Publications by authors named "Vincent Gnanapragasam"

94Publications

A novel split mode TFBAR device for quantitative measurements of prostate specific antigen in a small sample of whole blood.

Nanoscale 2020 May 22;12(17):9647-9652. Epub 2020 Apr 22.

Electrical Engineering, University of Cambridge, 9 JJ Thomson Avenue, Cambridge, CB3 0FA, UK.

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http://dx.doi.org/10.1039/d0nr00416bDOI Listing
May 2020

Diagnostic accuracy of biparametric versus multiparametric prostate MRI: assessment of contrast benefit in clinical practice.

Eur Radiol 2020 Jul 12;30(7):4039-4049. Epub 2020 Mar 12.

Department of Radiology, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1007/s00330-020-06782-0DOI Listing
July 2020

The effect of capped biparametric magnetic resonance imaging slots on weekly prostate cancer imaging workload.

Br J Radiol 2020 Apr 3;93(1108):20190929. Epub 2020 Feb 3.

Department of Radiology, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1259/bjr.20190929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362922PMC
April 2020

Prostate cancer treatment choices: the GP's role in shared decision making.

Br J Gen Pract 2019 12 28;69(689):588-589. Epub 2019 Nov 28.

Academic Urology Group, Department of Surgery, University of Cambridge and Translational Prostate Cancer Group, CRUK Cambridge Cancer Centre, Cambridge Biomedical Campus, Cambridge.

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http://dx.doi.org/10.3399/bjgp19X706685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867197PMC
December 2019

Removing rician bias in diffusional kurtosis of the prostate using real-data reconstruction.

Magn Reson Med 2020 06 18;83(6):2243-2252. Epub 2019 Nov 18.

Department of Radiology, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/mrm.28080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065237PMC
June 2020

Adherence to Active Surveillance Protocols for Low-risk Prostate Cancer: Results of the Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance Initiative.

Eur Urol Oncol 2020 02 26;3(1):80-91. Epub 2019 Sep 26.

Department of Surgery, Faculty of Medicine, Monash University, Melbourne, Victoria, Australia; Department of Urology, Monash Health, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.euo.2019.08.014DOI Listing
February 2020

Informing informed decision-making in primary prostate cancer treatment selection.

BJU Int 2020 02 3;125(2):194-196. Epub 2019 Oct 3.

Department of Surgery, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/bju.14910DOI Listing
February 2020

Impact of hospital nephrectomy volume on intermediate- to long-term survival in renal cell carcinoma.

BJU Int 2020 01 15;125(1):56-63. Epub 2019 Jul 15.

Department of Urology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

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http://dx.doi.org/10.1111/bju.14848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973244PMC
January 2020

Consistent Biopsy Quality and Gleason Grading Within the Global Active Surveillance Global Action Plan 3 Initiative: A Prerequisite for Future Studies.

Eur Urol Oncol 2019 05 13;2(3):333-336. Epub 2018 Sep 13.

Erasmus Medical Center, Rotterdam, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S25889311183013
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http://dx.doi.org/10.1016/j.euo.2018.08.017DOI Listing
May 2019

The Quest for the Optimal Prostate Biopsy Regime for the 21st Century.

Eur Urol 2019 05 5;75(5):741-742. Epub 2019 Jan 5.

Translational Prostate Cancer Group, University of Cambridge, Cambridge, UK; Urological Malignancies Programme, CRUK Cambridge Cancer Centre, Cambridge, UK; Department of Radiology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/j.eururo.2018.12.031DOI Listing
May 2019

Repeatability of diffusion-weighted MRI of the prostate using whole lesion ADC values, skew and histogram analysis.

Eur J Radiol 2019 Jan 17;110:22-29. Epub 2018 Nov 17.

Department of Radiology, University of Cambridge, Cambridge, UK; Department of Radiology, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1016/j.ejrad.2018.11.014DOI Listing
January 2019

Using prognosis to guide early detection and treatment selection in non-metastatic prostate cancer.

BJU Int 2019 04 28;123(4):562-563. Epub 2018 Dec 28.

Translational Prostate Cancer Group, Cancer Research UK (CRUK) Cambridge Cancer Centre, Cambridge, UK.

