Vikram Khurana

Vikram Khurana

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Vikram Khurana

Vikram Khurana

Publications by authors named "Vikram Khurana"

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Small fiber neuropathy and phosphorylated alpha-synuclein in the skin of E46K-SNCA mutation carriers.

Parkinsonism Relat Disord 2019 Aug 5;65:139-145. Epub 2019 Jun 5.

Neurodegenerative Diseases Group, Biocruces Bizkaia Health Research Institute, Cruces-Barakaldo, Bizkaia, Spain; Neurology Department, Cruces University Hospital, Cruces-Barakaldo, Bizkaia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2019.05.038DOI Listing
August 2019

In Situ Peroxidase Labeling and Mass Spectrometry of Alpha-Synuclein in Rat Cortical Neurons.

Methods Mol Biol 2019 ;1948:235-246

Ann Romney Center for Neurologic Disease, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://link.springer.com/10.1007/978-1-4939-9124-2_18
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http://dx.doi.org/10.1007/978-1-4939-9124-2_18DOI Listing
July 2019

Proteome-Scale Mapping of Perturbed Proteostasis in Living Cells.

Cold Spring Harb Perspect Biol 2019 Mar 25. Epub 2019 Mar 25.

Ann Romney Center for Neurologic Disease, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1101/cshperspect.a034124DOI Listing
March 2019

Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting.

Neurology 2018 01 13;90(2):74-82. Epub 2017 Dec 13.

From Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ; Department of Neurology (F.K., G.K.W., W.P., K.S., N.S.), Medical University Innsbruck, Austria; National Institute of Neurological Disorders and Stroke (W.R.G., W.J.K.), NIH, Bethesda, MD; Department of Neurology (P.A.L.), Mayo Clinic, Rochester, MN; Brain and Mind Centre (G.H.), Sydney Medical School, the University of Sydney; UNSW Medicine & Neuroscience Research Australia (G.H.), Sydney; Queen Square Brain Bank (J.H.), UCL Institute of Neurology (N.P.Q.), London, UK; UPS, INSERM, and CHU de Toulouse (O.R.), University de Toulouse; Centre de Référence Maladie Rare contre l'AMS (O.R.), Centre d'Investigation Clinique CIC1436, Départments de Pharmacologie Clinique et de Neurosciences, NeuroToul/COEN Center of Excellence in Neurodegeneration, Toulouse, France; Department of Pathology & Laboratory Medicine (L.M.S.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Center for Neurosciences (D.E.), The Feinstein Institute for Medical Research, Manhasset, NY; The Multiple System Atrophy (MSA) Coalition, Inc. (P. B., J.B., P.F., L.K., C.L., C.R., S.S.), Charlotte, NC; Cleveland Clinic Lou Ruvo Center for Brain Health (J.L.C.), Las Vegas, NV; Medical Affairs (V.A.), Teva Pharmaceuticals, Frazer, PA; Department of Neurology (G.B.), David Geffen School of Medicine, Brain Research Institute, and Molecular Biology Institute, University of California at Los Angeles; Institute of Neurology (D.J.B.), University of Newcastle upon Tyne, UK; Van Andel Research Institute (P. Brundin), Center for Neurodegenerative Science, Grand Rapids, MI; Center for Neurological Restoration (H.F.), Cleveland Clinic, OH; Defeat MSA (P.F.); MSA Shoe Charity (P.F., C.R.), Saint Clair Shores, MI; Department of Neurology (R.F.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Neurodegenerative Diseases (T.G.), Hertie Institute of Clinical Brain Research, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (T.G.), Tübingen, Germany; Lundbeck LLC (A.H.), Deerfield, IL; German Center for Neurodegenerative Diseases (DZNE) (G.U.H.), Munich; Department of Neurology (G.U.H.), Technical University of Munich, Germany; Neurogenomics Division (M.J.H.), The Translational Genomics Research Institute, Phoenix, AZ; Dandrite & Department of Biomedicine (P.H.J.), Aarhus University, Denmark; Quanterix (A.J.), Lexington, MA; Department of Neurology (U.J.K.), Columbia University Medical Center; Department of Neurology (H.K.), New York University School of Medicine, New York; Whitehead Institute for Biomedical Research (V.K.), Cambridge; Ann Romney Center for Neurologic Disease (V.K.), Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston; Harvard Stem Cell Institute (V.K.), Cambridge, MA; Department of Neurology (T.K.), University of Bonn; German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany; Brain and Mind Centre (W.S.K.), Sydney Medical School, University of Sydney, Australia; Department of Neurology (P.L.), Henry Ford Hospital; Department of Neurology (P.L.), Wayne State University School of Medicine, Detroit, MI; Division of Neurosciences (E.M.), National Institute on Aging/NIH, Bethesda, MD; Centre de Référence Maladie Rare AMS (W.M.), Hôpital Pellegrin, CHU de Bordeaux; Université de Bordeaux (W.M.), Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux; Paris Saclay Institute of Neuroscience (R.M.), CNRS, Gif-sur-Yvette, France; Genentech Inc. (S.O.), South San Francisco; Cedars-Sinai Medical Center (S.P.), Los Angeles, CA; Department of Neurology (D.R.), Vanderbilt University Medical Center, Nashville, TN; MSA NJ (C.R.), Howell, NJ; Prothena Biosciences (D.S.), South San Francisco, CA; Division of Neurology (M.S.), Department of Medicine, The Ottawa Hospital, Canada; Department of Neurology (J.D.S.), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Cure MSA Foundation (L.S.), Fremont, CA; Avid Radiopharmaceuticals (A.S.), Philadelphia, PA; Department of Neurological Sciences (G.T.S.), Rush University Medical Center, Chicago, IL; Department of Neurology (S.T.), Graduate School of Medicine, Tokyo University, Tokyo, Japan; and University of Washington (J.Z.), Seattle. W.R.G. is currently affiliated with Janssen Research and Development, Titusville, NJ.

