Vinay Tergaonkar

Vinay Tergaonkar

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Vinay Tergaonkar

Publications by authors named "Vinay Tergaonkar"

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When alpha meets beta, mast cells get hyper.

J Exp Med 2019 Oct 30;216(10):2229-2230. Epub 2019 Jul 30.

Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology, and Research), Singapore

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http://dx.doi.org/10.1084/jem.20191169DOI Listing
October 2019

Leptin signaling impairs macrophage defenses against Typhimurium.

Proc Natl Acad Sci U S A 2019 08 26;116(33):16551-16560. Epub 2019 Jul 26.

Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany;

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http://dx.doi.org/10.1073/pnas.1904885116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697794PMC
August 2019

A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis.

Cell Rep 2019 Jul;28(4):949-965.e7

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.

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http://dx.doi.org/10.1016/j.celrep.2019.06.036DOI Listing
July 2019

Indian Hedgehog links obesity to development of hepatocellular carcinoma.

Oncogene 2019 03 23;38(12):2206-2222. Epub 2018 Nov 23.

Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, A*STAR, Singapore, Singapore.

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http://dx.doi.org/10.1038/s41388-018-0585-5DOI Listing
March 2019

The expanding roles of long non-coding RNAs in the regulation of cancer stem cells.

Int J Biochem Cell Biol 2019 03 7;108:17-20. Epub 2019 Jan 7.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13572725193000
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http://dx.doi.org/10.1016/j.biocel.2019.01.003DOI Listing
March 2019

Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer.

Int J Mol Sci 2019 Feb 11;20(3). Epub 2019 Feb 11.

Department of Pharmacology, JSS College of Pharmacy, Ooty 643001, India.

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http://www.mdpi.com/1422-0067/20/3/749
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http://dx.doi.org/10.3390/ijms20030749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387291PMC
February 2019

Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression.

Biomedicines 2018 Jul 27;6(3). Epub 2018 Jul 27.

Institute of Molecular and Cellular Biology (A*STAR), 61 Biopolis Drive, Singapore 138673, Singapore.

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http://dx.doi.org/10.3390/biomedicines6030082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163404PMC
July 2018

Meeting Report: The 8th Barossa Meeting-Cell Signaling in Cancer Medicine in the Barossa Valley, Australia.

Cell Death Dis 2018 02 15;9(3):284. Epub 2018 Feb 15.

Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, 5000, SA, Australia.

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http://dx.doi.org/10.1038/s41419-018-0285-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833355PMC
February 2018

Noncoding RNAs: Master Regulators of Inflammatory Signaling.

Trends Mol Med 2018 01 12;24(1):66-84. Epub 2017 Dec 12.

Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore 117597, Singapore; Cancer Science Institute of Singapore, Singapore 117599, Singapore; Centre for Cancer Biology (University of South Australia and SA Pathology), Adelaide, SA 5000, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14714914173020
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http://dx.doi.org/10.1016/j.molmed.2017.11.003DOI Listing
January 2018

Runx Family Genes in Tissue Stem Cell Dynamics.

Adv Exp Med Biol 2017 ;962:117-138

Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1007/978-981-10-3233-2_9DOI Listing
September 2017

PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK-ERK signaling.

Nat Genet 2017 Sep 24;49(9):1354-1363. Epub 2017 Jul 24.

Methyltransferases in Development and Disease Group, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore.

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http://dx.doi.org/10.1038/ng.3922DOI Listing
September 2017

The transcriptional program, functional heterogeneity, and clinical targeting of mast cells.

J Exp Med 2017 Sep 15;214(9):2491-2506. Epub 2017 Aug 15.

Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia, Australia

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http://www.jem.org/lookup/doi/10.1084/jem.20170910
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http://dx.doi.org/10.1084/jem.20170910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584128PMC
September 2017

Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection.

Exp Cell Res 2017 07 12;356(1):74-84. Epub 2017 Apr 12.

Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Research Centre of Heart, Brain, Hormone, and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; School of Biomedical Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2017.04.012DOI Listing
July 2017

A circRNA from SEPALLATA3 regulates splicing of its cognate mRNA through R-loop formation.

Nat Plants 2017 04 18;3:17053. Epub 2017 Apr 18.