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http://dx.doi.org/10.1111/bju.14637DOI Listing
April 2019

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Nat Genet 2018 05 16;50(5):682-692. Epub 2018 Apr 16.

The Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/s41588-018-0086-z
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http://dx.doi.org/10.1038/s41588-018-0086-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372064PMC
May 2018

Time trends in service provision and survival outcomes for patients with renal cancer treated by nephrectomy in England 2000-2010.

BJU Int 2018 10 20;122(4):599-609. Epub 2018 Apr 20.

Department of Urology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

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http://dx.doi.org/10.1111/bju.14217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175431PMC
October 2018

Influence of hospital volume on nephrectomy mortality and complications: a systematic review and meta-analysis stratified by surgical type.

BMJ Open 2017 Sep 5;7(9):e016833. Epub 2017 Sep 5.

Department of Urology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

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http://dx.doi.org/10.1136/bmjopen-2017-016833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588977PMC
September 2017

Comparative Oncologic and Toxicity Outcomes of Salvage Radical Prostatectomy Versus Nonsurgical Therapies for Radiorecurrent Prostate Cancer: A Meta-Regression Analysis.

Eur Urol Focus 2016 Jun 4;2(2):158-171. Epub 2015 Oct 4.

Department of Urology, Addenbrooke's University Hospital, Cambridge, UK; Academic Urology Group, Department of Surgery and Oncology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.euf.2015.09.004DOI Listing
June 2016

Novel concepts for risk stratification in prostate cancer.

J Clin Urol 2016 Dec 1;9(2 Suppl):18-23. Epub 2016 Dec 1.

Academic Urology Group, University of Cambridge, UK.

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http://journals.sagepub.com/doi/10.1177/2051415816673502
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http://dx.doi.org/10.1177/2051415816673502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356178PMC
December 2016

The drama of prostate cancer diagnostics.

Lancet Oncol 2017 03 2;18(3):e132. Epub 2017 Mar 2.

Department of Urology/CamPARI Clinic, Cambridge University Hospitals, Cambridge, UK; Academic Urology Group, Department of Surgery, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/S1470-2045(17)30121-3DOI Listing
March 2017

Loss of hSef promotes metastasis through upregulation of EMT in prostate cancer.

Int J Cancer 2017 04 30;140(8):1881-1887. Epub 2017 Jan 30.

Academic Urology Group, Department of Surgery, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/ijc.30604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324539PMC
April 2017

Improving clinical prognostic stratification models for men with prostate cancer: a practical step closer to more individualized care without added costs.

BJU Int 2017 03 10;119(3):366-367. Epub 2016 Dec 10.

Department of Pathology, Cambridge University Hospitals NHS Trust, Cambridge, UK.

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http://doi.wiley.com/10.1111/bju.13721
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http://dx.doi.org/10.1111/bju.13721DOI Listing
March 2017

Improving Clinical Risk Stratification at Diagnosis in Primary Prostate Cancer: A Prognostic Modelling Study.

PLoS Med 2016 08 2;13(8):e1002063. Epub 2016 Aug 2.

National Cancer Registration Service Eastern Office, Public Health England, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.1002063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970710PMC
August 2016

Magnetic Resonance and Ultrasound Image Fusion Supported Transperineal Prostate Biopsy Using the Ginsburg Protocol: Technique, Learning Points, and Biopsy Results.

Eur Urol 2016 08 16;70(2):332-40. Epub 2016 Mar 16.

CamPARI Clinic, Addenbrooke's Hospital and University of Cambridge, Cambridge, UK; Department of Urology, Addenbrooke's Hospital, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.02.064DOI Listing
August 2016

Ratio of Tumor to Normal Prostate Tissue Apparent Diffusion Coefficient as a Method for Quantifying DWI of the Prostate.

AJR Am J Roentgenol 2015 Dec;205(6):W585-93

1 Department of Radiology, Addenbrooke's Hospital and the University of Cambridge, Hills Rd, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.2214/AJR.15.14338DOI Listing
December 2015

Active surveillance of prostate cancer: a questionnaire survey of urologists, clinical oncologists and urology nurse specialists across three cancer networks in the United Kingdom.

