Publications by authors named "Viji Shridhar"

99Publications

Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer.

Authors:
Yinan Xiao Ling Jin Chaolin Deng Ye Guan Eleftheria Kalogera Upasana Ray Prabhu Thirusangu Julie Staub Sayantani Sarkar Bhattacharya Haotian Xu Xiaoling Fang Viji Shridhar

Oncogene 2021 Jan 8. Epub 2021 Jan 8.

Department of Experimental Pathology, Mayo Clinic, Rochester, MN, USA.

View Article and Find Full Text PDF
January 2021

Sulfated glycolipid PG545 induces endoplasmic reticulum stress and augments autophagic flux by enhancing anticancer chemotherapy efficacy in endometrial cancer.

Authors:
Robert Hoffmann Sayantani Sarkar Bhattacharya Debarshi Roy Boris Winterhoff Ralf Schmidmaier Keith Dredge Edward Hammond Viji Shridhar

Biochem Pharmacol 2020 08 28;178:114003. Epub 2020 Apr 28.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States. Electronic address:

View Article and Find Full Text PDF
August 2020

Signals from the Metastatic Niche Regulate Early and Advanced Ovarian Cancer Metastasis through miR-4454 Downregulation.

Authors:
Subramanyam Dasari Taruni Pandhiri Tommaso Grassi Daniel W Visscher Francesco Multinu Komal Agarwal Andrea Mariani Viji Shridhar Anirban K Mitra

Mol Cancer Res 2020 08 29;18(8):1202-1217. Epub 2020 Apr 29.

Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana.

View Article and Find Full Text PDF
August 2020

Analysis of DNA methylation in endometrial biopsies to predict risk of endometrial cancer.

Authors:
Francesco Multinu Jun Chen Joseph D Madison Michelle Torres Jvan Casarin Daniel Visscher Viji Shridhar Jamie Bakkum-Gamez Mark Sherman Nicolas Wentzensen Andrea Mariani Marina Walther-Antonio

Gynecol Oncol 2020 03 3;156(3):682-688. Epub 2020 Jan 3.

Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, United States of America; Department of Surgery, Mayo Clinic, Rochester, MN, United States of America; Microbiome Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, United States of America. Electronic address:

View Article and Find Full Text PDF
March 2020

Combining copy number, methylation markers, and mutations as a panel for endometrial cancer detection via intravaginal tampon collection.

Authors:
Ajleeta Sangtani Chen Wang Amy Weaver Nicole L Hoppman Sarah E Kerr Alexej Abyzov Viji Shridhar Julie Staub Jean-Pierre A Kocher Jesse S Voss Karl C Podratz Nicolas Wentzensen John B Kisiel Mark E Sherman Jamie N Bakkum-Gamez

Gynecol Oncol 2020 02 28;156(2):387-392. Epub 2019 Nov 28.

Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, United States of America. Electronic address:

View Article and Find Full Text PDF
February 2020

Coiled-Coil and C2 Domain-Containing Protein 1A (CC2D1A) Promotes Chemotherapy Resistance in Ovarian Cancer.

Authors:
Sanjeev Kumar Derek B Oien Ashwani Khurana William Cliby Lynn Hartmann Jeremy Chien Viji Shridhar

Front Oncol 2019 1;9:986. Epub 2019 Oct 1.

Division of Experimental Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN, United States.

View Article and Find Full Text PDF
October 2019

Correction: The heparan sulfate mimetic PG545 interferes with Wnt/β-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine.

Authors:
Deok-Beom Jung Miyong Yun Eun-Ok Kim Jaekwang Kim Bonglee Kim Ji Hoon Jung Enfeng Wang Debabrata Mukopadhyay Edward Hammond Keith Dredge Viji Shridhar Sung-Hoon Kim

Oncotarget 2019 Sep 24;10(54):5669. Epub 2019 Sep 24.

College of Korean Medicine, Kyung Hee University, Seoul, South Korea.

View Article and Find Full Text PDF
September 2019

Repurposing quinacrine for treatment-refractory cancer.

Authors:
Derek B Oien Christopher L Pathoulas Upasana Ray Prabhu Thirusangu Eleftheria Kalogera Viji Shridhar

Semin Cancer Biol 2019 Sep 25. Epub 2019 Sep 25.

Division of Experimental Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN, United States. Electronic address:

View Article and Find Full Text PDF
September 2019

PFKFB3 inhibition reprograms malignant pleural mesothelioma to nutrient stress-induced macropinocytosis and ER stress as independent binary adaptive responses.

Authors:
Sayantani Sarkar Bhattacharya Prabhu Thirusangu Ling Jin Debarshi Roy Deokbeom Jung Yinan Xiao Julie Staub Bhaskar Roy Julian R Molina Viji Shridhar

Cell Death Dis 2019 09 27;10(10):725. Epub 2019 Sep 27.

Department of Experimental Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN, USA.

View Article and Find Full Text PDF
September 2019

Genes associated with bowel metastases in ovarian cancer.

Authors:
Andrea Mariani Chen Wang Ann L Oberg Shaun M Riska Michelle Torres Joseph Kumka Francesco Multinu Gunisha Sagar Debarshi Roy Deok-Beom Jung Qing Zhang Tommaso Grassi Daniel W Visscher Vatsal P Patel Ling Jin Julie K Staub William A Cliby Saravut J Weroha Kimberly R Kalli Lynn C Hartmann Scott H Kaufmann Ellen L Goode Viji Shridhar

Gynecol Oncol 2019 09 14;154(3):495-504. Epub 2019 Jun 14.

Department of Obstetrics and Gynecology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address:

View Article and Find Full Text PDF
September 2019

Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers.

Authors:
Susmita Mondal Debarshi Roy Sayantani Sarkar Bhattacharya Ling Jin Deokbeom Jung Song Zhang Eleftheria Kalogera Julie Staub Yaxian Wang Wen Xuyang Ashwani Khurana Jeremey Chien Sucheta Telang Jason Chesney Gilles Tapolsky Dzeja Petras Viji Shridhar

Int J Cancer 2019 01 30;144(1):178-189. Epub 2018 Oct 30.

Department of Experimental Pathology, Mayo Clinic, Rochester, MN.

View Article and Find Full Text PDF
January 2019

Genetic Evidence for Early Peritoneal Spreading in Pelvic High-Grade Serous Cancer.

Authors:
Jeremy Chien Lisa Neums Alexis F L A Powell Michelle Torres Kimberly R Kalli Francesco Multinu Viji Shridhar Andrea Mariani

Front Oncol 2018 7;8:58. Epub 2018 Mar 7.

Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, United States.

View Article and Find Full Text PDF
March 2018

Quinacrine upregulates p21/p27 independent of p53 through autophagy-mediated downregulation of p62-Skp2 axis in ovarian cancer.

Authors:
DeokBeom Jung Ashwani Khurana Debarshi Roy Eleftheria Kalogera Jamie Bakkum-Gamez Jeremy Chien Viji Shridhar

Sci Rep 2018 02 6;8(1):2487. Epub 2018 Feb 6.

Department of Experimental Pathology, Mayo Clinic, Rochester, MN, USA.

View Article and Find Full Text PDF
February 2018

Quinacrine in endometrial cancer: Repurposing an old antimalarial drug.