Laboratoire de Physiologie Cellulaire and Végétale, CNRS, CEA, INRA, Université Grenoble-Alpes, BIG, UMR 5168, Grenoble 38000, France.

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http://dx.doi.org/10.1038/nplants.2017.53DOI Listing
April 2017

Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway.

Cell Rep 2017 03;18(10):2464-2479

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.02.041DOI Listing
March 2017

Current Insights to Regulation and Role of Telomerase in Human Diseases.

Antioxidants (Basel) 2017 Feb 28;6(1). Epub 2017 Feb 28.

Division of Cancer Genetics and Therapeutics, Laboratory of NFκB Signaling, Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore.

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http://www.mdpi.com/2076-3921/6/1/17
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http://dx.doi.org/10.3390/antiox6010017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384180PMC
February 2017

Inhibition of NUCKS Facilitates Corneal Recovery Following Alkali Burn.

Sci Rep 2017 01 20;7:41224. Epub 2017 Jan 20.

Department of Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1038/srep41224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247723PMC
January 2017

Wanted DEAD/H or Alive: Helicases Winding Up in Cancers.

J Natl Cancer Inst 2017 01 25;109(6). Epub 2017 Jan 25.

Affiliations of authors: Cancer Science Institute of Singapore, National University of Singapore, Singapore (WC, GR, SSS, CW, YY, TZT, HY, BCG, TB, APK); Departments of Pharmacology (WC, GR, SSS, CW, BCG, GS, APK), Physiology (ZXC, ZC, CTY), and Biochemistry (VT), Yong Loo Lin School of Medicine, National University of Singapore, Singapore; KK Women's and Children's Hospital, Singapore (ZXC); Stem Cell and Cancer Biology Laboratory (FA), School of Biomedical Sciences (GS, APK), Curtin Health Innovation Research Institute, Curtin Medical School (APK), Curtin University, Perth, WA, Australia; National University Cancer Institute, National University Health System, Singapore (CTY, BCG, APK); 2 Department of Pediatrics, Semmelweis University, Budapest, Hungary (LSP); MTA TTK Lendület Cancer Biomarker Research Group, Research Centre for Natural Sciences, Budapest, Hungary (LSP); Department of Renal Medicine (MBL) and Department of Haematology-Oncology (BCG), National University Health System, Singapore; Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore (VT); Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, Australia (VT); Department of Biological Sciences, University of North Texas, Denton, TX (APK).

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http://dx.doi.org/10.1093/jnci/djw278DOI Listing
January 2017

Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC.

Front Cell Dev Biol 2017 26;5. Epub 2017 Jan 26.

Laboratory of NFκB Signaling, Institute of Molecular and Cell Biology, ASTARSingapore, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of SingaporeSingapore, Singapore; Centre for Cancer Biology, University of South Australia and SA PathologyAdelaide, SA, Australia.

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http://journal.frontiersin.org/article/10.3389/fcell.2017.00
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http://dx.doi.org/10.3389/fcell.2017.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266692PMC
January 2017

Activation of mutant TERT promoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomas.

Proc Natl Acad Sci U S A 2016 12 23;113(50):14402-14407. Epub 2016 Nov 23.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138673;

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http://dx.doi.org/10.1073/pnas.1611106113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167176PMC
December 2016

Cyclin A2 regulates erythrocyte morphology and numbers.

Cell Cycle 2016 Nov 22;15(22):3070-3081. Epub 2016 Sep 22.

a Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research) , Singapore , Republic of Singapore.

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http://dx.doi.org/10.1080/15384101.2016.1234546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134699PMC
November 2016

Long-Range Chromatin Interactions Drive Mutant TERT Promoter Activation.

Cancer Discov 2016 11 20;6(11):1276-1291. Epub 2016 Sep 20.

Division of Cancer Genetics and Therapeutics, Laboratory of NFκB Signaling, Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore.

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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://dx.doi.org/10.1158/2159-8290.CD-16-0177DOI Listing
November 2016

Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds.