BMC Urol 2015 Jun 13;15:52. Epub 2015 Jun 13.

Academic Urology Group, Department of Surgery & Oncology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1186/s12894-015-0049-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465007PMC
June 2015

Trends and outcome from radical therapy for primary non-metastatic prostate cancer in a UK population.

PLoS One 2015 5;10(3):e0119494. Epub 2015 Mar 5.

Academic Urology Group, Department of Surgery & Oncology, University of Cambridge, Cambridge, United Kingdom; Translational Prostate Cancer Group, Hutchison/MRC Research centre, University of Cambridge, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119494PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351083PMC
January 2016

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

Nat Genet 2015 Apr 2;47(4):367-372. Epub 2015 Mar 2.

Urological Research Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge, UK.

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https://ueaeprints.uea.ac.uk/52532/2/39739_3_merged_14193243
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http://www.nature.com/doifinder/10.1038/ng.3221
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http://dx.doi.org/10.1038/ng.3221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380509PMC
April 2015

Multi-transcript profiling in archival diagnostic prostate cancer needle biopsies to evaluate biomarkers in non-surgically treated men.

BMC Cancer 2014 Sep 16;14:673. Epub 2014 Sep 16.

Translational Prostate Cancer Group, Hutchison/MRC research centre, University of Cambridge, Hills Road, CB1 0XZ Cambridge, UK.

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http://dx.doi.org/10.1186/1471-2407-14-673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174634PMC
September 2014

Preoperative 3-T diffusion-weighted MRI for the qualitative and quantitative assessment of extracapsular extension in patients with intermediate- or high-risk prostate cancer.

AJR Am J Roentgenol 2014 Sep;203(3):W280-6

1 Department of Radiology, University of Cambridge, Addenbrooke's Hospital, Box 218, Level 5, Hills Rd, Cambridge CB2 0QQ UK.

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http://dx.doi.org/10.2214/AJR.13.11754DOI Listing
September 2014

Molecular markers to guide primary radical treatment selection in localized prostate cancer.

Expert Rev Mol Diagn 2014 Sep 4;14(7):871-81. Epub 2014 Jul 4.

Translational Prostate Cancer Group, University of Cambridge, Hill's Road, Cambridge, Cambridgeshire CB2 0XZ, UK.

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http://dx.doi.org/10.1586/14737159.2014.936851DOI Listing
September 2014

Incidence of needle-tract seeding following prostate biopsy for suspected cancer: a review of the literature.

BJU Int 2015 May 22;115(5):698-704. Epub 2014 Oct 22.

Department of Urology, Addenbrooke's University Hospital, Cambridge, UK.

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http://dx.doi.org/10.1111/bju.12849DOI Listing
May 2015

To treat or not to treat: is the way forward clearer in low-risk prostate cancer?

BJU Int 2013 Aug 7;112(3):285-7. Epub 2013 Mar 7.

Translational Prostate Cancer Group, Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/j.1464-410X.2012.11723.xDOI Listing
August 2013

The role of treatment modality on the utility of predictive tissue biomarkers in clinical prostate cancer: a systematic review.

J Cancer Res Clin Oncol 2013 Jan 28;139(1):1-24. Epub 2012 Nov 28.

Translational Prostate Cancer Group, Hutchison MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK.

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http://dx.doi.org/10.1007/s00432-012-1351-7DOI Listing
January 2013

Radiotherapy and surgery for high-risk localized prostate cancer: a UK questionnaire survey of urologists and clinical oncologists.

BJU Int 2012 Sep 5;110(5):608-12. Epub 2012 Jul 5.

Translational Prostate Cancer Group, University of Cambridge and Department of Urology, Addenbrookes Hospital, Cambridge, UK.

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http://dx.doi.org/10.1111/j.1464-410X.2012.11328.xDOI Listing
September 2012

The emerging role of diffusion-weighted MRI in prostate cancer management.

Nat Rev Urol 2012 Jan 17;9(2):94-101. Epub 2012 Jan 17.

Department of Radiology, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge CB2 1QQ, UK.

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http://dx.doi.org/10.1038/nrurol.2011.222DOI Listing
January 2012

Role and expression of FRS2 and FRS3 in prostate cancer.