Authors:
Eleftheria Kalogera Debarshi Roy Ashwani Khurana Susmita Mondal Amy L Weaver Xiaoping He Sean C Dowdy Viji Shridhar

Gynecol Oncol 2017 07 22;146(1):187-195. Epub 2017 May 22.

Department of Experimental Pathology, Mayo Clinic, Rochester, USA. Electronic address:

View Article and Find Full Text PDF
July 2017

Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer.

Authors:
Debarshi Roy Susmita Mondal Ashwani Khurana Deok-Beom Jung Robert Hoffmann Xiaoping He Eleftheria Kalogera Thomas Dierks Edward Hammond Keith Dredge Viji Shridhar

Sci Rep 2017 02 7;7:41977. Epub 2017 Feb 7.

Department of Experimental Pathology, Mayo Clinic, Rochester, MN, USA.

View Article and Find Full Text PDF
February 2017

Bevacizumab May Differentially Improve Ovarian Cancer Outcome in Patients with Proliferative and Mesenchymal Molecular Subtypes.

Authors:
Stefan Kommoss Boris Winterhoff Ann L Oberg Gottfried E Konecny Chen Wang Shaun M Riska Jian-Bing Fan Matthew J Maurer Craig April Viji Shridhar Friedrich Kommoss Andreas du Bois Felix Hilpert Sven Mahner Klaus Baumann Willibald Schroeder Alexander Burges Ulrich Canzler Jeremy Chien Andrew C Embleton Mahesh Parmar Richard Kaplan Timothy Perren Lynn C Hartmann Ellen L Goode Sean C Dowdy Jacobus Pfisterer

Clin Cancer Res 2017 Jul 3;23(14):3794-3801. Epub 2017 Feb 3.

Gynecologic Oncology Center, Kiel, Germany.

View Article and Find Full Text PDF
July 2017

AMP-Activated Protein Kinase Suppresses Autoimmune Central Nervous System Disease by Regulating M1-Type Macrophage-Th17 Axis.

Authors:
Ashutosh K Mangalam Ramandeep Rattan Hamid Suhail Jaspreet Singh Md Nasrul Hoda Mandar Deshpande Sadanand Fulzele Alexander Denic Viji Shridhar Ashok Kumar Benoit Viollet Moses Rodriguez Shailendra Giri

J Immunol 2016 08 27;197(3):747-60. Epub 2016 Jun 27.

Department of Neurology, Henry Ford Health System, Detroit, MI 48202;

View Article and Find Full Text PDF
August 2016

Expression signature distinguishing two tumour transcriptome classes associated with progression-free survival among rare histological types of epithelial ovarian cancer.

Authors:
Chen Wang Boris J Winterhoff Kimberly R Kalli Matthew S Block Sebastian M Armasu Melissa C Larson Hsiao-Wang Chen Gary L Keeney Lynn C Hartmann Viji Shridhar Gottfried E Konecny Ellen L Goode Brooke L Fridley

Br J Cancer 2016 06 2;114(12):1412-20. Epub 2016 Jun 2.

Department of Biostatistics, Kansas University Medical Center, Kansas City, KS 66160, USA.

View Article and Find Full Text PDF
June 2016

Quinacrine promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth.

Authors:
Ashwani Khurana Debarshi Roy Eleftheria Kalogera Susmita Mondal Xuyang Wen Xiaoping He Sean Dowdy Viji Shridhar

Oncotarget 2015 Nov;6(34):36354-69

Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA.

View Article and Find Full Text PDF
November 2015

HSulf-1 deficiency dictates a metabolic reprograming of glycolysis and TCA cycle in ovarian cancer.

Authors:
Susmita Mondal Debarshi Roy Juliana Camacho-Pereira Ashwani Khurana Eduardo Chini Lifeng Yang Joelle Baddour Katherine Stilles Seth Padmabandu Sam Leung Steve Kalloger Blake Gilks Val Lowe Thomas Dierks Edward Hammond Keith Dredge Deepak Nagrath Viji Shridhar

Oncotarget 2015 Oct;6(32):33705-19

Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA.

View Article and Find Full Text PDF
October 2015

Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer.

Authors:
Lacey M Litchfield Abir Mukherjee Mark A Eckert Alyssa Johnson Kathryn A Mills Shawn Pan Viji Shridhar Ernst Lengyel Iris L Romero

Oncotarget 2015 Sep;6(27):23548-60

Department of Obstetrics and Gynecology, Gordon Center for Integrative Science, University of Chicago, Chicago, Illinois, USA.

View Article and Find Full Text PDF
September 2015

TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer.

Authors:
Jeremy Chien Hugues Sicotte Jian-Bing Fan Sean Humphray Julie M Cunningham Kimberly R Kalli Ann L Oberg Steven N Hart Ying Li Jaime I Davila Saurabh Baheti Chen Wang Sabine Dietmann Elizabeth J Atkinson Yan W Asmann Debra A Bell Takayo Ota Yaman Tarabishy Rui Kuang Marina Bibikova R Keira Cheetham Russell J Grocock Elizabeth M Swisher John Peden David Bentley Jean-Pierre A Kocher Scott H Kaufmann Lynn C Hartmann Viji Shridhar Ellen L Goode

Nucleic Acids Res 2015 Aug 27;43(14):6945-58. Epub 2015 Apr 27.

Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
August 2015

PG545 enhances anti-cancer activity of chemotherapy in ovarian models and increases surrogate biomarkers such as VEGF in preclinical and clinical plasma samples.

Authors:
Boris Winterhoff Luisa Freyer Edward Hammond Shailendra Giri Susmita Mondal Debarshi Roy Attila Teoman Sally A Mullany Robert Hoffmann Antonia von Bismarck Jeremy Chien Matthew S Block Michael Millward Darryn Bampton Keith Dredge Viji Shridhar

Eur J Cancer 2015 May 5;51(7):879-892. Epub 2015 Mar 5.

Mayo Clinic College of Medicine, Department of Experimental Pathology, Minnesota, USA.

View Article and Find Full Text PDF
May 2015

Detection of endometrial cancer via molecular analysis of DNA collected with vaginal tampons.

Authors:
Jamie N Bakkum-Gamez Nicolas Wentzensen Matthew J Maurer Kieran M Hawthorne Jesse S Voss Trynda N Kroneman Abimbola O Famuyide Amy C Clayton Kevin C Halling Sarah E Kerr William A Cliby Sean C Dowdy Benjamin R Kipp Andrea Mariani Ann L Oberg Karl C Podratz Viji Shridhar Mark E Sherman

Gynecol Oncol 2015 Apr 10;137(1):14-22. Epub 2015 Feb 10.

Hormonal and Reproductive Branch (HREB), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), USA.

View Article and Find Full Text PDF
April 2015

The heparan sulfate mimetic PG545 interferes with Wnt/β-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine.

Authors:
Deok-Beom Jung Miyong Yun Eun-Ok Kim Jaekwang Kim Bonglee Kim Ji Hoon Jung Enfeng Wang Debabrata Mukhopadhyay Edward Hammond Keith Dredge Viji Shridhar Sung-Hoon Kim

Oncotarget 2015 Mar;6(7):4992-5004

College of Korean Medicine, Kyung Hee University, Seoul, South Korea.

View Article and Find Full Text PDF
March 2015

Targeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells.

Authors:
Xuan Zhang Lihua Cheng Kay Minn Rashna Madan Andrew K Godwin Viji Shridhar Jeremy Chien

Oncotarget 2014 Nov;5(22):11365-80

Department of Cancer Biology, University of Kansas Medical Center, Kansas City, Kansas, U.S.A.

