Viji Shridhar

Viji Shridhar

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Viji Shridhar

Publications by authors named "Viji Shridhar"

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Coiled-Coil and C2 Domain-Containing Protein 1A (CC2D1A) Promotes Chemotherapy Resistance in Ovarian Cancer.

Front Oncol 2019 1;9:986. Epub 2019 Oct 1.

Division of Experimental Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN, United States.

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http://dx.doi.org/10.3389/fonc.2019.00986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779793PMC
October 2019

Genes associated with bowel metastases in ovarian cancer.

Gynecol Oncol 2019 09 14;154(3):495-504. Epub 2019 Jun 14.

Department of Obstetrics and Gynecology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2019.06.010DOI Listing
September 2019

Repurposing quinacrine for treatment-refractory cancer.

Semin Cancer Biol 2019 Sep 25. Epub 2019 Sep 25.

Division of Experimental Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2019.09.021DOI Listing
September 2019

Quinacrine in endometrial cancer: Repurposing an old antimalarial drug.

Gynecol Oncol 2017 07 22;146(1):187-195. Epub 2017 May 22.

Department of Experimental Pathology, Mayo Clinic, Rochester, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2017.04.022DOI Listing
July 2017

Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer.

Oncotarget 2015 Sep;6(27):23548-60

Department of Obstetrics and Gynecology, Gordon Center for Integrative Science, University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.18632/oncotarget.4556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695136PMC
September 2015

Preclinical therapeutic potential of a nitrosylating agent in the treatment of ovarian cancer.

PLoS One 2014 2;9(6):e97897. Epub 2014 Jun 2.

Department of Experimental Pathology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097897PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041717PMC
January 2015

Loss of HSulf-1 expression enhances tumorigenicity by inhibiting Bim expression in ovarian cancer.

Int J Cancer 2014 Oct 28;135(8):1783-9. Epub 2014 Mar 28.

Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN.

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http://doi.wiley.com/10.1002/ijc.28818
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http://dx.doi.org/10.1002/ijc.28818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346160PMC
October 2014

Non-metastatic 2 (NME2)-mediated suppression of lung cancer metastasis involves transcriptional regulation of key cell adhesion factor vinculin.

Nucleic Acids Res 2014 Oct 23;42(18):11589-600. Epub 2014 Sep 23.

Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110 007, India G.N.R. Knowledge Centre for Genome Informatics, Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110 007, India Academy of Scientific and Innovative Research (AcSIR), New Delhi, India

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http://dx.doi.org/10.1093/nar/gku860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191424PMC
October 2014

Tumor hypomethylation at 6p21.3 associates with longer time to recurrence of high-grade serous epithelial ovarian cancer.

Cancer Res 2014 Jun 11;74(11):3084-91. Epub 2014 Apr 11.

Authors' Affiliations: Departments of Health Sciences Research, Medical Oncology, Obstetrics and Gynecology, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles; Department of Research, Illumina, San Diego, California; Departments of Cancer Biology and Biostatistics, University of Kansas Medical Center, Kansas City, Kansas; and Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, Florida

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054691PMC
June 2014

High levels of Wilms' tumor 1 (WT1) expression were associated with aggressive clinical features in ovarian cancer.

Anticancer Res 2014 May;34(5):2331-40

Department of Obstetrics and Gynecology, Yamagata University, School of Medicine, 2-2-2 Iidanishi, Yamagata 990-9585, Japan.

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May 2014

Assessment of resistance to anoikis in ovarian cancer.

Methods Mol Biol 2013 ;1049:347-54

Mayo Clinic College of Medicine, Rochester, MN, USA.

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http://dx.doi.org/10.1007/978-1-62703-547-7_26DOI Listing
March 2014

APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.

Cancer Res 2013 Dec 23;73(24):7222-31. Epub 2013 Oct 23.