Semin Cancer Biol 2016 10 30;40-41:35-47. Epub 2016 Mar 30.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore; School of Biomedical Sciences, Curtin Health Innovation Research Institute, Biosciences Research Precinct, Curtin University, Western Australia 6009, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2016.03.005DOI Listing
October 2016

Rap1 induces cytokine production in pro-inflammatory macrophages through NFκB signaling and is highly expressed in human atherosclerotic lesions.

Cell Cycle 2015 ;14(22):3580-92

a Department of Pharmacology and Pharmacy and State Key Laboratory of Pharmaceutical Biotechnology ; Li Ka Shing Faculty of Medicine; The University of Hong Kong ; Hong Kong , China.

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http://dx.doi.org/10.1080/15384101.2015.1100771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825742PMC
September 2016

RNAi Reveals Phase-Specific Global Regulators of Human Somatic Cell Reprogramming.

Cell Rep 2016 06 9;15(12):2597-607. Epub 2016 Jun 9.

Epigenetics and Cell Fates Laboratory, A(∗)STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore 138673, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.049DOI Listing
June 2016

HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer.

Proc Natl Acad Sci U S A 2016 06 14;113(26):E3735-44. Epub 2016 Jun 14.

Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Agency for Science, Technology and Research, Biopolis, Singapore 138672; Cancer Research Institute, Jinan University, Guangzhou 510632, China; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597; Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School Singapore, Singapore 169857

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http://dx.doi.org/10.1073/pnas.1602079113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932959PMC
June 2016

RNA helicase DP103 and TAK1: a new connection in cancer.

Mol Cell Oncol 2015 Jul-Sep;2(3):e985911. Epub 2015 Jan 26.

Institute of Molecular and Cellular Biology; ASTAR, Singapore; Department of Biochemistry; Yong Loo Lin School of Medicine; National University of Singapore; Singapore.

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http://dx.doi.org/10.4161/23723556.2014.985911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905301PMC
June 2016

NFκB drives TERT promoter reactivation in cancer.

Authors:
Vinay Tergaonkar

Cell Cycle 2016 ;15(2):156-7

a Laboratory of NFκB Signaling, IMCB , Singapore.

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http://dx.doi.org/10.1080/15384101.2015.1118908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825903PMC
May 2016

Noncanonical NF-κB Signaling in Health and Disease.

Trends Mol Med 2016 05 7;22(5):414-429. Epub 2016 Apr 7.

Laboratory of NF-κB Signaling, Institute of Molecular and Cell Biology (IMCB), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore 117597, Singapore; Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA 5000, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2016.03.002DOI Listing
May 2016

Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet.

Sci Rep 2016 05 16;6:25844. Epub 2016 May 16.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, 61 Biopolis Drive, Singapore 138673, Singapore.

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http://dx.doi.org/10.1038/srep25844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867603PMC
May 2016

Reactivation of telomerase in cancer.

Cell Mol Life Sci 2016 Apr 4;73(8):1659-70. Epub 2016 Feb 4.

Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Proteos, 61, Biopolis Drive, Singapore, 138673, Singapore.

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http://link.springer.com/content/pdf/10.1007%2Fs00018-016-21
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http://link.springer.com/10.1007/s00018-016-2146-9
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http://dx.doi.org/10.1007/s00018-016-2146-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805692PMC
April 2016

Telomerase reactivation in cancers: Mechanisms that govern transcriptional activation of the wild-type vs. mutant TERT promoters.

Transcription 2016 03 30;7(2):44-9. Epub 2016 Mar 30.

a Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research) , Singapore , Singapore.

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http://dx.doi.org/10.1080/21541264.2016.1160173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853035PMC
March 2016

Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.

Nat Cell Biol 2015 Oct 21;17(10):1327-38. Epub 2015 Sep 21.

Institute of Molecular and Cell Biology (IMCB), A∗STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore.

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http://dx.doi.org/10.1038/ncb3240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772727PMC
October 2015

Systematic identification of factors for provirus silencing in embryonic stem cells.

Cell 2015 Sep 10;163(1):230-45. Epub 2015 Sep 10.

Epigenetics and Cell Fates Laboratory, A(∗)STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore 138673, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(15)01089-2.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S009286741501089
Publisher Site
http://dx.doi.org/10.1016/j.cell.2015.08.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686136PMC
September 2015

Hypothalamic NUCKS regulates peripheral glucose homoeostasis.

