Vincent Gnanapragasam

Vincent Gnanapragasam

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Vincent Gnanapragasam

Vincent Gnanapragasam

Publications by authors named "Vincent Gnanapragasam"

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Informing informed decision-making in primary prostate cancer treatment selection.

BJU Int 2019 Sep 12. Epub 2019 Sep 12.

Department of Surgery, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/bju.14910DOI Listing
September 2019

Adherence to Active Surveillance Protocols for Low-risk Prostate Cancer: Results of the Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance Initiative.

Eur Urol Oncol 2019 Sep 26. Epub 2019 Sep 26.

Department of Surgery, Faculty of Medicine, Monash University, Melbourne, Victoria, Australia; Department of Urology, Monash Health, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.euo.2019.08.014DOI Listing
September 2019

Impact of hospital nephrectomy volume on intermediate- to long-term survival in renal cell carcinoma.

BJU Int 2019 Jun 17. Epub 2019 Jun 17.

Department of Urology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

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http://dx.doi.org/10.1111/bju.14848DOI Listing
June 2019

The Quest for the Optimal Prostate Biopsy Regime for the 21st Century.

Eur Urol 2019 05 5;75(5):741-742. Epub 2019 Jan 5.

Translational Prostate Cancer Group, University of Cambridge, Cambridge, UK; Urological Malignancies Programme, CRUK Cambridge Cancer Centre, Cambridge, UK; Department of Radiology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/j.eururo.2018.12.031DOI Listing
May 2019

Consistent Biopsy Quality and Gleason Grading Within the Global Active Surveillance Global Action Plan 3 Initiative: A Prerequisite for Future Studies.

Eur Urol Oncol 2019 May 13;2(3):333-336. Epub 2018 Sep 13.

Erasmus Medical Center, Rotterdam, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S25889311183013
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http://dx.doi.org/10.1016/j.euo.2018.08.017DOI Listing
May 2019

Using prognosis to guide early detection and treatment selection in non-metastatic prostate cancer.

BJU Int 2019 Apr 28;123(4):562-563. Epub 2018 Dec 28.

Translational Prostate Cancer Group, Cancer Research UK (CRUK) Cambridge Cancer Centre, Cambridge, UK.

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http://dx.doi.org/10.1111/bju.14637DOI Listing
April 2019

Repeatability of diffusion-weighted MRI of the prostate using whole lesion ADC values, skew and histogram analysis.

Eur J Radiol 2019 Jan 17;110:22-29. Epub 2018 Nov 17.

Department of Radiology, University of Cambridge, Cambridge, UK; Department of Radiology, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1016/j.ejrad.2018.11.014DOI Listing
January 2019

Time trends in service provision and survival outcomes for patients with renal cancer treated by nephrectomy in England 2000-2010.

BJU Int 2018 10 20;122(4):599-609. Epub 2018 Apr 20.

Department of Urology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

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http://dx.doi.org/10.1111/bju.14217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175431PMC
October 2018

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Nat Genet 2018 05 16;50(5):682-692. Epub 2018 Apr 16.

The Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/s41588-018-0086-z
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http://dx.doi.org/10.1038/s41588-018-0086-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372064PMC
May 2018

Influence of hospital volume on nephrectomy mortality and complications: a systematic review and meta-analysis stratified by surgical type.

BMJ Open 2017 Sep 5;7(9):e016833. Epub 2017 Sep 5.

Department of Urology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

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http://dx.doi.org/10.1136/bmjopen-2017-016833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588977PMC
September 2017

Loss of hSef promotes metastasis through upregulation of EMT in prostate cancer.

Int J Cancer 2017 04 30;140(8):1881-1887. Epub 2017 Jan 30.

Academic Urology Group, Department of Surgery, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/ijc.30604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324539PMC
April 2017

Improving clinical prognostic stratification models for men with prostate cancer: a practical step closer to more individualized care without added costs.

BJU Int 2017 03 10;119(3):366-367. Epub 2016 Dec 10.

Department of Pathology, Cambridge University Hospitals NHS Trust, Cambridge, UK.

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http://doi.wiley.com/10.1111/bju.13721
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http://dx.doi.org/10.1111/bju.13721DOI Listing
March 2017

The drama of prostate cancer diagnostics.

Lancet Oncol 2017 03 2;18(3):e132. Epub 2017 Mar 2.

Department of Urology/CamPARI Clinic, Cambridge University Hospitals, Cambridge, UK; Academic Urology Group, Department of Surgery, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/S1470-2045(17)30121-3DOI Listing
March 2017

Novel concepts for risk stratification in prostate cancer.

J Clin Urol 2016 Dec 1;9(2 Suppl):18-23. Epub 2016 Dec 1.

Academic Urology Group, University of Cambridge, UK.

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http://journals.sagepub.com/doi/10.1177/2051415816673502
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http://dx.doi.org/10.1177/2051415816673502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356178PMC
December 2016

Magnetic Resonance and Ultrasound Image Fusion Supported Transperineal Prostate Biopsy Using the Ginsburg Protocol: Technique, Learning Points, and Biopsy Results.

