Vincent Timmerman

Vincent Timmerman

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Vincent Timmerman

Vincent Timmerman

Publications by authors named "Vincent Timmerman"

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Defects in Axonal Transport in Inherited Neuropathies.

J Neuromuscul Dis 2019 Sep 20. Epub 2019 Sep 20.

Peripheral Neuropathy Research Group, Department of Biomedical Sciences, University of Antwerp, Antwerpen, Belgium.

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http://dx.doi.org/10.3233/JND-190427DOI Listing
September 2019

Report of a novel ATP7A mutation causing distal motor neuropathy.

Neuromuscul Disord 2019 Aug 23. Epub 2019 Aug 23.

Department of Medical Sciences, Section of Medical Genetics, University of Ferrara - Unit of Medical Genetics - University Hospital, Via Fossato di Mortara, 74, 44121 Ferrara, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.nmd.2019.08.008DOI Listing
August 2019

Small heat shock proteins: multifaceted proteins with important implications for life.

Cell Stress Chaperones 2019 03 13;24(2):295-308. Epub 2019 Feb 13.

Laboratory of Cell and Developmental Genetics, IBIS, and Department of Molecular Biology, Medical Biochemistry and Pathology, Medical School, Université Laval, QC, Québec, G1V 0A6, Canada.

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http://dx.doi.org/10.1007/s12192-019-00979-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439001PMC
March 2019

Challenges in modelling the Charcot-Marie-Tooth neuropathies for therapy development.

J Neurol Neurosurg Psychiatry 2019 Jan 17;90(1):58-67. Epub 2018 Jul 17.

Peripheral Neuropathy Research Group, University of Antwerp, Antwerp, Belgium

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http://dx.doi.org/10.1136/jnnp-2018-318834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327864PMC
January 2019

Sensory-Neuropathy-Causing Mutations in ATL3 Cause Aberrant ER Membrane Tethering.

Cell Rep 2018 05;23(7):2026-2038

Laboratory of ER stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium; Department of Internal Medicine, Ghent University, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.04.071DOI Listing
May 2018

A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8.

Acta Neuropathol 2018 01 5;135(1):131-148. Epub 2017 Aug 5.

Peripheral Neuropathy Research Group, Department of Biomedical Sciences and Institute Born Bunge, University of Antwerp, Universiteitsplein 1, 2610, Antwerpen, Belgium.

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http://dx.doi.org/10.1007/s00401-017-1756-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756276PMC
January 2018

Novel insights in the disease biology of mutant small heat shock proteins in neuromuscular diseases.

Brain 2017 Oct;140(10):2541-2549

Peripheral Neuropathy Research Group, Institute Born Bunge, University of Antwerp, Antwerpen, Belgium.

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http://academic.oup.com/brain/article/140/10/2541/4082543
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http://dx.doi.org/10.1093/brain/awx187DOI Listing
October 2017

Autophagy as an Emerging Common Pathomechanism in Inherited Peripheral Neuropathies.

Front Mol Neurosci 2017 11;10:143. Epub 2017 May 11.

Peripheral Neuropathy Research Group, Institute Born Bunge, University of AntwerpAntwerpen, Belgium.

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http://dx.doi.org/10.3389/fnmol.2017.00143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425483PMC
May 2017

The hnRNP family: insights into their role in health and disease.

Hum Genet 2016 08 23;135(8):851-67. Epub 2016 May 23.

Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Parking P4, Building V, Room 1.30, Universiteitsplein 1, 2610, Antwerp, Belgium.

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http://dx.doi.org/10.1007/s00439-016-1683-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947485PMC
August 2016

Characterization of New Transgenic Mouse Models for Two Charcot-Marie-Tooth-Causing HspB1 Mutations using the Rosa26 Locus.

J Neuromuscul Dis 2016 05;3(2):183-200

Peripheral Neuropathy Group, VIB Department of Molecular Genetics and Institute Born Bunge, University of Antwerp, Antwerpen, Belgium.

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http://dx.doi.org/10.3233/JND-150144DOI Listing
May 2016

Mitochondria-associated membranes as hubs for neurodegeneration.

Acta Neuropathol 2016 Apr 7;131(4):505-23. Epub 2016 Jan 7.

Unit Immunoregulation and Mucosal Immunology, VIB Inflammation Research Centre, University of Ghent, Zwijnaarde, Belgium.

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http://dx.doi.org/10.1007/s00401-015-1528-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789254PMC
April 2016

Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes.

J Neuroinflammation 2015 Aug 8;12:143. Epub 2015 Aug 8.

