Publications by authors named "Vijay Ramaswamy"

100Publications

Outcomes of BRAF V600E Pediatric Gliomas Treated With Targeted BRAF Inhibition.

JCO Precis Oncol 2020 20;4. Epub 2020 May 20.

Department of Hematology and Oncology, Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1200/PO.19.00298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446502PMC
May 2020

Neurotrophin Signaling in Medulloblastoma.

Cancers (Basel) 2020 Sep 7;12(9). Epub 2020 Sep 7.

Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil.

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http://dx.doi.org/10.3390/cancers12092542DOI Listing
September 2020

Causes of death in pediatric neuro-oncology: the sickkids experience from 2000 to 2017.

J Neurooncol 2020 Aug 14;149(1):181-189. Epub 2020 Aug 14.

Division of Hematology/Oncology, the Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1007/s11060-020-03590-wDOI Listing
August 2020

Radiation-induced intracranial aneurysm presenting with acute hemorrhage in a child treated for medulloblastoma.

Childs Nerv Syst 2020 Aug 9. Epub 2020 Aug 9.

Department of Diagnostic Imaging, Division of Neuroradiology, The Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, ON, M5G 1X8, Canada.

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http://dx.doi.org/10.1007/s00381-020-04853-7DOI Listing
August 2020

Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.

Cell 2020 Jun 22;181(6):1329-1345.e24. Epub 2020 May 22.

The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.04.047DOI Listing
June 2020

Advances in the molecular classification of pediatric brain tumors: a guide to the galaxy.

J Pathol 2020 Jul 10;251(3):249-261. Epub 2020 Jun 10.

Division of Haematology/Oncology, Department of Pediatrics, University of Toronto and The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/path.5457DOI Listing
July 2020

Reply to S.A. Milgrom et al.

J Clin Oncol 2020 Jul 6;38(19):2212-2213. Epub 2020 May 6.

Lisa S. Kahalley, PhD, Department of Pediatrics, Section of Psychology, Baylor College of Medicine, Houston, TX; Rachel Peterson, PhD, Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada; M. Douglas Ris, PhD, Department of Pediatrics, Section of Psychology, Baylor College of Medicine, Houston, TX; Laura Janzen, PhD, Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada; M. Fatih Okcu, MPH, MD, Department of Pediatrics, Section of Hematology Oncology, Baylor College of Medicine, Houston, TX; David R. Grosshans, MD, PhD, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX; Vijay Ramaswamy, MD, PhD, Division of Haematology/Oncology, The Hospital for Sick Children, and Department of Paediatrics, The University of Toronto, Toronto, Ontario, Canada; Arnold C. Paulino, MD, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX; David Hodgson, MPH, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Anita Mahajan, MD, Department of Radiation Oncology, The Mayo Clinic, Rochester, MN; Derek S. Tsang, MSc, MD and Normand Laperriere, MD, Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; WilliamE. Whitehead, MPH, MD and Robert C.Dauser, MD, Department of Neurosurgery, Division of Pediatric Neurosurgery, Baylor College of Medicine, Houston, TX; Michael D. Taylor, MD, PhD, Division of Neurosurgery, The Hospital for Sick Children, and Department of Surgery, The University of Toronto, Toronto, Ontario, Canada; Eric Bouffet, MD, Division of Haematology/Oncology, The Hospital for Sick Children, and Department of Paediatrics, The University of Toronto, Toronto, Ontario, Canada; Murali Chintagumpala, MD, Department of Pediatrics, Section of Hematology Oncology, Baylor College of Medicine, Houston, TX; and Donald Mabbott, PhD, Program in Neurosciences and Mental Health, Research Institute, The Hospital for Sick Children, and Department of Psychology, The University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.20.00344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325365PMC
July 2020

Bevacizumab for NF2-associated vestibular schwannomas of childhood and adolescence.

Pediatr Blood Cancer 2020 05 2;67(5):e28228. Epub 2020 Mar 2.

Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.28228DOI Listing
May 2020

HDAC and MAPK/ERK Inhibitors Cooperate To Reduce Viability and Stemness in Medulloblastoma.

J Mol Neurosci 2020 Jun 13;70(6):981-992. Epub 2020 Feb 13.

Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.

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http://dx.doi.org/10.1007/s12031-020-01505-yDOI Listing
June 2020

Immunohistochemical and nanoString-Based Subgrouping of Clinical Medulloblastoma Samples.

J Neuropathol Exp Neurol 2020 Apr;79(4):437-447

Division of Pathology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/jnen/nlaa005DOI Listing
April 2020

The molecular biology of medulloblastoma metastasis.

Brain Pathol 2020 05 15;30(3):691-702. Epub 2020 Jan 15.

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/bpa.12811DOI Listing
May 2020

Minimizing General Anesthetic Use in Pediatric Radiation Therapy.

Pract Radiat Oncol 2020 May - Jun;10(3):e159-e165. Epub 2019 Dec 10.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.prro.2019.12.001DOI Listing
December 2019

Indolent course of brainstem tumors with K27M-H3.3 mutation.

Pediatr Blood Cancer 2020 03 2;67(3):e28102. Epub 2019 Dec 2.

Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/pbc.28102DOI Listing
March 2020

Less treatment for Wing less medulloblastoma: germline data re-emphasize this.

Neuro Oncol 2020 01;22(1):7-9

Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/neuonc/noz213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954387PMC
January 2020

Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma.

Nature 2019 10 9;574(7780):707-711. Epub 2019 Oct 9.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41586-019-1650-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141958PMC
October 2019

Re-irradiation for children with recurrent medulloblastoma in Toronto, Canada: a 20-year experience.

J Neurooncol 2019 Oct 29;145(1):107-114. Epub 2019 Aug 29.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1007/s11060-019-03272-2DOI Listing
October 2019

Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma.

Front Pharmacol 2019 26;10:698. Epub 2019 Jun 26.

Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

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http://dx.doi.org/10.3389/fphar.2019.00698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606946PMC
June 2019

Repeat irradiation for children with supratentorial high-grade glioma.

Pediatr Blood Cancer 2019 09 17;66(9):e27881. Epub 2019 Jun 17.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.27881DOI Listing
September 2019

Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma.

BMC Cancer 2019 Jun 11;19(1):571. Epub 2019 Jun 11.

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1186/s12885-019-5742-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560914PMC
June 2019

Redefining Ventricular Target Volume in Germinoma: Is Inclusion of Temporal Horns Necessary?

Int J Radiat Oncol Biol Phys 2019 07 30;104(4):852-858. Epub 2019 Mar 30.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03603016193056
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http://dx.doi.org/10.1016/j.ijrobp.2019.03.039DOI Listing
July 2019

Effective and safe tumor inhibition using vinblastine in medulloblastoma.

Pediatr Blood Cancer 2019 06 8;66(6):e27694. Epub 2019 Mar 8.

Programme in Developmental and Stem Cell Biology, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.27694DOI Listing
June 2019

Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors.

Acta Neuropathol Commun 2018 12 4;6(1):134. Epub 2018 Dec 4.

Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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https://actaneurocomms.biomedcentral.com/articles/10.1186/s4
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http://dx.doi.org/10.1186/s40478-018-0630-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278135PMC
December 2018

Pediatric Brain Tumor Genetics: What Radiologists Need to Know.

Radiographics 2018 Nov-Dec;38(7):2102-2122

From the Departments of Diagnostic Imaging (J.A., W.M.), Neurooncology (M.Z., V.R.), and Pediatric Neuroradiology (H.B., C.R., S.L.), The Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, ON, Canada M5G 1X8; and Departments of Diagnostic Imaging (J.A., P.H.) and Pediatric Interventional Radiology (W.M.), Sidra Medical and Research Center, Doha, Ad Dawhah, Qatar.

