Vidu Garg

Vidu Garg

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Vidu Garg

Publications by authors named "Vidu Garg"

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Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated mutation.

Dis Model Mech 2019 Jun 24;12(6). Epub 2019 Jun 24.

Center for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH 43205, USA

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http://dx.doi.org/10.1242/dmm.036764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602309PMC
June 2019

Shaping the future heart: transgenerational outcomes of maternal metabolic syndrome.

Am J Physiol Heart Circ Physiol 2019 May 15;316(5):H1141-H1143. Epub 2019 Mar 15.

Center for Cardiovascular Research, Nationwide Children's Hospital , Columbus, Ohio.

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http://dx.doi.org/10.1152/ajpheart.00156.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580394PMC
May 2019

Another Notch in the Genetic Puzzle of Tetralogy of Fallot.

Circ Res 2019 Feb;124(4):462-464

From the Center for Cardiovascular Research and Heart Center, Nationwide Children's Hospital, Columbus, OH (A.M.-N., J.Y., V.G.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383779PMC
February 2019

Maternal hyperglycemia and fetal cardiac development: Clinical impact and underlying mechanisms.

Birth Defects Res 2018 12;110(20):1504-1516

Center for Cardiovascular Research and Heart Center, Nationwide Children's Hospital, Columbus, Ohio.

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http://dx.doi.org/10.1002/bdr2.1435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310016PMC
December 2018

Nestin expression is dynamically regulated in cardiomyocytes during embryogenesis.

J Cell Physiol 2018 04 27;233(4):3218-3229. Epub 2017 Sep 27.

Research Center, Montreal Heart Institute and Université de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1002/jcp.26165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783184PMC
April 2018

The Role of Lipoprotein(a) in Calcific Aortic Valve Disease: Insights From a Large-Cohort Genetic Study.

Authors:
Vidu Garg

JAMA Cardiol 2018 01;3(1):24-25

Center for Cardiovascular Research, Nationwide Children's Hospital, Columbus, Ohio.

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http://dx.doi.org/10.1001/jamacardio.2017.4267DOI Listing
January 2018

Abnormal Longitudinal Growth of the Aorta in Children with Familial Bicuspid Aortic Valve.

Pediatr Cardiol 2017 Dec 25;38(8):1709-1715. Epub 2017 Sep 25.

Center for Cardiovascular Research, Research Institute at Nationwide Children's Hospital, Columbus, OH, 43205, USA.

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http://dx.doi.org/10.1007/s00246-017-1740-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798863PMC
December 2017

Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease.

JCI Insight 2017 10 19;2(20). Epub 2017 Oct 19.

Center for Cardiovascular Research and Heart Center, Nationwide Children's Hospital, Columbus, Ohio, USA.

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http://dx.doi.org/10.1172/jci.insight.95085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846898PMC
October 2017

Genetic basis of aortic valvular disease.

Curr Opin Cardiol 2017 Feb 2. Epub 2017 Feb 2.

aCenter for Cardiovascular Research bThe Heart Center, Nationwide Children's Hospital cBiomedical Sciences Graduate Program dDepartment of Pediatrics eDepartment of Molecular Genetics, Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1097/HCO.0000000000000384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783785PMC
February 2017

Utilization of Whole Exome Sequencing to Identify Causative Mutations in Familial Congenital Heart Disease.

Circ Cardiovasc Genet 2016 Aug 14;9(4):320-9. Epub 2016 Jul 14.

From the Center for Cardiovascular Research, The Research Institute (S.L., M.B., S.F.-B., G.Z., K.B., K.L.M., V.G.), The Heart Center (S.L., M.B., J.L.B., S.F.-B., K.L.M., V.G.), and Biomedical Genomics Core and the Center for Microbial Pathogenesis, The Research Institute (D.C., P.W.), Nationwide Children's Hospital, Columbus, OH; and Department of Molecular Genetics (S.L., V.G.) and Department of Pediatrics (J.L.B., S.F.-B., K.L.M., P.W., V.G.), The Ohio State University, Columbus.

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http://dx.doi.org/10.1161/CIRCGENETICS.115.001324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412122PMC
August 2016

Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract.

J Am Heart Assoc 2016 04 22;5(4). Epub 2016 Apr 22.

Center for Cardiovascular and Pulmonary Research and The Heart Center, Nationwide Children's Hospital, Columbus, OH Department of Pediatrics, The Ohio State University, Columbus, OH Department of Molecular Genetics, The Ohio State University, Columbus, OH

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http://dx.doi.org/10.1161/JAHA.115.003075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843530PMC
April 2016

Percutaneous Patent Ductus Arteriosus (PDA) Closure in Very Preterm Infants: Feasibility and Complications.

J Am Heart Assoc 2016 Feb 12;5(2). Epub 2016 Feb 12.

Center for Cardiovascular and Pulmonary Research, Nationwide Children's Hospital, Columbus, OH The Heart Center, Nationwide Children's Hospital, Columbus, OH Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH.

