Publications by authors named "Vincent Bordas"

9Publications

FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor.

Authors:
Vito Guagnano Audrey Kauffmann Simon Wöhrle Christelle Stamm Moriko Ito Louise Barys Astrid Pornon Yao Yao Fang Li Yun Zhang Zhi Chen Christopher J Wilson Vincent Bordas Mickaël Le Douget L Alex Gaither Jason Borawski John E Monahan Kavitha Venkatesan Thomas Brümmendorf David M Thomas Carlos Garcia-Echeverria Francesco Hofmann William R Sellers Diana Graus-Porta

Cancer Discov 2012 Dec 20;2(12):1118-33. Epub 2012 Sep 20.

Global Discovery Chemistry, 2Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.

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December 2012

Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.

Authors:
Vito Guagnano Pascal Furet Carsten Spanka Vincent Bordas Mickaël Le Douget Christelle Stamm Josef Brueggen Michael R Jensen Christian Schnell Herbert Schmid Markus Wartmann Joerg Berghausen Peter Drueckes Alfred Zimmerlin Dirksen Bussiere Jeremy Murray Diana Graus Porta

J Med Chem 2011 Oct 21;54(20):7066-83. Epub 2011 Sep 21.

Novartis Institute for BioMedical Research, CH-4002 Basel, Switzerland.

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October 2011

Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification.

Authors:
Tom D Heightman Jackie S Scott Mark Longley Vincent Bordas David K Dean Richard Elliott Gail Hutley Jason Witherington Lee Abberley Barry Passingham Manuela Berlanga Maite de Los Frailes Alan Wise Ben Powney Alison Muir Fiona McKay Sharon Butler Kim Winborn Christopher Gardner Jill Darton Colin Campbell Gareth Sanger

Bioorg Med Chem Lett 2007 Dec 25;17(23):6584-7. Epub 2007 Sep 25.

Department of Medicinal Chemistry & DMPK, Neurology & GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK.

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December 2007

Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists.

Authors:
Jason Witherington Emma L Blaney Vincent Bordas Richard L Elliott Alessandra Gaiba Neil Garton Philip M Green Antoinette Naylor David G Smith David J Spalding Andrew K Takle Robert W Ward

Bioorg Med Chem Lett 2006 Nov 22;16(21):5538-41. Epub 2006 Aug 22.

Department of DMPK and Medicinal Chemistry, Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research Limited, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK.

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November 2006

Pyridone derivatives as potent and selective VLA-4 integrin antagonists.

Authors:
Jason Witherington Vincent Bordas Alessandra Gaiba Phil M Green Antoinette Naylor Nigel Parr David G Smith Andrew K Takle Robert W Ward

Bioorg Med Chem Lett 2006 Apr 7;16(8):2256-9. Epub 2006 Feb 7.

Department of Medicinal Chemistry, Neurology & GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research Limited, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK.

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April 2006

6-heteroaryl-pyrazolo[3,4-b]pyridines: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).

Authors:
Jason Witherington Vincent Bordas Alessandra Gaiba Antoinette Naylor Anthony D Rawlings Brian P Slingsby David G Smith Andrew K Takle Robert W Ward

Bioorg Med Chem Lett 2003 Sep;13(18):3059-62

Department of Medicinal Chemistry, Neurology & GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research Limited, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK.

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September 2003

6-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

Authors:
Jason Witherington Vincent Bordas Alessandra Gaiba Neil S Garton Antoinette Naylor Anthony D Rawlings Brian P Slingsby David G Smith Andrew K Takle Robert W Ward

Bioorg Med Chem Lett 2003 Sep;13(18):3055-7

Department of Medicinal Chemistry, Neurology & GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research Limited, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK.

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September 2003

5-aryl-pyrazolo[3,4-b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

Authors:
Jason Witherington Vincent Bordas David Haigh Deirdre M B Hickey Robert J Ife Anthony D Rawlings Brian P Slingsby David G Smith Robert W Ward

Bioorg Med Chem Lett 2003 May;13(9):1581-4

Department of Medicinal Chemistry, Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline Research Limited, New Frontiers Science Park, Third Avenue, Essex CM19 5AW, Harlow, UK.

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May 2003

5-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

Authors:
Jason Witherington Vincent Bordas Stephen L Garland Deirdre M B Hickey Robert J Ife John Liddle Martin Saunders David G Smith Robert W Ward

Bioorg Med Chem Lett 2003 May;13(9):1577-80

Department of Medicinal Chemistry, Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline Research Limited, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK.

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May 2003