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http://dx.doi.org/10.1148/rg.2018180109DOI Listing
September 2019

Bioinformatic Strategies for the Genomic and Epigenomic Characterization of Brain Tumors.

Methods Mol Biol 2019 ;1869:37-56

Division of Neurosurgery, Hospital for Sick Children, Toronto, ON, Canada.

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http://link.springer.com/10.1007/978-1-4939-8805-1_4
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http://dx.doi.org/10.1007/978-1-4939-8805-1_4DOI Listing
May 2019

Clinical and pre-clinical utility of genomics in medulloblastoma.

Expert Rev Neurother 2018 08 26;18(8):633-647. Epub 2018 Jul 26.

b Labatt Brain Tumour Research Centre , Hospital for Sick Children , Toronto , ON , Canada.

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http://dx.doi.org/10.1080/14737175.2018.1503536DOI Listing
August 2018

Infant medulloblastoma - learning new lessons from old strata.

Nat Rev Clin Oncol 2018 11;15(11):659-660

Division of Haematology/Oncology, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.

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http://www.nature.com/articles/s41571-018-0071-6
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http://dx.doi.org/10.1038/s41571-018-0071-6DOI Listing
November 2018

CD271 Cells Are Diagnostic and Prognostic and Exhibit Elevated MAPK Activity in SHH Medulloblastoma.

Cancer Res 2018 08 21;78(16):4745-4759. Epub 2018 Jun 21.

Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0027DOI Listing
August 2018

The clinical importance of medulloblastoma extent of resection: a systematic review.

J Neurooncol 2018 Sep 23;139(3):523-539. Epub 2018 May 23.

Division of Haematology/Oncology, The Arthur and Sonia Labatt Brain Tumour Research Centre, Programme in Neuroscience and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s11060-018-2906-5DOI Listing
September 2018

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

Lancet Oncol 2018 06 9;19(6):785-798. Epub 2018 May 9.

Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183024
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http://dx.doi.org/10.1016/S1470-2045(18)30242-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984248PMC
June 2018

CAR T cells for childhood diffuse midline gliomas.

Nat Med 2018 05;24(5):534-535

Division of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41591-018-0031-9DOI Listing
May 2018

Medulloblastoma: From Molecular Subgroups to Molecular Targeted Therapies.

Annu Rev Neurosci 2018 07 11;41:207-232. Epub 2018 Apr 11.

Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA; email:

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http://dx.doi.org/10.1146/annurev-neuro-070815-013838DOI Listing
July 2018

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.

Cell 2018 02;172(5):1050-1062.e14

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.01.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346737PMC
February 2018

Review of molecular classification and treatment implications of pediatric brain tumors.

Curr Opin Pediatr 2018 02;30(1):3-9

The Arthur and Sonia Labatt Brain Tumour Research Centre and the Developmental & Stem Cell Biology Program, The Hospital for Sick Children.

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http://dx.doi.org/10.1097/MOP.0000000000000562DOI Listing
February 2018

Erratum. Differential patterns of metastatic dissemination across medulloblastoma subgroups.

Authors:
Vijay Ramaswamy

J Neurosurg Pediatr 2018 03 5;21(3):336. Epub 2018 Jan 5.

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http://dx.doi.org/10.3171/2017.12.PEDS17264aDOI Listing
March 2018

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.

Nature 2018 01 20;553(7686):101-105. Epub 2017 Dec 20.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nature25169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993422PMC
January 2018

Pontine Infantile Glioma Simplified.

Cancer Cell 2017 11;32(5):548-549

Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.10.013DOI Listing
November 2017

Comprehensive Analysis of Hypermutation in Human Cancer.

Cell 2017 Nov 19;171(5):1042-1056.e10. Epub 2017 Oct 19.

Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849393PMC
November 2017

Adolescents and young adults with brain tumors in the context of molecular advances in neuro-oncology.

Pediatr Blood Cancer 2018 Feb 19;65(2). Epub 2017 Oct 19.