Unit Immunoregulation and Mucosal Immunology, GROUP-ID Consortium, VIB Inflammation Research Centre, Technologiepark 927, B-9052, Gent, Belgium.

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http://dx.doi.org/10.1186/s12974-015-0367-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528710PMC
August 2015

Novel mutations in the DYNC1H1 tail domain refine the genetic and clinical spectrum of dyneinopathies.

Hum Mutat 2015 Mar;36(3):287-91

Molecular Neurogenomics Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Neurogenetics Laboratory, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1002/humu.22744DOI Listing
March 2015

Recent advances in Charcot-Marie-Tooth disease.

Curr Opin Neurol 2014 Oct;27(5):532-40

aNeurogenetics Group bPeripheral Neuropathy Group, VIB-Department of Molecular Genetics cLaboratory of Neurogenetics, Institute Born-Bunge dDepartment of Neurology, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1097/WCO.0000000000000131DOI Listing
October 2014

CMT-associated mutations in glycyl- and tyrosyl-tRNA synthetases exhibit similar pattern of toxicity and share common genetic modifiers in Drosophila.

Neurobiol Dis 2014 Aug 5;68:180-9. Epub 2014 May 5.

Molecular Neurogenomics Group, Department of Molecular Genetics, VIB, University of Antwerp, Antwerp 2610, Belgium; Neurogenetics Laboratory, Institute Born-Bunge, University of Antwerp, Antwerp 2610, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086162PMC
August 2014

Human Rab7 mutation mimics features of Charcot-Marie-Tooth neuropathy type 2B in Drosophila.

Neurobiol Dis 2014 May 9;65:211-9. Epub 2014 Feb 9.

Molecular Genetics Department, VIB, University of Antwerp, B-2610 Antwerpen, Belgium; Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, B-2610 Antwerpen, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.01.021DOI Listing
May 2014

HSPB1 facilitates the formation of non-centrosomal microtubules.

PLoS One 2013 24;8(6):e66541. Epub 2013 Jun 24.

Department of Molecular Genetics, VIB and University of Antwerp, Antwerpen, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066541PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691211PMC
March 2014

Promising riboflavin treatment for motor neuron disorder.

Brain 2014 Jan;137(Pt 1):2-3

Molecular Genetics Department, VIB, Institute Born Bunge and University of Antwerp, Belgium E-mail:

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http://dx.doi.org/10.1093/brain/awt342DOI Listing
January 2014

Genetics of Charcot-Marie-Tooth (CMT) Disease within the Frame of the Human Genome Project Success.

Genes (Basel) 2014 Jan 22;5(1):13-32. Epub 2014 Jan 22.

Department of Human Genetics, Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Biomedical Research Building, Room 523, LC: M-860, 1501 NW 10 Ave., Miami, FL 33136, USA.

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http://dx.doi.org/10.3390/genes5010013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978509PMC
January 2014

Animal models and therapeutic prospects for Charcot-Marie-Tooth disease.

Ann Neurol 2013 Sep;74(3):391-6

Peripheral Neuropathy Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Institute Born Bunge, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1002/ana.23987DOI Listing
September 2013

Overlapping molecular pathological themes link Charcot-Marie-Tooth neuropathies and hereditary spastic paraplegias.

Exp Neurol 2013 Aug 18;246:14-25. Epub 2012 Jan 18.

Peripheral Neuropathy Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium.

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http://dx.doi.org/10.1016/j.expneurol.2012.01.010DOI Listing
August 2013

The neuroinflammatory role of Schwann cells in disease.

Neurobiol Dis 2013 Jul 21;55:95-103. Epub 2013 Mar 21.

Peripheral Neuropathy Group, Department of Molecular Genetics, VIB and University of Antwerp, Antwerpen, Belgium.

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http://dx.doi.org/10.1016/j.nbd.2013.03.005DOI Listing
July 2013

Charcot-Marie-Tooth causing HSPB1 mutations increase Cdk5-mediated phosphorylation of neurofilaments.

Acta Neuropathol 2013 Jul 1;126(1):93-108. Epub 2013 Jun 1.

Department of Molecular Genetics, VIB and University of Antwerp, 2610 Antwerpen, Belgium.

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http://dx.doi.org/10.1007/s00401-013-1133-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963106PMC
July 2013

Molecular defects in the motor adaptor BICD2 cause proximal spinal muscular atrophy with autosomal-dominant inheritance.

Am J Hum Genet 2013 Jun 9;92(6):955-64. Epub 2013 May 9.

Molecular Neurogenomics Group, Department of Molecular Genetics, VIB, Antwerp 2610, Belgium; Neurogenetics Laboratory, Institute Born-Bunge, University of Antwerp, Antwerp 2610, Belgium.

