Publications by authors named "Vikneswari Rajasegaran"

30Publications

Bizarre giant cells in human angiosarcoma exhibit chemoresistance and contribute to poor survival outcomes.

Authors:
Grace Fangmin Tan Shane Goh Abner Herbert Lim Wei Liu Jing Yi Lee Vikneswari Rajasegaran Xin Xiu Sam Timothy Kwang Yong Tay Sathiyamoorthy Selvarajan Cedric Chuan-Young Ng Bin Tean Teh Jason Yongsheng Chan

Cancer Sci 2020 Nov 8. Epub 2020 Nov 8.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore City, Singapore.

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November 2020

Whole-genome sequencing identifies responders to Pembrolizumab in relapse/refractory natural-killer/T cell lymphoma.

Authors:
Jing Quan Lim Dachuan Huang Tiffany Tang Daryl Tan Yurike Laurensia Rou-Jun Peng Esther Kam Yin Wong Daryl Ming Zhe Cheah Burton Kuan Hui Chia Jabed Iqbal Nicholas Francis Grigoropoulos Maarja-Liisa Nairismägi Cedric Chuan Young Ng Vikneswari Rajasegaran Huangming Hong Seok Jin Kim Junhun Cho Eric Tse Benjamin Mow Qi-Chun Cai Li-Mei Poon Qing-Qing Cai Jing Tan Jason Yongsheng Chan Johnathan Xiande Lim Yeow Tee Goh Colin Phipps Olaf Rötzschke Chee Leong Cheng Jeslin Chian Hung Ha Lay Poh Khoo Yvonne Su Ming Loh Rex Au-Yeung Thomas Sau-Yan Chan Yok-Lam Kwong William Hwang Won Seog Kim Jin-Xin Bei Tongyu Lin Choon Kiat Ong Soon Thye Lim

Leukemia 2020 12 5;34(12):3413-3419. Epub 2020 Aug 5.

Director's office, National Cancer Centre Singapore, Singapore, Singapore.

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December 2020

Morphologic and genetic heterogeneity in breast fibroepithelial lesions-a comprehensive mapping study.

Authors:
Benjamin Yongcheng Tan Nur Diyana Md Nasir Huan Ying Chang Cedric Chuan Young Ng Peiyong Guan Sanjanaa Nagarajan Vikneswari Rajasegaran Jing Yi Lee Jing Quan Lim Aye Aye Thike Bin Tean Teh Puay Hoon Tan

Mod Pathol 2020 09 22;33(9):1732-1745. Epub 2020 Apr 22.

Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.

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September 2020

Lack of Targetable FGFR2 Fusions in Endemic Fluke-Associated Cholangiocarcinoma.

Authors:
Sarinya Kongpetch Apinya Jusakul Jing Quan Lim Cedric Chuan Young Ng Jason Yongsheng Chan Vikneswari Rajasegaran Tse Hui Lim Kiat Hon Lim Su Pin Choo Simona Dima Irinel Popescu Dan G Duda Veerapol Kukongviriyapan Narong Khuntikeo Chawalit Pairojkul Steven G Rozen Patrick Tan Bin Tean Teh

JCO Glob Oncol 2020 04;6:628-638

Laboratory of Cancer Epigenome, Division of Medical Science, National Cancer Centre Singapore, Singapore.

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April 2020

An Optimised Protocol Harnessing Laser Capture Microdissection for Transcriptomic Analysis on Matched Primary and Metastatic Colorectal Tumours.

Authors:
Chin-Ann J Ong Qiu Xuan Tan Hui Jun Lim Nicholas B Shannon Weng Khong Lim Josephine Hendrikson Wai Har Ng Joey W S Tan Kelvin K N Koh Seettha D Wasudevan Cedric C Y Ng Vikneswari Rajasegaran Tony Kiat Hon Lim Choon Kiat Ong Oi Lian Kon Bin Tean Teh Grace H C Tan Claramae Shulyn Chia Khee Chee Soo Melissa C C Teo

Sci Rep 2020 01 20;10(1):682. Epub 2020 Jan 20.

Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, Singapore, S169610, Singapore.

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January 2020

A novel genomic panel as an adjunctive diagnostic tool for the characterization and profiling of breast Fibroepithelial lesions.