Division of Hematology/Oncology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/pbc.26861DOI Listing
February 2018

Cancer: Drain the swamp to beat glioma.

Nature 2017 09 20;549(7673):460-461. Epub 2017 Sep 20.

Division of Neurosurgery and Vijay Ramaswamy is in the Division of Haematology/Oncology and the Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1038/nature24141DOI Listing
September 2017

Integrating RNA sequencing into neuro-oncology practice.

Transl Res 2017 11 8;189:93-104. Epub 2017 Jul 8.

Department of Pediatrics, University of Michigan School of Medicine, Ann Arbor, Mich. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19315244173022
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http://dx.doi.org/10.1016/j.trsl.2017.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659901PMC
November 2017

Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas.

J Clin Oncol 2017 Sep 20;35(25):2934-2941. Epub 2017 Jul 20.

Alvaro Lassaletta, Michal Zapotocky, Matthew Mistry, Vijay Ramaswamy, Marion Honnorat, Rahul Krishnatry, Ana Guerreiro Stucklin, Nataliya Zhukova, Anthony Arnoldo, Scott Ryall, Catriona Ling, Tara McKeown, Jim Loukides, James T. Rutka, Peter Dirks, Michael D. Taylor, Shiyi Chen, Ute Bartels, Annie Huang, Eric Bouffet, Cynthia Hawkins, and Uri Tabori, The Hospital for Sick Children, Toronto; Adam Fleming, McMaster Children's Hospital, McMaster University, Hamilton; Shayna Zelcer, Children's Hospital of Western Ontario, London, Ontario; David Eisenstat and Bev Wilson, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta; Anne Sophie Carret, Hospital Sainte Justine; Nada Jabado, McGill University, Montreal; Valerie Larouche, Centre Hospitalier Universitaire de Québec, Québec City, Quebec, Canada; Ofelia Cruz and Carmen de Torres, Hospital Sant Joan de Déu, Barcelona, Spain; Cheng-Ying Ho, University of Maryland School of Medicine, Baltimore, MD; Roger J. Packer, Children's National Health System, Washington, DC; Ruth Tatevossian, Ibrahim Qaddoumi, Julie H. Harreld, James D. Dalton, and David W. Ellison, St Jude Children's Research Hospital, Memphis, TN; Jean Mulcahy-Levy and Nicholas Foreman, Children's Hospital Colorado, Aurora, CO; Matthias A. Karajannis, Shiyang Wang, and Matija Snuderl, New York University Langone Medical Center, New York, NY; Amulya Nageswara Rao and Caterina Giannini, The Mayo Clinic, Rochester, MN; Mark Kieran and Keith L. Ligon, Dana-Farber Cancer Institute, Boston Children's Hospital, Boston, MA; Maria Luisa Garre, Paolo Nozza, Samantha Mascelli, and Alessandro Raso, Istituto Giannina Gaslini, Genoa, Italy; Sabine Mueller and Theodore Nicolaides, University of California, San Francisco, San Francisco, CA; Karen Silva and Romain Perbet, Hospices Civils de Lyon; Alexandre Vasiljevic, Cécile Faure Conter, and Didier Frappaz, Institute of Pediatric Hematology and Oncology, Lyon, France; Sarah Leary and Courtney Crane, Seattle Children's Hospital, Seattle, WA; Aden Chan and Ho-Keung Ng, The Chinese University of Hong Kong, Hong Kong; Zhi-Feng Shi and Ying Mao, Huashan Hospital, Fudan University, Shanghai, People's Republic of China; Elizabeth Finch, University of North Carolina, School of Medicine, Chapel Hill, NC; Peter Hauser, Semmelweis University, Budapest, Hungary; and David Sumerauer and Lenka Krskova, University Hospital Motol, Charles University, 2nd Medical School, Prague, Czech Republic.

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http://dx.doi.org/10.1200/JCO.2016.71.8726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791837PMC
September 2017

The whole-genome landscape of medulloblastoma subtypes.

