Publications Authored by Victor L J Tybulewicz

Gene expression dysregulation domains are not a specific feature of Down syndrome.

Authors:

Helena Ahlfors Nneka Anyanwu Edvinas Pakanavicius Natalia Dinischiotu Eva Lana-Elola Sheona Watson-Scales Justin Tosh Frances Wiseman James Briscoe Karen Page Elizabeth M C Fisher Victor L J Tybulewicz

Nat Commun 2019 06 6;10(1):2489. Epub 2019 Jun 6.

The Francis Crick Institute, London, NW1 1AT, UK.

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http://dx.doi.org/10.1038/s41467-019-10129-9	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554309	PMC

June 2019

Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus.

Authors:

Simone Granno Jonathon Nixon-Abell Daniel C Berwick Justin Tosh George Heaton Sultan Almudimeegh Zenisha Nagda Jean-Christophe Rain Manuela Zanda Vincent Plagnol Victor L J Tybulewicz Karen Cleverley Frances K Wiseman Elizabeth M C Fisher Kirsten Harvey

Sci Rep 2019 May 13;9(1):7322. Epub 2019 May 13.

Department of Pharmacology, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.

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http://dx.doi.org/10.1038/s41598-019-43820-4	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513850	PMC

May 2019

Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years.

Authors:

Rosalyn Hithersay Carla M Startin Sarah Hamburg Kin Y Mok John Hardy Elizabeth M C Fisher Victor L J Tybulewicz Dean Nizetic André Strydom

JAMA Neurol 2019 Feb;76(2):152-160

Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.

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http://dx.doi.org/10.1001/jamaneurol.2018.3616	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439956	PMC

February 2019

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.

Brain 2018 08;141(8):2457-2474

Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG UK.

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http://dx.doi.org/10.1093/brain/awy159	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061702	PMC

August 2018

Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration.

Authors:

Sheona Watson-Scales Bernadett Kalmar Eva Lana-Elola Dorota Gibbins Federica La Russa Frances Wiseman Matthew Williamson Rachele Saccon Amy Slender Anna Olerinyova Radma Mahmood Emma Nye Heather Cater Sara Wells Y Eugene Yu David L H Bennett Linda Greensmith Elizabeth M C Fisher Victor L J Tybulewicz

PLoS Genet 2018 05 10;14(5):e1007383. Epub 2018 May 10.

The Francis Crick Institute, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1007383	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963810	PMC

May 2018

Rodent models in Down syndrome research: impact and future opportunities.

Authors:

Yann Herault Jean M Delabar Elizabeth M C Fisher Victor L J Tybulewicz Eugene Yu Veronique Brault

Dis Model Mech 2017 10;10(10):1165-1186

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, 1 rue Laurent Fries, 67404 Illkirch, France.

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http://dx.doi.org/10.1242/dmm.029728	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665454	PMC

October 2017

Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models.

Authors:

Alain D Dekker Yannick Vermeiren Christelle Albac Eva Lana-Elola Sheona Watson-Scales Dorota Gibbins Tony Aerts Debby Van Dam Elizabeth M C Fisher Victor L J Tybulewicz Marie-Claude Potier Peter P De Deyn

Neurobiol Dis 2017 Sep 15;105:235-244. Epub 2017 Jun 15.

Department of Neurology and Alzheimer Research Center, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands; Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2017.06.007	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536154	PMC

September 2017

TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.

Authors:

Edina Schweighoffer Josquin Nys Lesley Vanes Nicholas Smithers Victor L J Tybulewicz

J Exp Med 2017 05 29;214(5):1269-1280. Epub 2017 Mar 29.

The Francis Crick Institute, London NW1 1AT, England, UK

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http://dx.doi.org/10.1084/jem.20161117	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413329	PMC

May 2017

Corrigendum: WNK1 kinase balances T cell adhesion versus migration in vivo.

Authors:

Robert Köchl Flavian Thelen Lesley Vanes Tiago F Brazão Kathryn Fountain Jian Xie Chou-Long Huang Ruth Lyck Jens V Stein Victor L J Tybulewicz

Nat Immunol 2017 01;18(2):246

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http://dx.doi.org/10.1038/ni0217-246a	DOI Listing

January 2017

WNK1 kinase balances T cell adhesion versus migration in vivo.