View Article and Find Full Text PDF
November 2014

The Wilms' Tumor Gene WT1 - 17AA/- KTS Splice Variant Increases Tumorigenic Activity Through Up-Regulation of Vascular Endothelial Growth Factor in an In Vivo Ovarian Cancer Model.

Authors:
Keiko Yamanouchi Tsuyoshi Ohta Zhiyang Liu Yusuke Oji Haruo Sugiyama Viji Shridhar Sohei Matsumura Toshifumi Takahashi Kazuhiro Takahashi Hirohisa Kurachi

Transl Oncol 2014 Oct 24;7(5):580-9. Epub 2014 Oct 24.

Department of Obstetrics and Gynecology, Yamagata University, School of Medicine, Yamagata, Japan.

View Article and Find Full Text PDF
October 2014

Non-metastatic 2 (NME2)-mediated suppression of lung cancer metastasis involves transcriptional regulation of key cell adhesion factor vinculin.

Authors:
Ram Krishna Thakur Vinod Kumar Yadav Akinchan Kumar Ankita Singh Krishnendu Pal Luke Hoeppner Dhurjhoti Saha Gunjan Purohit Richa Basundra Anirban Kar Rashi Halder Pankaj Kumar Aradhita Baral M J Mahesh Kumar Alfonso Baldi Bruno Vincenzi Laura Lorenzon Rajkumar Banerjee Praveen Kumar Viji Shridhar Debabrata Mukhopadhyay Shantanu Chowdhury

Nucleic Acids Res 2014 Oct 23;42(18):11589-600. Epub 2014 Sep 23.

Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110 007, India G.N.R. Knowledge Centre for Genome Informatics, Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110 007, India Academy of Scientific and Innovative Research (AcSIR), New Delhi, India

View Article and Find Full Text PDF
October 2014

Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer.

Authors:
Debarshi Roy Susmita Mondal Chen Wang Xiaoping He Ashwani Khurana Shailendra Giri Robert Hoffmann Deok-Beom Jung Sung H Kim Eduardo N Chini Juliana Camacho Periera Clifford D Folmes Andrea Mariani Sean C Dowdy Jamie N Bakkum-Gamez Shaun M Riska Ann L Oberg Edward D Karoly Lauren N Bell Jeremy Chien Viji Shridhar

Cancer Metab 2014 18;2:13. Epub 2014 Aug 18.

Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
September 2014

The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics.

Authors:
Edward Hammond Ashwani Khurana Viji Shridhar Keith Dredge

Front Oncol 2014 24;4:195. Epub 2014 Jul 24.

Progen Pharmaceuticals Ltd. , Brisbane, QLD , Australia.

View Article and Find Full Text PDF
August 2014

Preclinical therapeutic potential of a nitrosylating agent in the treatment of ovarian cancer.

Authors:
Shailendra Giri Ramandeep Rattan Mandar Deshpande Jacie L Maguire Zachary Johnson Rondell P Graham Viji Shridhar

PLoS One 2014 2;9(6):e97897. Epub 2014 Jun 2.

Department of Experimental Pathology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.

View Article and Find Full Text PDF
January 2015

High levels of Wilms' tumor 1 (WT1) expression were associated with aggressive clinical features in ovarian cancer.

Authors:
Zhiyang Liu Keiko Yamanouchi Tsuyoshi Ohtao Sohei Matsumura Manabu Seino Viji Shridhar Toshifumi Takahashi Kazuhiro Takahashi Hirohisa Kurachi

Anticancer Res 2014 May;34(5):2331-40

Department of Obstetrics and Gynecology, Yamagata University, School of Medicine, 2-2-2 Iidanishi, Yamagata 990-9585, Japan.

View Article and Find Full Text PDF
May 2014

Methylation of leukocyte DNA and ovarian cancer: relationships with disease status and outcome.

Authors:
Brooke L Fridley Sebastian M Armasu Mine S Cicek Melissa C Larson Chen Wang Stacey J Winham Kimberly R Kalli Devin C Koestler David N Rider Viji Shridhar Janet E Olson Julie M Cunningham Ellen L Goode

BMC Med Genomics 2014 Apr 28;7:21. Epub 2014 Apr 28.

Department of Biostatistics, University of Kansas, Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.

View Article and Find Full Text PDF
April 2014

Tumor hypomethylation at 6p21.3 associates with longer time to recurrence of high-grade serous epithelial ovarian cancer.

Authors:
Chen Wang Mine S Cicek Bridget Charbonneau Kimberly R Kalli Sebastian M Armasu Melissa C Larson Gottfried E Konecny Boris Winterhoff Jian-Bing Fan Marina Bibikova Jeremy Chien Viji Shridhar Matthew S Block Lynn C Hartmann Daniel W Visscher Julie M Cunningham Keith L Knutson Brooke L Fridley Ellen L Goode

Cancer Res 2014 Jun 11;74(11):3084-91. Epub 2014 Apr 11.

Authors' Affiliations: Departments of Health Sciences Research, Medical Oncology, Obstetrics and Gynecology, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles; Department of Research, Illumina, San Diego, California; Departments of Cancer Biology and Biostatistics, University of Kansas Medical Center, Kansas City, Kansas; and Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, Florida

View Article and Find Full Text PDF
June 2014

Discovery and validation of methylation markers for endometrial cancer.

Authors:
Nicolas Wentzensen Jamie N Bakkum-Gamez J Keith Killian Joshua Sampson Richard Guido Andrew Glass Lisa Adams Patricia Luhn Louise A Brinton Brenda Rush Lori d'Ambrosio Munira Gunja Hannah P Yang Montserrat Garcia-Closas James V Lacey Jolanta Lissowska Karl Podratz Paul Meltzer Viji Shridhar Mark E Sherman

Int J Cancer 2014 Oct 31;135(8):1860-8. Epub 2014 Mar 31.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

View Article and Find Full Text PDF
October 2014

Loss of HSulf-1 expression enhances tumorigenicity by inhibiting Bim expression in ovarian cancer.

Authors:
Xiaoping He Ashwani Khurana Debarshi Roy Scott Kaufmann Viji Shridhar

Int J Cancer 2014 Oct 28;135(8):1783-9. Epub 2014 Mar 28.

Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN.

View Article and Find Full Text PDF
October 2014

Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer.

Authors:
Debarshi Roy Susmita Mondal Chen Wang Xiaoping He Ashwani Khurana Shailendra Giri Robert Hoffmann Deok-Beom Jung Sung H Kim Eduardo N Chini Juliana Camacho Periera Clifford D Folmes Andrea Mariani Sean C Dowdy Jamie N Bakkum-Gamez Shaun M Riska Ann L Oberg Edward D Karoly Lauren N Bell Jeremy Chien Viji Shridhar

Cancer Metab 2014 4;2:24. Epub 2014 Nov 4.

Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905 USA.

View Article and Find Full Text PDF
June 2015

APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.

