Vincent M Christoffels

Vincent M Christoffels

UNVERIFIED PROFILE

Are you Vincent M Christoffels?   Register this Author

Register author
Vincent M Christoffels

Vincent M Christoffels

Publications by authors named "Vincent M Christoffels"

Are you Vincent M Christoffels?   Register this Author

99Publications

2259Reads

10Profile Views

Reptiles as a Model System to Study Heart Development.

Cold Spring Harb Perspect Biol 2019 Nov 11. Epub 2019 Nov 11.

Department of Medical Biology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC 1105AZ, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/cshperspect.a037226DOI Listing
November 2019

Low incidence of atrial septal defects in nonmammalian vertebrates.

Evol Dev 2019 Oct 9:e12322. Epub 2019 Oct 9.

Department of Medical Biology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ede.12322DOI Listing
October 2019

Conserved NPPB+ Border Zone Switches From MEF2- to AP-1-Driven Gene Program.

Circulation 2019 Sep 1;140(10):864-879. Epub 2019 Jul 1.

Departments of Medical Biology, Amsterdam Cardiovascular Sciences (K.v.D., J.C.K.M., R.J., M.G., I.B.H., P.B., V.M.C.), Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038944DOI Listing
September 2019

Identification and Characterization of a Transcribed Distal Enhancer Involved in Cardiac Kcnh2 Regulation.

Cell Rep 2019 Sep;28(10):2704-2714.e5

Amsterdam UMC, University of Amsterdam, Department of Medical Biology, Amsterdam Cardiovascular Sciences, 1105AZ Amsterdam, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.08.007DOI Listing
September 2019

Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function.

Circ Res 2019 Aug 1;125(6):575-589. Epub 2019 Aug 1.

From the Herman B Wells Center for Pediatric Research, Departments of Pediatrics, Anatomy and Medical and Molecular Genetics, Indiana Medical School, Indianapolis (J.W.V., B.A.F., K.P.T., M.R.L., A.B.F.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.119.315313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715539PMC
August 2019

Identification of the building blocks of ventricular septation in monitor lizards (Varanidae).

Development 2019 Jul 29;146(14). Epub 2019 Jul 29.

University of Amsterdam, Amsterdam UMC, Department of Medical Biology, Amsterdam Cardiovascular Sciences, Meibergdreef 15, 1105AZ, Amsterdam, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.177121DOI Listing
July 2019

Gradual differentiation and confinement of the cardiac conduction system as indicated by marker gene expression.

Biochim Biophys Acta Mol Cell Res 2019 Jul 12. Epub 2019 Jul 12.

Department of Medical Biology, Amsterdam UMC, University of Amsterdam, Amsterdam 1105, AZ, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamcr.2019.07.004DOI Listing
July 2019

Sinus venosus incorporation: contentious issues and operational criteria for developmental and evolutionary studies.

J Anat 2019 May 12;234(5):583-591. Epub 2019 Mar 12.

Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/joa.12962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481585PMC
May 2019

Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program.

Development 2019 Apr 25;146(8). Epub 2019 Apr 25.

Department of Medical Biology, University of Amsterdam, Amsterdam University Medical Centers, Amsterdam 1105 AZ, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.173161DOI Listing
April 2019

Comparative analysis of avian hearts provides little evidence for variation among species with acquired endothermy.

J Morphol 2019 Mar 22;280(3):395-410. Epub 2019 Jan 22.

Department of Medical Biology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Meibergdreef 15, 1105AZ, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jmor.20952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590421PMC
March 2019

TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme.

Development 2018 11 26;145(23). Epub 2018 Nov 26.

Institut für Molekularbiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.171827DOI Listing
November 2018

Transcriptional regulation of the cardiac conduction system.

Nat Rev Cardiol 2018 10;15(10):617-630

Department of Medical Biology, Amsterdam Cardiovascular Sciences, Academic Medical Center, Amsterdam, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41569-018-0031-yDOI Listing
October 2018

Embryonic Tbx3 cardiomyocytes form the mature cardiac conduction system by progressive fate restriction.

Development 2018 09 3;145(17). Epub 2018 Sep 3.

Department of Medical Biology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.167361DOI Listing
September 2018

Developmental Origin of the Cardiac Conduction System: Insight from Lineage Tracing.