Authors:

Robert Köchl Flavian Thelen Lesley Vanes Tiago F Brazão Kathryn Fountain Jian Xie Chou-Long Huang Ruth Lyck Jens V Stein Victor L J Tybulewicz

Nat Immunol 2016 09 11;17(9):1075-83. Epub 2016 Jul 11.

The Francis Crick Institute, London, UK.

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http://www.nature.com/articles/ni.3495	Publisher Site
http://dx.doi.org/10.1038/ni.3495	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994873	PMC

September 2016

Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome.

Authors:

Nick M Powell Marc Modat M Jorge Cardoso Da Ma Holly E Holmes Yichao Yu James O'Callaghan Jon O Cleary Ben Sinclair Frances K Wiseman Victor L J Tybulewicz Elizabeth M C Fisher Mark F Lythgoe Sébastien Ourselin

PLoS One 2016;11(9):e0162974. Epub 2016 Sep 22.

Translational Imaging Group, Centre for Medical Image Computing, University College London, 3rd Floor, Wolfson House, 4 Stephenson Way, London NW1 2HE, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033246	PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162974	PLOS

September 2016

Long noncoding RNAs in B-cell development and activation.

Authors:

Tiago F Brazão Jethro S Johnson Jennifer Müller Andreas Heger Chris P Ponting Victor L J Tybulewicz

Blood 2016 08 5;128(7):e10-9. Epub 2016 Jul 5.

The Francis Crick Institute, London, United Kingdom; Imperial College, London, United Kingdom.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2015-11	Publisher Site
http://dx.doi.org/10.1182/blood-2015-11-680843	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000579	PMC

August 2016

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes.

PLoS Genet 2016 05 19;12(5):e1006033. Epub 2016 May 19.

Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.1371/journal.pgen.1006033	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873152	PMC

May 2016

Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory.

Authors:

Jessica H Hall Frances K Wiseman Elizabeth M C Fisher Victor L J Tybulewicz John L Harwood Mark A Good

Neurobiol Learn Mem 2016 Apr 8;130:118-28. Epub 2016 Feb 8.

School of Psychology, Cardiff University, CF10 3AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nlm.2016.02.002	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898594	PMC

April 2016

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome.

Authors:

Frances K Wiseman Tamara Al-Janabi John Hardy Annette Karmiloff-Smith Dean Nizetic Victor L J Tybulewicz Elizabeth M C Fisher André Strydom

Nat Rev Neurosci 2015 Sep 5;16(9):564-74. Epub 2015 Aug 5.

Division of Psychiatry, University College London, Maple House, 149 Tottenham Court Road, London W1T 7NF, UK.

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http://dx.doi.org/10.1038/nrn3983	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678594	PMC

September 2015

BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.

Authors:

Emilie Jacque Edina Schweighoffer Victor L J Tybulewicz Steven C Ley

J Exp Med 2015 Jun 18;212(6):883-92. Epub 2015 May 18.

Division of Immune Cell Biology, MRC National Institute for Medical Research London, London NW7 1AA, England, UK

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http://dx.doi.org/10.1084/jem.20142127	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451135	PMC

June 2015

Syk tyrosine kinase is critical for B cell antibody responses and memory B cell survival.

Authors:

Jochen A Ackermann Josquin Nys Edina Schweighoffer Scott McCleary Nicholas Smithers Victor L J Tybulewicz

J Immunol 2015 May 10;194(10):4650-6. Epub 2015 Apr 10.

Division of Immune Cell Biology, MRC National Institute for Medical Research, London NW7 1AA, United Kingdom; and

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http://dx.doi.org/10.4049/jimmunol.1500461	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416743	PMC

May 2015

Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9.

Authors:

Shaikh M Atif Seung-Joo Lee Lin-Xi Li Satoshi Uematsu Shizuo Akira Sara Gorjestani Xin Lin Edina Schweighoffer Victor L J Tybulewicz Stephen J McSorley

Eur J Immunol 2015 Feb 8;45(2):513-24. Epub 2014 Dec 8.

Center for Comparative Medicine, Department of Anatomy, Physiology, and Cell Biology, University of California Davis, Davis, CA, USA.

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http://dx.doi.org/10.1002/eji.201444744	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324162	PMC

February 2015

IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen.