Authors:
Brandon Leonard Steven N Hart Michael B Burns Michael A Carpenter Nuri A Temiz Anurag Rathore Rachel I Vogel Jason B Nikas Emily K Law William L Brown Ying Li Yuji Zhang Matthew J Maurer Ann L Oberg Julie M Cunningham Viji Shridhar Debra A Bell Craig April David Bentley Marina Bibikova R Keira Cheetham Jian-Bing Fan Russell Grocock Sean Humphray Zoya Kingsbury John Peden Jeremy Chien Elizabeth M Swisher Lynn C Hartmann Kimberly R Kalli Ellen L Goode Hugues Sicotte Scott H Kaufmann Reuben S Harris

Cancer Res 2013 Dec 23;73(24):7222-31. Epub 2013 Oct 23.

Authors' Affiliations: Biochemistry, Molecular Biology and Biophysics Department; Masonic Cancer Center, University of Minnesota, Minneapolis; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; Medical Genome Facility and Department of Laboratory Medicine and Pathology; Department of Laboratory Medicine and Pathology; Division of Medical Oncology, Department of Oncology; Division of Epidemiology, Department of Health Sciences Research; Division of Oncology Research, Department of Oncology; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic; Women's Cancer Program, Mayo Clinic Cancer Center, Rochester, Minnesota; Department of Cancer Biology, University of Kansas, Kansas City, Kansas; Department of Obstetrics & Gynecology, University of Washington School of Medicine, Seattle, Washington; and Illumina Cambridge Ltd, Chesterford Research Park, Little Chesterford, Cambridge, United Kingdom.

View Article and Find Full Text PDF
December 2013

Platinum-sensitive recurrence in ovarian cancer: the role of tumor microenvironment.

Authors:
Jeremy Chien Rui Kuang Charles Landen Viji Shridhar

Front Oncol 2013 Sep 24;3:251. Epub 2013 Sep 24.

Department of Cancer Biology, University of Kansas Medical Center , Kansas City, KS , USA.

View Article and Find Full Text PDF
September 2013

Assessment of resistance to anoikis in ovarian cancer.

Authors:
Xiaoping He Jeremy Chien Viji Shridhar

Methods Mol Biol 2013 ;1049:347-54

Mayo Clinic College of Medicine, Rochester, MN, USA.

View Article and Find Full Text PDF
March 2014

Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel.

Authors:
Mine S Cicek Devin C Koestler Brooke L Fridley Kimberly R Kalli Sebastian M Armasu Melissa C Larson Chen Wang Stacey J Winham Robert A Vierkant David N Rider Matthew S Block Brandy Klotzle Gottfried Konecny Boris J Winterhoff Habib Hamidi Viji Shridhar Jian-Bing Fan Daniel W Visscher Janet E Olson Lynn C Hartmann Marina Bibikova Jeremy Chien Julie M Cunningham Ellen L Goode

Hum Mol Genet 2013 Aug 9;22(15):3038-47. Epub 2013 Apr 9.

Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
August 2013

Network-based survival analysis reveals subnetwork signatures for predicting outcomes of ovarian cancer treatment.

Authors:
Wei Zhang Takayo Ota Viji Shridhar Jeremy Chien Baolin Wu Rui Kuang

PLoS Comput Biol 2013 21;9(3):e1002975. Epub 2013 Mar 21.

Department of Computer Science and Engineering, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America.

View Article and Find Full Text PDF
November 2013

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer.

Authors:
Hui Shen Brooke L Fridley Honglin Song Kate Lawrenson Julie M Cunningham Susan J Ramus Mine S Cicek Jonathan Tyrer Douglas Stram Melissa C Larson Martin Köbel Argyrios Ziogas Wei Zheng Hannah P Yang Anna H Wu Eva L Wozniak Yin Ling Woo Boris Winterhoff Elisabeth Wik Alice S Whittemore Nicolas Wentzensen Rachel Palmieri Weber Allison F Vitonis Daniel Vincent Robert A Vierkant Ignace Vergote David Van Den Berg Anne M Van Altena Shelley S Tworoger Pamela J Thompson Daniel C Tessier Kathryn L Terry Soo-Hwang Teo Claire Templeman Daniel O Stram Melissa C Southey Weiva Sieh Nadeem Siddiqui Yurii B Shvetsov Xiao-Ou Shu Viji Shridhar Shan Wang-Gohrke Gianluca Severi Ira Schwaab Helga B Salvesen Iwona K Rzepecka Ingo B Runnebaum Mary Anne Rossing Lorna Rodriguez-Rodriguez Harvey A Risch Stefan P Renner Elizabeth M Poole Malcolm C Pike Catherine M Phelan Liisa M Pelttari Tanja Pejovic James Paul Irene Orlow Siti Zawiah Omar Sara H Olson Kunle Odunsi Stefan Nickels Heli Nevanlinna Roberta B Ness Steven A Narod Toru Nakanishi Kirsten B Moysich Alvaro N A Monteiro Joanna Moes-Sosnowska Francesmary Modugno Usha Menon John R McLaughlin Valerie McGuire Keitaro Matsuo Noor Azmi Mat Adenan Leon F A G Massuger Galina Lurie Lene Lundvall Jan Lubiński Jolanta Lissowska Douglas A Levine Arto Leminen Alice W Lee Nhu D Le Sandrina Lambrechts Diether Lambrechts Jolanta Kupryjanczyk Camilla Krakstad Gottfried E Konecny Susanne Krüger Kjaer Lambertus A Kiemeney Linda E Kelemen Gary L Keeney Beth Y Karlan Rod Karevan Kimberly R Kalli Hiroaki Kajiyama Bu-Tian Ji Allan Jensen Anna Jakubowska Edwin Iversen Satoyo Hosono Claus K Høgdall Estrid Høgdall Maureen Hoatlin Peter Hillemanns Florian Heitz Rebecca Hein Philipp Harter Mari K Halle Per Hall Jacek Gronwald Martin Gore Marc T Goodman Graham G Giles Aleksandra Gentry-Maharaj Montserrat Garcia-Closas James M Flanagan Peter A Fasching Arif B Ekici Robert Edwards Diana Eccles Douglas F Easton Matthias Dürst Andreas du Bois Thilo Dörk Jennifer A Doherty Evelyn Despierre Agnieszka Dansonka-Mieszkowska Cezary Cybulski Daniel W Cramer Linda S Cook Xiaoqing Chen Bridget Charbonneau Jenny Chang-Claude Ian Campbell Ralf Butzow Clareann H Bunker Doerthe Brueggmann Robert Brown Angela Brooks-Wilson Louise A Brinton Natalia Bogdanova Matthew S Block Elizabeth Benjamin Jonathan Beesley Matthias W Beckmann Elisa V Bandera Laura Baglietto François Bacot Sebastian M Armasu Natalia Antonenkova Hoda Anton-Culver Katja K Aben Dong Liang Xifeng Wu Karen Lu Michelle A T Hildebrandt Joellen M Schildkraut Thomas A Sellers David Huntsman Andrew Berchuck Georgia Chenevix-Trench Simon A Gayther Paul D P Pharoah Peter W Laird Ellen L Goode Celeste Leigh Pearce

Nat Commun 2013 ;4:1628

USC Epigenome Center, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.

View Article and Find Full Text PDF
October 2013

Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31.

