Viktor Umansky

Viktor Umansky

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Viktor Umansky

Viktor Umansky

Publications by authors named "Viktor Umansky"

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ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12.

Cell Death Dis 2019 Oct 7;10(10):760. Epub 2019 Oct 7.

Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1038/s41419-019-2010-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779894PMC
October 2019

Melanoma Extracellular Vesicles Generate Immunosuppressive Myeloid Cells by Upregulating PD-L1 via TLR4 Signaling.

Cancer Res 2019 Sep 23;79(18):4715-4728. Epub 2019 Jul 23.

Clinical Cooperation Unit Dermato-Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-0053DOI Listing
September 2019

SOX2 in development and cancer biology.

Semin Cancer Biol 2019 Aug 11. Epub 2019 Aug 11.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2019.08.007DOI Listing
August 2019

Opposing roles of eosinophils in cancer.

Cancer Immunol Immunother 2019 May 9;68(5):823-833. Epub 2018 Oct 9.

Skin Cancer Unit, Clinical Cooperation Unit Dermato-Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://link.springer.com/10.1007/s00262-018-2255-4
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http://dx.doi.org/10.1007/s00262-018-2255-4DOI Listing
May 2019

Interactions among myeloid regulatory cells in cancer.

Cancer Immunol Immunother 2019 Apr 12;68(4):645-660. Epub 2018 Jul 12.

Institute of Pulmonary Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1007/s00262-018-2200-6DOI Listing
April 2019

Deciphering myeloid-derived suppressor cells: isolation and markers in humans, mice and non-human primates.

Cancer Immunol Immunother 2019 Apr 25;68(4):687-697. Epub 2019 Jan 25.

Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 28, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00262-019-02302-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447515PMC
April 2019

Targeting the Post-Irradiation Tumor Microenvironment in Glioblastoma via Inhibition of CXCL12.

Cancers (Basel) 2019 Feb 26;11(3). Epub 2019 Feb 26.

Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.

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http://dx.doi.org/10.3390/cancers11030272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468743PMC
February 2019

SOX2-mediated upregulation of CD24 promotes adaptive resistance toward targeted therapy in melanoma.

Int J Cancer 2018 12 16;143(12):3131-3142. Epub 2018 Oct 16.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, D-68135, Germany.

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http://dx.doi.org/10.1002/ijc.31609DOI Listing
December 2018

Loss of neural crest-associated gene FOXD1 impairs melanoma invasion and migration via RAC1B downregulation.

Int J Cancer 2018 12 29;143(11):2962-2972. Epub 2018 Sep 29.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://doi.wiley.com/10.1002/ijc.31799
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http://dx.doi.org/10.1002/ijc.31799DOI Listing
December 2018

Targeting SOX2 in anticancer therapy.

Expert Opin Ther Targets 2018 12 26;22(12):983-991. Epub 2018 Oct 26.

a Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology , University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg , Mannheim , Germany.

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https://www.tandfonline.com/doi/full/10.1080/14728222.2018.1
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http://dx.doi.org/10.1080/14728222.2018.1538359DOI Listing
December 2018

T-lymphocyte profiles differ between keratoacanthomas and invasive squamous cell carcinomas of the human skin.

Cancer Immunol Immunother 2018 07 24;67(7):1147-1157. Epub 2018 May 24.

Department of Dermatology, Venereology and Allergy, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University and Centre of Excellence of Dermatology of Baden-Württemberg, Mannheim, Germany.

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http://dx.doi.org/10.1007/s00262-018-2171-7DOI Listing
July 2018

Editorial: Two MDSC faces in obesity: Correcting metabolic dysfunctions but promoting tumor development.

J Leukoc Biol 2018 03 15;103(3):373-375. Epub 2017 Dec 15.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht Karl University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1002/JLB.3CE1017-416RDOI Listing
March 2018

The role of hypoxia in shaping the recruitment of proangiogenic and immunosuppressive cells in the tumor microenvironment.

Contemp Oncol (Pozn) 2018 Mar 5;22(1A):7-13. Epub 2018 Mar 5.

Laboratory of Molecular oncology, Military Institute of Medicine, Warsaw, Poland.

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http://dx.doi.org/10.5114/wo.2018.73874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885081PMC
March 2018

CCR5 Myeloid-Derived Suppressor Cells Are Enriched and Activated in Melanoma Lesions.