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http://dx.doi.org/10.1016/j.ajhg.2013.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675262PMC
June 2013

Biopsy in a patient with PMP22 exon 2 mutation recapitulates pathology of Trembler-J mouse.

Neuromuscul Disord 2013 Apr 10;23(4):345-8. Epub 2013 Jan 10.

George A. Jervis Clinic, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.

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http://dx.doi.org/10.1016/j.nmd.2012.12.005DOI Listing
April 2013

Neurofilament phosphorylation and their proline-directed kinases in health and disease.

J Peripher Nerv Syst 2012 Dec;17(4):365-76

Peripheral Neuropathy Group, VIB Department of Molecular Genetics, University of Antwerp, Antwerpen, Belgium.

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http://dx.doi.org/10.1111/j.1529-8027.2012.00434.xDOI Listing
December 2012

Mutant HSPB8 causes protein aggregates and a reduced mitochondrial membrane potential in dermal fibroblasts from distal hereditary motor neuropathy patients.

Neuromuscul Disord 2012 Aug 15;22(8):699-711. Epub 2012 May 15.

Peripheral Neuropathy Group, Department of Molecular Genetics, VIB and University of Antwerp, Antwerpen 2610, Belgium.

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http://dx.doi.org/10.1016/j.nmd.2012.04.005DOI Listing
August 2012

Acute injury in the peripheral nervous system triggers an alternative macrophage response.

J Neuroinflammation 2012 Jul 20;9:176. Epub 2012 Jul 20.

Peripheral Neuropathy Group, Department of Molecular Genetics, VIB and University of Antwerp, Antwerpen, Belgium.

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http://dx.doi.org/10.1186/1742-2094-9-176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419084PMC
July 2012

Drosophila as a platform to predict the pathogenicity of novel aminoacyl-tRNA synthetase mutations in CMT.

Amino Acids 2012 May 8;42(5):1661-8. Epub 2011 Mar 8.

Department of Molecular Genetics, VIB, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.

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http://dx.doi.org/10.1007/s00726-011-0868-4DOI Listing
May 2012

Mechanisms of disease in hereditary sensory and autonomic neuropathies.

Nat Rev Neurol 2012 Jan 24;8(2):73-85. Epub 2012 Jan 24.

VIB Department of Molecular Genetics, University of Antwerp, Universiteitsplein 1, 2610 Antwerpen, Belgium.

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http://dx.doi.org/10.1038/nrneurol.2011.227DOI Listing
January 2012

Reduced penetrance in hereditary motor neuropathy caused by TRPV4 Arg269Cys mutation.

J Neurol 2011 Aug 19;258(8):1413-21. Epub 2011 Feb 19.

Service of Neurology, University Hospital "Marqués de Valdecilla" (IFIMAV), "Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas" (CIBERNED), University of Cantabria (UC), 39008 Santander, Spain.

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http://dx.doi.org/10.1007/s00415-011-5947-7DOI Listing
August 2011

Inherited peripheral neuropathies: a myriad of genes and complex phenotypes.

Brain 2011 Jun;134(Pt 6):1587-90

VIB Department of Molecular Genetics, Neurogenetics Group, University of Antwerp, Universiteitsplein 1, 2610 Antwerpen, Belgium.

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http://dx.doi.org/10.1093/brain/awr114DOI Listing
June 2011

Toll-like receptor expression in the peripheral nerve.

Glia 2010 Nov;58(14):1701-9

Peripheral Neuropathy Group, Department of Molecular Genetics, VIB and University of Antwerp, Universiteitsplein 1, B-2610 Antwerpen, Belgium.

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http://dx.doi.org/10.1002/glia.21041DOI Listing
November 2010

Clinical utility gene card for: HMSN/HNPP HMSN types 1, 2, 3, 6 (CMT1,2,4, DSN, CHN, GAN, CCFDN, HNA); HNPP.

Eur J Hum Genet 2010 Sep 26;18(9). Epub 2010 May 26.

Institute of Human Genetics, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1038/ejhg.2010.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987431PMC
September 2010

Cell death-mediated cleavage of the attraction signal p43 in human atherosclerosis: implications for plaque destabilization.

Arterioscler Thromb Vasc Biol 2010 Jul 22;30(7):1415-22. Epub 2010 Apr 22.

Division of Pharmacology, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.110.206029
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http://dx.doi.org/10.1161/ATVBAHA.110.206029DOI Listing
July 2010

Humoral immunodeficiency in congenital insensitivity to pain with anhidrosis.