Authors:
Jennifer Permuth-Wey Kate Lawrenson Howard C Shen Aneliya Velkova Jonathan P Tyrer Zhihua Chen Hui-Yi Lin Y Ann Chen Ya-Yu Tsai Xiaotao Qu Susan J Ramus Rod Karevan Janet Lee Nathan Lee Melissa C Larson Katja K Aben Hoda Anton-Culver Natalia Antonenkova Antonis C Antoniou Sebastian M Armasu François Bacot Laura Baglietto Elisa V Bandera Jill Barnholtz-Sloan Matthias W Beckmann Michael J Birrer Greg Bloom Natalia Bogdanova Louise A Brinton Angela Brooks-Wilson Robert Brown Ralf Butzow Qiuyin Cai Ian Campbell Jenny Chang-Claude Stephen Chanock Georgia Chenevix-Trench Jin Q Cheng Mine S Cicek Gerhard A Coetzee Linda S Cook Fergus J Couch Daniel W Cramer Julie M Cunningham Agnieszka Dansonka-Mieszkowska Evelyn Despierre Jennifer A Doherty Thilo Dörk Andreas du Bois Matthias Dürst Douglas F Easton Diana Eccles Robert Edwards Arif B Ekici Peter A Fasching David A Fenstermacher James M Flanagan Montserrat Garcia-Closas Aleksandra Gentry-Maharaj Graham G Giles Rosalind M Glasspool Jesus Gonzalez-Bosquet Marc T Goodman Martin Gore Bohdan Górski Jacek Gronwald Per Hall Mari K Halle Philipp Harter Florian Heitz Peter Hillemanns Maureen Hoatlin Claus K Høgdall Estrid Høgdall Satoyo Hosono Anna Jakubowska Allan Jensen Heather Jim Kimberly R Kalli Beth Y Karlan Stanley B Kaye Linda E Kelemen Lambertus A Kiemeney Fumitaka Kikkawa Gottfried E Konecny Camilla Krakstad Susanne Krüger Kjaer Jolanta Kupryjanczyk Diether Lambrechts Sandrina Lambrechts Johnathan M Lancaster Nhu D Le Arto Leminen Douglas A Levine Dong Liang Boon Kiong Lim Jie Lin Jolanta Lissowska Karen H Lu Jan Lubiński Galina Lurie Leon F A G Massuger Keitaro Matsuo Valerie McGuire John R McLaughlin Usha Menon Francesmary Modugno Kirsten B Moysich Toru Nakanishi Steven A Narod Lotte Nedergaard Roberta B Ness Heli Nevanlinna Stefan Nickels Houtan Noushmehr Kunle Odunsi Sara H Olson Irene Orlow James Paul Celeste L Pearce Tanja Pejovic Liisa M Pelttari Malcolm C Pike Elizabeth M Poole Paola Raska Stefan P Renner Harvey A Risch Lorna Rodriguez-Rodriguez Mary Anne Rossing Anja Rudolph Ingo B Runnebaum Iwona K Rzepecka Helga B Salvesen Ira Schwaab Gianluca Severi Viji Shridhar Xiao-Ou Shu Yurii B Shvetsov Weiva Sieh Honglin Song Melissa C Southey Beata Spiewankiewicz Daniel Stram Rebecca Sutphen Soo-Hwang Teo Kathryn L Terry Daniel C Tessier Pamela J Thompson Shelley S Tworoger Anne M van Altena Ignace Vergote Robert A Vierkant Daniel Vincent Allison F Vitonis Shan Wang-Gohrke Rachel Palmieri Weber Nicolas Wentzensen Alice S Whittemore Elisabeth Wik Lynne R Wilkens Boris Winterhoff Yin Ling Woo Anna H Wu Yong-Bing Xiang Hannah P Yang Wei Zheng Argyrios Ziogas Famida Zulkifli Catherine M Phelan Edwin Iversen Joellen M Schildkraut Andrew Berchuck Brooke L Fridley Ellen L Goode Paul D P Pharoah Alvaro N A Monteiro Thomas A Sellers Simon A Gayther

Nat Commun 2013 ;4:1627

Department of Cancer Epidemiology, Division of Population Sciences, Moffitt Cancer Center, Tampa, Florida, USA.

View Article and Find Full Text PDF
October 2013

Matrix detachment and proteasomal inhibitors diminish Sulf-2 expression in breast cancer cell lines and mouse xenografts.

Authors:
Ashwani Khurana Deok Jung-Beom Xiaoping He Sung-Hoon Kim Robert C Busby Laura Lorenzon Massimo Villa Alfonso Baldi Julian Molina Matthew P Goetz Viji Shridhar

Clin Exp Metastasis 2013 Apr 15;30(4):407-15. Epub 2013 Feb 15.

Department of Experimental Pathology, Mayo Clinic College of Medicine, 200 First Street, S.W., 2-46 Stabile, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
April 2013

Nanoceria: a rare-earth nanoparticle as a novel anti-angiogenic therapeutic agent in ovarian cancer.

Authors:
Shailendra Giri Ajay Karakoti Rondell P Graham Jacie L Maguire Christopher M Reilly Sudipta Seal Ramandeep Rattan Viji Shridhar

PLoS One 2013 31;8(1):e54578. Epub 2013 Jan 31.

Department of Experimental Pathology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

View Article and Find Full Text PDF
August 2013

Role of heparan sulfatases in ovarian and breast cancer.

Authors:
Ashwani Khurana Daniah Beleford Xiaoping He Jeremy Chien Viji Shridhar

Am J Cancer Res 2013 18;3(1):34-45. Epub 2013 Jan 18.

Department of Experimental Pathology, Mayo Clinic College of Medicine Rochester, MN, USA.

View Article and Find Full Text PDF
January 2013

Metformin intake is associated with better survival in ovarian cancer: a case-control study.

Authors:
Sanjeev Kumar Alexandra Meuter Prabin Thapa Carrie Langstraat Shailendra Giri Jeremy Chien Ramandeep Rattan William Cliby Viji Shridhar

Cancer 2013 Feb 3;119(3):555-62. Epub 2012 Dec 3.

Department of Gynecologic Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA.

View Article and Find Full Text PDF
February 2013

Metformin is synthetically lethal with glucose withdrawal in cancer cells.

Authors:
Ashwani Khurana Viji Shridhar

Cell Cycle 2012 Aug 1;11(15):2779-80. Epub 2012 Aug 1.

View Article and Find Full Text PDF
August 2012

Plumbagin inhibits tumorigenesis and angiogenesis of ovarian cancer cells in vivo.

Authors:
Sutapa Sinha Krishnendu Pal Ahmed Elkhanany Shamit Dutta Ying Cao Gourish Mondal Seethalakshmi Iyer Veena Somasundaram Fergus J Couch Viji Shridhar Resham Bhattacharya Debabrata Mukhopadhyay Priya Srinivas

Int J Cancer 2013 Mar 27;132(5):1201-12. Epub 2012 Jul 27.

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
March 2013

A phase 2 trial of flavopiridol (Alvocidib) and cisplatin in platin-resistant ovarian and primary peritoneal carcinoma: MC0261.

Authors:
Keith C Bible Prema P Peethambaram Ann L Oberg William Maples David L Groteluschen Matthew Boente Jill K Burton Leigh C Gomez Dahl Jennifer D Tibodeau Crescent R Isham Jacie L Maguire Viji Shridhar Andrea K Kukla Kalli J Voll Mathew J Mauer Alexander D Colevas John Wright L Austin Doyle Charles Erlichman

Gynecol Oncol 2012 Oct 1;127(1):55-62. Epub 2012 Jun 1.