Cancer Res 2018 01 31;78(1):157-167. Epub 2017 Oct 31.

Skin Cancer Unit, German Cancer Research Center (DKFZ), University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0348DOI Listing
January 2018

T-Cell Therapy Enabling Adenoviruses Coding for IL2 and TNFα Induce Systemic Immunomodulation in Mice With Spontaneous Melanoma.

J Immunother 2016 Nov/Dec;39(9):343-354

*Cancer Gene Therapy Group, Department of Pathology, Faculty of Medicine, University of Helsinki §TILT Biotherapeutics Ltd ∥Department of Obstetrics and Gynecology ¶Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland †Skin Cancer Unit, German Cancer Research Center (DKFZ) ‡Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1097/CJI.0000000000000144DOI Listing
December 2017

CCR5 Directs the Mobilization of CD11bGr1Ly6C Polymorphonuclear Myeloid Cells from the Bone Marrow to the Blood to Support Tumor Development.

Cell Rep 2017 Nov;21(8):2212-2222

Department of Immunology, Technion- Israel Institute of Technology, P.O. Box 9697, Haifa 31096, Israel; Faculty of Medicine, Technion- Israel Institute of Technology, P.O. Box 9697, Haifa 31096, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.10.104DOI Listing
November 2017

CCR5 in recruitment and activation of myeloid-derived suppressor cells in melanoma.

Cancer Immunol Immunother 2017 Aug 5;66(8):1015-1023. Epub 2017 Apr 5.

Skin Cancer Unit (G300), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00262-017-1988-9DOI Listing
August 2017

Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response.

Stem Cell Reports 2017 05 6;8(5):1379-1391. Epub 2017 Apr 6.

Skin Cancer Unit (G300), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, 68167 Mannheim, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425615PMC
May 2017

Tadalafil has biologic activity in human melanoma. Results of a pilot trial with Tadalafil in patients with metastatic Melanoma (TaMe).

Oncoimmunology 2017 16;6(9):e1326440. Epub 2017 May 16.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1080/2162402X.2017.1326440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599085PMC
May 2017

Myeloid-derived suppressor cells and tumor escape from immune surveillance.

Semin Immunopathol 2017 04 27;39(3):295-305. Epub 2016 Oct 27.

Skin Cancer Unit, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00281-016-0597-6DOI Listing
April 2017

The Role of Myeloid-Derived Suppressor Cells (MDSC) in Cancer Progression.

Vaccines (Basel) 2016 Nov 3;4(4). Epub 2016 Nov 3.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.

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http://dx.doi.org/10.3390/vaccines4040036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192356PMC
November 2016

Inhibition of mouse breast adenocarcinoma growth by ablation with intratumoral alpha-irradiation combined with inhibitors of immunosuppression and CpG.

Cancer Immunol Immunother 2016 10 6;65(10):1149-58. Epub 2016 Aug 6.

Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, P.O.Box 39040, 6997801, Tel Aviv, Israel.

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http://dx.doi.org/10.1007/s00262-016-1878-6DOI Listing
October 2016

Ret mouse very large tumors (VLTs) display altered ratios of infiltrating memory to naive T cells: Roles in tumor expansion.

Pathophysiology 2016 Sep 27;23(3):211-20. Epub 2016 Jun 27.

Skin Cancer Unit, German Cancer Research Center and University Hospital Mannheim, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pathophys.2016.06.001DOI Listing
September 2016

Redefining cancer immunotherapy-optimization, personalization, and new predictive biomarkers: 4th Cancer Immunotherapy and Immunomonitoring (CITIM) meeting, April 27-30, 2015, Ljubljana, Slovenia.

Cancer Immunol Immunother 2016 07 25;65(7):875-83. Epub 2016 Jan 25.

Skin Cancer Unit, German Cancer Research Center (DKFZ), INF 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00262-016-1795-8DOI Listing
July 2016

TGF-β induces SOX2 expression in a time-dependent manner in human melanoma cells.

Pigment Cell Melanoma Res 2016 07;29(4):453-8

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1111/pcmr.12483DOI Listing
July 2016

Predictive immune markers in advanced melanoma patients treated with ipilimumab.