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http://dx.doi.org/10.1161/JAHA.115.002923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802484PMC
February 2016

Dynamic Heterogeneity of the Heart Valve Interstitial Cell Population in Mitral Valve Health and Disease.

J Cardiovasc Dev Dis 2015 Sep 17;2(3):214-232. Epub 2015 Aug 17.

Center for Cardiovascular and Pulmonary Research and The Heart Center at Nationwide Children's Hospital Research Institute, 575 Children's Drive, Research Building III, WB4239, Columbus, OH 43215, USA; (T.E.H.); (M.V.); (S.N.K.); (L.J.A.); (V.G.).

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http://dx.doi.org/10.3390/jcdd2030214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625550PMC
September 2015

Lifetime prevalence of sexual intercourse and contraception use at last sex among adolescents and young adults with congenital heart disease.

J Adolesc Health 2015 Apr;56(4):396-401

Center for Cardiovascular and Pulmonary Research, The Research Institute, Nationwide Children's Hospital, Columbus, Ohio; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.jadohealth.2014.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821850PMC
April 2015

Rationale for the Cytogenomics of Cardiovascular Malformations Consortium: A Phenotype Intensive Registry Based Approach.

J Cardiovasc Dev Dis 2015 Apr 29;2(2):76-92. Epub 2015 Apr 29.

Departments of Pediatrics and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.3390/jcdd2020076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753096PMC
April 2015

Etiology of valvular heart disease-genetic and developmental origins.

Circ J 2014 7;78(8):1801-7. Epub 2014 Jul 7.

Center for Cardiovascular and Pulmonary Research and The Heart Center at Nationwide Children's Hospital.

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http://dx.doi.org/10.1253/circj.cj-14-0510DOI Listing
March 2015

Genetics of valvular heart disease.

Curr Cardiol Rep 2014 ;16(6):487

Center for Cardiovascular and Pulmonary Research and The Heart Center, Room WB4221, Nationwide Children's Hospital, Columbus, OH, 43205, USA.

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http://dx.doi.org/10.1007/s11886-014-0487-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531840PMC
January 2015

MicroRNA miR145 regulates TGFBR2 expression and matrix synthesis in vascular smooth muscle cells.

Circ Res 2015 Jan 16;116(1):23-34. Epub 2014 Oct 16.

From the Center for Cardiovascular and Pulmonary Research and Heart Center, Nationwide Children's Hospital, Department of Pediatrics, The Ohio State University, Columbus.

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http://dx.doi.org/10.1161/CIRCRESAHA.115.303970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299754PMC
January 2015

Evidence of Aortopathy in Mice with Haploinsufficiency of in -Null Background.

J Cardiovasc Dev Dis 2015;2(1):17-30

The Center for Cardiovascular and Pulmonary Research and Heart Center, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA ; Department of Pediatrics, The Ohio State University, 700 Children's Drive, Columbus, OH 43205, USA ; Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA.

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http://dx.doi.org/10.3390/jcdd2010017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407710PMC
January 2015

Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation.

Hum Mol Genet 2014 Oct 8;23(19):5025-35. Epub 2014 May 8.

Center for Cardiovascular and Pulmonary Research and The Heart Center, Nationwide Children's Hospital, Department of Pediatrics and Department of Molecular Genetics, The Ohio State University, Columbus, OH 43205, USA

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http://dx.doi.org/10.1093/hmg/ddu215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159147PMC
October 2014

Pharmacological inhibitor of notch signaling stabilizes the progression of small abdominal aortic aneurysm in a mouse model.

J Am Heart Assoc 2014 Oct 27;3(6):e001064. Epub 2014 Oct 27.

Center for Cardiovascular and Pulmonary Research and The Heart Center, Nationwide Children's Hospital, The Ohio State University, Columbus, OH (J.C., S.N.K., V.G., C.P.H.) Department of Pediatrics, The Ohio State University, Columbus, OH (V.G., C.P.H.).

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http://dx.doi.org/10.1161/JAHA.114.001064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338693PMC
October 2014

Rare GATA5 sequence variants identified in individuals with bicuspid aortic valve.

Pediatr Res 2014 Aug 5;76(2):211-6. Epub 2014 May 5.

1] Department of Pediatrics, The Ohio State University, Columbus, Ohio [2] Center for Cardiovascular and Pulmonary Research, Nationwide Children's Hospital, Columbus, Ohio [3] The Heart Center, Nationwide Children's Hospital, Columbus, Ohio [4] Department of Molecular Genetics, The Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1038/pr.2014.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717758PMC
August 2014

Beyond genetics: focusing on maternal environment for congenital heart disease prevention.

Evid Based Med 2014 Apr 26;19(2):e8. Epub 2013 Nov 26.

Center for Cardiovascular and Pulmonary Research, Nationwide Children's Hospital, , Columbus, Ohio, USA.

