Publications by authors named "Vincent Thominet"

6 Publications

  • Page 1 of 1

Non-invasive recognition of eye torsion through optical imaging of the iris pattern in ocular proton therapy.

Phys Med Biol 2021 Jul 1;66(13). Epub 2021 Jul 1.

Paul Scherrer Institut, Switzerland.

The introduction of non-invasive imaging techniques such as MRI imaging for treatment planning and optical eye tracking for in-room eye localization would obviate the requirement of clips implantation for many patients undergoing ocular proton therapy. This study specifically addresses the issue of torsional eye movement detection during patient positioning. Non-invasive detection of eye torsion is performed by measuring the iris pattern rotations using a beams eye view optical camera. When handling images of patients to be treated using proton therapy, a number of additional challenges are encountered, such as changing eye position, pupil dilatation and illumination. A method is proposed to address these extra challenges while also compensating for the effect of cornea distortion in eye torsion computation. The accuracy of the proposed algorithm was evaluated against corresponding measurement of eye torsion using the clips configuration measured on x-ray images. This study involves twenty patients who received ocular proton therapy at Paul Scherrer Institute and it is covered by ethical approval (EKNZ 2019-01987).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6560/ac0afbDOI Listing
July 2021

SwissFEL Aramis beamline photon diagnostics.

J Synchrotron Radiat 2018 Jul 12;25(Pt 4):1238-1248. Epub 2018 Jun 12.

SwissFEL, Paul Scherrer Institut, Villigen 5232, Switzerland.

The SwissFEL Aramis beamline, covering the photon energies between 1.77 keV and 12.7 keV, features a suite of online photon diagnostics tools to help both users and FEL operators in analysing data and optimizing experimental and beamline performance. Scientists will be able to obtain information about the flux, spectrum, position, pulse length, and arrival time jitter versus the experimental laser for every photon pulse, with further information about beam shape and size available through the use of destructive screens. This manuscript is an overview of the diagnostics tools available at SwissFEL and presents their design, working principles and capabilities. It also features new developments like the first implementation of a THz-streaking based temporal diagnostics for a hard X-ray FEL, capable of measuring pulse lengths to 5 fs r.m.s. or better.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1107/S1600577518005775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038612PMC
July 2018

D3, the new diffractometer for the macromolecular crystallography beamlines of the Swiss Light Source.

J Synchrotron Radiat 2014 Mar 4;21(Pt 2):340-51. Epub 2014 Feb 4.

Swiss Light Source, Paul Scherrer Institute, 5232 Villigen PSI, Switzerland.

A new diffractometer for microcrystallography has been developed for the three macromolecular crystallography beamlines of the Swiss Light Source. Building upon and critically extending previous developments realised for the high-resolution endstations of the two undulator beamlines X06SA and X10SA, as well as the super-bend dipole beamline X06DA, the new diffractometer was designed to the following core design goals. (i) Redesign of the goniometer to a sub-micrometer peak-to-peak cylinder of confusion for the horizontal single axis. Crystal sizes down to at least 5 µm and advanced sample-rastering and scanning modes are supported. In addition, it can accommodate the new multi-axis goniometer PRIGo (Parallel Robotics Inspired Goniometer). (ii) A rapid-change beam-shaping element system with aperture sizes down to a minimum of 10 µm for microcrystallography measurements. (iii) Integration of the on-axis microspectrophotometer MS3 for microscopic sample imaging with 1 µm image resolution. Its multi-mode optical spectroscopy module is always online and supports in situ UV/Vis absorption, fluorescence and Raman spectroscopy. (iv) High stability of the sample environment by a mineral cast support construction and by close containment of the cryo-stream. Further features are the support for in situ crystallization plate screening and a minimal achievable detector distance of 120 mm for the Pilatus 6M, 2M and the macromolecular crystallography group's planned future area detector Eiger 16M.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1107/S160057751400006XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945418PMC
March 2014

A new on-axis micro-spectrophotometer for combining Raman, fluorescence and UV/Vis absorption spectroscopy with macromolecular crystallography at the Swiss Light Source.

J Synchrotron Radiat 2013 Sep 5;20(Pt 5):765-76. Epub 2013 Jul 5.

Paul Scherrer Institut, CH-5232 Villigen, Switzerland.

The combination of X-ray diffraction experiments with optical methods such as Raman, UV/Vis absorption and fluorescence spectroscopy greatly enhances and complements the specificity of the obtained information. The upgraded version of the in situ on-axis micro-spectrophotometer, MS2, at the macromolecular crystallography beamline X10SA of the Swiss Light Source is presented. The instrument newly supports Raman and resonance Raman spectroscopy, in addition to the previously available UV/Vis absorption and fluorescence modes. With the recent upgrades of the spectral bandwidth, instrument stability, detection efficiency and control software, the application range of the instrument and its ease of operation were greatly improved. Its on-axis geometry with collinear X-ray and optical axes to ensure optimal control of the overlap of sample volumes probed by each technique is still unique amongst comparable facilities worldwide and the instrument has now been in general user operation for over two years.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1107/S0909049513016063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747950PMC
September 2013

A new on-axis multimode spectrometer for the macromolecular crystallography beamlines of the Swiss Light Source.

J Synchrotron Radiat 2009 Mar 25;16(Pt 2):173-82. Epub 2009 Feb 25.

Swiss Light Source, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.

X-ray crystallography at third-generation synchrotron sources permits tremendous insight into the three-dimensional structure of macromolecules. Additional information is, however, often required to aid the transition from structure to function. In situ spectroscopic methods such as UV-Vis absorption and (resonance) Raman can provide this, and can also provide a means of detecting X-ray-induced changes. Here, preliminary results are introduced from an on-axis UV-Vis absorption and Raman multimode spectrometer currently being integrated into the beamline environment at X10SA of the Swiss Light Source. The continuing development of the spectrometer is also outlined.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1107/S0909049508040120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651763PMC
March 2009
-->