Vincent Peterkin

Vincent Peterkin

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Vincent Peterkin

Vincent Peterkin

Publications by authors named "Vincent Peterkin"

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9Publications

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Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors.

Bioorg Med Chem Lett 2020 Apr 25;30(7):126986. Epub 2020 Jan 25.

Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL 60064, United States.

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http://dx.doi.org/10.1016/j.bmcl.2020.126986DOI Listing
April 2020

Validation of a total IC method which enables in vitro assessment of transporter inhibition under semi-physiological conditions.

Xenobiotica 2017 Sep 3;47(9):825-832. Epub 2016 Oct 3.

a Department of Drug Metabolism and Pharmacokinetics , AbbVie Inc , North Chicago , IL , USA.

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http://dx.doi.org/10.1080/00498254.2016.1233372DOI Listing
September 2017

A High Throughput, 384-Well, Semi-Automated, Hepatocyte Intrinsic Clearance Assay for Screening New Molecular Entities in Drug Discovery.

Comb Chem High Throughput Screen 2015 ;18(5):442-52

Department of Drug Metabolism, AbbVie Inc., North Chicago, IL 60064, USA.

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http://dx.doi.org/10.2174/1386207318666150401101737DOI Listing
February 2016

A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation.

Drug Metab Dispos 2010 May 2;38(5):879-86. Epub 2010 Feb 2.

Department of Pharmacokinetics, Dynamics, and Metabolism, St. Louis Laboratories, Pfizer Global Research and Development, Chesterfield, MO 63017, USA.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.109.030130
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http://dx.doi.org/10.1124/dmd.109.030130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872941PMC
May 2010

Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes.

Br J Clin Pharmacol 2007 Oct 6;64(4):458-68. Epub 2007 Jun 6.

Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA.

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http://dx.doi.org/10.1111/j.1365-2125.2007.02923.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2048551PMC
October 2007

Udp-glucuronosyltransferase 2b7 is the major enzyme responsible for gemcabene glucuronidation in human liver microsomes.

Drug Metab Dispos 2005 Sep 24;33(9):1349-54. Epub 2005 Jun 24.

Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA.

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http://dx.doi.org/10.1124/dmd.105.005108DOI Listing
September 2005

Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios.

Drug Metab Dispos 2004 Nov 10;32(11):1201-8. Epub 2004 Aug 10.

Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA.

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http://dx.doi.org/10.1124/dmd.104.000794DOI Listing
November 2004