Authors:

Emilie Jacque Edina Schweighoffer Alexander Visekruna Stamatia Papoutsopoulou Julia Janzen Rachel Zillwood David M Tarlinton Victor L J Tybulewicz Steven C Ley

J Exp Med 2014 Sep 15;211(10):2085-101. Epub 2014 Sep 15.

Division of Immune Cell Biology, MRC National Institute for Medical Research, London NW7 1AA, England, UK

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http://dx.doi.org/10.1084/jem.20132019	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172221	PMC

September 2014

Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down syndrome.

Authors:

Matilda A Haas Donald Bell Amy Slender Eva Lana-Elola Sheona Watson-Scales Elizabeth M C Fisher Victor L J Tybulewicz François Guillemot

PLoS One 2013 30;8(10):e78561. Epub 2013 Oct 30.

Division of Molecular Neurobiology, Medical Research Council National Institute for Medical Research, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078561	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813676	PMC

August 2014

Themis2 is not required for B cell development, activation, and antibody responses.

Authors:

Harald Hartweger Edina Schweighoffer Sophia Davidson Matthew J Peirce Andreas Wack Victor L J Tybulewicz

J Immunol 2014 Jul 6;193(2):700-7. Epub 2014 Jun 6.

Medical Research Council, National Institute for Medical Research, London NW7 1AA, United Kingdom; and

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http://dx.doi.org/10.4049/jimmunol.1400943	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082722	PMC

July 2014

A key regulatory role for Vav1 in controlling lipopolysaccharide endotoxemia via macrophage-derived IL-6.

Authors:

Stefanie Zenker Julia Panteleev-Ivlev Stefan Wirtz Tadamitsu Kishimoto Maximilian J Waldner Olga Ksionda Victor L J Tybulewicz Markus F Neurath Imke Atreya

J Immunol 2014 Mar 14;192(6):2830-2836. Epub 2014 Feb 14.

Medical Clinic 1, Friedrich-Alexander University of Erlangen-Nürnberg, University Hospital of Erlangen, Germany.

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http://dx.doi.org/10.4049/jimmunol.1300157	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951479	PMC

March 2014

Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome.

PLoS One 2013 15;8(4):e60482. Epub 2013 Apr 15.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060482	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626651	PMC

October 2013

Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain.

Authors:

Md Mahiuddin Ahmed A Ranjitha Dhanasekaran Suhong Tong Frances K Wiseman Elizabeth M C Fisher Victor L J Tybulewicz Katheleen J Gardiner

Hum Mol Genet 2013 May 24;22(9):1709-24. Epub 2013 Jan 24.

Department of Pediatrics, Linda Crnic Institute for Down Syndrome, University of Colorado Denver School of Medicine, 12700 E 19th Avenue, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1093/hmg/ddt017	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613160	PMC

May 2013

The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.

Authors:

Edina Schweighoffer Lesley Vanes Josquin Nys Doreen Cantrell Scott McCleary Nicholas Smithers Victor L J Tybulewicz

Immunity 2013 Mar 28;38(3):475-88. Epub 2013 Feb 28.

Division of Immune Cell Biology, MRC National Institute for Medical Research, London NW7 1AA, UK.

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http://dx.doi.org/10.1016/j.immuni.2012.11.015	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627223	PMC

March 2013

Mechanism and function of Vav1 localisation in TCR signalling.

Authors:

Olga Ksionda Alexander Saveliev Robert Köchl Jonathan Rapley Mustapha Faroudi Jennifer E Smith-Garvin Christoph Wülfing Katrin Rittinger Tom Carter Victor L J Tybulewicz

J Cell Sci 2012 Nov 6;125(Pt 22):5302-14. Epub 2012 Sep 6.

Division of Immune Cell Biology, MRC National Institute for Medical Research, London NW7 1AA, UK.

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http://dx.doi.org/10.1242/jcs.105148	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561853	PMC

November 2012

Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.

Authors:

Julia Grizenkova Shaheen Akhtar Holger Hummerich Andrew Tomlinson Emmanuel A Asante Adam Wenborn Jérémie Fizet Mark Poulter Frances K Wiseman Elizabeth M C Fisher Victor L J Tybulewicz Sebastian Brandner John Collinge Sarah E Lloyd

Proc Natl Acad Sci U S A 2012 Aug 6;109(34):13722-7. Epub 2012 Aug 6.

Medical Research Council (MRC) Prion Unit, University College London (UCL) Institute of Neurology, London, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1208917109	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427081	PMC

August 2012

Mouse models of aneuploidy.