Eur Urol 2016 08 16;70(2):332-40. Epub 2016 Mar 16.

CamPARI Clinic, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK; Department of Urology, Addenbrooke's Hospital, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.02.064DOI Listing
August 2016

Improving Clinical Risk Stratification at Diagnosis in Primary Prostate Cancer: A Prognostic Modelling Study.

PLoS Med 2016 08 2;13(8):e1002063. Epub 2016 Aug 2.

National Cancer Registration Service Eastern Office, Public Health England, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.1002063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970710PMC
August 2016

Comparative Oncologic and Toxicity Outcomes of Salvage Radical Prostatectomy Versus Nonsurgical Therapies for Radiorecurrent Prostate Cancer: A Meta-Regression Analysis.

Eur Urol Focus 2016 Jun 4;2(2):158-171. Epub 2015 Oct 4.

Department of Urology, Addenbrooke's University Hospital, Cambridge, UK; Academic Urology Group, Department of Surgery and Oncology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.euf.2015.09.004DOI Listing
June 2016

Trends and outcome from radical therapy for primary non-metastatic prostate cancer in a UK population.

PLoS One 2015 5;10(3):e0119494. Epub 2015 Mar 5.

Academic Urology Group, Department of Surgery & Oncology, University of Cambridge, Cambridge, United Kingdom; Translational Prostate Cancer Group, Hutchison/MRC Research centre, University of Cambridge, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119494PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351083PMC
January 2016

Ratio of Tumor to Normal Prostate Tissue Apparent Diffusion Coefficient as a Method for Quantifying DWI of the Prostate.

AJR Am J Roentgenol 2015 Dec;205(6):W585-93

1 Department of Radiology, Addenbrooke's Hospital and the University of Cambridge, Hills Rd, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.2214/AJR.15.14338DOI Listing
December 2015

Active surveillance of prostate cancer: a questionnaire survey of urologists, clinical oncologists and urology nurse specialists across three cancer networks in the United Kingdom.

BMC Urol 2015 Jun 13;15:52. Epub 2015 Jun 13.

Academic Urology Group, Department of Surgery & Oncology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1186/s12894-015-0049-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465007PMC
June 2015

Incidence of needle-tract seeding following prostate biopsy for suspected cancer: a review of the literature.

BJU Int 2015 May 22;115(5):698-704. Epub 2014 Oct 22.

Department of Urology, Addenbrooke's University Hospital, Cambridge, UK.

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http://dx.doi.org/10.1111/bju.12849DOI Listing
May 2015

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

Nat Genet 2015 Apr 2;47(4):367-372. Epub 2015 Mar 2.

Urological Research Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge, UK.

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https://ueaeprints.uea.ac.uk/52532/2/39739_3_merged_14193243
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http://www.nature.com/doifinder/10.1038/ng.3221
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http://dx.doi.org/10.1038/ng.3221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380509PMC
April 2015

Molecular markers to guide primary radical treatment selection in localized prostate cancer.

Expert Rev Mol Diagn 2014 Sep 4;14(7):871-81. Epub 2014 Jul 4.

Translational Prostate Cancer Group, University of Cambridge, Hill's Road, Cambridge, Cambridgeshire CB2 0XZ, UK.

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http://dx.doi.org/10.1586/14737159.2014.936851DOI Listing
September 2014

Preoperative 3-T diffusion-weighted MRI for the qualitative and quantitative assessment of extracapsular extension in patients with intermediate- or high-risk prostate cancer.

AJR Am J Roentgenol 2014 Sep;203(3):W280-6

1 Department of Radiology, University of Cambridge, Addenbrooke's Hospital, Box 218, Level 5, Hills Rd, Cambridge CB2 0QQ UK.

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http://dx.doi.org/10.2214/AJR.13.11754DOI Listing
September 2014

Multi-transcript profiling in archival diagnostic prostate cancer needle biopsies to evaluate biomarkers in non-surgically treated men.

BMC Cancer 2014 Sep 16;14:673. Epub 2014 Sep 16.

Translational Prostate Cancer Group, Hutchison/MRC research centre, University of Cambridge, Hills Road, CB1 0XZ Cambridge, UK.

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http://dx.doi.org/10.1186/1471-2407-14-673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174634PMC
September 2014

To treat or not to treat: is the way forward clearer in low-risk prostate cancer?

BJU Int 2013 Aug 7;112(3):285-7. Epub 2013 Mar 7.

Translational Prostate Cancer Group, Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/j.1464-410X.2012.11723.xDOI Listing
August 2013

The role of treatment modality on the utility of predictive tissue biomarkers in clinical prostate cancer: a systematic review.

J Cancer Res Clin Oncol 2013 Jan 28;139(1):1-24. Epub 2012 Nov 28.

Translational Prostate Cancer Group, Hutchison MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK.