Authors:
Yirong Sim Gwendolene Xin Pei Ng Cedric Chuan Young Ng Vikneswari Rajasegaran Suet Far Wong Wei Liu Peiyong Guan Sanjanaa Nagarajan Wai Yee Ng Aye Aye Thike Jeffrey Chun Tatt Lim Nur Diyana Binte Md Nasir Veronique Kiak Mien Tan Preetha Madhukumar Wei Sean Yong Chow Yin Wong Benita Kiat Tee Tan Kong Wee Ong Bin Tean Teh Puay Hoon Tan

BMC Med Genomics 2019 10 23;12(1):142. Epub 2019 Oct 23.

Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.

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October 2019

Genomic characterisation of breast fibroepithelial lesions in an international cohort.

Authors:
Nur Diyana Md Nasir Cedric Chuan Young Ng Vikneswari Rajasegaran Suet Far Wong Wei Liu Gwendolene Xin Pei Ng Jing Yi Lee Peiyong Guan Jing Quan Lim Aye Aye Thike Valerie Cui Yun Koh Benjamin Nathanael Loke Kenneth Tou En Chang Mihir Ananta Gudi Derrick Wen Quan Lian Preetha Madhukumar Benita Kiat Tee Tan Veronique Kiak Mien Tan Chow Yin Wong Wei Sean Yong Gay Hui Ho Kong Wee Ong Patrick Tan Bin Tean Teh Puay Hoon Tan

J Pathol 2019 12 8;249(4):447-460. Epub 2019 Oct 8.

Department of Anatomical Pathology, Singapore General Hospital, Singapore.

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December 2019

Genomic profile of breast sarcomas: a comparison with malignant phyllodes tumours.

Authors:
Sue Zann Lim Cedric Chuan Young Ng Vikneswari Rajasegaran Peiyong Guan Sathiyamoorthy Selvarajan Aye Aye Thike Nur Diyana Binte Md Nasir Valerie Cui Yun Koh Benita Kiat Tee Tan Kong Wee Ong Bin Tean Teh Puay Hoon Tan

Breast Cancer Res Treat 2019 Apr 3;174(2):365-373. Epub 2018 Dec 3.

Division of Pathology, Singapore General Hospital, Level 7, Diagnostics Tower, Academia, 20 College Road, Singapore, 169856, Singapore.

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April 2019

Molecular insights into paediatric breast fibroepithelial tumours.

Authors:
Timothy K Y Tay Peiyong Guan Benjamin N Loke Nur Diana M Nasir Vikneswari Rajasegaran Aye Aye Thike Derrick Lian Kenneth T E Chang Bin Tean Teh Cedric C Y Ng Puay-Hoon Tan

Histopathology 2018 Nov 22;73(5):809-818. Epub 2018 Aug 22.

Division of Pathology, Singapore General Hospital, Singapore.

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November 2018

The draft genome of tropical fruit durian (Durio zibethinus).

Authors:
Bin Tean Teh Kevin Lim Chern Han Yong Cedric Chuan Young Ng Sushma Ramesh Rao Vikneswari Rajasegaran Weng Khong Lim Choon Kiat Ong Ki Chan Vincent Kin Yuen Cheng Poh Sheng Soh Sanjay Swarup Steven G Rozen Niranjan Nagarajan Patrick Tan

Nat Genet 2017 Nov 9;49(11):1633-1641. Epub 2017 Oct 9.

Thorn Biosystems Pte Ltd, Singapore.

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November 2017

Clear cell sarcomas of the kidney are characterised by BCOR gene abnormalities, including exon 15 internal tandem duplications and BCOR-CCNB3 gene fusion.

Authors:
Meng K Wong Cedric C Y Ng Chik H Kuick Sze J Aw Vikneswari Rajasegaran Jing Q Lim Jain Sudhanshi Eva Loh Minzhi Yin Jing Ma Zhongde Zhang Prasad Iyer Amos H P Loh Derrick W Q Lian Shi Wang Shaun G H Goh Tse H Lim Alvin S T Lim Tony Ng Angela Goytain Alwin H L Loh Puay H Tan Bin T Teh Kenneth T E Chang

Histopathology 2018 Jan 30;72(2):320-329. Epub 2017 Oct 30.

VIVA-KKH Paediatric Brain and Solid Tumour Laboratory, KK Women's and Children's Hospital, Singapore.

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January 2018

Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.