Authors:

Olivia Sheppard Frances K Wiseman Aarti Ruparelia Victor L J Tybulewicz Elizabeth M C Fisher

ScientificWorldJournal 2012 3;2012:214078. Epub 2012 Jan 3.

Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

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http://dx.doi.org/10.1100/2012/214078	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259538	PMC

June 2012

Vav1 GEF activity is required for T cell mediated allograft rejection.

Authors:

Dirk Haubert Jianping Li Alexander Saveliev Thomas Calzascia Esther Sutter Barbara Metzler Daniel Kaiser Victor L J Tybulewicz Gisbert Weckbecker

Transpl Immunol 2012 Jun 21;26(4):212-9. Epub 2012 Mar 21.

Novartis Institutes of BioMedical Research, Autoimmunity, Transplantation & Inflammation, 4002 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.trim.2012.03.003	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485565	PMC

June 2012

Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.

Authors:

Olivia Sheppard Florian Plattner Anna Rubin Amy Slender Jacqueline M Linehan Sebastian Brandner Victor L J Tybulewicz Elizabeth M C Fisher Frances K Wiseman

Neurobiol Aging 2012 Apr 16;33(4):828.e31-44. Epub 2011 Aug 16.

University College London Institute of Neurology, London, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.06.025	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314962	PMC

April 2012

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

Authors:

Brenda A Finney Edina Schweighoffer Leyre Navarro-Núñez Cecile Bénézech Francesca Barone Craig E Hughes Stacey A Langan Kate L Lowe Alice Y Pollitt Diego Mourao-Sa Steve Sheardown Gerard B Nash Nicholas Smithers Caetano Reis e Sousa Victor L J Tybulewicz Steve P Watson

Blood 2012 Feb 20;119(7):1747-56. Epub 2011 Dec 20.

Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.

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http://www.bloodjournal.org/content/119/7/1747.full.pdf	Web Search
http://www.bloodjournal.org/content/early/2011/12/20/blood-2	Web Search
http://core.ac.uk/download/pdf/1631320.pdf	Web Search
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-09-38	Publisher Site
http://dx.doi.org/10.1182/blood-2011-09-380709	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351942	PMC

February 2012

Genomically humanized mice: technologies and promises.

Authors:

Anny Devoy Rosie K A Bunton-Stasyshyn Victor L J Tybulewicz Andrew J H Smith Elizabeth M C Fisher

Nat Rev Genet 2011 Dec 16;13(1):14-20. Epub 2011 Dec 16.

Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

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http://dx.doi.org/10.1038/nrg3116	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782217	PMC

December 2011

Itk controls the spatiotemporal organization of T cell activation.

Authors:

Kentner L Singleton Monica Gosh Radhika D Dandekar Byron B Au-Yeung Olga Ksionda Victor L J Tybulewicz Amnon Altman Deborah J Fowell Christoph Wülfing

Sci Signal 2011 Oct;4(193):ra66

Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1126/scisignal.2001821	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248797	PMC

October 2011

Down syndrome: searching for the genetic culprits.

Authors:

Eva Lana-Elola Sheona D Watson-Scales Elizabeth M C Fisher Victor L J Tybulewicz

Dis Model Mech 2011 Sep;4(5):586-95

MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK.

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http://dx.doi.org/10.1242/dmm.008078	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180222	PMC

September 2011

Structural correlates of active-staining following magnetic resonance microscopy in the mouse brain.

Authors:

Jon O Cleary Frances K Wiseman Francesca C Norris Anthony N Price Mankin Choy Victor L J Tybulewicz Roger J Ordidge Sebastian Brandner Elizabeth M C Fisher Mark F Lythgoe

Neuroimage 2011 Jun 16;56(3):974-83. Epub 2011 Feb 16.

Centre for Advanced Biomedical Imaging, Department of Medicine and Institute of Child Health, University College London, London, UK.

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http://dx.doi.org/10.1016/j.neuroimage.2011.01.082	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590453	PMC

June 2011

The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome.

Authors:

Arnaud Duchon Stéphanie Pothion Véronique Brault Andrew J Sharp Victor L J Tybulewicz Elizabeth M C Fisher Yann Herault

Behav Brain Res 2011 Mar 31;217(2):271-81. Epub 2010 Oct 31.