Authors' Affiliations: Biochemistry, Molecular Biology and Biophysics Department; Masonic Cancer Center, University of Minnesota, Minneapolis; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; Medical Genome Facility and Department of Laboratory Medicine and Pathology; Department of Laboratory Medicine and Pathology; Division of Medical Oncology, Department of Oncology; Division of Epidemiology, Department of Health Sciences Research; Division of Oncology Research, Department of Oncology; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic; Women's Cancer Program, Mayo Clinic Cancer Center, Rochester, Minnesota; Department of Cancer Biology, University of Kansas, Kansas City, Kansas; Department of Obstetrics & Gynecology, University of Washington School of Medicine, Seattle, Washington; and Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Cambridge, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867573PMC
December 2013

Network-based survival analysis reveals subnetwork signatures for predicting outcomes of ovarian cancer treatment.

PLoS Comput Biol 2013 21;9(3):e1002975. Epub 2013 Mar 21.

Department of Computer Science and Engineering, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1002975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605061PMC
November 2013

Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31.

Authors:
Jennifer Permuth-Wey Kate Lawrenson Howard C Shen Aneliya Velkova Jonathan P Tyrer Zhihua Chen Hui-Yi Lin Y Ann Chen Ya-Yu Tsai Xiaotao Qu Susan J Ramus Rod Karevan Janet Lee Nathan Lee Melissa C Larson Katja K Aben Hoda Anton-Culver Natalia Antonenkova Antonis C Antoniou Sebastian M Armasu François Bacot Laura Baglietto Elisa V Bandera Jill Barnholtz-Sloan Matthias W Beckmann Michael J Birrer Greg Bloom Natalia Bogdanova Louise A Brinton Angela Brooks-Wilson Robert Brown Ralf Butzow Qiuyin Cai Ian Campbell Jenny Chang-Claude Stephen Chanock Georgia Chenevix-Trench Jin Q Cheng Mine S Cicek Gerhard A Coetzee Linda S Cook Fergus J Couch Daniel W Cramer Julie M Cunningham Agnieszka Dansonka-Mieszkowska Evelyn Despierre Jennifer A Doherty Thilo Dörk Andreas du Bois Matthias Dürst Douglas F Easton Diana Eccles Robert Edwards Arif B Ekici Peter A Fasching David A Fenstermacher James M Flanagan Montserrat Garcia-Closas Aleksandra Gentry-Maharaj Graham G Giles Rosalind M Glasspool Jesus Gonzalez-Bosquet Marc T Goodman Martin Gore Bohdan Górski Jacek Gronwald Per Hall Mari K Halle Philipp Harter Florian Heitz Peter Hillemanns Maureen Hoatlin Claus K Høgdall Estrid Høgdall Satoyo Hosono Anna Jakubowska Allan Jensen Heather Jim Kimberly R Kalli Beth Y Karlan Stanley B Kaye Linda E Kelemen Lambertus A Kiemeney Fumitaka Kikkawa Gottfried E Konecny Camilla Krakstad Susanne Krüger Kjaer Jolanta Kupryjanczyk Diether Lambrechts Sandrina Lambrechts Johnathan M Lancaster Nhu D Le Arto Leminen Douglas A Levine Dong Liang Boon Kiong Lim Jie Lin Jolanta Lissowska Karen H Lu Jan Lubiński Galina Lurie Leon F A G Massuger Keitaro Matsuo Valerie McGuire John R McLaughlin Usha Menon Francesmary Modugno Kirsten B Moysich Toru Nakanishi Steven A Narod Lotte Nedergaard Roberta B Ness Heli Nevanlinna Stefan Nickels Houtan Noushmehr Kunle Odunsi Sara H Olson Irene Orlow James Paul Celeste L Pearce Tanja Pejovic Liisa M Pelttari Malcolm C Pike Elizabeth M Poole Paola Raska Stefan P Renner Harvey A Risch Lorna Rodriguez-Rodriguez Mary Anne Rossing Anja Rudolph Ingo B Runnebaum Iwona K Rzepecka Helga B Salvesen Ira Schwaab Gianluca Severi Viji Shridhar Xiao-Ou Shu Yurii B Shvetsov Weiva Sieh Honglin Song Melissa C Southey Beata Spiewankiewicz Daniel Stram Rebecca Sutphen Soo-Hwang Teo Kathryn L Terry Daniel C Tessier Pamela J Thompson Shelley S Tworoger Anne M van Altena Ignace Vergote Robert A Vierkant Daniel Vincent Allison F Vitonis Shan Wang-Gohrke Rachel Palmieri Weber Nicolas Wentzensen Alice S Whittemore Elisabeth Wik Lynne R Wilkens Boris Winterhoff Yin Ling Woo Anna H Wu Yong-Bing Xiang Hannah P Yang Wei Zheng Argyrios Ziogas Famida Zulkifli Catherine M Phelan Edwin Iversen Joellen M Schildkraut Andrew Berchuck Brooke L Fridley Ellen L Goode Paul D P Pharoah Alvaro N A Monteiro Thomas A Sellers Simon A Gayther

Nat Commun 2013 ;4:1627

Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, Florida, USA.