Oncoimmunology 2016 Jun 29;5(6):e1158901. Epub 2016 Apr 29.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg , Heidelberg, Germany.

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http://dx.doi.org/10.1080/2162402X.2016.1158901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938357PMC
June 2016

mRNA-based dendritic cell immunization improves survival in ret transgenic mouse melanoma model.

Oncoimmunology 2016 Jun 22;5(6):e1160183. Epub 2016 Apr 22.

Department of Immunology, Weizmann Institute of Science , Rehovot, Israel.

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http://dx.doi.org/10.1080/2162402X.2016.1160183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938378PMC
June 2016

Directed Dedifferentiation Using Partial Reprogramming Induces Invasive Phenotype in Melanoma Cells.

Stem Cells 2016 Apr 19;34(4):832-46. Epub 2016 Jan 19.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/stem.2284DOI Listing
April 2016

Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab.

Clin Cancer Res 2015 Dec 19;21(24):5453-9. Epub 2015 Aug 19.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0676DOI Listing
December 2015

Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment.

Oncoimmunology 2015 Jun 19;4(6):e1008371. Epub 2015 Mar 19.

Institute of Neurology (Edinger Institute); Frankfurt University Medical School; German Cancer Consortium (DKTK); German Cancer Research Center (DKFZ) ; Frankfurt, Heidelberg, Germany.

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http://dx.doi.org/10.1080/2162402X.2015.1008371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485784PMC
June 2015

Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients.

Int J Cancer 2015 May 12;136(10):2352-60. Epub 2014 Nov 12.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany; Department of Obstetrics and Gynecology, Center for Reproductive Medicine, The First Hospital Affiliated to Anhui Medical University, Hefei, China.

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http://dx.doi.org/10.1002/ijc.29297DOI Listing
May 2015

Tumor ablation by intratumoral Ra-224-loaded wires induces anti-tumor immunity against experimental metastatic tumors.

Cancer Immunol Immunother 2015 Feb 18;64(2):191-9. Epub 2014 Oct 18.

Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, P.O. Box 39040, Tel Aviv, Israel.

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http://dx.doi.org/10.1007/s00262-014-1626-8DOI Listing
February 2015

Leukocyte count restoration under dabrafenib treatment in a melanoma patient with vemurafenib-induced leukopenia: case report.

Medicine (Baltimore) 2014 Dec;93(28):e161

From the Skin Cancer Unit (EO, VU, CG, JU), German Cancer Research Center (DKFZ), Heidelberg; and Department of Dermatology, Venereology and Allergology (EO, BZ, VU, CG, JU), University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1097/MD.0000000000000161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603073PMC
December 2014

CTLA-4 and PD-L1 checkpoint blockade enhances oncolytic measles virus therapy.

Mol Ther 2014 Nov 26;22(11):1949-59. Epub 2014 Aug 26.

1] Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany [2] Department of Medical Oncology, National Center for Tumor Diseases and Heidelberg University Hospital, Heidelberg, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S15250016163024
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http://dx.doi.org/10.1038/mt.2014.160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429737PMC
November 2014

Myeloid-derived suppressor cells in malignant melanoma.

J Dtsch Dermatol Ges 2014 Nov 28;12(11):1021-7. Epub 2014 Sep 28.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1111/ddg.12411DOI Listing
November 2014

Extracellular adenosine metabolism in immune cells in melanoma.

Cancer Immunol Immunother 2014 Oct 23;63(10):1073-80. Epub 2014 Apr 23.

Skin Cancer Unit (G300), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany,

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http://link.springer.com/content/pdf/10.1007%2Fs00262-014-15
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http://link.springer.com/10.1007/s00262-014-1553-8
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http://dx.doi.org/10.1007/s00262-014-1553-8DOI Listing
October 2014

Novel insights into exosome-induced, tumor-associated inflammation and immunomodulation.

Semin Cancer Biol 2014 Oct 24;28:51-7. Epub 2014 Apr 24.

Skin Cancer Unit, German Cancer Research Center DKFZ, Heidelberg, Germany; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.semcancer.2014.04.008DOI Listing
October 2014

Two immune faces of pancreatic adenocarcinoma: possible implication for immunotherapy.

