 2016 Sep 26.
Medical Research Council Human Immunology Unit, National Institute for Health Research Biomedical Research Center, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, England, UK

Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood.
Proc Natl Acad Sci U S A 2016 Feb 11;113(7):1853-8. Epub 2016 Jan 11.
WHO Collaborative Center for Vaccine Immunology, Departments of Pathology-Immunology and Pediatrics, University of Geneva, 1211 Geneva, Switzerland

The actin cytoskeleton modulates the activation of iNKT cells by segregating CD1d nanoclusters on antigen-presenting cells.
Proc Natl Acad Sci U S A 2016 Feb 21;113(6):E772-81. Epub 2016 Jan 21.
ICFO-Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, 08860 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain


Human autoreactive T cells recognize CD1b and phospholipids.
Proc Natl Acad Sci U S A 2016 Jan 30;113(2):380-5. Epub 2015 Nov 30.
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115;

Analysis of B Cell Repertoire Dynamics Following Hepatitis B Vaccination in Humans, and Enrichment of Vaccine-specific Antibody Sequences.
EBioMedicine 2015 Dec 24;2(12):2070-9. Epub 2015 Nov 24.
Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Center, Oxford OX3 7LE, United Kingdom.

BCR repertoire sequencing: different patterns of B-cell activation after two Meningococcal vaccines.
Immunol Cell Biol 2015 Nov 15;93(10):885-95. Epub 2015 May 15.
Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Center, Oxford, UK.


Bee venom processes human skin lipids for presentation by CD1a.
J Exp Med 2015 Feb 12;212(2):149-63. Epub 2015 Jan 12.
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine and University of Oxford NIHR Biomedical Research Centre, Oxford, Oxfordshire OX3 9DS, England, UK MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine and University of Oxford NIHR Biomedical Research Centre, Oxford, Oxfordshire OX3 9DS, England, UK

Essential role for autophagy during invariant NKT cell development.
Proc Natl Acad Sci U S A 2014 Dec 15;111(52):E5678-87. Epub 2014 Dec 15.
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Headington, Oxford OX3 9DS, United Kingdom;

Classification of current anticancer immunotherapies.
Oncotarget 2014 Dec;5(24):12472-508
Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France. INSERM, U1138, Paris, France. Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France. Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France. Pôle de Biologie, Hôpital Européen Georges Pompidou (HEGP), AP-HP, Paris, France.

High frequency of cytolytic 21-hydroxylase-specific CD8+ T cells in autoimmune Addison's disease patients.
J Immunol 2014 Sep 25;193(5):2118-26. Epub 2014 Jul 25.
Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, United Kingdom;

Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway.
J Immunol 2014 Mar 31;192(5):2029-2033. Epub 2014 Jan 31.
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD. 20892.

Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.
Proc Natl Acad Sci U S A 2013 Dec 18;110(49):E4753-61. Epub 2013 Nov 18.
Medical Research Council Human Immunology Unit, Radcliffe Department of Medicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DS, United Kingdom.


DOCK8 is critical for the survival and function of NKT cells.
Blood 2013 Sep 8;122(12):2052-61. Epub 2013 Aug 8.
Medical Research Council Human Immunology Unit, Weatherall Institute for Molecular Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom;

Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment.
Blood 2013 Aug 3;122(5):749-58. Epub 2013 Jun 3.
Medical Research Council Human Immunology Unit, Radcliffe Department ofMedicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome.
J Immunol 2013 Jun 29;190(11):5722-30. Epub 2013 Apr 29.
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.



Discovery of deoxyceramides and diacylglycerols as CD1b scaffold lipids among diverse groove-blocking lipids of the human CD1 system.
Proc Natl Acad Sci U S A 2011 Nov 15;108(48):19335-40. Epub 2011 Nov 15.
Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses.
Nat Immunol 2011 Nov 27;13(1):35-43. Epub 2011 Nov 27.
Department of Pathogens and Immunity, John Curtin School of Medical Research, Australian National University, Canberra, Australia.


Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A.
Nat Immunol 2010 Nov 3;11(11):1039-46. Epub 2010 Oct 3.
Medical Research Council Human Immunology Unit, Nuffield Department of Medicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.




Constitutively active Lck kinase in T cells drives antigen receptor signal transduction.
Immunity 2010 Jun 11;32(6):766-77. Epub 2010 Jun 11.
T Cell Signaling Laboratory, Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.


Quantitating T cell cross-reactivity for unrelated peptide antigens.
J Immunol 2009 Oct 4;183(7):4337-45. Epub 2009 Sep 4.
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda MD 20892, USA.


Rational development of high-affinity T-cell receptor-like antibodies.
Proc Natl Acad Sci U S A 2009 Apr 23;106(14):5784-8. Epub 2009 Mar 23.
Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom.


B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo.
Proc Natl Acad Sci U S A 2008 Jun 11;105(24):8345-50. Epub 2008 Jun 11.
Lymphocyte Interaction Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom.


Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
Proc Natl Acad Sci U S A 2008 Feb 29;105(5):1656-61. Epub 2008 Jan 29.
Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge, Hills Road, Cambridge CB2 0XY, United Kingdom.

Immunization with a lentivector that targets tumor antigen expression to dendritic cells induces potent CD8+ and CD4+ T-cell responses.
J Virol 2008 Jan 24;82(1):86-95. Epub 2007 Oct 24.
Division of Infection and Immunity, University College London, Windeyer Building, 46 Cleveland Street, London W1T 4JF, United Kingdom.

Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation.
Proc Natl Acad Sci U S A 2007 Dec 11;104(51):20490-5. Epub 2007 Dec 11.
Tumor Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom.

Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding.
Immunity 2007 Dec;27(6):885-99
Cancer Research UK Receptor Structure Research Group, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Headington, Oxford OX3 7BN, UK.

Co-delivery of PLGA encapsulated invariant NKT cell agonist with antigenic protein induce strong T cell-mediated antitumor immune responses.
Oncoimmunology 2016;5(1):e1068493. Epub 2015 Aug 12.
Department of Tumor Immunology, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences , Nijmegen, The Netherlands.

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