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http://dx.doi.org/10.1038/ncomms2613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709460PMC
October 2013

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer.

Authors:
Hui Shen Brooke L Fridley Honglin Song Kate Lawrenson Julie M Cunningham Susan J Ramus Mine S Cicek Jonathan Tyrer Douglas Stram Melissa C Larson Martin Köbel Argyrios Ziogas Wei Zheng Hannah P Yang Anna H Wu Eva L Wozniak Yin Ling Woo Boris Winterhoff Elisabeth Wik Alice S Whittemore Nicolas Wentzensen Rachel Palmieri Weber Allison F Vitonis Daniel Vincent Robert A Vierkant Ignace Vergote David Van Den Berg Anne M Van Altena Shelley S Tworoger Pamela J Thompson Daniel C Tessier Kathryn L Terry Soo-Hwang Teo Claire Templeman Daniel O Stram Melissa C Southey Weiva Sieh Nadeem Siddiqui Yurii B Shvetsov Xiao-Ou Shu Viji Shridhar Shan Wang-Gohrke Gianluca Severi Ira Schwaab Helga B Salvesen Iwona K Rzepecka Ingo B Runnebaum Mary Anne Rossing Lorna Rodriguez-Rodriguez Harvey A Risch Stefan P Renner Elizabeth M Poole Malcolm C Pike Catherine M Phelan Liisa M Pelttari Tanja Pejovic James Paul Irene Orlow Siti Zawiah Omar Sara H Olson Kunle Odunsi Stefan Nickels Heli Nevanlinna Roberta B Ness Steven A Narod Toru Nakanishi Kirsten B Moysich Alvaro N A Monteiro Joanna Moes-Sosnowska Francesmary Modugno Usha Menon John R McLaughlin Valerie McGuire Keitaro Matsuo Noor Azmi Mat Adenan Leon F A G Massuger Galina Lurie Lene Lundvall Jan Lubiński Jolanta Lissowska Douglas A Levine Arto Leminen Alice W Lee Nhu D Le Sandrina Lambrechts Diether Lambrechts Jolanta Kupryjanczyk Camilla Krakstad Gottfried E Konecny Susanne Krüger Kjaer Lambertus A Kiemeney Linda E Kelemen Gary L Keeney Beth Y Karlan Rod Karevan Kimberly R Kalli Hiroaki Kajiyama Bu-Tian Ji Allan Jensen Anna Jakubowska Edwin Iversen Satoyo Hosono Claus K Høgdall Estrid Høgdall Maureen Hoatlin Peter Hillemanns Florian Heitz Rebecca Hein Philipp Harter Mari K Halle Per Hall Jacek Gronwald Martin Gore Marc T Goodman Graham G Giles Aleksandra Gentry-Maharaj Montserrat Garcia-Closas James M Flanagan Peter A Fasching Arif B Ekici Robert Edwards Diana Eccles Douglas F Easton Matthias Dürst Andreas du Bois Thilo Dörk Jennifer A Doherty Evelyn Despierre Agnieszka Dansonka-Mieszkowska Cezary Cybulski Daniel W Cramer Linda S Cook Xiaoqing Chen Bridget Charbonneau Jenny Chang-Claude Ian Campbell Ralf Butzow Clareann H Bunker Doerthe Brueggmann Robert Brown Angela Brooks-Wilson Louise A Brinton Natalia Bogdanova Matthew S Block Elizabeth Benjamin Jonathan Beesley Matthias W Beckmann Elisa V Bandera Laura Baglietto François Bacot Sebastian M Armasu Natalia Antonenkova Hoda Anton-Culver Katja K Aben Dong Liang Xifeng Wu Karen Lu Michelle A T Hildebrandt Joellen M Schildkraut Thomas A Sellers David Huntsman Andrew Berchuck Georgia Chenevix-Trench Simon A Gayther Paul D P Pharoah Peter W Laird Ellen L Goode Celeste Leigh Pearce

Nat Commun 2013 ;4:1628

USC Epigenome Center, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1038/ncomms2629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848248PMC
October 2013

Platinum-sensitive recurrence in ovarian cancer: the role of tumor microenvironment.