Pediatr Cardiol 2018 Aug 17;39(6):1107-1114. Epub 2018 May 17.

Department of Medical Biology, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00246-018-1906-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096846PMC
August 2018

Development, Proliferation, and Growth of the Mammalian Heart.

Mol Ther 2018 07 19;26(7):1599-1609. Epub 2018 Jun 19.

Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Amsterdam, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymthe.2018.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037201PMC
July 2018

Direct Reprograming to Regenerate Myocardium and Repair Its Pacemaker and Conduction System.

Medicines (Basel) 2018 06 4;5(2). Epub 2018 Jun 4.

Department of Medical Biology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/medicines5020048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023490PMC
June 2018

Structure and function of the Nppa-Nppb cluster locus during heart development and disease.

Cell Mol Life Sci 2018 04 4;75(8):1435-1444. Epub 2018 Jan 4.

Department of Medical Biology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-017-2737-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852170PMC
April 2018

Specialized impulse conduction pathway in the alligator heart.

Elife 2018 03 22;7. Epub 2018 Mar 22.

Department of Medical Biology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.32120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940360PMC
March 2018

Origins and consequences of congenital heart defects affecting the right ventricle.

Cardiovasc Res 2017 Oct;113(12):1509-1520

Department of Anatomy, Embryology, and Physiology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvx155DOI Listing
October 2017

Lineages of the Cardiac Conduction System.

J Cardiovasc Dev Dis 2017 May 2;4(2). Epub 2017 May 2.

Department of Medical Biology, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcdd4020005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715704PMC
May 2017

On the Evolution of the Cardiac Pacemaker.

J Cardiovasc Dev Dis 2017 Apr 27;4(2). Epub 2017 Apr 27.

Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcdd4020004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715705PMC
April 2017

Excessive trabeculations in noncompaction do not have the embryonic identity.

Int J Cardiol 2017 Jan 9;227:325-330. Epub 2016 Nov 9.

Department of Anatomy, Embryology & Physiology, Academic Medical Center, University of Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2016.11.089DOI Listing
January 2017

Cardiac defects, nuchal edema and abnormal lymphatic development are not associated with morphological changes in the ductus venosus.

Early Hum Dev 2016 10 9;101:39-48. Epub 2016 Jul 9.

Department of Obstetrics and Gynecology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.earlhumdev.2016.05.017DOI Listing
October 2016

