Publications by authors named "Vijay Gokhale"

49 Publications

An Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43 Yields Neuroprotective Properties.

Authors:
Niloufar Mollasalehi Liberty Francois-Moutal David D Scott Judith A Tello Haley Williams Brendan Mahoney Jacob M Carlson Yue Dong Xingli Li Victor G Miranda Vijay Gokhale Wei Wang Sami J Barmada May Khanna

ACS Chem Biol 2020 11 12;15(11):2854-2859. Epub 2020 Oct 12.

Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, United States.

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November 2020

Erratum: Nucleolin represses transcription of the androgen receptor gene through a G-quadruplex.

Authors:
Cindy K Miranti Sara Moore Yongeun Kim Venkateshwar Reddy Chappeta Kui Wu Biswanath De Vijay Gokhale Laurence H Hurley Elsa M Reyes-Reyes

Oncotarget 2020 Jun 30;11(26):2586. Epub 2020 Jun 30.

University of Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA.

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June 2020

Nucleolin represses transcription of the androgen receptor gene through a G-quadruplex.

Authors:
Cindy K Miranti Sara Moore Yongeun Kim Venkateshwar Reddy Chappeta Kui Wu Biswanath De Vijay Gokhale Laurence H Hurley Elsa M Reyes-Reyes

Oncotarget 2020 May 12;11(19):1758-1776. Epub 2020 May 12.

University of Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA.

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May 2020

In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells.

Authors:
Justin J Montoya Megan A Turnidge Daniel H Wai Apurvi R Patel David W Lee Vijay Gokhale Laurence H Hurley Robert J Arceci Cynthia Wetmore David O Azorsa

BMC Cancer 2019 Dec 27;19(1):1251. Epub 2019 Dec 27.

The Institute of Molecular Medicine at Phoenix Children's Hospital, 475 N 5th Street, Phoenix, AZ, 85004, USA.

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December 2019

Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Model of Amyotrophic Lateral Sclerosis (ALS).

Authors:
Liberty François-Moutal Razaz Felemban David D Scott Melissa R Sayegh Victor G Miranda Samantha Perez-Miller Rajesh Khanna Vijay Gokhale Daniela C Zarnescu May Khanna

ACS Chem Biol 2019 09 27;14(9):2006-2013. Epub 2019 Aug 27.

Department of Pharmacology, College of Medicine , University of Arizona , Tucson , Arizona 85724 , United States.

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September 2019

Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death.

Authors:
Jin H Song Hyun-Jin Kang Libia A Luevano Vijay Gokhale Kui Wu Ritu Pandey H-H Sherry Chow Laurence H Hurley Andrew S Kraft

Cell Chem Biol 2019 08 30;26(8):1110-1121.e4. Epub 2019 May 30.

University of Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85724, USA. Electronic address:

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August 2019

Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy.

Authors:
Rajesh Khanna Jie Yu Xiaofang Yang Aubin Moutal Aude Chefdeville Vijay Gokhale Zunaira Shuja Lindsey A Chew Shreya S Bellampalli Shizhen Luo Liberty François-Moutal Maria J Serafini Taehwan Ha Samantha Perez-Miller Ki Duk Park Amol M Patwardhan John M Streicher Henry M Colecraft May Khanna

Pain 2019 07;160(7):1644-1661

Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States.

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July 2019

A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).

Authors:
Liberty François-Moutal Shahriyar Jahanbakhsh Andrew D L Nelson Debashish Ray David D Scott Matthew R Hennefarth Aubin Moutal Samantha Perez-Miller Andrew J Ambrose Ahmed Al-Shamari Philippe Coursodon Bessie Meechoovet Rebecca Reiman Eric Lyons Mark Beilstein Eli Chapman Quaid D Morris Kendall Van Keuren-Jensen Timothy R Hughes Rajesh Khanna Carla Koehler Joanna Jen Vijay Gokhale May Khanna

ACS Chem Biol 2018 10 6;13(10):3000-3010. Epub 2018 Sep 6.

Department of Pharmacology , College of Medicine, University of Arizona , Tucson , Arizona 85724 , United States.

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October 2018

Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels.

Authors:
Liberty François-Moutal David Donald Scott Samantha Perez-Miller Vijay Gokhale May Khanna Rajesh Khanna

Channels (Austin) 2018 6;12(1):219-227. Epub 2018 Aug 6.

a Departments of Pharmacology College of Medicine , University of Arizona , Tucson , Arizona USA.

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August 2019

Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain.

Authors:
Liberty François-Moutal Erik T Dustrude Yue Wang Tatiana Brustovetsky Angie Dorame Weina Ju Aubin Moutal Samantha Perez-Miller Nickolay Brustovetsky Vijay Gokhale May Khanna Rajesh Khanna

Pain 2018 Oct;159(10):2115-2127

Department of Pharmacology, Graduate Interdisciplinary Program, College of Medicine, Tucson, AZ, United States.