Front Oncol 2013 Sep 24;3:251. Epub 2013 Sep 24.

Department of Cancer Biology, University of Kansas Medical Center , Kansas City, KS , USA.

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http://dx.doi.org/10.3389/fonc.2013.00251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781360PMC
September 2013

Matrix detachment and proteasomal inhibitors diminish Sulf-2 expression in breast cancer cell lines and mouse xenografts.

Clin Exp Metastasis 2013 Apr 15;30(4):407-15. Epub 2013 Feb 15.

Department of Experimental Pathology, Mayo Clinic College of Medicine, 200 First Street, S.W., 2-46 Stabile, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1007/s10585-012-9546-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619208PMC
April 2013

Metformin intake is associated with better survival in ovarian cancer: a case-control study.

Cancer 2013 Feb 3;119(3):555-62. Epub 2012 Dec 3.

Department of Gynecologic Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA.

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http://dx.doi.org/10.1002/cncr.27706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553259PMC
February 2013

Role of heparan sulfatases in ovarian and breast cancer.

Am J Cancer Res 2013 18;3(1):34-45. Epub 2013 Jan 18.

Department of Experimental Pathology, Mayo Clinic College of Medicine Rochester, MN, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555198PMC
January 2013

Hypoxia negatively regulates heparan sulfatase 2 expression in renal cancer cell lines.

Mol Carcinog 2012 Jul 7;51(7):565-75. Epub 2011 Jul 7.

Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1002/mc.20824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192919PMC
July 2012

HtrA1 sensitizes ovarian cancer cells to cisplatin-induced cytotoxicity by targeting XIAP for degradation.

Int J Cancer 2012 Mar 25;130(5):1029-35. Epub 2011 Apr 25.

Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA.

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http://dx.doi.org/10.1002/ijc.26044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206182PMC
March 2012

Silencing of HSulf-2 expression in MCF10DCIS.com cells attenuate ductal carcinoma in situ progression to invasive ductal carcinoma in vivo.

Breast Cancer Res 2012 Mar 12;14(2):R43. Epub 2012 Mar 12.

Department of Experimental Pathology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1186/bcr3140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446377PMC
March 2012

Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo.

Neoplasia 2011 May;13(5):483-91

Department of Experimental Pathology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084625PMC
http://dx.doi.org/10.1593/neo.11148DOI Listing
May 2011

HSulf-1 modulates FGF2- and hypoxia-mediated migration and invasion of breast cancer cells.

Cancer Res 2011 Mar 25;71(6):2152-61. Epub 2011 Jan 25.

Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059381PMC
March 2011

Comparison of gene expression patterns between avian and human ovarian cancers.

Gynecol Oncol 2011 Feb 19;120(2):256-64. Epub 2010 Nov 19.

Gynecologic Oncology, Department of Women's Oncology, Moffitt Cancer and Research Center, Tampa, FL 33612, USA.

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http://dx.doi.org/10.1016/j.ygyno.2010.10.030DOI Listing
February 2011

Expression and functional significance of HtrA1 loss in endometrial cancer.

Clin Cancer Res 2011 Feb 23;17(3):427-36. Epub 2010 Nov 23.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wake Forest Medical Center, Salem, North Carolina, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-3069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057564PMC
February 2011

The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein.

Mol Cancer Res 2010 Sep 29;8(9):1248-60. Epub 2010 Jul 29.

Department of Biochemistry, Section of Pathology, Second University of Naples, Via L. Armanni 5, 80138 Naples, Italy.

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http://dx.doi.org/10.1158/1541-7786.MCR-09-0473DOI Listing
September 2010

High temperature requirement A3 (HtrA3) promotes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell lines.