Institut de Génétique Biologie Moléculaire et Cellulaire, Université de Strasbourg, Illkirch, France.

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http://dx.doi.org/10.1016/j.bbr.2010.10.023	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590452	PMC

March 2011

PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils.

Authors:

Karen E Anderson Tamara A M Chessa Keith Davidson Robert B Henderson Simon Walker Tanya Tolmachova Katarzyna Grys Oliver Rausch Miguel C Seabra Victor L J Tybulewicz Len R Stephens Phillip T Hawkins

Blood 2010 Dec 2;116(23):4978-89. Epub 2010 Sep 2.

Inositide Laboratory, Babraham Institute, Babraham Research Campus, Cambridge, UK.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-03-27	Publisher Site
http://dx.doi.org/10.1182/blood-2010-03-275602	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368544	PMC

December 2010

Critical roles for Rac GTPases in T-cell migration to and within lymph nodes.

Authors:

Mustapha Faroudi Miroslav Hons Agnieszka Zachacz Celine Dumont Ruth Lyck Jens V Stein Victor L J Tybulewicz

Blood 2010 Dec 24;116(25):5536-47. Epub 2010 Sep 24.

Medical Research Council National Institute for Medical Research, London, UK.

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http://dx.doi.org/10.1182/blood-2010-08-299438	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368586	PMC

December 2010

Generation of a panel of antibodies against proteins encoded on human chromosome 21.

Authors:

Frances K Wiseman Olivia Sheppard Jacqueline M Linehan Sebastian Brandner Victor L J Tybulewicz Elizabeth M C Fisher

J Negat Results Biomed 2010 Aug 20;9. Epub 2010 Aug 20.

Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.

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http://dx.doi.org/10.1186/1477-5751-9-7	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936279	PMC

August 2010

The SYK tyrosine kinase: a crucial player in diverse biological functions.

Authors:

Attila Mócsai Jürgen Ruland Victor L J Tybulewicz

Nat Rev Immunol 2010 Jun;10(6):387-402

Department of Physiology, Semmelweis University School of Medicine, 1094 Budapest, Hungary.

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http://dx.doi.org/10.1038/nri2765	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782221	PMC

June 2010

Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome.

Nature 2010 Jun;465(7299):813-7

Adhesion and Angiogenesis Laboratory, Barts Institute of Cancer, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.

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http://dx.doi.org/10.1038/nature09106	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479956	PMC

June 2010

Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome.

Authors:

Kate A Alford Amy Slender Lesley Vanes Zhe Li Elizabeth M C Fisher Dean Nizetic Stuart H Orkin Irene Roberts Victor L J Tybulewicz

Blood 2010 Apr 12;115(14):2928-37. Epub 2010 Feb 12.

Division of Immune Cell Biology, Medical Research Council National Institute for Medical Research, London, UK.

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http://dx.doi.org/10.1182/blood-2009-06-227629	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854435	PMC

April 2010

A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.

Authors:

Robert B Henderson Katarzyna Grys Anne Vehlow Carine de Bettignies Agnieszka Zachacz Tom Henley Martin Turner Facundo Batista Victor L J Tybulewicz

J Exp Med 2010 Apr 22;207(4):837-53. Epub 2010 Mar 22.

Division of Immune Cell Biology, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK.

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http://dx.doi.org/10.1084/jem.20091489	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856036	PMC

April 2010

Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21.

Authors:

Aarti Ruparelia Frances Wiseman Olivia Sheppard Victor L J Tybulewicz Elizabeth M C Fisher

J Biomed Res 2010 Mar;24(2):87-99

Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.1016/S1674-8301(10)60016-4	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596542	PMC

March 2010

New approaches for modelling sporadic genetic disease in the mouse.

Authors:

Elizabeth M C Fisher Eva Lana-Elola Sheona D Watson George Vassiliou Victor L J Tybulewicz

Dis Model Mech 2009 Sep-Oct;2(9-10):446-53

Department of Neurodegenerative Disease, UCL Institute of Neurology, London WC1N3BG, UK.

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http://dx.doi.org/10.1242/dmm.001644	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737055	PMC

January 2010

Function of the nucleotide exchange activity of vav1 in T cell development and activation.