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http://dx.doi.org/10.1136/eb-2013-101556DOI Listing
April 2014

Genetic abnormalities in FOXP1 are associated with congenital heart defects.

Hum Mutat 2013 Sep 11;34(9):1226-30. Epub 2013 Jul 11.

Center for Cardiovascular and Pulmonary Research and The Heart Center, Nationwide Children's Hospital, Columbus, Ohio, USA.

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http://dx.doi.org/10.1002/humu.22366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717756PMC
September 2013

Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.

J Mol Cell Cardiol 2013 Jul 11;60:27-35. Epub 2013 Apr 11.

Center for Cardiovascular and Pulmonary Research at Nationwide Children's Hospital, Columbus, OH 43205, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2013.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058883PMC
July 2013

Compacting the heart with Notch.

Nat Med 2013 Feb;19(2):133-4

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http://dx.doi.org/10.1038/nm.3071DOI Listing
February 2013

Inhibition of Notch1 signaling reduces abdominal aortic aneurysm in mice by attenuating macrophage-mediated inflammation.

Arterioscler Thromb Vasc Biol 2012 Dec 18;32(12):3012-23. Epub 2012 Oct 18.

Center for Cardiovascular and Pulmonary Research and The Heart Center, Nationwide Children’s Hospital, Columbus, OH 43205, USA.

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http://dx.doi.org/10.1161/ATVBAHA.112.254219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467024PMC
December 2012

Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo.

PLoS Genet 2012 10;8(5):e1002690. Epub 2012 May 10.

Center for Cardiovascular and Pulmonary Research and the Heart Center, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1002690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349729PMC
September 2012

Submicroscopic chromosomal copy number variations identified in children with hypoplastic left heart syndrome.

Pediatr Cardiol 2012 Jun 21;33(5):757-63. Epub 2012 Feb 21.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://link.springer.com/content/pdf/10.1007/s00246-012-0208
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http://link.springer.com/10.1007/s00246-012-0208-9
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http://dx.doi.org/10.1007/s00246-012-0208-9DOI Listing
June 2012

Inhibitory role of Notch1 in calcific aortic valve disease.

PLoS One 2011 16;6(11):e27743. Epub 2011 Nov 16.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027743PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218038PMC
March 2012

Heredity of bicuspid aortic valve: is family screening indicated?

Heart 2011 Aug 1;97(15):1193-5. Epub 2011 Apr 1.

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http://dx.doi.org/10.1136/hrt.2011.222489DOI Listing
August 2011

Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development.

Eur J Hum Genet 2011 May 2;19(5):540-6. Epub 2011 Feb 2.

McDermott Center for Human Growth and Development and Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1038/ejhg.2010.245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083624PMC
May 2011

Impact of Mendelian inheritance in cardiovascular disease.

Ann N Y Acad Sci 2010 Dec 19;1214:122-37. Epub 2010 Oct 19.

Departments of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA.

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http://doi.wiley.com/10.1111/j.1749-6632.2010.05791.x
Publisher Site
http://dx.doi.org/10.1111/j.1749-6632.2010.05791.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489013PMC
December 2010

Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development.

Dev Biol 2010 Nov 19;347(1):92-108. Epub 2010 Aug 19.

Department of Pediatrics, University of Utah, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1016/j.ydbio.2010.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133699PMC
November 2010

Identification of GATA6 sequence variants in patients with congenital heart defects.

Pediatr Res 2010 Oct;68(4):281-5

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1203/PDR.0b013e3181ed17e4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940936PMC
October 2010

Genetics of congenital heart disease.

Curr Cardiol Rev 2010 May;6(2):91-7

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.2174/157340310791162703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892081PMC
May 2010

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development.

Dev Biol 2009 Feb 20;326(2):368-77. Epub 2008 Nov 20.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1016/j.ydbio.2008.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651674PMC
February 2009

A rare human sequence variant reveals myocardin autoinhibition.

J Biol Chem 2008 Dec 13;283(51):35845-52. Epub 2008 Oct 13.

Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1074/jbc.M805909200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602885PMC
December 2008

Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease.

Am J Med Genet A 2007 Apr;143A(8):817-23

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148, USA.

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http://dx.doi.org/10.1002/ajmg.a.31652DOI Listing
April 2007

Molecular genetics of aortic valve disease.

Authors:
Vidu Garg

Curr Opin Cardiol 2006 May;21(3):180-4

Departments of Pediatrics and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1097/01.hco.0000221578.18254.70DOI Listing
May 2006

Mutations in NOTCH1 cause aortic valve disease.

Nature 2005 Sep 17;437(7056):270-4. Epub 2005 Jul 17.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148, USA.

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http://dx.doi.org/10.1038/nature03940DOI Listing
September 2005

GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5.

Nature 2003 Jul 6;424(6947):443-7. Epub 2003 Jul 6.

Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Rm. NA8.124, Dallas, Texas 75390-9148, USA.

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http://dx.doi.org/10.1038/nature01827DOI Listing
July 2003