Biochem J 2015 Aug 11;469(3):391-8. Epub 2015 Jun 11.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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http://dx.doi.org/10.1042/BJ20150450DOI Listing
August 2015

Hematopoietic stem cell enhancer: a powerful tool in stem cell biology.

Histol Histopathol 2015 Jun 9;30(6):661-72. Epub 2015 Jan 9.

Cancer Science Institute of Singapore, National University of Singapore, Institute of Bioengineering and Nanotechnology, A*STAR, Department of Paediatrics, National University of Singapore, Singapore and International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.

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http://dx.doi.org/10.14670/HH-30.661DOI Listing
June 2015

Catalytically inactive telomerase in oncogenesis.

Authors:
Vinay Tergaonkar

Oncotarget 2015 Jun;6(17):14725-6

Institute of Molecular and Cell Biology (A*STAR), Proteos, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558106PMC
http://dx.doi.org/10.18632/oncotarget.4404DOI Listing
June 2015

NUCKS: a potential biomarker in cancer and metabolic disease.

Clin Sci (Lond) 2015 May;128(10):715-21

*Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, 138673, Singapore.

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http://dx.doi.org/10.1042/CS20140656DOI Listing
May 2015

Hematopoiesis specific loss of Cdk2 and Cdk4 results in increased erythrocyte size and delayed platelet recovery following stress.

Haematologica 2015 Apr 23;100(4):431-8. Epub 2015 Jan 23.

Institute of Molecular and Cell Biology, A*STAR Agency for Science, Technology and Research, Republic of Singapore National University of Singapore, Department of Biochemistry, Republic of Singapore

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http://dx.doi.org/10.3324/haematol.2014.106468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380715PMC
April 2015

Quantitative assessment of telomerase components in cancer cell lines.

FEBS Lett 2015 Apr 5;589(9):974-84. Epub 2015 Mar 5.

Laboratory of NF-κB Signaling, Institute of Molecular and Cell Biology (IMCB), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore 117597, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2015.02.035DOI Listing
April 2015

Inhibition of RAP1 enhances corneal recovery following alkali injury.

Invest Ophthalmol Vis Sci 2015 Jan 8;56(2):711-21. Epub 2015 Jan 8.

Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, Hong Kong, China.

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http://dx.doi.org/10.1167/iovs.14-15268DOI Listing
January 2015

An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma.

Nat Commun 2015 Jan 29;6:6184. Epub 2015 Jan 29.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 61, Biopolis Drive, Proteos, Singapore 138673, Singapore.

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http://dx.doi.org/10.1038/ncomms7184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317502PMC
January 2015

A role of autophagy in PTP4A3-driven cancer progression.

Autophagy 2014 Oct 1;10(10):1787-800. Epub 2014 Aug 1.

Institute of Molecular and Cell Biology; A*STAR (Agency for Science, Technology and Research); Singapore; Department of Biochemistry; Yong Loo Lin School of Medicine; National University of Singapore; Singapore.

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http://dx.doi.org/10.4161/auto.29989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198363PMC
October 2014

Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects.

Cell Rep 2014 Aug 24;8(3):767-82. Epub 2014 Jul 24.

Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore; Institute of Molecular and Cell Biology, A(∗)STAR, Singapore 138673, Singapore; Institute of Bioengineering and Nanotechnology, A(∗)STAR, Singapore 138669, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.06.046DOI Listing
August 2014

RUNX1 point mutations potentially identify a subset of early immature T-cell acute lymphoblastic leukaemia that may originate from differentiated T-cells.

Gene 2014 Jul 2;545(1):111-6. Epub 2014 May 2.

Cancer Science Institute of Singapore, National University of Singapore, Singapore; Institute of Bioengineering and Nanotechnology, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2014.04.074DOI Listing
July 2014

Rho protein GTPases and their interactions with NFκB: crossroads of inflammation and matrix biology.

Biosci Rep 2014 Jun 25;34(3). Epub 2014 Jun 25.

∥Institute of Molecular and Cell Biology, A*Star Institute in Singapore, Singapore.

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http://dx.doi.org/10.1042/BSR20140021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069681PMC
June 2014

NUCKS is a positive transcriptional regulator of insulin signaling.

