Publications by authors named "Victor L Villemagne"

100Publications

Amyloid-PET and F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias.

Lancet Neurol 2020 Nov;19(11):951-962

Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany; German Center for Neurodegenerative Diseases, Bonn-Cologne, Germany; Institute of Neuroscience and Medicine, Molecular Organization of the Brain, Forschungszentrum Jülich, Germany.

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http://dx.doi.org/10.1016/S1474-4422(20)30314-8DOI Listing
November 2020

Reduced striatal vesicular monoamine transporter 2 in REM sleep behavior disorder: imaging prodromal parkinsonism.

Sci Rep 2020 Oct 23;10(1):17631. Epub 2020 Oct 23.

Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.

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http://dx.doi.org/10.1038/s41598-020-74495-xDOI Listing
October 2020

Plasma Amyloid-β Biomarker Associated with Cognitive Decline in Preclinical Alzheimer's Disease.

J Alzheimers Dis 2020 ;77(3):1057-1065

Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.

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http://dx.doi.org/10.3233/JAD-200475DOI Listing
January 2020

Impact of APOE-ε4 carriage on the onset and rates of neocortical Aβ-amyloid deposition.

Neurobiol Aging 2020 Jun 10;95:46-55. Epub 2020 Jun 10.

Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, Victoria, Australia; Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1016/j.neurobiolaging.2020.06.001DOI Listing
June 2020

Exploiting the Full Potential of β-Amyloid and Tau PET Imaging for Drug Efficacy Testing.

J Nucl Med 2020 Aug 15;61(8):1105-1106. Epub 2020 May 15.

Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.2967/jnumed.119.228346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413238PMC
August 2020

A head-to-head comparison of cerebral blood flow SPECT and F-FDG PET in the diagnosis of Alzheimer's Disease.

Intern Med J 2020 May 10. Epub 2020 May 10.

Department of Molecular Imaging and Therapy, Austin Hospital, 145 Studley Road, Heidelberg, Victoria, 3084, Australia.

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http://dx.doi.org/10.1111/imj.14890DOI Listing
May 2020

Elecsys CSF biomarker immunoassays demonstrate concordance with amyloid-PET imaging.

Alzheimers Res Ther 2020 03 31;12(1):36. Epub 2020 Mar 31.

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Melbourne, Victoria, 3010, Australia.

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http://dx.doi.org/10.1186/s13195-020-00595-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110644PMC
March 2020

Total Aβ/Aβ ratio in plasma predicts amyloid-PET status, independent of clinical AD diagnosis.

Neurology 2020 04 16;94(15):e1580-e1591. Epub 2020 Mar 16.

From the CSIRO Health and Biosecurity/Australian E-Health Research Centre (J.D.D.), Royal Brisbane and Women's Hospital, Herston, Queensland, Australia; R&D Department (V.P.-G., N.F., P.P., M.S.), Araclon Biotech Ltd, Zaragoza, Spain; and The Florey Institute of Neuroscience and Mental Health (C.F., V.L.V., C.L.M.), University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1212/WNL.0000000000009240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251518PMC
April 2020

Identification of Pre-Clinical Alzheimer's Disease in a Population of Elderly Cognitively Normal Participants.

J Alzheimers Dis 2020 ;73(2):683-693

CSIRO Health and Biosecurity/Australian e-Health Research Centre, Herston, Queensland, Australia.

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http://dx.doi.org/10.3233/JAD-191095DOI Listing
January 2020

Can amyloid PET differentiate "pure" LBD from AD with or without LBD copathology?

Neurology 2020 01 20;94(3):103-104. Epub 2019 Dec 20.

From the Helen Wills Neuroscience Institute (S.M.L.), University of California, Berkeley; and Department of Molecular Imaging and Therapy (V.L.V.), Centre for PET, Austin Health, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1212/WNL.0000000000008812DOI Listing
January 2020

Amyloid-β, Tau, and 18F-Fluorodeoxyglucose Positron Emission Tomography in Posttraumatic Stress Disorder.

J Alzheimers Dis 2020 ;73(1):163-173

Department of Molecular Imaging and Therapy, Austin Health, The University of Melbourne, Melbourne, VIC, Australia.

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http://dx.doi.org/10.3233/JAD-190913DOI Listing
January 2020

Validation of a priori candidate Alzheimer's disease SNPs with brain amyloid-beta deposition.

Sci Rep 2019 11 19;9(1):17069. Epub 2019 Nov 19.

Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, 6027, Western Australia, Australia.

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http://dx.doi.org/10.1038/s41598-019-53604-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863876PMC
November 2019

The dawn of robust individualised risk models for dementia.