Authors:
Apinya Jusakul Ioana Cutcutache Chern Han Yong Jing Quan Lim Mi Ni Huang Nisha Padmanabhan Vishwa Nellore Sarinya Kongpetch Alvin Wei Tian Ng Ley Moy Ng Su Pin Choo Swe Swe Myint Raynoo Thanan Sanjanaa Nagarajan Weng Khong Lim Cedric Chuan Young Ng Arnoud Boot Mo Liu Choon Kiat Ong Vikneswari Rajasegaran Stefanus Lie Alvin Soon Tiong Lim Tse Hui Lim Jing Tan Jia Liang Loh John R McPherson Narong Khuntikeo Vajaraphongsa Bhudhisawasdi Puangrat Yongvanit Sopit Wongkham Yasushi Totoki Hiromi Nakamura Yasuhito Arai Satoshi Yamasaki Pierce Kah-Hoe Chow Alexander Yaw Fui Chung London Lucien Peng Jin Ooi Kiat Hon Lim Simona Dima Dan G Duda Irinel Popescu Philippe Broet Sen-Yung Hsieh Ming-Chin Yu Aldo Scarpa Jiaming Lai Di-Xian Luo André Lopes Carvalho André Luiz Vettore Hyungjin Rhee Young Nyun Park Ludmil B Alexandrov Raluca Gordân Steven G Rozen Tatsuhiro Shibata Chawalit Pairojkul Bin Tean Teh Patrick Tan

Cancer Discov 2017 10 30;7(10):1116-1135. Epub 2017 Jun 30.

Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.

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October 2017

Genomic and proteomic characterization of ARID1A chromatin remodeller in ampullary tumors.

Authors:
Anca Nastase Jin Yao Teo Hong Lee Heng Cedric Chuan Young Ng Swe Swe Myint Vikneswari Rajasegaran Jia Liang Loh Ser Yee Lee London Lucien Ooi Alexander Yaw Fui Chung Pierce Kah Hoe Chow Peng Chung Cheow Wei Keat Wan Rafy Azhar Avery Khoo Sam Xin Xiu Syed Muhammad Fahmy Alkaff Ioana Cutcutache Jing Quan Lim Choon Kiat Ong Vlad Herlea Simona Dima Dan G Duda Bin Tean Teh Irinel Popescu Tony Kiat Hon Lim

Am J Cancer Res 2017 1;7(3):484-502. Epub 2017 Mar 1.

Department of Pathology, Singapore General Hospital Singapore, Singapore.

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March 2017

MED12 protein expression in breast fibroepithelial lesions: correlation with mutation status and oestrogen receptor expression.

Authors:
Wai Jin Tan Jason Yongsheng Chan Aye Aye Thike Jeffrey Chun Tatt Lim Nur Diyana Md Nasir Jane Sie Yong Tan Valerie Cui Yun Koh Weng Khong Lim Jing Tan Cedric Chuan Yong Ng Vikneswari Rajasegaran Sanjanaa Nagarajan Boon Huat Bay Bin Tean Teh Puay Hoon Tan

J Clin Pathol 2016 Oct 7;69(10):858-65. Epub 2016 Apr 7.

Department of Pathology, Singapore General Hospital, Singapore Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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October 2016

Genomic landscapes of breast fibroepithelial tumors.

Authors:
Jing Tan Choon Kiat Ong Weng Khong Lim Cedric Chuan Young Ng Aye Aye Thike Ley Moy Ng Vikneswari Rajasegaran Swe Swe Myint Sanjanaa Nagarajan Saranya Thangaraju Sucharita Dey Nur Diyana Md Nasir Giovani Claresta Wijaya Jing Quan Lim Dachuan Huang Zhimei Li Bernice Huimin Wong Jason Yong Sheng Chan John R McPherson Ioana Cutcutache Gregory Poore Su Ting Tay Wai Jin Tan Thomas Choudary Putti Buhari Shaik Ahmad Philip Iau Ching Wan Chan Anthony P H Tang Wei Sean Yong Preetha Madhukumar Gay Hui Ho Veronique Kiak Mien Tan Chow Yin Wong Mikael Hartman Kong Wee Ong Benita K T Tan Steven G Rozen Patrick Tan Puay Hoon Tan Bin Tean Teh

Nat Genet 2015 Nov 5;47(11):1341-5. Epub 2015 Oct 5.

Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.

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November 2015

Whole-exome sequencing of breast cancer, malignant peripheral nerve sheath tumor and neurofibroma from a patient with neurofibromatosis type 1.

Authors:
John Richard McPherson Choon-Kiat Ong Cedric Chuan-Young Ng Vikneswari Rajasegaran Hong-Lee Heng Willie Shun-Shing Yu Benita Kiat-Tee Tan Preetha Madhukumar Melissa Ching-Ching Teo Joanne Ngeow Aye-Aye Thike Steven George Rozen Puay-Hoon Tan Ann Siew-Gek Lee Bin-Tean Teh Yoon-Sim Yap

Cancer Med 2015 Dec 3;4(12):1871-8. Epub 2015 Oct 3.

Division of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, Singapore, 169610, Singapore.

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December 2015

SETD2 histone modifier loss in aggressive GI stromal tumours.

Authors:
Kie Kyon Huang John R McPherson Su Ting Tay Kakoli Das Iain Beehuat Tan Cedric Chuan Young Ng Na-Yu Chia Shen Li Zhang Swe Swe Myint Longyu Hu Vikneswari Rajasegaran Dachuan Huang Jia Liang Loh Anna Gan Alisa Noor Hidayah Sairi Xin Xiu Sam Lourdes Trinidad Dominguez Minghui Lee Khee Chee Soo London Lucien Peng Jin Ooi Hock Soo Ong Alexander Chung Pierce Kah-Hoe Chow Wai Keong Wong Sathiyamoorthy Selvarajan Choon Kiat Ong Kiat Hon Lim Tannistha Nandi Steve Rozen Bin Tean Teh Richard Quek Patrick Tan

Gut 2016 12 3;65(12):1960-1972. Epub 2015 Sep 3.

Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, Singapore, Singapore.

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December 2016

MED12 is frequently mutated in breast phyllodes tumours: a study of 112 cases.

Authors:
Cedric Chuan Young Ng Jing Tan Choon Kiat Ong Weng Khong Lim Vikneswari Rajasegaran Nur Diyana Md Nasir Jeffrey Chun Tatt Lim Aye Aye Thike Syed Ahmed Salahuddin Jabed Iqbal Inny Busmanis Angela Phek Yoon Chong Bin Tean Teh Puay Hoon Tan

J Clin Pathol 2015 Sep 27;68(9):685-91. Epub 2015 May 27.

Department of Pathology, Singapore General Hospital, Singapore.

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September 2015

Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma.

Authors:
Weng Khong Lim Choon Kiat Ong Jing Tan Aye Aye Thike Cedric Chuan Young Ng Vikneswari Rajasegaran Swe Swe Myint Sanjanaa Nagarajan Nur Diyana Md Nasir John R McPherson Ioana Cutcutache Gregory Poore Su Ting Tay Wei Siong Ooi Veronique Kiak Mien Tan Mikael Hartman Kong Wee Ong Benita K T Tan Steven G Rozen Puay Hoon Tan Patrick Tan Bin Tean Teh

Nat Genet 2014 Aug 20;46(8):877-80. Epub 2014 Jul 20.

1] Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore. [2] Division of Cancer and Stem Cell Biology, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore. [3] Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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August 2014

Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers.

Authors:
Waraporn Chan-On Maarja-Liisa Nairismägi Choon Kiat Ong Weng Khong Lim Simona Dima Chawalit Pairojkul Kiat Hon Lim John R McPherson Ioana Cutcutache Hong Lee Heng London Ooi Alexander Chung Pierce Chow Peng Chung Cheow Ser Yee Lee Su Pin Choo Iain Bee Huat Tan Dan Duda Anca Nastase Swe Swe Myint Bernice Huimin Wong Anna Gan Vikneswari Rajasegaran Cedric Chuan Young Ng Sanjanaa Nagarajan Apinya Jusakul Shenli Zhang Priya Vohra Willie Yu DaChuan Huang Paiboon Sithithaworn Puangrat Yongvanit Sopit Wongkham Narong Khuntikeo Vajaraphongsa Bhudhisawasdi Irinel Popescu Steven G Rozen Patrick Tan Bin Tean Teh

Nat Genet 2013 Dec 3;45(12):1474-8. Epub 2013 Nov 3.

1] Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore. [2] Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore. [3] Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. [4].

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December 2013