Division of Medical Oncology, Department of Health Science Research, Mayo Clinic, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
October 2012

Silencing of HSulf-2 expression in MCF10DCIS.com cells attenuate ductal carcinoma in situ progression to invasive ductal carcinoma in vivo.

Authors:
Ashwani Khurana Hiedi McKean Hyunseok Kim Sung-Hoon Kim Jacie mcguire Lewis R Roberts Matthew P Goetz Viji Shridhar

Breast Cancer Res 2012 Mar 12;14(2):R43. Epub 2012 Mar 12.

Department of Experimental Pathology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
March 2012

Hypoxia negatively regulates heparan sulfatase 2 expression in renal cancer cell lines.

Authors:
Ashwani Khurana Han W Tun Laura Marlow John A Copland Keith Dredge Viji Shridhar

Mol Carcinog 2012 Jul 7;51(7):565-75. Epub 2011 Jul 7.

Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
July 2012

Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo.

Authors:
Ramandeep Rattan Rondell P Graham Jacie L Maguire Shailendra Giri Viji Shridhar

Neoplasia 2011 May;13(5):483-91

Department of Experimental Pathology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN, USA.

View Article and Find Full Text PDF
May 2011

HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer.

Authors:
Vincenzo Catalano Pasquale Mellone Alfredo d'Avino Viji Shridhar Maria Pia Staccioli Francesco Graziano Paolo Giordani David Rossi Anna Maria Baldelli Paolo Alessandroni Daniele Santini Laura Lorenzon Enrica Testa Silvia D'Emidio Michele De Nictolis Pietro Muretto Stefano Luzi Fedeli Alfonso Baldi

Histopathology 2011 Apr 30;58(5):669-78. Epub 2011 Mar 30.

Medical Oncology, Azienda Ospedaliera Ospedale San Salvatore, Pesaro, Italy.

View Article and Find Full Text PDF
April 2011

HtrA1 sensitizes ovarian cancer cells to cisplatin-induced cytotoxicity by targeting XIAP for degradation.

Authors:
Xiaoping He Ashwani Khurana Jacie L Maguire Jeremy Chien Viji Shridhar

Int J Cancer 2012 Mar 25;130(5):1029-35. Epub 2011 Apr 25.

Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA.

View Article and Find Full Text PDF
March 2012

HSulf-1 modulates FGF2- and hypoxia-mediated migration and invasion of breast cancer cells.

Authors:
Ashwani Khurana Peng Liu Pasquale Mellone Laura Lorenzon Bruno Vincenzi Kaustubh Datta Bo Yang Robert J Linhardt Wilma Lingle Jeremy Chien Alfonso Baldi Viji Shridhar

Cancer Res 2011 Mar 25;71(6):2152-61. Epub 2011 Jan 25.

Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

View Article and Find Full Text PDF
March 2011

Expression and functional significance of HtrA1 loss in endometrial cancer.

Authors:
Sally A Mullany Mehdi Moslemi-Kebria Ramandeep Rattan Ashwani Khurana Amy Clayton Takayo Ota Andrea Mariani Karl C Podratz Jeremy Chien Viji Shridhar

Clin Cancer Res 2011 Feb 23;17(3):427-36. Epub 2010 Nov 23.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Wake Forest Medical Center, Salem, North Carolina, USA.

View Article and Find Full Text PDF
February 2011

Comparison of gene expression patterns between avian and human ovarian cancers.

Authors:
Jesus Gonzalez Bosquet Abraham Peedicayil Jacie Maguire Jeremy Chien Gustavo C Rodriguez Regina Whitaker James N Petitte Kenneth E Anderson H John Barnes Viji Shridhar William A Cliby

Gynecol Oncol 2011 Feb 19;120(2):256-64. Epub 2010 Nov 19.

Gynecologic Oncology, Department of Women's Oncology, Moffitt Cancer and Research Center, Tampa, FL 33612, USA.

View Article and Find Full Text PDF
February 2011

Minichromosome maintenance protein 7 as a potential prognostic factor for progression-free survival in high-grade serous carcinomas of the ovary.

Authors:
Takayo Ota Amy C Clayton Douglas M Minot Viji Shridhar Lynn C Hartmann C Blake Gilks Jeremy R Chien

Mod Pathol 2011 Feb 12;24(2):277-87. Epub 2010 Nov 12.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

View Article and Find Full Text PDF
February 2011

The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein.

Authors:
Mara Campioni Anna Severino Lucrezia Manente Ioana L Tuduce Stefano Toldo Michele Caraglia Stefania Crispi Michael Ehrmann Xiaoping He Jacie Maguire Maria De Falco Antonio De Luca Viji Shridhar Alfonso Baldi

Mol Cancer Res 2010 Sep 29;8(9):1248-60. Epub 2010 Jul 29.

Department of Biochemistry, Section of Pathology, Second University of Naples, Via L. Armanni 5, 80138 Naples, Italy.

View Article and Find Full Text PDF
September 2010

Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells.

Authors:
Xiaoping He Takayo Ota Peng Liu Changqing Su Jeremy Chien Viji Shridhar

Cancer Res 2010 Apr 13;70(8):3109-18. Epub 2010 Apr 13.

Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

View Article and Find Full Text PDF
April 2010

High temperature requirement A3 (HtrA3) promotes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell lines.

Authors:
Daniah Beleford Ramandeep Rattan Jeremy Chien Viji Shridhar

J Biol Chem 2010 Apr 12;285(16):12011-27. Epub 2010 Feb 12.

Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

View Article and Find Full Text PDF
April 2010

Methylation induced gene silencing of HtrA3 in smoking-related lung cancer.

Authors:
Daniah Beleford Zhixue Liu Ramandeep Rattan Lucio Quagliuolo Mariarosaria Boccellino Alfonso Baldi Jacie Maguire Julie Staub Julian Molina Viji Shridhar

Clin Cancer Res 2010 Jan 12;16(2):398-409. Epub 2010 Jan 12.

Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

View Article and Find Full Text PDF
January 2010

HtrA serine proteases as potential therapeutic targets in cancer.

Authors:
Jeremy Chien Mara Campioni Viji Shridhar Alfonso Baldi

Curr Cancer Drug Targets 2009 Jun;9(4):451-68

Department Biochemistry, Sect. Pathology, Via L. Armanni, 5, 80138 Naples, Italy.

View Article and Find Full Text PDF
June 2009

Regulation of HSulf-1 expression by variant hepatic nuclear factor 1 in ovarian cancer.

Authors:
Peng Liu Ashwani Khurana Ramandeep Rattan Xiaoping He Steve Kalloger Sean Dowdy Blake Gilks Viji Shridhar

Cancer Res 2009 Jun;69(11):4843-50

Departments of Experimental Pathology, University of British Columbia, Vancouver, British Columbia, Canada.

View Article and Find Full Text PDF
June 2009

Serine protease HtrA1 associates with microtubules and inhibits cell migration.

Authors:
Jeremy Chien Takayo Ota Giovanni Aletti Ravi Shridhar Mariarosaria Boccellino Lucio Quagliuolo Alfonso Baldi Viji Shridhar

Mol Cell Biol 2009 Aug 26;29(15):4177-87. Epub 2009 May 26.

Experimental Pathology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
August 2009

Analysis of gene expression in stage I serous tumors identifies critical pathways altered in ovarian cancer.