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http://dx.doi.org/10.1007/s00432-012-1351-7DOI Listing
January 2013

Radiotherapy and surgery for high-risk localized prostate cancer: a UK questionnaire survey of urologists and clinical oncologists.

BJU Int 2012 Sep 5;110(5):608-12. Epub 2012 Jul 5.

Translational Prostate Cancer Group, University of Cambridge and Department of Urology, Addenbrookes Hospital, Cambridge, UK.

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http://dx.doi.org/10.1111/j.1464-410X.2012.11328.xDOI Listing
September 2012

The role of surgery in high-risk localised prostate cancer.

BJU Int 2012 Mar 27;109(5):648-58. Epub 2011 Sep 27.

Translational Prostate Cancer Group, Department of Oncology, Hutchison/MRC research centre, University of Cambridge, Cambridge, UK.

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http://doi.wiley.com/10.1111/j.1464-410X.2011.10596.x
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http://dx.doi.org/10.1111/j.1464-410X.2011.10596.xDOI Listing
March 2012

The emerging role of diffusion-weighted MRI in prostate cancer management.

Nat Rev Urol 2012 Jan 17;9(2):94-101. Epub 2012 Jan 17.

Department of Radiology, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge CB2 1QQ, UK.

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http://dx.doi.org/10.1038/nrurol.2011.222DOI Listing
January 2012

Laser-capture microdissection and transcriptional profiling in archival FFPE tissue in prostate cancer.

Methods Mol Biol 2011 ;755:291-300

Translational Prostate Cancer Group, Hutchison MRC Research Centre, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1007/978-1-61779-163-5_24DOI Listing
November 2011

Role and expression of FRS2 and FRS3 in prostate cancer.

BMC Cancer 2011 Nov 11;11:484. Epub 2011 Nov 11.

Translational Prostate Cancer Group, Department of Oncology, Hutchison/MRC research centre, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1186/1471-2407-11-484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231952PMC
November 2011

Prostate cancer metabolite quantification relative to water in 1H-MRSI in vivo at 3 Tesla.

Magn Reson Med 2011 Apr 16;65(4):914-9. Epub 2010 Nov 16.

Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/mrm.22703DOI Listing
April 2011

Expression and functional role of negative signalling regulators in tumour development and progression.

Int J Cancer 2010 Dec;127(11):2491-9

Hutchison MRC Research Centre, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/ijc.25542DOI Listing
December 2010

Evidence for distinct alterations in the FGF axis in prostate cancer progression to an aggressive clinical phenotype.

J Pathol 2010 Mar;220(4):452-60

Translational Prostate Cancer Group, Hutchison MRC Research Centre, University of Cambridge, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1002/path.2657DOI Listing
March 2010

Unlocking the molecular archive: the emerging use of formalin-fixed paraffin-embedded tissue for biomarker research in urological cancer.

BJU Int 2010 Jan 10;105(2):274-8. Epub 2009 Jun 10.

Uro-oncology Group, Department of Oncology, Hutchison MRC Research Centre, University of Cambridge, UK.

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http://dx.doi.org/10.1111/j.1464-410X.2009.08665.xDOI Listing
January 2010

Application of transcript profiling in formalin-fixed paraffin-embedded diagnostic prostate cancer needle biopsies.

BJU Int 2008 Aug 11;102(3):364-70. Epub 2008 Apr 11.

Nothern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/j.1464-410X.2008.07627.xDOI Listing
August 2008

One-step immunostrip test for the simultaneous detection of free and total prostate specific antigen in serum.

J Immunol Methods 2005 Dec 24;307(1-2):1-12. Epub 2005 Oct 24.

School of Clinical and Laboratory Sciences, The Medical School, University of Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1016/j.jim.2005.08.014DOI Listing
December 2005

Identification and validation of risk factors for vesicourethral leaks following radical retropubic prostatectomy.

Int J Urol 2005 Nov;12(11):948-52

Department of Urology and Radiology, James Cook University Hospital, Middlesbrough, UK.

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http://dx.doi.org/10.1111/j.1442-2042.2005.01166.xDOI Listing
November 2005

Epigenetic inactivation of the human sprouty2 (hSPRY2) homologue in prostate cancer.

Oncogene 2005 Mar;24(13):2166-74

Urology Research Group, Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne NE2 4AD, UK.

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http://dx.doi.org/10.1038/sj.onc.1208371DOI Listing
March 2005

Expression of Tip60, an androgen receptor coactivator, and its role in prostate cancer development.

Oncogene 2003 Apr;22(16):2466-77

1Prostate Research Group, School of Surgical and Reproductive Sciences, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1038/sj.onc.1206342DOI Listing
April 2003

Regulation of FGF8 expression by the androgen receptor in human prostate cancer.

Oncogene 2002 Aug;21(33):5069-80

Prostate Research Group, School of Surgical Sciences, University of Newcastle-upon-Tyne, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1038/sj.onc.1205663DOI Listing
August 2002