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October 2018

Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X.

Authors:
Carika Weldon Justine G Dacanay Vijay Gokhale Peda Venkat L Boddupally Isabelle Behm-Ansmant Glenn A Burley Christiane Branlant Laurence H Hurley Cyril Dominguez Ian C Eperon

Nucleic Acids Res 2018 01;46(2):886-896

Leicester Institute of Structural & Chemical Biology and Department of Molecular & Cell Biology, University of Leicester, Leicester LE1 7RH, UK.

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January 2018

Dyrk1 inhibition improves Alzheimer's disease-like pathology.

Authors:
Caterina Branca Darren M Shaw Ramona Belfiore Vijay Gokhale Arthur Y Shaw Christopher Foley Breland Smith Christopher Hulme Travis Dunckley Bessie Meechoovet Antonella Caccamo Salvatore Oddo

Aging Cell 2017 10 4;16(5):1146-1154. Epub 2017 Aug 4.

The Arizona State University-Banner Neurodegenerative Disease Research Center at the Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA.

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October 2017

A simple mathematical approach to the analysis of polypharmacology and polyspecificity data.

Authors:
Gerry Maggiora Vijay Gokhale

F1000Res 2017 6;6. Epub 2017 Jun 6.

BIO5 Institute, University of Arizona, 1657 East Helen Street, Tucson, AZ, 85719, USA.

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June 2017

Simultaneous Drug Targeting of the Promoter MYC G-Quadruplex and BCL2 i-Motif in Diffuse Large B-Cell Lymphoma Delays Tumor Growth.

Authors:
Samantha Kendrick Andrea Muranyi Vijay Gokhale Laurence H Hurley Lisa M Rimsza

J Med Chem 2017 08 25;60(15):6587-6597. Epub 2017 Jul 25.

Department of Pathology, University of Arizona , 1501 North Campbell Avenue, Tucson, Arizona 85724, United States.

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August 2017

The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Targeting of Both Structures by Small Molecules To Downregulate Gene Expression.

Authors:
Robert V Brown Ting Wang Venkateshwar Reddy Chappeta Guanhui Wu Buket Onel Reena Chawla Hector Quijada Sara M Camp Eddie T Chiang Quinea R Lassiter Carmen Lee Shivani Phanse Megan A Turnidge Ping Zhao Joe G N Garcia Vijay Gokhale Danzhou Yang Laurence H Hurley

J Am Chem Soc 2017 06 19;139(22):7456-7475. Epub 2017 May 19.

College of Pharmacy, University of Arizona , 1703 East Mabel Street, Tucson, Arizona 85721, United States.

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June 2017

Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.

Authors:
Aubin Moutal Wennan Li Yue Wang Weina Ju Shizhen Luo Song Cai Liberty François-Moutal Samantha Perez-Miller Jackie Hu Erik T Dustrude Todd W Vanderah Vijay Gokhale May Khanna Rajesh Khanna

Br J Pharmacol 2018 06 17;175(12):2244-2260. Epub 2017 Mar 17.

Department of Pharmacology, University of Arizona, Tucson, AZ, USA.

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June 2018

A Pharmacological Chaperone Molecule Induces Cancer Cell Death by Restoring Tertiary DNA Structures in Mutant hTERT Promoters.

Authors:
Hyun-Jin Kang Yunxi Cui Holly Yin Amy Scheid William P D Hendricks Jessica Schmidt Aleksandar Sekulic Deming Kong Jeffrey M Trent Vijay Gokhale Hanbin Mao Laurence H Hurley

J Am Chem Soc 2016 Oct 5;138(41):13673-13692. Epub 2016 Oct 5.

University of Arizona , College of Pharmacy, 1703 East Mabel Street, Tucson, Arizona 85721, United States.

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October 2016

Correction to "The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure".

Authors:
Samantha Kendrick Hyun-Jin Kang Mohammad P Alam Manikandadas M Madathil Prashansa Agrawal Vijay Gokhale Danzhou Yang Sidney M Hecht Laurence H Hurley

J Am Chem Soc 2016 09 29;138(35):11408. Epub 2016 Aug 29.

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September 2016

TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors.

Authors:
Amit Dipak Amin Lingxiao Li Soumya S Rajan Vijay Gokhale Matthew J Groysman Praechompoo Pongtornpipat Edgar O Tapia Mengdie Wang Jonathan H Schatz

Oncotarget 2016 Apr;7(17):23715-29

Department of Medicine, Division of Hematology-Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.

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April 2016

Structure-Function Analysis of the Non-Muscle Myosin Light Chain Kinase (nmMLCK) Isoform by NMR Spectroscopy and Molecular Modeling: Influence of MYLK Variants.