52 Genetic Loci Influencing Myocardial Mass.

Authors:
Pim van der Harst Jessica van Setten Niek Verweij Georg Vogler Lude Franke Matthew T Maurano Xinchen Wang Irene Mateo Leach Mark Eijgelsheim Nona Sotoodehnia Caroline Hayward Rossella Sorice Osorio Meirelles Leo-Pekka Lyytikäinen Ozren Polašek Toshiko Tanaka Dan E Arking Sheila Ulivi Stella Trompet Martina Müller-Nurasyid Albert V Smith Marcus Dörr Kathleen F Kerr Jared W Magnani Fabiola Del Greco M Weihua Zhang Ilja M Nolte Claudia T Silva Sandosh Padmanabhan Vinicius Tragante Tõnu Esko Gonçalo R Abecasis Michiel E Adriaens Karl Andersen Phil Barnett Joshua C Bis Rolf Bodmer Brendan M Buckley Harry Campbell Megan V Cannon Aravinda Chakravarti Lin Y Chen Alessandro Delitala Richard B Devereux Pieter A Doevendans Anna F Dominiczak Luigi Ferrucci Ian Ford Christian Gieger Tamara B Harris Eric Haugen Matthias Heinig Dena G Hernandez Hans L Hillege Joel N Hirschhorn Albert Hofman Norbert Hubner Shih-Jen Hwang Annamaria Iorio Mika Kähönen Manolis Kellis Ivana Kolcic Ishminder K Kooner Jaspal S Kooner Jan A Kors Edward G Lakatta Kasper Lage Lenore J Launer Daniel Levy Alicia Lundby Peter W Macfarlane Dalit May Thomas Meitinger Andres Metspalu Stefania Nappo Silvia Naitza Shane Neph Alex S Nord Teresa Nutile Peter M Okin Jesper V Olsen Ben A Oostra Josef M Penninger Len A Pennacchio Tune H Pers Siegfried Perz Annette Peters Yigal M Pinto Arne Pfeufer Maria Grazia Pilia Peter P Pramstaller Bram P Prins Olli T Raitakari Soumya Raychaudhuri Ken M Rice Elizabeth J Rossin Jerome I Rotter Sebastian Schafer David Schlessinger Carsten O Schmidt Jobanpreet Sehmi Herman H W Silljé Gianfranco Sinagra Moritz F Sinner Kamil Slowikowski Elsayed Z Soliman Timothy D Spector Wilko Spiering John A Stamatoyannopoulos Ronald P Stolk Konstantin Strauch Sian-Tsung Tan Kirill V Tarasov Bosco Trinh Andre G Uitterlinden Malou van den Boogaard Cornelia M van Duijn Wiek H van Gilst Jorma S Viikari Peter M Visscher Veronique Vitart Uwe Völker Melanie Waldenberger Christian X Weichenberger Harm-Jan Westra Cisca Wijmenga Bruce H Wolffenbuttel Jian Yang Connie R Bezzina Patricia B Munroe Harold Snieder Alan F Wright Igor Rudan Laurie A Boyer Folkert W Asselbergs Dirk J van Veldhuisen Bruno H Stricker Bruce M Psaty Marina Ciullo Serena Sanna Terho Lehtimäki James F Wilson Stefania Bandinelli Alvaro Alonso Paolo Gasparini J Wouter Jukema Stefan Kääb Vilmundur Gudnason Stephan B Felix Susan R Heckbert Rudolf A de Boer Christopher Newton-Cheh Andrew A Hicks John C Chambers Yalda Jamshidi Axel Visel Vincent M Christoffels Aaron Isaacs Nilesh J Samani Paul I W de Bakker

J Am Coll Cardiol 2016 09;68(13):1435-1448

Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Epidemiology, University Medical Center Utrecht, Utrecht, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacc.2016.07.729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478167PMC
September 2016

Absence of an anatomical origin for altered ductus venosus flow velocity waveforms in first-trimester human fetuses with increased nuchal translucency.

Prenat Diagn 2016 Jun 10;36(6):537-44. Epub 2016 May 10.

Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pd.4820DOI Listing
June 2016

EMERGE: a flexible modelling framework to predict genomic regulatory elements from genomic signatures.

Nucleic Acids Res 2016 Mar 3;44(5):e42. Epub 2015 Nov 3.

Department of Anatomy, Embryology & Physiology, Academic Medical Centre, Meibergdreef 15, 1105AZ Amsterdam, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkv1144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797259PMC
March 2016

Embryonic development of the right ventricular outflow tract and arrhythmias.

Heart Rhythm 2016 Feb 14;13(2):616-22. Epub 2015 Nov 14.

Department of Anatomy, Embryology and Physiology.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrthm.2015.11.014DOI Listing
February 2016

Genetics of congenital heart disease: the contribution of the noncoding regulatory genome.

J Hum Genet 2016 Jan 30;61(1):13-9. Epub 2015 Jul 30.

Department of Anatomy, Embryology & Physiology, Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/jhg.2015.98DOI Listing
January 2016

The formation and function of the cardiac conduction system.

Development 2016 Jan;143(2):197-210

Department of Anatomy, Embryology & Physiology, Academic Medical Center, Amsterdam 1105 AZ, The Netherlands

View Article

Download full-text PDF

Source
http://dev.biologists.org/content/143/2/197.full-text.pdf
Web Search
http://dev.biologists.org/cgi/doi/10.1242/dev.124883
Publisher Site
http://dx.doi.org/10.1242/dev.124883DOI Listing
January 2016

The past, present, and future of pacemaker therapies.

Trends Cardiovasc Med 2015 Nov 20;25(8):661-73. Epub 2015 Feb 20.

Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tcm.2015.02.005DOI Listing
November 2015

GATA-dependent transcriptional and epigenetic control of cardiac lineage specification and differentiation.

Cell Mol Life Sci 2015 Oct 1;72(20):3871-81. Epub 2015 Jul 1.

Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-015-1974-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575685PMC
October 2015

Integrating multi-scale knowledge on cardiac development into a computational model of ventricular trabeculation.