J Biol Chem 2010 Apr 12;285(16):12011-27. Epub 2010 Feb 12.

Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.097790
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http://dx.doi.org/10.1074/jbc.M109.097790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852939PMC
April 2010

Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells.

Cancer Res 2010 Apr 13;70(8):3109-18. Epub 2010 Apr 13.

Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-09-3557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579484PMC
April 2010

Methylation induced gene silencing of HtrA3 in smoking-related lung cancer.

Clin Cancer Res 2010 Jan 12;16(2):398-409. Epub 2010 Jan 12.

Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1677DOI Listing
January 2010

Serine protease HtrA1 associates with microtubules and inhibits cell migration.

Mol Cell Biol 2009 Aug 26;29(15):4177-87. Epub 2009 May 26.

Experimental Pathology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1128/MCB.00035-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715801PMC
August 2009

Analysis of gene expression in stage I serous tumors identifies critical pathways altered in ovarian cancer.

Gynecol Oncol 2009 Jul 1;114(1):3-11. Epub 2009 May 1.

Division of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.ygyno.2009.04.002DOI Listing
July 2009

Additive effect of apicidin and doxorubicin in sulfatase 1 expressing hepatocellular carcinoma in vitro and in vivo.

J Hepatol 2009 Jun 9;50(6):1112-21. Epub 2009 Mar 9.

Miles and Shirley Fiterman Center for Digestive Diseases, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.jhep.2008.12.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756527PMC
June 2009

Regulation of HSulf-1 expression by variant hepatic nuclear factor 1 in ovarian cancer.

Cancer Res 2009 Jun;69(11):4843-50

Departments of Experimental Pathology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713066PMC
June 2009

HtrA serine proteases as potential therapeutic targets in cancer.

Curr Cancer Drug Targets 2009 Jun;9(4):451-68

Department Biochemistry, Sect. Pathology, Via L. Armanni, 5, 80138 Naples, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905973PMC
http://dx.doi.org/10.2174/156800909788486704DOI Listing
June 2009

Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening.

J Cell Biochem 2009 May;107(2):253-63

Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1002/jcb.22121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983094PMC
May 2009

Role of hedgehog signaling in ovarian cancer.

Clin Cancer Res 2008 Dec;14(23):7659-66

Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-1414DOI Listing
December 2008

Elevated expression of serine protease HtrA1 in preeclampsia and its role in trophoblast cell migration and invasion.

Am J Obstet Gynecol 2008 Nov 29;199(5):557.e1-10. Epub 2008 Jul 29.

Department of Obstetrics, The Ohio State University Medical Center, Columbus, OH, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000293780800498
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http://dx.doi.org/10.1016/j.ajog.2008.04.046DOI Listing
November 2008

Molecular pathogenesis and therapeutic targets in epithelial ovarian cancer.

J Cell Biochem 2007 Dec;102(5):1117-29

Department of Experimental Pathology, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1002/jcb.21552DOI Listing
December 2007

Loss of HSulf-1 expression enhances autocrine signaling mediated by amphiregulin in breast cancer.

J Biol Chem 2007 May 15;282(19):14413-20. Epub 2007 Mar 15.

Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic Cancer Center, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1074/jbc.M611395200DOI Listing
May 2007

A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.

Science 2006 Nov 19;314(5801):992-3. Epub 2006 Oct 19.

Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1126/science.1133811DOI Listing
November 2006

DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding protein.

Biochem Biophys Res Commun 2006 Aug 19;347(1):22-30. Epub 2006 Jun 19.

Department of Laboratory Medicine and Pathology, Mayo Clinic/Mayo Medical School, Rochester, MN 55905, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0601284
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http://dx.doi.org/10.1016/j.bbrc.2006.06.050DOI Listing
August 2006

Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity.

J Clin Invest 2006 Jul 8;116(7):1994-2004. Epub 2006 Jun 8.

Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA, Medical Oncology Unit and Department of Histopathology, San Salvatore Hospital, Pesaro, Italy.

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http://www.jci.org/cgi/doi/10.1172/JCI27698
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http://dx.doi.org/10.1172/JCI27698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474818PMC
July 2006

SULF1 inhibits tumor growth and potentiates the effects of histone deacetylase inhibitors in hepatocellular carcinoma.