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http://dx.doi.org/10.1212/WNL.0000000000004798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772155PMC
January 2018

Specification of Physiologic and Disease States by Distinct Proteins and Protein Conformations.

Cell 2017 Nov;171(5):1001-1014

Ann Romney Center for Neurologic Disease, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.10.047DOI Listing
November 2017

In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons.

Cell Syst 2017 02 25;4(2):242-250.e4. Epub 2017 Jan 25.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.cels.2017.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578869PMC
February 2017

From Yeast to Patients: The Audacity and Vision of Susan Lindquist.

Cell Syst 2017 02;4(2):147-148

Yumanity Therapeutics, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.cels.2017.02.007DOI Listing
February 2017

Toward stem cell-based phenotypic screens for neurodegenerative diseases.

Nat Rev Neurol 2015 Jun 19;11(6):339-50. Epub 2015 May 19.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1038/nrneurol.2015.79DOI Listing
June 2015

From yeast to patient neurons and back again: powerful new discovery platform.

Mov Disord 2014 Sep 14;29(10):1231-40. Epub 2014 Aug 14.

Whitehead Institute for Biomedical Research (WIBR), Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1002/mds.25989DOI Listing
September 2014

Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study.

Neurology 2013 Oct 25;81(17):1531-7. Epub 2013 Sep 25.

From the Neurogenomics Laboratory (H.D., K.D., K.C.L., A.N.H., K.D., A.T.-L., C.R.S.), Harvard Medical School and Brigham & Women's Hospital, Cambridge; Biomarkers Program (K.D., K.C.L., A.N.H., K.D., A.T.-L., M.T.H., U.S.S., B.M., N.M., V.K., S.N.G., D.J.S., M.A.S., M.G.S., B.T.H., J.H.G., C.R.S.), Harvard NeuroDiscovery Center, Boston; Department of Neurology (J.J.L., U.S.S., A.-M.W., A.W.F., A.Y.H., N.M., V.K., S.N.G., M.A.S., B.T.H., J.H.G., C.R.S.), Massachusetts General Hospital, Boston; Department of Neurology (M.T.H., A.Y.H., D.J.S., L.R.S., C.R.S.), Brigham and Women's Hospital, Boston, MA; Paracelsus-Elena-Klinik (B.M.), Kassel, Germany; and Division of Neurology, the Ottawa Hospital, University of Ottawa (M.G.S.), Canada.

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http://dx.doi.org/10.1212/WNL.0b013e3182a95818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888173PMC
October 2013

A neuroprotective role for the DNA damage checkpoint in tauopathy.

Aging Cell 2012 Apr 1;11(2):360-2. Epub 2012 Feb 1.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1111/j.1474-9726.2011.00778.xDOI Listing
April 2012

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.

PLoS Genet 2010 Jul 15;6(7):e1001026. Epub 2010 Jul 15.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1001026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904797PMC
July 2010

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

Nat Rev Neurosci 2010 06 28;11(6):436-49. Epub 2010 Apr 28.

Department of Neurology, Brigham and Women's and Massachusetts General Hospitals, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nrn2809DOI Listing
June 2010

Modeling Tauopathy in the fruit fly Drosophila melanogaster.

Authors:
Vikram Khurana

J Alzheimers Dis 2008 Dec;15(4):541-53

Department of Neurology, Massachusetts General and Brigham and Women's Hospitals, Boston, MA 02115, USA.

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http://dx.doi.org/10.3233/jad-2008-15403DOI Listing
December 2008

Connecting cell-cycle activation to neurodegeneration in Drosophila.

Biochim Biophys Acta 2007 Apr 18;1772(4):446-56. Epub 2006 Oct 18.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Harvard New Research Building Room 652, 77 Louis Pasteur Avenue, Boston, MA 02115, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09254439060021
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http://dx.doi.org/10.1016/j.bbadis.2006.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562667PMC
April 2007

Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.

Nat Cell Biol 2007 Feb 24;9(2):139-48. Epub 2006 Dec 24.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Harvard New Research Building Room 652, 77 Louis Pasteur Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/ncb1528DOI Listing
February 2007

TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.

Curr Biol 2006 Feb;16(3):230-41

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Harvard New Research Building Room 652, 77 Louis Pasteur Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.cub.2005.12.042DOI Listing
February 2006

Senseless makes sense for spinocerebellar ataxia-1.

Nat Neurosci 2005 Nov;8(11):1422-4

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http://dx.doi.org/10.1038/nn1105-1422DOI Listing
November 2005

Enhancing encoding of a motor memory in the primary motor cortex by cortical stimulation.

J Neurophysiol 2004 May 7;91(5):2110-6. Epub 2004 Jan 7.

Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA.

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http://dx.doi.org/10.1152/jn.01038.2003DOI Listing
May 2004