Wiley Interdiscip Rev Syst Biol Med 2014 Nov-Dec;6(6):389-97. Epub 2014 Oct 6.

Department of Anatomy, Embryology and Physiology, Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/wsbm.1285DOI Listing
June 2015

Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium.

PLoS One 2014 24;9(10):e110191. Epub 2014 Oct 24.

Department of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore, Singapore; Program in Cancer & Stem Cell Biology, Duke-NUS Graduate Medical School Singapore, Singapore, Singapore; Department of Physiology, National University of Singapore, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110191PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208772PMC
June 2015

Why increased nuchal translucency is associated with congenital heart disease: a systematic review on genetic mechanisms.

Prenat Diagn 2015 Jun 19;35(6):517-28. Epub 2015 May 19.

Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/pd.4586
Publisher Site
http://dx.doi.org/10.1002/pd.4586DOI Listing
June 2015

OccuPeak: ChIP-Seq peak calling based on internal background modelling.

PLoS One 2014 17;9(6):e99844. Epub 2014 Jun 17.

Department of Anatomy, Embryology & Physiology, Academic Medical Centre, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099844PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061025PMC
February 2015

Canonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties.

Circ Res 2015 Jan 6;116(3):398-406. Epub 2014 Nov 6.

From the Department of Medicine, Cardiovascular Division (B.S.G., A.C., H.A., S.R.), and Department of Developmental Biology (B.S.G., A.C., H.A., S.R.), Washington University School of Medicine, St. Louis, MO; Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland (T.V., K.B.); Department of Anatomy, Embryology, and Physiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (V.M.C.); and Department of Biomedical Engineering, Washington University, St. Louis, MO (I.R.E., B.J.B., S.R.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.116.304731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312529PMC
January 2015

Involvement of neurons and retinoic acid in lymphatic development: new insights in increased nuchal translucency.

Prenat Diagn 2014 Dec 22;34(13):1312-9. Epub 2014 Aug 22.

Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pd.4473DOI Listing
December 2014

A mutation in the Kozak sequence of GATA4 hampers translation in a family with atrial septal defects.

Am J Med Genet A 2014 Nov 5;164A(11):2732-8. Epub 2014 Aug 5.

Department of Anatomy, Embryology & Physiology, Academic Medical Center, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.a.36703DOI Listing
November 2014

Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart.

Circ Res 2014 Oct 4;115(9):790-9. Epub 2014 Sep 4.

From the Department of Anatomy, Embryology and Physiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (M.S.R., V.M.C.); CNRS, IBDM UMR 7288 (M.T.-R., C.D.B., K.M., A.F., M.R., R.G.K.) and Inserm, GMGF UMR S910, Faculté de Médecine de la Timone (M.R., B.L., S.Z.), Aix Marseille Université, IBDM, CNRS UMR 7288 (M.T.-R., C.D.B., K.M., A.F., M.R., R.G.K) and GMGF Inserm URM S910 (M.R., B.L., S.Z.), Marseille, France; Department of Experimental Biology, University of Jaén, Jaén, Spain (J.N.D.); Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom (R.H.A.); and MRC National Institute for Medical Research, Mill Hill, London, United Kingdom (T.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.115.305020DOI Listing
October 2014

Genetic determinants of P wave duration and PR segment.

Circ Cardiovasc Genet 2014 Aug 21;7(4):475-81. Epub 2014 May 21.

From the Department of Cardiology (N.V., I.M.L., D.J.v.V., H.L.H., W.H.v.G., R.A.d.B., P.v.d.H.) and Department of Genetics (P.v.d.H.), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Anatomy, Embryology and Physiology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands (M.v.d.B., V.M.C., P.B.); and Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands (P.v.d.H.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.113.000373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141024PMC
August 2014

A large permissive regulatory domain exclusively controls Tbx3 expression in the cardiac conduction system.

Circ Res 2014 Aug 24;115(4):432-41. Epub 2014 Jun 24.

