Vincent P Mauro

Vincent P Mauro

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Vincent P Mauro

Vincent P Mauro

Publications by authors named "Vincent P Mauro"

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Considerations in the Use of Codon Optimization for Recombinant Protein Expression.

Methods Mol Biol 2018 ;1850:275-288

Leidos, San Diego, CA, USA.

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http://dx.doi.org/10.1007/978-1-4939-8730-6_18DOI Listing
May 2019

Codon Optimization in the Production of Recombinant Biotherapeutics: Potential Risks and Considerations.

Authors:
Vincent P Mauro

BioDrugs 2018 Feb;32(1):69-81

The Scripps Research Institute, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1007/s40259-018-0261-xDOI Listing
February 2018

Translation regulation by ribosomes: Increased complexity and expanded scope.

RNA Biol 2016 09 29;13(9):748-55. Epub 2015 Oct 29.

b The Scripps Research Institute , La Jolla , CA , USA.

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http://dx.doi.org/10.1080/15476286.2015.1107701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013984PMC
September 2016

Physical evidence supporting a ribosomal shunting mechanism of translation initiation for BACE1 mRNA.

Translation (Austin) 2013 1;1(1):e24400. Epub 2013 Apr 1.

Department of Cell and Molecular Biology; The Scripps Research Institute; La Jolla, CA USA.

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http://dx.doi.org/10.4161/trla.24400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718059PMC
January 2016

A critical analysis of codon optimization in human therapeutics.

Trends Mol Med 2014 Nov 25;20(11):604-13. Epub 2014 Sep 25.

Department of Cell and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://www.cell.com/trends/molecular-medicine/pdf/S1471-4914
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http://dx.doi.org/10.1016/j.molmed.2014.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253638PMC
November 2014

Base pairing between hepatitis C virus RNA and 18S rRNA is required for IRES-dependent translation initiation in vivo.

Proc Natl Acad Sci U S A 2014 Oct 13;111(43):15385-9. Epub 2014 Oct 13.

Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037; and Promosome, LLC, San Diego, CA 92121

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http://dx.doi.org/10.1073/pnas.1413472111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217472PMC
October 2014

Analysis of rRNA processing and translation in mammalian cells using a synthetic 18S rRNA expression system.

Nucleic Acids Res 2012 Sep 20;40(16):8085-98. Epub 2012 Jun 20.

Department of Neurobiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1093/nar/gks530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439915PMC
September 2012

Determinants of initiation codon selection during translation in mammalian cells.

PLoS One 2010 Nov 24;5(11):e15057. Epub 2010 Nov 24.

Department of Neurobiology, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, La Jolla, California, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015057PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991327PMC
November 2010

Reconciling contradictory reports regarding translation of BACE1 mRNA: initiation mechanism is altered by different expression systems.

RNA Biol 2009 Jan-Mar;6(1):54-8. Epub 2009 Jan 5.

Department of Neurobiology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.4161/rna.6.1.7567DOI Listing
April 2009

Antisense masking reveals contributions of mRNA-rRNA base pairing to translation of Gtx and FGF2 mRNAs.

J Biol Chem 2008 Nov 2;283(48):33087-93. Epub 2008 Oct 2.

Department of Neurobiology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M804904200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586266PMC
November 2008

Analysis of ribosomal shunting during translation initiation in eukaryotic mRNAs.

Methods Enzymol 2007 ;429:323-54

Department of Neurobiology, The Scripps Research Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1016/S0076-6879(07)29015-9DOI Listing
December 2007

The ribosome filter redux.

Cell Cycle 2007 Sep 29;6(18):2246-51. Epub 2007 Jun 29.

Department of Neurobiology, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, La Jolla, California 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930609PMC
http://dx.doi.org/10.4161/cc.6.18.4739DOI Listing
September 2007

Ribosomal tethering and clustering as mechanisms for translation initiation.

Proc Natl Acad Sci U S A 2006 Nov 16;103(48):18077-82. Epub 2006 Nov 16.

Department of Neurobiology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0608212103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838709PMC
November 2006

Ribosomal shunting mediated by a translational enhancer element that base pairs to 18S rRNA.

Proc Natl Acad Sci U S A 2006 Jun 12;103(25):9488-93. Epub 2006 Jun 12.

Department of Neurobiology, The Scripps Research Institute, and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0603597103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1480434PMC
June 2006

An mRNA-rRNA base-pairing mechanism for translation initiation in eukaryotes.

Nat Struct Mol Biol 2006 Jan 11;13(1):30-4. Epub 2005 Dec 11.

Department of Neurobiology, The Scripps Research Institute, and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nsmb1031DOI Listing
January 2006

A positive feedback vector for identification of nucleotide sequences that enhance translation.

Proc Natl Acad Sci U S A 2005 May 21;102(18):6273-8. Epub 2005 Apr 21.

Department of Neurobiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0409892102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1088366PMC
May 2005

Cold stress-induced protein Rbm3 binds 60S ribosomal subunits, alters microRNA levels, and enhances global protein synthesis.

Proc Natl Acad Sci U S A 2005 Feb 31;102(6):1865-70. Epub 2005 Jan 31.

Department of Neurobiology, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0409764102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC548588PMC
February 2005

Reevaluation of the conclusion that IRES-activity reported within the 5' leader of the TIF4631 gene is due to promoter activity.

RNA 2004 Jun;10(6):895-7; discussion 898

Department of Neurobiology, The Scripps Research Institute, and The Skaggs Institute for Chemical Biology, La Jolla, California 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370579PMC
http://dx.doi.org/10.1261/rna.7160404DOI Listing
June 2004

Biochemical and functional analysis of a 9-nt RNA sequence that affects translation efficiency in eukaryotic cells.

Proc Natl Acad Sci U S A 2004 Jun 21;101(26):9590-4. Epub 2004 Jun 21.

Department of Neurobiology, The Scripps Research Institute, and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0308759101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC470719PMC
June 2004

Differential utilization of upstream AUGs in the beta-secretase mRNA suggests that a shunting mechanism regulates translation.

Proc Natl Acad Sci U S A 2004 Mar 23;101(9):2794-9. Epub 2004 Feb 23.

Department of Neurobiology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0308576101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC365699PMC
March 2004

The internal ribosome entry site (IRES) contained within the RNA-binding motif protein 3 (Rbm3) mRNA is composed of functionally distinct elements.

J Biol Chem 2003 Sep 24;278(36):33793-800. Epub 2003 Jun 24.

Department of Neurobiology, The Scripps Research Institute, and The Skaggs Institute for Chemical Biology, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M303495200DOI Listing
September 2003

Isolation and identification of short nucleotide sequences that affect translation initiation in Saccharomyces cerevisiae.

Proc Natl Acad Sci U S A 2003 Apr 4;100(8):4457-62. Epub 2003 Apr 4.

Department of Neurobiology, The Scripps Research Institute, and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0437993100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC153577PMC
April 2003

The ribosome filter hypothesis.

Proc Natl Acad Sci U S A 2002 Sep 9;99(19):12031-6. Epub 2002 Sep 9.

Department of Neurobiology, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.192442499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129393PMC
September 2002