Neurogenetics 2009 Apr 17;10(2):161-5. Epub 2008 Dec 17.

Department of Pediatric Immunology, Uludağ University School of Medicine, Gorukle, Bursa, 16059, Turkey.

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http://dx.doi.org/10.1007/s10048-008-0165-xDOI Listing
April 2009

A systematic comparison of all mutations in hereditary sensory neuropathy type I (HSAN I) reveals that the G387A mutation is not disease associated.

Neurogenetics 2009 Apr 9;10(2):135-43. Epub 2009 Jan 9.

Department for Clinical Chemistry, University Hospital Zurich, Raemistrasse 100, 8051, Zürich, Switzerland.

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http://dx.doi.org/10.1007/s10048-008-0168-7DOI Listing
April 2009

Peripheral neuropathy and 46XY gonadal dysgenesis: a heterogeneous entity.

Neuromuscul Disord 2009 Feb 22;19(2):172-5. Epub 2009 Jan 22.

Neurogenetics group, VIB Department of Molecular Genetics, University of Antwerp, Universiteitsplein 1, B-2610 Antwerpen, Belgium.

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http://dx.doi.org/10.1016/j.nmd.2008.11.006DOI Listing
February 2009

Magnetic resonance imaging findings of leg musculature in Charcot-Marie-Tooth disease type 2 due to dynamin 2 mutation.

J Neurol 2008 Jul 17;255(7):986-92. Epub 2008 Jun 17.

Services of Radiology, Clinical Neurophysiology and Neurology, University Hospital Marqués de Valdecilla, (CIBERNED and IFIMAV), Santander, Spain.

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http://dx.doi.org/10.1007/s00415-008-0808-8DOI Listing
July 2008

[Silver syndrome--case report].

Neurol Neurochir Pol 2007 Nov-Dec;41(6):562-6

Zespół Badawczo-Leczniczy Chorób Nerwowo-Mieśniowych, Instytut Medycyny Dooewiadczalnej i Klinicznej Polskiej Akademii Nauk im. M. Mossakowskiego w Warszawie.

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April 2008

Clinical and electrophysiological features in Charcot-Marie-Tooth disease with mutations in the NEFL gene.

Arch Neurol 2007 Jul;64(7):966-70

Section of Clinical Genetics, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1001/archneur.64.7.966DOI Listing
July 2007

Molecular genetics, biology, and therapy for inherited peripheral neuropathies.

Neuromolecular Med 2006 ;8(1-2):1-2

Peripheral Neuropathy Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium.

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http://dx.doi.org/10.1385/NMM:8:1:1DOI Listing
March 2007

Unraveling the genetics of distal hereditary motor neuronopathies.

Neuromolecular Med 2006 ;8(1-2):131-46

Peripheral Neuropathy Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium.

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March 2007

Recent advances in hereditary sensory and autonomic neuropathies.

Curr Opin Neurol 2006 Oct;19(5):474-80

Peripheral Neuropathy Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium.

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http://dx.doi.org/10.1097/01.wco.0000245370.82317.f6DOI Listing
October 2006

Genetics of motor neuron disease.

Curr Neurol Neurosci Rep 2006 Sep;6(5):423-31

Neurobiology, Campus Gasthuisberg O&N2 PB1022,Herestraat 49, B-3000 Leuven, Belgium.

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September 2006

Disease mechanisms in hereditary sensory and autonomic neuropathies.

Neurobiol Dis 2006 Feb 23;21(2):247-55. Epub 2005 Sep 23.

Peripheral Neuropathy Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, B-2610 Antwerpen, Belgium.

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http://dx.doi.org/10.1016/j.nbd.2005.08.004DOI Listing
February 2006

Small heat shock proteins in inherited peripheral neuropathies.

Ann Med 2005 ;37(6):413-22

Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Institute Born-Bunge, University of Antwerp, Antwerpen, Belgium.

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http://dx.doi.org/10.1080/07853890500296410DOI Listing
January 2006

Novel frameshift and splice site mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with hereditary sensory neuropathy type IV.

Neuromuscul Disord 2006 Jan 20;16(1):19-25. Epub 2005 Dec 20.

Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, B-2610 Antwerpen, Belgium.

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http://dx.doi.org/10.1016/j.nmd.2005.10.007DOI Listing
January 2006

Synaptopodin and 4 novel genes identified in primary sensory neurons.

Mol Cell Neurosci 2005 Nov 1;30(3):316-25. Epub 2005 Sep 1.

Peripheral Neuropathy Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, B-2610 Antwerpen, Belgium.

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http://dx.doi.org/10.1016/j.mcn.2005.07.005DOI Listing
November 2005