Lancet Neurol 2019 11 13;18(11):985-987. Epub 2019 Sep 13.

Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.

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http://dx.doi.org/10.1016/S1474-4422(19)30353-9DOI Listing
November 2019

A harmonized longitudinal biomarkers and cognition database for assessing the natural history of preclinical Alzheimer's disease from young adulthood and for designing prevention trials.

Alzheimers Dement 2019 11 7;15(11):1448-1457. Epub 2019 Sep 7.

Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Departments of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1016/j.jalz.2019.06.4955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874758PMC
November 2019

Four-repeat tauopathies.

Prog Neurobiol 2019 09 22;180:101644. Epub 2019 Jun 22.

Dept. of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany; Dept. of Neurology, Technical University of Munich, School of Medicine, 81675 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany; Dept. of Neurology, Hannover Medical School, 30625 Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pneurobio.2019.101644DOI Listing
September 2019

The trinity of tau, trauma, and time.

Lancet Neurol 2019 08 11;18(8):715-717. Epub 2019 Jun 11.

Health and Biosecurity Flagship, The Australian eHealth Research Centre, CSIRO, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1016/S1474-4422(19)30219-4DOI Listing
August 2019

Sensitivity of a Preclinical Alzheimer's Cognitive Composite (PACC) to amyloid β load in preclinical Alzheimer's disease.

J Clin Exp Neuropsychol 2019 08 29;41(6):591-600. Epub 2019 Mar 29.

a The Florey Institute of Neuroscience and Mental Health , The University of Melbourne , Melbourne , VIC , Australia.

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http://dx.doi.org/10.1080/13803395.2019.1593949DOI Listing
August 2019

Klotho allele status is not associated with Aβ and APOE ε4-related cognitive decline in preclinical Alzheimer's disease.

Neurobiol Aging 2019 04 6;76:162-165. Epub 2019 Jan 6.

Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Cooperative Research Centre for Mental Health, Carlton South, Victoria, Australia; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.12.014DOI Listing
April 2019

Imaging of tau deposits in adults with Niemann-Pick type C disease: a case-control study.

Eur J Nucl Med Mol Imaging 2019 May 28;46(5):1132-1138. Epub 2019 Jan 28.

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/s00259-019-4273-7DOI Listing
May 2019

Risk of Alzheimer's Disease in Obstructive Sleep Apnea Syndrome: Amyloid-β and Tau Imaging.

J Alzheimers Dis 2018 ;66(2):733-741

Department of Molecular Imaging and Therapy, Austin Health, The University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.3233/JAD-180640DOI Listing
October 2019

Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia.

Ann Neurol 2018 11;84(5):729-740

Alzheimer center Amsterdam, Amsterdam UMC, Amsterdam Neuroscience, VU University, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1002/ana.25333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354051PMC
November 2018

Targeting metals rescues the phenotype in an animal model of tauopathy.

Metallomics 2018 09;10(9):1339-1347

The Florey Institute for Neuroscience and Mental Health and The University of Melbourne, Parkville, 30 Royal Parade, Victoria 3052, Australia.

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http://dx.doi.org/10.1039/c8mt00153gDOI Listing
September 2018

Implementing the centiloid transformation for C-PiB and β-amyloid F-PET tracers using CapAIBL.

Neuroimage 2018 12 18;183:387-393. Epub 2018 Aug 18.

Department of Molecular Imaging, Austin Health, Melbourne, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S10538119183074
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http://dx.doi.org/10.1016/j.neuroimage.2018.08.044DOI Listing
December 2018

Estimates of age-related memory decline are inflated by unrecognized Alzheimer's disease.

Neurobiol Aging 2018 10 11;70:170-179. Epub 2018 Jun 11.

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia; CogState Ltd., Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.06.005DOI Listing
October 2018

Author Correction: Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions.

Nat Rev Neurol 2018 Jul;14(7):446

Department of Molecular Imaging and Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1038/s41582-018-0021-zDOI Listing
July 2018

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.