Cell Rep 2014 Jun 12;7(6):1876-86. Epub 2014 Jun 12.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.05.030DOI Listing
June 2014

Noncanonical functions of telomerase: implications in telomerase-targeted cancer therapies.

Cancer Res 2014 Mar 5;74(6):1639-44. Epub 2014 Mar 5.

Authors' Affiliations: Division of Cancer Genetics and Therapeutics, Laboratory of NF-κB Signaling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR); and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3568DOI Listing
March 2014

Telomerase: central regulator of all of the hallmarks of cancer.

Trends Biochem Sci 2013 Sep 7;38(9):426-34. Epub 2013 Aug 7.

Division of Cancer Genetics and Therapeutics, Laboratory of NFκB Signaling, Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore 138673.

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http://dx.doi.org/10.1016/j.tibs.2013.07.001DOI Listing
September 2013

Chronic adipose tissue inflammation: all immune cells on the stage.

Trends Mol Med 2013 Aug 6;19(8):487-500. Epub 2013 Jun 6.

Laboratory of NF-κB Signaling, Institute of Molecular and Cell Biology (IMCB), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.

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http://dx.doi.org/10.1016/j.molmed.2013.05.001DOI Listing
August 2013

Runx3 deficiency results in myeloproliferative disorder in aged mice.

Blood 2013 Jul 5;122(4):562-6. Epub 2013 Jun 5.

Institute of Molecular and Cell Biology, Singapore.

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http://dx.doi.org/10.1182/blood-2012-10-460618DOI Listing
July 2013

Telomerase directly regulates NF-κB-dependent transcription.

Nat Cell Biol 2012 Dec 18;14(12):1270-81. Epub 2012 Nov 18.

Laboratory of NFκB Signaling, IMCB, Proteos, 138673, Singapore.

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http://dx.doi.org/10.1038/ncb2621DOI Listing
December 2012

A role of Rab7 in stabilizing EGFR-Her2 and in sustaining Akt survival signal.

J Cell Physiol 2012 Jun;227(6):2788-97

School of Pharmaceutical Sciences, Institute for Biomedical Research, Xiamen University, Fujian, China.

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http://doi.wiley.com/10.1002/jcp.23023
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http://dx.doi.org/10.1002/jcp.23023DOI Listing
June 2012

Multifaceted link between cancer and inflammation.

Biosci Rep 2012 Feb;32(1):1-15

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

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February 2012

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration.

Nat Cell Biol 2011 Aug 28;13(10):1272-9. Epub 2011 Aug 28.

Section of Inflammation and Signal Transduction, Department of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462316PMC
August 2011

Telomeres and inflammation: Rap1 joins the ends?

Cell Cycle 2010 Oct 18;9(19):3834-5. Epub 2010 Oct 18.

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http://dx.doi.org/10.4161/cc.9.19.13383DOI Listing
October 2010

The POPX2 phosphatase regulates cancer cell motility and invasiveness.

Cell Cycle 2010 Jan 22;9(1):179-87. Epub 2010 Jan 22.

School of Biological Sciences, Nanyang Technological University, Singapore.

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January 2010

p53 and NFkappaB: fresh breath in the cross talk.

Authors:
Vinay Tergaonkar

Cell Res 2009 Dec;19(12):1313-5

Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673.

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http://www.nature.com/articles/cr2009132
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December 2009

Potential pharmacological control of the NF-κB pathway.

Trends Pharmacol Sci 2009 Jun 14;30(6):313-21. Epub 2009 May 14.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore.

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June 2009

WIP1 phosphatase is a negative regulator of NF-kappaB signalling.

Nat Cell Biol 2009 May 19;11(5):659-66. Epub 2009 Apr 19.

Laboratory of NF- kappaB signalling, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673.

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May 2009

NFkappaB signaling in carcinogenesis and as a potential molecular target for cancer therapy.

Apoptosis 2009 Apr;14(4):348-63

Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Republic of Singapore.

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April 2009

Roles of NF-kappaB in health and disease: mechanisms and therapeutic potential.

