Publications by authors named "Vijay Gokhale"

49 Publications

Nucleolin represses transcription of the androgen receptor gene through a G-quadruplex.

Oncotarget 2020 May 12;11(19):1758-1776. Epub 2020 May 12.

University of Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA.

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May 2020

Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death.

Cell Chem Biol 2019 08 30;26(8):1110-1121.e4. Epub 2019 May 30.

University of Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85724, USA. Electronic address:

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August 2019

Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X.

Nucleic Acids Res 2018 01;46(2):886-896

Leicester Institute of Structural & Chemical Biology and Department of Molecular & Cell Biology, University of Leicester, Leicester LE1 7RH, UK.

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January 2018

Dyrk1 inhibition improves Alzheimer's disease-like pathology.

Aging Cell 2017 10 4;16(5):1146-1154. Epub 2017 Aug 4.

The Arizona State University-Banner Neurodegenerative Disease Research Center at the Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA.

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October 2017

A simple mathematical approach to the analysis of polypharmacology and polyspecificity data.

F1000Res 2017 6;6. Epub 2017 Jun 6.

BIO5 Institute, University of Arizona, 1657 East Helen Street, Tucson, AZ, 85719, USA.

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June 2017

Simultaneous Drug Targeting of the Promoter MYC G-Quadruplex and BCL2 i-Motif in Diffuse Large B-Cell Lymphoma Delays Tumor Growth.

J Med Chem 2017 08 25;60(15):6587-6597. Epub 2017 Jul 25.

Department of Pathology, University of Arizona , 1501 North Campbell Avenue, Tucson, Arizona 85724, United States.

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August 2017

TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors.

Oncotarget 2016 Apr;7(17):23715-29

Department of Medicine, Division of Hematology-Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.

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April 2016

Structure-Function Analysis of the Non-Muscle Myosin Light Chain Kinase (nmMLCK) Isoform by NMR Spectroscopy and Molecular Modeling: Influence of MYLK Variants.

PLoS One 2015 25;10(6):e0130515. Epub 2015 Jun 25.

Institute for Personalized Respiratory Medicine, Section of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois at Chicago, Chicago, Illinois, United States of America; Arizona Respiratory Center and Department of Medicine, University of Arizona, Tucson, Arizona, United States of America.

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March 2016

The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.

J Biol Chem 2015 Jan 4;290(3):1623-38. Epub 2014 Dec 4.

From the Department of Pharmacology and Toxicology, College of Pharmacy and Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724

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January 2015

Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?

ACS Chem Neurosci 2012 Nov 28;3(11):857-72. Epub 2012 Aug 28.

Department of Chemistry & Biochemistry, the University of Arizona, Tucson, Arizona 85721, United States; BIO5 Oro Valley, the University of Arizona, 1580 East Hanley Boulevard, Oro Valley, Arizona 85737, United States.

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November 2012

Redox-active magnetic resonance imaging contrast agents: studies with thiol-bearing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid derivatives.

J Med Chem 2012 Dec 28;55(23):10378-86. Epub 2012 Nov 28.

Department of Chemistry and Biochemistry, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85721-0041, United States.

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December 2012

Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells.

Bioorg Med Chem Lett 2012 May 28;22(10):3567-70. Epub 2012 Mar 28.

BIO5 Oro Valley, The University of Arizona, Oro Valley, AZ 85737, United States.

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May 2012

Tertiary DNA structure in the single-stranded hTERT promoter fragment unfolds and refolds by parallel pathways via cooperative or sequential events.

J Am Chem Soc 2012 Mar 9;134(11):5157-64. Epub 2012 Mar 9.

Department of Chemistry and Biochemistry and School of Biomedical Sciences, Kent State University, Kent, Ohio 44242, United States.

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March 2012
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