Authors:
Niklas Mattsson Colin Groot Willemijn J Jansen Susan M Landau Victor L Villemagne Sebastiaan Engelborghs Mark M Mintun Alberto Lleo José Luis Molinuevo William J Jagust Giovanni B Frisoni Adrian Ivanoiu Gaël Chételat Catarina Resende de Oliveira Karen M Rodrigue Johannes Kornhuber Anders Wallin Aleksandra Klimkowicz-Mrowiec Ramesh Kandimalla Julius Popp Pauline P Aalten Dag Aarsland Daniel Alcolea Ina S Almdahl Inês Baldeiras Mark A van Buchem Enrica Cavedo Kewei Chen Ann D Cohen Stefan Förster Juan Fortea Kristian S Frederiksen Yvonne Freund-Levi Kiran Dip Gill Olymbia Gkatzima Timo Grimmer Harald Hampel Sanna-Kaisa Herukka Peter Johannsen Koen van Laere Mony J de Leon Wolfgang Maier Jan Marcusson Olga Meulenbroek Hanne M Møllergård John C Morris Barbara Mroczko Arto Nordlund Sudesh Prabhakar Oliver Peters Lorena Rami Eloy Rodríguez-Rodríguez Catherine M Roe Eckart Rüther Isabel Santana Johannes Schröder Sang W Seo Hilkka Soininen Luiza Spiru Erik Stomrud Hanne Struyfs Charlotte E Teunissen Frans R J Verhey Stephanie J B Vos Linda J C van Waalwijk van Doorn Gunhild Waldemar Åsa K Wallin Jens Wiltfang Rik Vandenberghe David J Brooks Tormod Fladby Christopher C Rowe Alexander Drzezga Marcel M Verbeek Marie Sarazin David A Wolk Adam S Fleisher William E Klunk Duk L Na Pascual Sánchez-Juan Dong Young Lee Agneta Nordberg Magda Tsolaki Vincent Camus Juha O Rinne Anne M Fagan Henrik Zetterberg Kaj Blennow Gil D Rabinovici Oskar Hansson Bart N M van Berckel Wiesje M van der Flier Philip Scheltens Pieter Jelle Visser Rik Ossenkoppele

Alzheimers Dement 2018 07 28;14(7):913-924. Epub 2018 Mar 28.

Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden; Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.02.009DOI Listing
July 2018

Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden.

Transl Psychiatry 2018 02 26;8(1):47. Epub 2018 Feb 26.

Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, 6027, WA, Australia.

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http://dx.doi.org/10.1038/s41398-018-0094-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865132PMC
February 2018

Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions.

Nat Rev Neurol 2018 04 16;14(4):225-236. Epub 2018 Feb 16.

Department of Molecular Imaging and Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1038/nrneurol.2018.9DOI Listing
April 2018

High performance plasma amyloid-β biomarkers for Alzheimer's disease.

Nature 2018 02 31;554(7691):249-254. Epub 2018 Jan 31.

Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan.

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http://dx.doi.org/10.1038/nature25456DOI Listing
February 2018

Amyloid burden and incident depressive symptoms in preclinical Alzheimer's disease.

J Affect Disord 2018 03 3;229:269-274. Epub 2018 Jan 3.

Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia; CogState Ltd., Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.jad.2017.12.101DOI Listing
March 2018

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.

Authors:
Willemijn J Jansen Rik Ossenkoppele Betty M Tijms Anne M Fagan Oskar Hansson William E Klunk Wiesje M van der Flier Victor L Villemagne Giovanni B Frisoni Adam S Fleisher Alberto Lleó Mark A Mintun Anders Wallin Sebastiaan Engelborghs Duk L Na Gäel Chételat José Luis Molinuevo Susan M Landau Niklas Mattsson Johannes Kornhuber Osama Sabri Christopher C Rowe Lucilla Parnetti Julius Popp Tormod Fladby William J Jagust Pauline Aalten Dong Young Lee Rik Vandenberghe Catarina Resende de Oliveira Elisabeth Kapaki Lutz Froelich Adrian Ivanoiu Tomasz Gabryelewicz Marcel M Verbeek Páscual Sanchez-Juan Helmut Hildebrandt Vincent Camus Marzena Zboch David J Brooks Alexander Drzezga Juha O Rinne Andrew Newberg Alexandre de Mendonça Marie Sarazin Gil D Rabinovici Karine Madsen Milica G Kramberger Agneta Nordberg Vincent Mok Barbara Mroczko David A Wolk Philipp T Meyer Magda Tsolaki Philip Scheltens Frans R J Verhey Pieter Jelle Visser Dag Aarsland Daniel Alcolea Myriam Alexander Ina S Almdahl Steven E Arnold Inês Baldeiras Henryk Barthel Bart N M van Berckel Kaj Blennow Mark A van Buchem Enrica Cavedo Kewei Chen Elena Chipi Ann D Cohen Stefan Förster Juan Fortea Kristian S Frederiksen Yvonne Freund-Levi Olymbia Gkatzima Mark Forrest Gordon Timo Grimmer Harald Hampel Lucrezia Hausner Sabine Hellwig Sanna-Kaisa Herukka Peter Johannsen Aleksandra Klimkowicz-Mrowiec Sebastian Köhler Norman Koglin Koen van Laere Mony de Leon Viviana Lisetti Wolfgang Maier Jan Marcusson Olga Meulenbroek Hanne M Møllergård John C Morris Arto Nordlund Gerald P Novak George P Paraskevas Gayan Perera Oliver Peters Inez H G B Ramakers Lorena Rami Eloy Rodríguez-Rodríguez Catherine M Roe Uros Rot Eckart Rüther Isabel Santana Johannes Schröder Sang W Seo Hilkka Soininen Luiza Spiru Erik Stomrud Hanne Struyfs Charlotte E Teunissen Stephanie J B Vos Linda J C van Waalwijk van Doorn Gunhild Waldemar Åsa K Wallin Jens Wiltfang Henrik Zetterberg