Authors:

Alexander Saveliev Lesley Vanes Olga Ksionda Jonathan Rapley Stephen J Smerdon Katrin Rittinger Victor L J Tybulewicz

Sci Signal 2009 Dec 15;2(101):ra83. Epub 2009 Dec 15.

1Division of Immune Cell Biology, MRC National Institute for Medical Research, London NW7 1AA, UK.

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http://stke.sciencemag.org/cgi/doi/10.1126/scisignal.2000420	Publisher Site
http://dx.doi.org/10.1126/scisignal.2000420	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434450	PMC

December 2009

Rho family GTPases and their regulators in lymphocytes.

Authors:

Victor L J Tybulewicz Robert B Henderson

Nat Rev Immunol 2009 Sep 21;9(9):630-44. Epub 2009 Aug 21.

Division of Immune Cell Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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http://www.nature.com/articles/nri2606	Publisher Site
http://dx.doi.org/10.1038/nri2606	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898593	PMC

September 2009

Essential role of Rac1 and Rac3 GTPases in neuronal development.

Authors:

Sara Corbetta Sara Gualdoni Gabriele Ciceri Marta Monari Emanuela Zuccaro Victor L J Tybulewicz Ivan de Curtis

FASEB J 2009 May 6;23(5):1347-57. Epub 2009 Jan 6.

Cell Adhesion Unit, San Raffaele Scientific Institute and University Vita-Salute San Raffaele, Via Olgettina 58-20132 Milano, Italy.

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http://www.fasebj.org/content/23/5/1347.full.pdf	Web Search
http://www.fasebj.org/cgi/doi/10.1096/fj.08-121574	Publisher Site
http://dx.doi.org/10.1096/fj.08-121574	DOI Listing

May 2009

Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome.

Authors:

Yuqin Wang Claire Mulligan Gareth Denyer Frederic Delom Franca Dagna-Bricarelli Victor L J Tybulewicz Elizabeth M C Fisher William J Griffiths Dean Nizetic Jürgen Groet

Mol Cell Proteomics 2009 Apr 10;8(4):585-95. Epub 2008 Nov 10.

Institute of Mass-Spectrometry, School of Medicine, Swansea University, Singleton Park, Swansea SA2 8PP, United Kingdom.

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http://dx.doi.org/10.1074/mcp.M800256-MCP200	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667343	PMC

April 2009

Rac GTPases play critical roles in early T-cell development.

Authors:

Celine Dumont Agnieszka Corsoni-Tadrzak Sandra Ruf Jasper de Boer Adam Williams Martin Turner Dimitris Kioussis Victor L J Tybulewicz

Blood 2009 Apr 16;113(17):3990-8. Epub 2008 Dec 16.

Division of Immune Cell Biology, Medical Research Council (MRC) National Institute for Medical Research, London, UK.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-09-18	Publisher Site
http://dx.doi.org/10.1182/blood-2008-09-181180	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673125	PMC

April 2009

Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome.

Authors:

Micaela Galante Harsha Jani Lesley Vanes Hervé Daniel Elizabeth M C Fisher Victor L J Tybulewicz Timothy V P Bliss Elise Morice

Hum Mol Genet 2009 Apr 29;18(8):1449-63. Epub 2009 Jan 29.

Laboratoire de Pharmacologie de la Synapse, CNRS UMR 8619, Université Paris-Sud, 91405 Orsay Cedex, France.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/	Publisher Site
http://dx.doi.org/10.1093/hmg/ddp055	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664148	PMC

April 2009

Lymphocyte signaling: beyond knockouts.

Authors:

Alexander Saveliev Victor L J Tybulewicz

Nat Immunol 2009 Apr 19;10(4):361-4. Epub 2009 Mar 19.

Medical Research Council National Institute for Medical Research, London, UK.

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http://dx.doi.org/10.1038/ni.1709	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898592	PMC

April 2009

Down syndrome--recent progress and future prospects.

Authors:

Frances K Wiseman Kate A Alford Victor L J Tybulewicz Elizabeth M C Fisher

Hum Mol Genet 2009 Apr;18(R1):R75-83

Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.1093/hmg/ddp010	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657943	PMC

April 2009

Species-specific transcription in mice carrying human chromosome 21.

Authors:

Michael D Wilson Nuno L Barbosa-Morais Dominic Schmidt Caitlin M Conboy Lesley Vanes Victor L J Tybulewicz Elizabeth M C Fisher Simon Tavaré Duncan T Odom

Science 2008 Oct 11;322(5900):434-8. Epub 2008 Sep 11.