Nature 2017 07;547(7663):311-317

Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature22973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905700PMC
July 2017

Medulloblastoma: From Myth to Molecular.

J Clin Oncol 2017 Jul 22;35(21):2355-2363. Epub 2017 Jun 22.

All authors: Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2017.72.7842DOI Listing
July 2017

H3 K27M mutations are extremely rare in posterior fossa group A ependymoma.

Childs Nerv Syst 2017 Jul 16;33(7):1047-1051. Epub 2017 Jun 16.

Division of Haematology/Oncology, Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, ON, M5G 1X8, Canada.

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http://dx.doi.org/10.1007/s00381-017-3481-3DOI Listing
July 2017

Intertumoral Heterogeneity within Medulloblastoma Subgroups.

Authors:
Florence M G Cavalli Marc Remke Ladislav Rampasek John Peacock David J H Shih Betty Luu Livia Garzia Jonathon Torchia Carolina Nor A Sorana Morrissy Sameer Agnihotri Yuan Yao Thompson Claudia M Kuzan-Fischer Hamza Farooq Keren Isaev Craig Daniels Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Ji Yeoun Lee Wieslawa A Grajkowska Marta Perek-Polnik Alexandre Vasiljevic Cecile Faure-Conter Anne Jouvet Caterina Giannini Amulya A Nageswara Rao Kay Ka Wai Li Ho-Keung Ng Charles G Eberhart Ian F Pollack Ronald L Hamilton G Yancey Gillespie James M Olson Sarah Leary William A Weiss Boleslaw Lach Lola B Chambless Reid C Thompson Michael K Cooper Rajeev Vibhakar Peter Hauser Marie-Lise C van Veelen Johan M Kros Pim J French Young Shin Ra Toshihiro Kumabe Enrique López-Aguilar Karel Zitterbart Jaroslav Sterba Gaetano Finocchiaro Maura Massimino Erwin G Van Meir Satoru Osuka Tomoko Shofuda Almos Klekner Massimo Zollo Jeffrey R Leonard Joshua B Rubin Nada Jabado Steffen Albrecht Jaume Mora Timothy E Van Meter Shin Jung Andrew S Moore Andrew R Hallahan Jennifer A Chan Daniela P C Tirapelli Carlos G Carlotti Maryam Fouladi José Pimentel Claudia C Faria Ali G Saad Luca Massimi Linda M Liau Helen Wheeler Hideo Nakamura Samer K Elbabaa Mario Perezpeña-Diazconti Fernando Chico Ponce de León Shenandoah Robinson Michal Zapotocky Alvaro Lassaletta Annie Huang Cynthia E Hawkins Uri Tabori Eric Bouffet Ute Bartels Peter B Dirks James T Rutka Gary D Bader Jüri Reimand Anna Goldenberg Vijay Ramaswamy Michael D Taylor

Cancer Cell 2017 06;31(6):737-754.e6

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163053PMC
June 2017

miR miR on the wall, who's the most malignant medulloblastoma miR of them all?

Neuro Oncol 2018 02;20(3):313-323

Developmental & Stem Cell Biology Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/neuonc/nox106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817951PMC
February 2018

Can telomerase activity be unleashed to refine prognosis within ependymoma subgroups?

Neuro Oncol 2017 09;19(9):1149-1151

Division of Haematology/Oncology, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada; Department of Pediatric Hematology and Oncology, 2nd School of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic; Programme in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/neuonc/nox059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570248PMC
September 2017

The role of angiogenesis in Group 3 medulloblastoma pathogenesis and survival.