Authors:
Kui Shen Benjamin Ramirez Brandon Mapes Grace R Shen Vijay Gokhale Mary E Brown Bernard Santarsiero Yoshitaka Ishii Steven M Dudek Ting Wang Joe G N Garcia

PLoS One 2015 25;10(6):e0130515. Epub 2015 Jun 25.

Institute for Personalized Respiratory Medicine, Section of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois at Chicago, Chicago, Illinois, United States of America; Arizona Respiratory Center and Department of Medicine, University of Arizona, Tucson, Arizona, United States of America.

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March 2016

The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.

Authors:
Angela L Davis Shuxi Qiao Jessica L Lesson Montserrat Rojo de la Vega Sophia L Park Carol M Seanez Vijay Gokhale Christopher M Cabello Georg T Wondrak

J Biol Chem 2015 Jan 4;290(3):1623-38. Epub 2014 Dec 4.

From the Department of Pharmacology and Toxicology, College of Pharmacy and Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724

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January 2015

The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure.

Authors:
Samantha Kendrick Hyun-Jin Kang Mohammad P Alam Manikandadas M Madathil Prashansa Agrawal Vijay Gokhale Danzhou Yang Sidney M Hecht Laurence H Hurley

J Am Chem Soc 2014 Mar 7;136(11):4161-71. Epub 2014 Mar 7.

Arizona Cancer Center, University of Arizona , Tucson, Arizona 85724, United States.

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March 2014

Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells.

Authors:
Federico Medda Earlphia Sells Hui-Hua Chang Justin Dietrich Shashi Chappeta Breland Smith Vijay Gokhale Emmanuelle J Meuillet Christopher Hulme

Bioorg Med Chem Lett 2013 Jan 21;23(2):528-31. Epub 2012 Nov 21.

BIO5 Oro Valley, The University of Arizona, 1580 E. Hanley Blvd., Oro Valley, AZ 85737, USA.

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January 2013

Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?

Authors:
Breland Smith Federico Medda Vijay Gokhale Travis Dunckley Christopher Hulme

ACS Chem Neurosci 2012 Nov 28;3(11):857-72. Epub 2012 Aug 28.

Department of Chemistry & Biochemistry, the University of Arizona, Tucson, Arizona 85721, United States; BIO5 Oro Valley, the University of Arizona, 1580 East Hanley Boulevard, Oro Valley, Arizona 85737, United States.

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November 2012

Redox-active magnetic resonance imaging contrast agents: studies with thiol-bearing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid derivatives.

Authors:
Bhumasamudram Jagadish Gerald P Guntle Dezheng Zhao Vijay Gokhale Tarik J Ozumerzifon Ali M Ahad Eugene A Mash Natarajan Raghunand

J Med Chem 2012 Dec 28;55(23):10378-86. Epub 2012 Nov 28.

Department of Chemistry and Biochemistry, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85721-0041, United States.

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December 2012

Gaining insights into the small molecule targeting of the G-quadruplex in the c-MYC promoter using NMR and an allele-specific transcriptional assay.

Authors:
Christine E Kaiser Vijay Gokhale Danzhou Yang Laurence H Hurley

Top Curr Chem 2013 ;330:1-21

College of Pharmacy, University of Arizona, 1703 E. Mabel Street, Tucson, AZ, 85721, USA.

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December 2013

Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter.

Authors:
Peda V L Boddupally Seongmin Hahn Cristina Beman Biswanath De Tracy A Brooks Vijay Gokhale Laurence H Hurley

J Med Chem 2012 Jul 25;55(13):6076-86. Epub 2012 Jun 25.

College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA.

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July 2012

Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells.

Authors:
Breland Smith Hui-Hua Chang Federico Medda Vijay Gokhale Justin Dietrich Angela Davis Emmanuelle J Meuillet Christopher Hulme

Bioorg Med Chem Lett 2012 May 28;22(10):3567-70. Epub 2012 Mar 28.

BIO5 Oro Valley, The University of Arizona, Oro Valley, AZ 85737, United States.

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May 2012

Tertiary DNA structure in the single-stranded hTERT promoter fragment unfolds and refolds by parallel pathways via cooperative or sequential events.

Authors:
Zhongbo Yu Vanessa Gaerig Yunxi Cui HyunJin Kang Vijay Gokhale Yuan Zhao Laurence H Hurley Hanbin Mao

J Am Chem Soc 2012 Mar 9;134(11):5157-64. Epub 2012 Mar 9.

Department of Chemistry and Biochemistry and School of Biomedical Sciences, Kent State University, Kent, Ohio 44242, United States.

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March 2012

Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex.

Authors:
Robert V Brown Forest L Danford Vijay Gokhale Laurence H Hurley Tracy A Brooks

J Biol Chem 2011 Nov 28;286(47):41018-27. Epub 2011 Sep 28.

College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA.

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November 2011
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