From the Department of Anatomy, Embryology, and Physiology, Academic Medical Center, Amsterdam, The Netherlands (J.H.v.W., I.B., M.v.d.B., S.S., P.B., V.M.C.); Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands (H.J.G.v.d.W., W.d.L.); Department of Cell Biology, Erasmus MC Rotterdam, Rotterdam, The Netherlands (H.J.G.v.d.W.); and Cardiovascular Development and Repair Department, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain (M.G.-V., C.B.-C., M.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.115.303591DOI Listing
August 2014

Development of the human aortic arch system captured in an interactive three-dimensional reference model.

Am J Med Genet A 2014 Jun 23;164A(6):1372-83. Epub 2013 Apr 23.

Heart Failure Research Center, Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.a.35881DOI Listing
June 2014

From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning.

Trends Cardiovasc Med 2014 Apr 17;24(3):99-104. Epub 2013 Dec 17.

Department of Anatomy, Embryology and Physiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10501738130012
Publisher Site
http://dx.doi.org/10.1016/j.tcm.2013.09.001DOI Listing
April 2014

GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development.

Nat Commun 2014 Apr 28;5:3680. Epub 2014 Apr 28.

Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105AZ Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms4680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015328PMC
April 2014

Homeobox transcription factor Pitx2: The rise of an asymmetry gene in cardiogenesis and arrhythmogenesis.

Trends Cardiovasc Med 2014 Jan 15;24(1):23-31. Epub 2013 Aug 15.

CNR-Institute of Neurosciences, Department of Biomedical Sciences, University of Padua, Padua, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tcm.2013.06.001DOI Listing
January 2014

Gene regulatory elements of the cardiac conduction system.

Brief Funct Genomics 2014 Jan 22;13(1):28-38. Epub 2013 Aug 22.

Department of Anatomy, Embryology & Physiology, Academic Medical Centre, L2-108, Meibergdreef 15, 1105 AZ Amsterdam, the Netherlands. Tel.: + 31 20 5667821; Fax: + 31 20 6976177;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bfgp/elt031DOI Listing
January 2014

A transgenic mouse model for the simultaneous monitoring of ANF and BNP gene activity during heart development and disease.

Cardiovasc Res 2014 Jan 8;101(1):78-86. Epub 2013 Oct 8.

Department of Anatomy, Embryology and Physiology, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvt228DOI Listing
January 2014

Regulation of expression of atrial and brain natriuretic peptide, biomarkers for heart development and disease.

Biochim Biophys Acta 2013 Dec 12;1832(12):2403-13. Epub 2013 Jul 12.

Dept of Anatomy, Embryology and Physiology, Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2013.07.003DOI Listing
December 2013

Systematic analysis of the development of the ductus venosus in wild type mouse and human embryos.

Early Hum Dev 2013 Dec 23;89(12):1067-73. Epub 2013 Aug 23.

Department of Obstetrics and Gynecology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.earlhumdev.2013.07.029DOI Listing
December 2013

Developing insights into cardiac regeneration.

Development 2013 Oct;140(19):3933-7

Department of Anatomy, Embryology, and Physiology, Heart Failure Research Center, Academic Medical Centre, University of Amsterdam, Amsterdam 1105AZ, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.096867DOI Listing
October 2013

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.

Nat Genet 2013 Sep 21;45(9):1044-9. Epub 2013 Jul 21.

Department of Clinical and Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.2712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869788PMC
September 2013

Reduced sodium channel function unmasks residual embryonic slow conduction in the adult right ventricular outflow tract.

Circ Res 2013 Jul 9;113(2):137-41. Epub 2013 May 9.

Department of Anatomy, Embryology, and Physiology, Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.113.301565DOI Listing
July 2013

Exploring a neurogenic basis of velopharyngeal dysfunction in Tbx1 mutant mice: no difference in volumes of the nucleus ambiguus.

Int J Pediatr Otorhinolaryngol 2013 Jun 1;77(6):1002-7. Epub 2013 May 1.

Department of Plastic Surgery, University Medical Center Utrecht, Postbus 85090, KE 04.140.0, 3508 AB Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijporl.2013.03.032DOI Listing
June 2013

Second heart field cardiac progenitor cells in the early mouse embryo.

Biochim Biophys Acta 2013 Apr 7;1833(4):795-8. Epub 2012 Oct 7.

Developmental Biology Institute of Marseille-Luminy, Marseille, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamcr.2012.10.003DOI Listing
April 2013

Evolution and development of the building plan of the vertebrate heart.