Authors:
Jeremy Chien Jian-Bing Fan Debra A Bell Craig April Brandy Klotzle Takayo Ota Wilma L Lingle Jesus Gonzalez Bosquet Viji Shridhar Lynn C Hartmann

Gynecol Oncol 2009 Jul 1;114(1):3-11. Epub 2009 May 1.

Division of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
July 2009

Additive effect of apicidin and doxorubicin in sulfatase 1 expressing hepatocellular carcinoma in vitro and in vivo.

Authors:
Jin-Ping Lai Dalbir S Sandhu Catherine D Moser Sophie C Cazanave Abdul M Oseini Abdirashid M Shire Viji Shridhar Schuyler O Sanderson Lewis R Roberts

J Hepatol 2009 Jun 9;50(6):1112-21. Epub 2009 Mar 9.

Miles and Shirley Fiterman Center for Digestive Diseases, College of Medicine, Mayo Clinic and Mayo Clinic Cancer Center, 200 First Street SW, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
June 2009

Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening.

Authors:
Jeremy Chien Xiaoping He Viji Shridhar

J Cell Biochem 2009 May;107(2):253-63

Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

View Article and Find Full Text PDF
May 2009

Role of hedgehog signaling in ovarian cancer.

Authors:
Resham Bhattacharya Junhye Kwon Bushra Ali Enfeng Wang Sujata Patra Viji Shridhar Priyabrata Mukherjee

Clin Cancer Res 2008 Dec;14(23):7659-66

Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

View Article and Find Full Text PDF
December 2008

The serine protease HtrA1 is a novel prognostic factor for human mesothelioma.

Authors:
Alfonso Baldi Marcella Mottolese Bruno Vincenzi Mara Campioni Pasquale Mellone Mariapia Di Marino Vincenzo G di Crescenzo Paolo Visca Simona Menegozzo Enrico P Spugnini Gennaro Citro Anna Ceribelli Alessandra Mirri Jeremy Chien Viji Shridhar Michael Ehrmann Mario Santini Francesco Facciolo

Pharmacogenomics 2008 Aug;9(8):1069-77

Department of Biochemistry and Biophysics, Section of Pathology, Second University of Naples, Via L Armanni 5, 80138 Naples, Italy.

View Article and Find Full Text PDF
August 2008

Elevated expression of serine protease HtrA1 in preeclampsia and its role in trophoblast cell migration and invasion.

Authors:
Funminiyi Ajayi Nicholas Kongoasa Thomas Gaffey Yan W Asmann William J Watson Alfonso Baldi Peeyush Lala Viji Shridhar Brian Brost Jeremy Chien

Am J Obstet Gynecol 2008 Nov 29;199(5):557.e1-10. Epub 2008 Jul 29.

Department of Obstetrics, The Ohio State University Medical Center, Columbus, OH, USA.

View Article and Find Full Text PDF
November 2008

Molecular pathogenesis and therapeutic targets in epithelial ovarian cancer.

Authors:
Jeremy R Chien Giovanni Aletti Debra A Bell Gary L Keeney Viji Shridhar Lynn C Hartmann

J Cell Biochem 2007 Dec;102(5):1117-29

Department of Experimental Pathology, Mayo Clinic, Rochester, Minnesota, USA.

View Article and Find Full Text PDF
December 2007

Loss of HSulf-1 expression enhances autocrine signaling mediated by amphiregulin in breast cancer.

Authors:
Keishi Narita Jeremy Chien Sally A Mullany Julie Staub Xiang Qian Wilma L Lingle Viji Shridhar

J Biol Chem 2007 May 15;282(19):14413-20. Epub 2007 Mar 15.

Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic Cancer Center, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
May 2007

Truncating variants in p53AIP1 disrupting DNA damage-induced apoptosis are associated with prostate cancer risk.

Authors:
Xianshu Wang Fengwei Wang Ken Taniguchi Ratnam S Seelan Liang Wang Katherine E Zarfas Shannon K McDonnell Chiping Qian Kaifeng Pan Youyong Lu Viji Shridhar Fergus J Couch Donald J Tindall Jennifer L Beebe-Dimmer Kathleen A Cooney William B Isaacs Steven J Jacobsen Daniel J Schaid Stephen N Thibodeau Wanguo Liu

Cancer Res 2006 Nov;66(21):10302-7

Department of Laboratory Medicine, Mayo Clinic/Mayo Clinical Medical College, Rochester, Minnesota 55905, USA.

View Article and Find Full Text PDF
November 2006

Piroxicam and cisplatin in a mouse model of peritoneal mesothelioma.

Authors:
Enrico P Spugnini Irene Cardillo Alessandra Verdina Stefania Crispi Silvia Saviozzi Raffaele Calogero Angela Nebbioso Lucia Altucci Giancarlo Cortese Rossella Galati Jeremy Chien Viji Shridhar Bruno Vincenzi Gennaro Citro Francesco Cognetti Ada Sacchi Alfonso Baldi

Clin Cancer Res 2006 Oct;12(20 Pt 1):6133-43

SAFU Department, CRS, Regina Elena Cancer Institute, Rome, Italy.

View Article and Find Full Text PDF
October 2006

A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.

Authors:
Zhenglin Yang Nicola J Camp Hui Sun Zongzhong Tong Daniel Gibbs D Joshua Cameron Haoyu Chen Yu Zhao Erik Pearson Xi Li Jeremy Chien Andrew Dewan Jennifer Harmon Paul S Bernstein Viji Shridhar Norman A Zabriskie Josephine Hoh Kimberly Howes Kang Zhang

Science 2006 Nov 19;314(5801):992-3. Epub 2006 Oct 19.

Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

View Article and Find Full Text PDF
November 2006

DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding protein.

Authors:
Xianshu Wang Li Zheng Zhaozhu Zeng Guangjin Zhou Jeremy Chien Chiping Qian George Vasmatzis Viji Shridhar Lin Chen Wanguo Liu

Biochem Biophys Res Commun 2006 Aug 19;347(1):22-30. Epub 2006 Jun 19.

Department of Laboratory Medicine and Pathology, Mayo Clinic/Mayo Medical School, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
August 2006

HSulf-1 inhibits angiogenesis and tumorigenesis in vivo.

Authors:
Keishi Narita Julie Staub Jeremy Chien Kristy Meyer Maret Bauer Andreas Friedl Sundaram Ramakrishnan Viji Shridhar

Cancer Res 2006 Jun;66(12):6025-32

Department of Experimental Pathology, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA.

View Article and Find Full Text PDF
June 2006

Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity.

Authors:
Jeremy Chien Giovanni Aletti Alfonso Baldi Vincenzo Catalano Pietro Muretto Gary L Keeney Kimberly R Kalli Julie Staub Michael Ehrmann William A Cliby Yean Kit Lee Keith C Bible Lynn C Hartmann Scott H Kaufmann Viji Shridhar

J Clin Invest 2006 Jul 8;116(7):1994-2004. Epub 2006 Jun 8.

Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA, Medical Oncology Unit and Department of Histopathology, San Salvatore Hospital, Pesaro, Italy.

View Article and Find Full Text PDF
July 2006

SULF1 inhibits tumor growth and potentiates the effects of histone deacetylase inhibitors in hepatocellular carcinoma.

Authors:
Jin-Ping Lai Chunrong Yu Catherine D Moser Ileana Aderca Tao Han Thomas D Garvey Linda M Murphy Megan M Garrity-Park Viji Shridhar Alex A Adjei Lewis R Roberts

Gastroenterology 2006 Jun;130(7):2130-44

Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

View Article and Find Full Text PDF
June 2006

Heterozygous ATR mutations in mismatch repair-deficient cancer cells have functional significance.