Cancer Immunol Immunother 2014 Jan 16;63(1):59-65. Epub 2013 Oct 16.

Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 156, 69120, Heidelberg, Germany,

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http://link.springer.com/content/pdf/10.1007/s00262-013-1485
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http://link.springer.com/10.1007/s00262-013-1485-8
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http://dx.doi.org/10.1007/s00262-013-1485-8DOI Listing
January 2014

Gender-specific immunological effects of the phosphodiesterase 5 inhibitor sildenafil in healthy mice.

Mol Immunol 2013 Dec 2;56(4):649-59. Epub 2013 Aug 2.

Department of General Surgery, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.molimm.2013.06.021DOI Listing
December 2013

Autochthonous mouse melanoma and mammary tumors do not express the pluripotency genes Oct4 and Nanog.

PLoS One 2013 28;8(2):e57465. Epub 2013 Feb 28.

Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057465PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585372PMC
September 2013

Overcoming immunosuppression as a new immunotherapeutic approach against pancreatic cancer.

Oncoimmunology 2013 Sep 23;2(9):e25736. Epub 2013 Jul 23.

Department of General Surgery; University of Heidelberg; Heidelberg, Germany.

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http://dx.doi.org/10.4161/onci.25736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850017PMC
September 2013

Tumor microenvironment and myeloid-derived suppressor cells.

Cancer Microenviron 2013 Aug 16;6(2):169-77. Epub 2012 Dec 16.

Skin Cancer Unit, German Cancer Research Center, 69120, Heidelberg, Germany,

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http://dx.doi.org/10.1007/s12307-012-0126-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717060PMC
August 2013

Low-dose gemcitabine depletes regulatory T cells and improves survival in the orthotopic Panc02 model of pancreatic cancer.

Int J Cancer 2013 Jul 10;133(1):98-107. Epub 2013 Jan 10.

Department of General Surgery, University of Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.27990DOI Listing
July 2013

Ret transgenic mouse model of spontaneous skin melanoma: focus on regulatory T cells.

Pigment Cell Melanoma Res 2013 Jul 25;26(4):457-63. Epub 2013 Apr 25.

Skin Cancer Unit, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1111/pcmr.12104DOI Listing
July 2013

Cyclophosphamide promotes chronic inflammation-dependent immunosuppression and prevents antitumor response in melanoma.

J Invest Dermatol 2013 Jun 6;133(6):1610-9. Epub 2012 Dec 6.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Heidelberg, Germany.

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http://dx.doi.org/10.1038/jid.2012.444DOI Listing
June 2013

Tumor-initiating properties of breast cancer and melanoma cells in vivo are not invariably reflected by spheroid formation in vitro, but can be increased by long-term culturing as adherent monolayers.

Int J Cancer 2013 Feb 7;132(3):E94-105. Epub 2012 Sep 7.

Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, University Heidelberg, 68167 Mannheim, Germany.

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http://doi.wiley.com/10.1002/ijc.27785
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http://dx.doi.org/10.1002/ijc.27785DOI Listing
February 2013

Myeloid-derived suppressor cells interact with tumors in terms of myelopoiesis, tumorigenesis and immunosuppression: thick as thieves.

J Cancer 2013 30;4(1):3-11. Epub 2012 Nov 30.

Skin Cancer Unit, German Cancer Research Center, Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.7150/jca.5047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564242PMC
February 2013

Application of paclitaxel in low non-cytotoxic doses supports vaccination with melanoma antigens in normal mice.

J Immunotoxicol 2012 Jul-Sep;9(3):275-81. Epub 2012 Mar 27.

Skin Cancer Unit, German Cancer Research Center and University Hospital Mannheim, Heidelberg, Germany.

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http://www.tandfonline.com/doi/full/10.3109/1547691X.2012.65
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http://dx.doi.org/10.3109/1547691X.2012.655343DOI Listing
December 2012

Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth.

J Immunol 2012 Dec 14;189(12):5602-11. Epub 2012 Nov 14.

Innate Immunity, Research Program Tumor Immunology, German Cancer Research Center, Heidelberg D-69120, Germany.

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http://dx.doi.org/10.4049/jimmunol.1201018DOI Listing
December 2012

Characterization and longitudinal monitoring of melanoma growth in ret-transgenic mice using a single-sequence MRI protocol.