JAMA Psychiatry 2018 01;75(1):84-95

Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1001/jamapsychiatry.2017.3391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786156PMC
January 2018

Selective Tau Imaging: .

J Nucl Med 2018 02 21;59(2):175-176. Epub 2017 Sep 21.

Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia; Department of Medicine, Austin Health, University of Melbourne, Melbourne, Australia; and Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia

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http://dx.doi.org/10.2967/jnumed.117.198325DOI Listing
February 2018

Tau positron emission tomography using [F]THK5351 and cerebral glucose hypometabolism in Alzheimer's disease.

Neurobiol Aging 2017 11 12;59:210-219. Epub 2017 Aug 12.

Department of Neurology, Gachon University Gil Medical Center, Incheon, Republic of Korea; Department of Health Science and Technology, GAIHST, Gachon University, Incheon, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.08.008DOI Listing
November 2017

Tau imaging with PET: an overview of challenges, current progress, and future applications.

Q J Nucl Med Mol Imaging 2017 Dec 27;61(4):405-413. Epub 2017 Jul 27.

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia -

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http://dx.doi.org/10.23736/S1824-4785.17.03012-6DOI Listing
December 2017

F-Florbetaben PET beta-amyloid binding expressed in Centiloids.

Eur J Nucl Med Mol Imaging 2017 Nov 22;44(12):2053-2059. Epub 2017 Jun 22.

Department of Molecular Imaging & Therapy, Centre for PET, Austin Health, Studley Road Heidelberg, Melbourne, VIC, 3084, Australia.

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http://dx.doi.org/10.1007/s00259-017-3749-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656696PMC
November 2017

A 'Disease Severity Index' to identify individuals with Subjective Memory Decline who will progress to mild cognitive impairment or dementia.

Sci Rep 2017 03 13;7:44368. Epub 2017 Mar 13.

Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1038/srep44368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347012PMC
March 2017

Cerebral Blood Flow and Aβ-Amyloid Estimates by WARM Analysis of [C]PiB Uptake Distinguish among and between Neurodegenerative Disorders and Aging.

Front Aging Neurosci 2016 11;8:321. Epub 2017 Jan 11.

Department of Neuroscience and Pharmacology, University of CopenhagenCopenhagen, Denmark; Department of Neurology and Neurosurgery, McGill University, MontréalQC, Canada; Division of Nuclear Medicine, Department of Radiology and Radiological Science, Johns Hopkins University, BaltimoreMD, USA; Neurosciences Research Center, Tabriz University of Medical SciencesTabriz, Iran; Department of Clinical Medicine - Department of Nuclear Medicine, University of Southern DenmarkOdense, Denmark.

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http://dx.doi.org/10.3389/fnagi.2016.00321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225115PMC
January 2017

Self-reported confusion is related to global and regional β-amyloid: data from the Women's healthy ageing project.

Brain Imaging Behav 2018 02;12(1):78-86

Centre for Medical Research, Royal Melbourne Hospital, Parkville, VIC, 3050, Australia.

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http://dx.doi.org/10.1007/s11682-016-9668-5DOI Listing
February 2018

Plasma Cortisol, Brain Amyloid-β, and Cognitive Decline in Preclinical Alzheimer's Disease: A 6-Year Prospective Cohort Study.

Biol Psychiatry Cogn Neurosci Neuroimaging 2017 01 7;2(1):45-52. Epub 2016 Sep 7.

The Florey Institute, The University of Melbourne, Parkville, Victoria; Department of Medicine, Austin Health, The University of Melbourne, Heidelberg; Cogstate Ltd., Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.bpsc.2016.08.006DOI Listing
January 2017

Aβ-amyloid and Tau Imaging in Dementia.

Semin Nucl Med 2017 Jan 13;47(1):75-88. Epub 2016 Oct 13.

Department of Molecular Imaging & Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australia; Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia.

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http://dx.doi.org/10.1053/j.semnuclmed.2016.09.006DOI Listing
January 2017