Biochim Biophys Acta 2013 Apr 11;1833(4):783-94. Epub 2012 Oct 11.

Department of Anatomy, Embryology and Physiology, University of Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamcr.2012.10.004DOI Listing
April 2013

Identifying the evolutionary building blocks of the cardiac conduction system.

PLoS One 2012 11;7(9):e44231. Epub 2012 Sep 11.

Department of Anatomy, Embryology & Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044231PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439475PMC
March 2013

Partial absence of pleuropericardial membranes in Tbx18- and Wt1-deficient mice.

PLoS One 2012 11;7(9):e45100. Epub 2012 Sep 11.

Institut für Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Hannover, Germany.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045100PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439432PMC
March 2013

Early repolarization in mice causes overestimation of ventricular activation time by the QRS duration.

Cardiovasc Res 2013 Jan 20;97(1):182-91. Epub 2012 Sep 20.

Department of Anatomy, Embryology, and Physiology, Academic Medical Center Amsterdam, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvs299DOI Listing
January 2013

Electrophysiological patterning of the heart.

Pediatr Cardiol 2012 Aug 25;33(6):900-6. Epub 2012 Feb 25.

Heart Failure Research Center, Department of Anatomy, Embryology and Physiology, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00246-012-0237-4DOI Listing
August 2012

Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.

J Clin Invest 2012 Jul 18;122(7):2519-30. Epub 2012 Jun 18.

Department of Anatomy, Embryology, and Physiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI62613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386824PMC
July 2012

T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.

Cardiovasc Res 2012 Jun 14;94(3):439-49. Epub 2012 Mar 14.

Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Room L2-108, 1105 AZ, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvs120DOI Listing
June 2012

Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis.

Hum Mol Genet 2012 Mar 24;21(6):1217-29. Epub 2011 Nov 24.

Developmental Biology Institute of Marseille-Luminy, Aix-Marseille University, CNRS UMR6216, Marseille, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddr553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491916PMC
March 2012

Popeye proteins: muscle for the aging sinus node.

J Clin Invest 2012 Mar 22;122(3):810-3. Epub 2012 Feb 22.

Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI62588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287239PMC
March 2012

Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial-mesenchymal transition via Bmp2.

Dev Biol 2011 Dec 1;360(2):381-90. Epub 2011 Oct 1.

Department of Developmental and Regenerative Biology, Center for Molecular Cardiology of the Child Health and Development Institute, the Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00121606110126
Publisher Site
http://dx.doi.org/10.1016/j.ydbio.2011.09.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217163PMC
December 2011

Molecular analysis of patterning of conduction tissues in the developing human heart.

Circ Arrhythm Electrophysiol 2011 Aug 16;4(4):532-42. Epub 2011 May 16.

Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCEP.111.963421DOI Listing
August 2011

Developmental aspects of cardiac arrhythmogenesis.

Cardiovasc Res 2011 Jul 12;91(2):243-51. Epub 2011 May 12.

Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvr134DOI Listing
July 2011

Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2.

Birth Defects Res A Clin Mol Teratol 2011 Jun 28;91(6):435-40. Epub 2011 Apr 28.

Hubrecht Institute, KNAW & University Medical Center Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bdra.20804DOI Listing
June 2011

Origin and development of the atrioventricular myocardial lineage: insight into the development of accessory pathways.

Birth Defects Res A Clin Mol Teratol 2011 Jun 31;91(6):565-77. Epub 2011 May 31.

Heart Failure Research Center, Academic Medical Center, Meibergdreef 15, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bdra.20826DOI Listing
June 2011

Three-dimensional and molecular analysis of the venous pole of the developing human heart.

Circulation 2010 Aug 9;122(8):798-807. Epub 2010 Aug 9.

Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.110.953844DOI Listing
August 2010

The cardiac pacemaker and conduction system develops from embryonic myocardium that retains its primitive phenotype.

J Cardiovasc Pharmacol 2010 Jul;56(1):6-15

Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FJC.0b013e3181e775d3DOI Listing
July 2010

The atrioventricular node: origin, development, and genetic program.

Trends Cardiovasc Med 2010 Jul;20(5):164-71

Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tcm.2011.02.001DOI Listing
July 2010