Authors:
Kriste A Lewis Sally Mullany Bijoy Thomas Jeremy Chien Ralitsa Loewen Viji Shridhar William A Cliby

Cancer Res 2005 Aug;65(16):7091-5

Department of Obstetrics and Gynecology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

View Article and Find Full Text PDF
August 2005

Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines.

Authors:
Sean C Dowdy Bobbie S Gostout Viji Shridhar Xiaosheng Wu David I Smith Karl C Podratz Shi-Wen Jiang

Gynecol Oncol 2005 Oct;99(1):126-34

Department of Obstetrics and Gynecology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
October 2005

Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer.

Authors:
Jeremy Chien Julie Staub Rajeswari Avula Heyu Zhang Wanguo Liu Lynn C Hartmann Scott H Kaufmann David I Smith Viji Shridhar

Oncogene 2005 Jul;24(32):5089-100

Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic/Foundation, 200 First Street, SW Rochester, MN 55905, USA.

View Article and Find Full Text PDF
July 2005

Implications of the serine protease HtrA1 in amyloid precursor protein processing.

Authors:
Sandra Grau Alfonso Baldi Rossana Bussani Xiaodan Tian Raluca Stefanescu Michael Przybylski Peter Richards Simon A Jones Viji Shridhar Tim Clausen Michael Ehrmann

Proc Natl Acad Sci U S A 2005 Apr;102(17):6021-6

School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom.

View Article and Find Full Text PDF
April 2005

Gene expression profiles predict early relapse in ovarian cancer after platinum-paclitaxel chemotherapy.

Authors:
Lynn C Hartmann Karen H Lu Gerald P Linette William A Cliby Kimberly R Kalli David Gershenson Robert C Bast James Stec Natalia Iartchouk David I Smith Jeffrey S Ross Sebastian Hoersch Viji Shridhar James Lillie Scott H Kaufmann Edwin A Clark Andrew I Damokosh

Clin Cancer Res 2005 Mar;11(6):2149-55

Mayo Clinic Cancer Center, 200 First Street Southwest, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
March 2005

Pattern of expression of HtrA1 during mouse development.

Authors:
Antonio De Luca Maria De Falco Luca De Luca Roberta Penta Viji Shridhar Feliciano Baldi Mara Campioni Marco G Paggi Alfonso Baldi

J Histochem Cytochem 2004 Dec;52(12):1609-17

Department of Medicine and Public Health, Section of Clinical Anatomy, Second University of Naples, Naples, Italy.

View Article and Find Full Text PDF
December 2004

Parkin gene alterations in hepatocellular carcinoma.

Authors:
Fang Wang Stacy Denison Jin-Ping Lai Leslie A Philips Damien Montoya Norman Kock Birgitt Schüle Christine Klein Viji Shridhar Lewis R Roberts David I Smith

Genes Chromosomes Cancer 2004 Jun;40(2):85-96

Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

View Article and Find Full Text PDF
June 2004

HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma.

Authors:
Jin-Ping Lai Jeremy Chien Scott E Strome Julie Staub Damian P Montoya Eddie L Greene David I Smith Lewis R Roberts Viji Shridhar

Oncogene 2004 Feb;23(7):1439-47

Division of Gastroenterology and Hepatology, Mayo Clinic Cancer Center, Mayo Clinic and Foundation, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
February 2004

A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer.

Authors:
Jeremy Chien Julie Staub Shou-Ih Hu Michele R Erickson-Johnson Fergus J Couch David I Smith Robert M Crowl Scott H Kaufmann Viji Shridhar

Oncogene 2004 Feb;23(8):1636-44

Mayo Clinic Cancer Center and Department of Experimental Pathology, Mayo Clinic, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
February 2004

Discovering novel phenotype-selective neurotrophic factors to treat neurodegenerative diseases.

Authors:
Penka S Petrova Andrei Raibekas Jonathan Pevsner Noel Vigo Mordechai Anafi Mary K Moore Amy Peaire Viji Shridhar David I Smith John Kelly Yves Durocher John W Commissiong

Prog Brain Res 2004 ;146:168-83

Prescient NeuroPharma Inc., Laboratories of Protein Chemistry, Molecular Biology and Cell Biology, Toronto, ON, Canada.

View Article and Find Full Text PDF
February 2004

hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling.

Authors:
Jin-Ping Lai Jeremy R Chien David R Moser Julie K Staub Ileana Aderca Damian P Montoya Tori A Matthews David M Nagorney Julie M Cunningham David I Smith Eddie L Greene Viji Shridhar Lewis R Roberts

Gastroenterology 2004 Jan;126(1):231-48

Division of Gastroenterology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
January 2004

MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons.

Authors:
Penka Petrova Andrei Raibekas Jonathan Pevsner Noel Vigo Mordechai Anafi Mary K Moore Amy E Peaire Viji Shridhar David I Smith John Kelly Yves Durocher John W Commissiong

J Mol Neurosci 2003 Apr;20(2):173-88

Laboratories of Protein Chemistry, Molecular Biology & Cell Biology, Prescient NeuroPharma Inc., 96 Skyway Avenue, Toronto, Ontario, Canada M9W 4Y9.

View Article and Find Full Text PDF
April 2003

Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer.

Authors:
Jinping Lai Jeremy Chien Julie Staub Rajeswari Avula Eddie L Greene Tori A Matthews David I Smith Scott H Kaufmann Lewis R Roberts Viji Shridhar

J Biol Chem 2003 Jun 9;278(25):23107-17. Epub 2003 Apr 9.

Mayo Clinic Cancer Center, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

View Article and Find Full Text PDF
June 2003

Characterization of the common fragile site FRA9E and its potential role in ovarian cancer.

Authors:
Gwen Callahan Stacy R Denison Leslie A Phillips Viji Shridhar David I Smith

Oncogene 2003 Jan;22(4):590-601

Tumor Biology Program, Mayo Graduate School, Mayo Foundation, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
January 2003

Transcriptional profiling reveals that several common fragile-site genes are downregulated in ovarian cancer.

Authors:
Stacy R Denison Nicole A Becker Matthew J Ferber Leslie A Phillips Kimberly R Kalli John Lee Jim Lillie David I Smith Viji Shridhar

Genes Chromosomes Cancer 2002 Aug;34(4):406-15

Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA.

View Article and Find Full Text PDF
August 2002

Identification of underexpressed genes in early- and late-stage primary ovarian tumors by suppression subtraction hybridization.

Authors:
Viji Shridhar Ami Sen Jeremy Chien Julie Staub Rajeswari Avula Steve Kovats John Lee Jim Lillie David I Smith

Cancer Res 2002 Jan;62(1):262-70

Department of Experimental Pathology, Division of Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

View Article and Find Full Text PDF
January 2002

Early detection of ovarian cancer: promise and reality.

Authors:
Robert C Bast Nicole Urban Viji Shridhar David Smith Zhen Zhang Steven Skates Karen Lu Jinsong Liu David Fishman Gordon Mills

Cancer Treat Res 2002 ;107:61-97

Departments of Experimental Therapeutics, Molecular Therapeutics, Gynecologic Oncology and Anatomic Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

View Article and Find Full Text PDF
April 2002