Neuro Oncol 2017 Sep;19(9):1217-1227

Department of Neurosurgery, Duke University, Durham, North Carolina; Preston Robert Tisch Brain Tumor Center, Duke University, Durham, North Carolina; Brain Imaging and Analysis Center, Duke University, Durham, North Carolina; Department of Radiology, Duke University, Durham, North Carolina; Department of Radiology, Stanford University, Palo Alto, California; Department of Medicine, Duke University, Durham, North Carolina; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany; and Department of Pediatric Neuro-Oncogenomics, German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany; Department of Pathology, Duke University, Durham, North Carolina; Division of Haematology/Oncology, the Arthur and Sonia Labatt Brain Tumour Research Centre, Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada; Division of Neurosurgery, the Arthur and Sonia Labatt Brain Tumour Research Centre, Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/neuonc/nox033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570262PMC
September 2017

The clinical significance of equivocal findings on spinal MRI in children with medulloblastoma.

Pediatr Blood Cancer 2017 Aug 16;64(8). Epub 2017 Feb 16.

Division of Hematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.26472DOI Listing
August 2017

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Authors:
Jonathon Torchia Brian Golbourn Shengrui Feng King Ching Ho Patrick Sin-Chan Alexandre Vasiljevic Joseph D Norman Paul Guilhamon Livia Garzia Natalia R Agamez Mei Lu Tiffany S Chan Daniel Picard Pasqualino de Antonellis Dong-Anh Khuong-Quang Aline C Planello Constanze Zeller Dalia Barsyte-Lovejoy Lucie Lafay-Cousin Louis Letourneau Mathieu Bourgey Man Yu Deena M A Gendoo Misko Dzamba Mark Barszczyk Tiago Medina Alexandra N Riemenschneider A Sorana Morrissy Young-Shin Ra Vijay Ramaswamy Marc Remke Christopher P Dunham Stephen Yip Ho-Keung Ng Jian-Qiang Lu Vivek Mehta Steffen Albrecht Jose Pimentel Jennifer A Chan Gino R Somers Claudia C Faria Lucia Roque Maryam Fouladi Lindsey M Hoffman Andrew S Moore Yin Wang Seung Ah Choi Jordan R Hansford Daniel Catchpoole Diane K Birks Nicholas K Foreman Doug Strother Almos Klekner Laszló Bognár Miklós Garami Péter Hauser Tibor Hortobágyi Beverly Wilson Juliette Hukin Anne-Sophie Carret Timothy E Van Meter Eugene I Hwang Amar Gajjar Shih-Hwa Chiou Hideo Nakamura Helen Toledano Iris Fried Daniel Fults Takafumi Wataya Chris Fryer David D Eisenstat Katrin Scheinemann Adam J Fleming Donna L Johnston Jean Michaud Shayna Zelcer Robert Hammond Samina Afzal David A Ramsay Nongnuch Sirachainan Suradej Hongeng Noppadol Larbcharoensub Richard G Grundy Rishi R Lulla Jason R Fangusaro Harriet Druker Ute Bartels Ronald Grant David Malkin C Jane McGlade Theodore Nicolaides Tarik Tihan Joanna Phillips Jacek Majewski Alexandre Montpetit Guillaume Bourque Gary D Bader Alyssa T Reddy G Yancey Gillespie Monika Warmuth-Metz Stefan Rutkowski Uri Tabori Mathieu Lupien Michael Brudno Ulrich Schüller Torsten Pietsch Alexander R Judkins Cynthia E Hawkins Eric Bouffet Seung-Ki Kim Peter B Dirks Michael D Taylor Anat Erdreich-Epstein Cheryl H Arrowsmith Daniel D De Carvalho James T Rutka Nada Jabado Annie Huang

Cancer Cell 2016 Dec;30(6):891-908

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500911PMC
December 2016

Current therapy and the evolving molecular landscape of paediatric ependymoma.

Eur J Cancer 2017 01 18;70:34-41. Epub 2016 Nov 18.

The Hospital for Sick Children, Division of Hematology/Oncology, 555 University Avenue, Toronto, ON M5G, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.10.013DOI Listing
January 2017

Treatment implications of posterior fossa ependymoma subgroups.

Chin J Cancer 2016 11 15;35(1):93. Epub 2016 Nov 15.

Division of Neurosurgery, Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.

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http://dx.doi.org/10.1186/s40880-016-0155-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111181PMC
November 2016