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1126/science.1160930	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717767	PMC

October 2008

DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome.

Am J Hum Genet 2008 Sep 4;83(3):388-400. Epub 2008 Sep 4.

Institute of Cell and Molecular Science, Barts & The London, Queen Mary's School of Medicine and Dentistry, University of London, 4 Newark Street, London E1 2AT, UK.

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http://dx.doi.org/10.1016/j.ajhg.2008.08.012	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556438	PMC

September 2008

Crucial structural role for the PH and C1 domains of the Vav1 exchange factor.

Authors:

Jonathan Rapley Victor L J Tybulewicz Katrin Rittinger

EMBO Rep 2008 Jul 30;9(7):655-61. Epub 2008 May 30.

Division of Molecular Structure, and National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.

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http://dx.doi.org/10.1038/embor.2008.80	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427238	PMC

July 2008

Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome.

Authors:

Elise Morice Laura C Andreae Sam F Cooke Lesley Vanes Elizabeth M C Fisher Victor L J Tybulewicz Timothy V P Bliss

Learn Mem 2008 Jul 14;15(7):492-500. Epub 2008 Jul 14.

Division of Neurophysiology, National Institute for Medical Research, London NW7 1AA, United Kingdom.

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http://dx.doi.org/10.1101/lm.969608	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2505316	PMC

July 2008

Characterization of the roles of Rac1 and Rac2 GTPases in lymphocyte development.

Authors:

Celine Dumont Robert Henderson Victor L J Tybulewicz

Methods Enzymol 2008 ;439:235-54

Division of Immune Cell Biology, National Institute for Medical Research, London, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00766879070041	Publisher Site
http://dx.doi.org/10.1016/S0076-6879(07)00418-1	DOI Listing

June 2008

Redundant role for Zap70 in B cell development and activation.

Authors:

Farnaz Fallah-Arani Edina Schweighoffer Lesley Vanes Victor L J Tybulewicz

Eur J Immunol 2008 Jun;38(6):1721-33

Division of Immune Cell Biology, MRC National Institute for Medical Research, London, UK.

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http://doi.wiley.com/10.1002/eji.200738026	Publisher Site
http://dx.doi.org/10.1002/eji.200738026	DOI Listing

June 2008

Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.

Authors:

Yoshinori Yamanishi Jiro Kitaura Kumi Izawa Takayuki Matsuoka Toshihiko Oki Yang Lu Fumi Shibata Satoshi Yamazaki Hidetoshi Kumagai Hideaki Nakajima Mari Maeda-Yamamoto Victor L J Tybulewicz Toshiyuki Takai Toshio Kitamura

Blood 2008 Jan 10;111(2):688-98. Epub 2007 Oct 10.

Institute of Medical Science, University of Tokyo, Japan.

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http://dx.doi.org/10.1182/blood-2007-04-085787	DOI Listing

January 2008

CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand.

Authors:

David Depoil Sebastian Fleire Bebhinn L Treanor Michele Weber Naomi E Harwood Kevin L Marchbank Victor L J Tybulewicz Facundo D Batista

Nat Immunol 2008 Jan 2;9(1):63-72. Epub 2007 Dec 2.

Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

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http://www.nature.com/articles/ni1547	Publisher Site
http://dx.doi.org/10.1038/ni1547	DOI Listing

January 2008

Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation.

Authors:

Eloisa Arana Anne Vehlow Naomi E Harwood Elena Vigorito Robert Henderson Martin Turner Victor L J Tybulewicz Facundo D Batista

Immunity 2008 Jan;28(1):88-99

Lymphocyte Interaction Laboratory, Cancer Research UK, London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S107476130700581	Publisher Site
http://dx.doi.org/10.1016/j.immuni.2007.12.003	DOI Listing

January 2008

Cutting edge: Rac GTPases sensitize activated T cells to die via Fas.

Authors:

Madhu Ramaswamy Celine Dumont Anthony C Cruz Jagan R Muppidi Timothy S Gomez Daniel D Billadeau Victor L J Tybulewicz Richard M Siegel

J Immunol 2007 Nov;179(10):6384-8

Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.179.10.6384	DOI Listing

November 2007

Syk-mediated translocation of PI3Kdelta to the leading edge controls lamellipodium formation and migration of leukocytes.