Gastroenterology 2006 Jun;130(7):2130-44

Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1053/j.gastro.2006.02.056DOI Listing
June 2006

HSulf-1 inhibits angiogenesis and tumorigenesis in vivo.

Cancer Res 2006 Jun;66(12):6025-32

Department of Experimental Pathology, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-3582DOI Listing
June 2006

Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines.

Gynecol Oncol 2005 Oct;99(1):126-34

Department of Obstetrics and Gynecology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.ygyno.2005.05.036DOI Listing
October 2005

Heterozygous ATR mutations in mismatch repair-deficient cancer cells have functional significance.

Cancer Res 2005 Aug;65(16):7091-5

Department of Obstetrics and Gynecology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-1019DOI Listing
August 2005

Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer.

Oncogene 2005 Jul;24(32):5089-100

Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic/Foundation, 200 First Street, SW Rochester, MN 55905, USA.

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http://www.nature.com/articles/1208700
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http://dx.doi.org/10.1038/sj.onc.1208700DOI Listing
July 2005

Pattern of expression of HtrA1 during mouse development.

J Histochem Cytochem 2004 Dec;52(12):1609-17

Department of Medicine and Public Health, Section of Clinical Anatomy, Second University of Naples, Naples, Italy.

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http://dx.doi.org/10.1369/jhc.4A6330.2004DOI Listing
December 2004

Parkin gene alterations in hepatocellular carcinoma.

Genes Chromosomes Cancer 2004 Jun;40(2):85-96

Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1002/gcc.20020DOI Listing
June 2004

Discovering novel phenotype-selective neurotrophic factors to treat neurodegenerative diseases.

Prog Brain Res 2004 ;146:168-83

Prescient NeuroPharma Inc., Laboratories of Protein Chemistry, Molecular Biology and Cell Biology, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/s0079-6123(03)46012-3DOI Listing
February 2004

A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer.

Oncogene 2004 Feb;23(8):1636-44

Mayo Clinic Cancer Center and Department of Experimental Pathology, Mayo Clinic, Rochester, MN 55905, USA.

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http://www.nature.com/articles/1207271
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http://dx.doi.org/10.1038/sj.onc.1207271DOI Listing
February 2004

HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma.

Oncogene 2004 Feb;23(7):1439-47

Division of Gastroenterology and Hepatology, Mayo Clinic Cancer Center, Mayo Clinic and Foundation, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1038/sj.onc.1207258DOI Listing
February 2004

Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer.

J Biol Chem 2003 Jun 9;278(25):23107-17. Epub 2003 Apr 9.

Mayo Clinic Cancer Center, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M302203200
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June 2003

MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons.

J Mol Neurosci 2003 Apr;20(2):173-88

Laboratories of Protein Chemistry, Molecular Biology & Cell Biology, Prescient NeuroPharma Inc., 96 Skyway Avenue, Toronto, Ontario, Canada M9W 4Y9.

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http://dx.doi.org/10.1385/jmn:20:2:173DOI Listing
April 2003

Characterization of the common fragile site FRA9E and its potential role in ovarian cancer.

Oncogene 2003 Jan;22(4):590-601

Tumor Biology Program, Mayo Graduate School, Mayo Foundation, Rochester, MN 55905, USA.

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http://www.nature.com/articles/1206171
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January 2003

Transcriptional profiling reveals that several common fragile-site genes are downregulated in ovarian cancer.

Genes Chromosomes Cancer 2002 Aug;34(4):406-15

Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA.

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http://doi.wiley.com/10.1002/gcc.10084
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August 2002

Early detection of ovarian cancer: promise and reality.

Cancer Treat Res 2002 ;107:61-97

Departments of Experimental Therapeutics, Molecular Therapeutics, Gynecologic Oncology and Anatomic Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/978-1-4757-3587-1_3DOI Listing
April 2002

Identification of underexpressed genes in early- and late-stage primary ovarian tumors by suppression subtraction hybridization.

Cancer Res 2002 Jan;62(1):262-70

Department of Experimental Pathology, Division of Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

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January 2002