Clin Sci (Lond) 2009 Mar;116(6):451-65

Laboratory of NF-kappaB Signaling, Institute for Molecular and Cell Biology (A*STAR), 61, Proteos, 138673 Singapore.

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March 2009

Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP.

Proc Natl Acad Sci U S A 2009 Feb 5;106(8):2629-34. Epub 2009 Feb 5.

Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0812256106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650315PMC
February 2009

Tumor suppressor SMAR1 represses IkappaBalpha expression and inhibits p65 transactivation through matrix attachment regions.

J Biol Chem 2009 Jan 3;284(2):1267-78. Epub 2008 Nov 3.

National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411007, Maharastra, India.

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http://dx.doi.org/10.1074/jbc.M801088200DOI Listing
January 2009

Hexamethylene bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF kappaB activity: implications for cancer therapy.

Cell Cycle 2008 Dec 10;7(23):3759-67. Epub 2008 Dec 10.

Laboratory of Cell Cycle Control, Institute of Molecular and Cell Biology, Proteos, Singapore, Singapore.

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December 2008

Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-kappaB pathways.

Nat Rev Drug Discov 2008 Dec;7(12):1031-40

Laboratory of Cell Cycle Control, Institute of Molecular and Cell Biology, Proteos, 138673 Singapore.

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http://www.nature.com/articles/nrd2759
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December 2008

Bruton's tyrosine kinase separately regulates NFkappaB p65RelA activation and cytokine interleukin (IL)-10/IL-12 production in TLR9-stimulated B Cells.

J Biol Chem 2008 Apr 13;283(17):11189-98. Epub 2008 Feb 13.

Laboratory of Immunology, Bioprocessing Technology Institute, Agency for Science, Technology, and Research, Singapore, Singapore.

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April 2008

Notch and NFkappaB signaling pathways: Do they collaborate in normal vertebrate brain development and function?

Bioessays 2007 Oct;29(10):1039-47

Laboratory of NFkappaB Signaling and Human Ailments, Institute of Molecular and Cell Biology, 61 Biopolis Drive (Proteos), Singapore 138673.

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http://doi.wiley.com/10.1002/bies.20647
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October 2007

A role for IkappaB kinase 2 in bipolar spindle assembly.

Proc Natl Acad Sci U S A 2007 Oct 15;104(43):16940-5. Epub 2007 Oct 15.

Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Drive, San Diego, CA 92121, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040438PMC
October 2007

Myeloid differentiation factor 88-independent Toll-like receptor pathway: Sustaining inflammation or promoting tolerance?

Int J Biochem Cell Biol 2007 3;39(9):1582-92. Epub 2007 May 3.

Bioinformatics Institute (A*STAR), Matrix, Biopolis Street, Singapore 138671, Singapore.

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September 2007

Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance.

J Immunol 2007 Sep;179(6):4083-92

Singapore Immunology Network, Biomedical Sciences Institutes, Agency for Science, Technology and Research, Immunos.

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http://dx.doi.org/10.4049/jimmunol.179.6.4083DOI Listing
September 2007

p53 and NF-kappaB crosstalk: IKKalpha tips the balance.

Mol Cell 2007 Apr;26(2):158-9

Institute of Molecular and Cell Biology, Proteos 61, Singapore.

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April 2007

A fourth IkappaB protein within the NF-kappaB signaling module.

Cell 2007 Jan;128(2):369-81

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.cell.2006.12.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1831796PMC
January 2007

NFkappaB pathway: a good signaling paradigm and therapeutic target.

Authors:
Vinay Tergaonkar

Int J Biochem Cell Biol 2006 ;38(10):1647-53

Institute for Molecular and Cell Biology, 61 Proteos, Biopolis Drive, Singapore 138673, Singapore.

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October 2006

Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival.

Cancer Cell 2006 Sep;10(3):215-26

Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

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September 2006

UV-mediated NF-kappaB activation is abolished in deficient XPC/D primary fibroblasts.

Cell Cycle 2006 May 15;5(10):1085-9. Epub 2006 May 15.

The Salk Institute for Biological Studies, La Jolla, California, USA.

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May 2006

Distinct roles of IkappaB proteins in regulating constitutive NF-kappaB activity.

Nat Cell Biol 2005 Sep;7(9):921-3

Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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September 2005