Exp Dermatol 2012 Nov;21(11):837-41

Department of Neuroradiology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1111/exd.12013DOI Listing
November 2012

Changing the tumor microenvironment: new strategies for immunotherapy.

Cancer Res 2012 Oct 23;72(20):5159-64. Epub 2012 Jul 23.

Division of Hepatology and Gene Therapy, Center for Applied Medical Research, University of Navarra Clinic, University of Navarra, Pamplona, Navarra, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1952DOI Listing
October 2012

Melanoma-induced immunosuppression and its neutralization.

Semin Cancer Biol 2012 Aug 13;22(4):319-26. Epub 2012 Feb 13.

Skin Cancer Unit, German Cancer Research Center and University Hospital Mannheim, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.semcancer.2012.02.003DOI Listing
August 2012

Immunosuppression in the tumor microenvironment: where are we standing?

Authors:
Viktor Umansky

Semin Cancer Biol 2012 Aug 15;22(4):273-4. Epub 2012 May 15.

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http://dx.doi.org/10.1016/j.semcancer.2012.05.001DOI Listing
August 2012

New strategies for melanoma immunotherapy: How to overcome immunosuppression in the tumor microenvironment.

Authors:
Viktor Umansky

Oncoimmunology 2012 Aug;1(5):765-767

Skin Cancer Unit; German Cancer Research Center; and, University Hospital Mannheim; Heidelberg, Germany.

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http://dx.doi.org/10.4161/onci.19713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429588PMC
August 2012

Regulatory T cells stimulate B7-H1 expression in myeloid-derived suppressor cells in ret melanomas.

J Invest Dermatol 2012 Apr 22;132(4):1239-46. Epub 2011 Dec 22.

Department of Dermatology, Ruprecht-Karls University of Heidelberg, Heidelberg, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S0022202X1535705
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http://dx.doi.org/10.1038/jid.2011.416DOI Listing
April 2012

T-Cell Mediated Immune Responses Induced in ret Transgenic Mouse Model of Malignant Melanoma.

Cancers (Basel) 2012 Apr 26;4(2):490-503. Epub 2012 Apr 26.

Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim , Heidelberg 69120, Germany.

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April 2012

From cell regulation to patient survival: 2nd Cancer Immunotherapy and Immunomonitoring (CITIM) meeting, Budapest, 2-5 May 2011.

Cancer Immunol Immunother 2012 Feb 28;61(2):295-301. Epub 2011 Sep 28.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

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February 2012

Overcoming immunosuppression in the melanoma microenvironment induced by chronic inflammation.

Cancer Immunol Immunother 2012 Feb 27;61(2):275-282. Epub 2011 Nov 27.

Skin Cancer Unit (G300), German Cancer Research Center and University Hospital Mannheim, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00262-011-1164-6DOI Listing
February 2012

Conference Scene: Immunotherapy reaches new milestones in cancer eradication.

Immunotherapy 2011 Oct;3(10):1131-7

Center of Surgical & Molecular Tumor pathology, Department of Molecular Immunology & Toxicology, National Institute of Oncology, 1122 Rath Gy Street 7-9, Budapest, Hungary.

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October 2011

Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells.

Mol Immunol 2010 Jan 24;47(4):678-84. Epub 2009 Nov 24.

Skin Cancer Unit, German Cancer Research Center and University Hospital Mannheim, 69120 Heidelberg, Germany.

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January 2010

Effect of artesunate on immune cells in ret-transgenic mouse melanoma model.

Anticancer Drugs 2009 Nov;20(10):910-7

German Cancer Research Center, Skin Cancer Unit (G300), Im Neuenheimer Feld, Heidelberg, Germany.

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November 2009

Skin melanoma development in ret transgenic mice despite the depletion of CD25+Foxp3+ regulatory T cells in lymphoid organs.

J Immunol 2009 Nov 19;183(10):6330-7. Epub 2009 Oct 19.

German Cancer Research Center, University Hospital Mannheim, Heidelberg, Germany.

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November 2009

New perspectives in cancer immunotherapy and immunomonitoring.

Future Oncol 2009 Sep;5(7):941-4

Skin Cancer Unit (G300), German Cancer Research Center, 69120 Heidelberg, Germany. v.umansky

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September 2009