BMC Cancer 2011 Nov 11;11:484. Epub 2011 Nov 11.

Translational Prostate Cancer Group, Department of Oncology, Hutchison/MRC research centre, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1186/1471-2407-11-484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231952PMC
November 2011

The role of surgery in high-risk localised prostate cancer.

BJU Int 2012 Mar 27;109(5):648-58. Epub 2011 Sep 27.

Translational Prostate Cancer Group, Department of Oncology, Hutchison/MRC research centre, University of Cambridge, Cambridge, UK.

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http://doi.wiley.com/10.1111/j.1464-410X.2011.10596.x
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http://dx.doi.org/10.1111/j.1464-410X.2011.10596.xDOI Listing
March 2012

Laser-capture microdissection and transcriptional profiling in archival FFPE tissue in prostate cancer.

Methods Mol Biol 2011 ;755:291-300

Translational Prostate Cancer Group, Hutchison MRC Research Centre, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1007/978-1-61779-163-5_24DOI Listing
November 2011

Prostate cancer metabolite quantification relative to water in 1H-MRSI in vivo at 3 Tesla.

Magn Reson Med 2011 Apr 16;65(4):914-9. Epub 2010 Nov 16.

Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/mrm.22703DOI Listing
April 2011

Expression and functional role of negative signalling regulators in tumour development and progression.

Int J Cancer 2010 Dec;127(11):2491-9

Hutchison MRC Research Centre, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/ijc.25542DOI Listing
December 2010

Evidence for distinct alterations in the FGF axis in prostate cancer progression to an aggressive clinical phenotype.

J Pathol 2010 Mar;220(4):452-60

Translational Prostate Cancer Group, Hutchison MRC Research Centre, University of Cambridge, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1002/path.2657DOI Listing
March 2010

Unlocking the molecular archive: the emerging use of formalin-fixed paraffin-embedded tissue for biomarker research in urological cancer.

BJU Int 2010 Jan 10;105(2):274-8. Epub 2009 Jun 10.

Uro-oncology Group, Department of Oncology, Hutchison MRC Research Centre, University of Cambridge, UK.

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http://dx.doi.org/10.1111/j.1464-410X.2009.08665.xDOI Listing
January 2010

Application of transcript profiling in formalin-fixed paraffin-embedded diagnostic prostate cancer needle biopsies.

BJU Int 2008 Aug 11;102(3):364-70. Epub 2008 Apr 11.

Nothern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/j.1464-410X.2008.07627.xDOI Listing
August 2008

Identification and validation of risk factors for vesicourethral leaks following radical retropubic prostatectomy.

Int J Urol 2005 Nov;12(11):948-52

Department of Urology and Radiology, James Cook University Hospital, Middlesbrough, UK.

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http://dx.doi.org/10.1111/j.1442-2042.2005.01166.xDOI Listing
November 2005

One-step immunostrip test for the simultaneous detection of free and total prostate specific antigen in serum.

J Immunol Methods 2005 Dec 24;307(1-2):1-12. Epub 2005 Oct 24.

School of Clinical and Laboratory Sciences, The Medical School, University of Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1016/j.jim.2005.08.014DOI Listing
December 2005

Epigenetic inactivation of the human sprouty2 (hSPRY2) homologue in prostate cancer.

Oncogene 2005 Mar;24(13):2166-74

Urology Research Group, Northern Institute for Cancer Research, The Medical School, University of Newcastle, Newcastle upon Tyne NE2 4AD, UK.

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http://dx.doi.org/10.1038/sj.onc.1208371DOI Listing
March 2005

Expression of Tip60, an androgen receptor coactivator, and its role in prostate cancer development.

Oncogene 2003 Apr;22(16):2466-77

1Prostate Research Group, School of Surgical and Reproductive Sciences, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1038/sj.onc.1206342DOI Listing
April 2003

Regulation of FGF8 expression by the androgen receptor in human prostate cancer.

Oncogene 2002 Aug;21(33):5069-80

Prostate Research Group, School of Surgical Sciences, University of Newcastle-upon-Tyne, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1038/sj.onc.1205663DOI Listing
August 2002