Authors:

Jürgen Schymeinsky Cornelia Then Anca Sindrilaru Ronald Gerstl Zoltán Jakus Victor L J Tybulewicz Karin Scharffetter-Kochanek Barbara Walzog

PLoS One 2007 Nov 7;2(11):e1132. Epub 2007 Nov 7.

Department of Physiology, Ludwig-Maximilians-University Munich, Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001132	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063580	PMC

November 2007

Requirement for Rac1 in a K-ras induced lung cancer in the mouse.

Authors:

Joseph L Kissil Marita J Walmsley Linda Hanlon Kevin M Haigis Carla F Bender Kim Alejandro Sweet-Cordero Matthew S Eckman David A Tuveson Anthony J Capobianco Victor L J Tybulewicz Tyler Jacks

Cancer Res 2007 Sep;67(17):8089-94

Program in Molecular Oncogenesis, The Wistar Institute, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2300	DOI Listing

September 2007

Functional analysis of activating receptor LMIR4 as a counterpart of inhibitory receptor LMIR3.

Authors:

Kumi Izawa Jiro Kitaura Yoshinori Yamanishi Takayuki Matsuoka Toshihiko Oki Fumi Shibata Hidetoshi Kumagai Hideaki Nakajima Mari Maeda-Yamamoto Jeffrey P Hauchins Victor L J Tybulewicz Toshiyuki Takai Toshio Kitamura

J Biol Chem 2007 Jun 16;282(25):17997-8008. Epub 2007 Apr 16.

Division of Cellular Therapy, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M701100200	Publisher Site
http://dx.doi.org/10.1074/jbc.M701100200	DOI Listing

June 2007

Beta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination.

Authors:

Alessandro Nodari Desirée Zambroni Angelo Quattrini Felipe A Court Alessandra D'Urso Alessandra Recchia Victor L J Tybulewicz Lawrence Wrabetz M Laura Feltri

J Cell Biol 2007 Jun;177(6):1063-75

Department of Biological and Technological Research, San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://www.jcb.org/lookup/doi/10.1083/jcb.200610014	Publisher Site
http://dx.doi.org/10.1083/jcb.200610014	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064366	PMC

June 2007

Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption.

Authors:

Wei Zou Hideki Kitaura Jennifer Reeve Fanxin Long Victor L J Tybulewicz Sanford J Shattil Mark H Ginsberg F Patrick Ross Steven L Teitelbaum

J Cell Biol 2007 Mar;176(6):877-88

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1083/jcb.200611083	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064061	PMC

March 2007

GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.

Authors:

Sascha C Hughan Craig E Hughes Owen J T McCarty Edina Schweighoffer Izoumroud Soultanova Jerry Ware Victor L J Tybulewicz Steve P Watson

Arterioscler Thromb Vasc Biol 2007 Feb 16;27(2):422-9. Epub 2006 Nov 16.

Centre for Cardiovascular Sciences, Institute of Biomedical Research, University of Birmingham, UK.

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http://dx.doi.org/10.1161/01.ATV.0000252826.96134.21	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990469	PMC

February 2007

New techniques to understand chromosome dosage: mouse models of aneuploidy.

Authors:

Victor L J Tybulewicz Elizabeth M C Fisher

Hum Mol Genet 2006 Oct;15 Spec No 2:R103-9

Division of Immune Cell Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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http://dx.doi.org/10.1093/hmg/ddl179	DOI Listing

October 2006

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

Authors:

Katsue Suzuki-Inoue Gemma L J Fuller Angel García Johannes A Eble Stefan Pöhlmann Osamu Inoue T Kent Gartner Sascha C Hughan Andrew C Pearce Gavin D Laing R David G Theakston Edina Schweighoffer Nicole Zitzmann Takashi Morita Victor L J Tybulewicz Yukio Ozaki Steve P Watson

Blood 2006 Jan 20;107(2):542-9. Epub 2005 Sep 20.

Department of Clinical and Laboratory Medicine, University of Yamanashi, Shimokato Tamaho Nakakoma, Yamanashi 409-3898, Japan.

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http://www.birmingham.ac.uk/Documents/college-mds/research/p	Web Search
http://www.bloodjournal.org/content/early/2005/09/20/blood-2	Web Search
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-05-19	Publisher Site
http://dx.doi.org/10.1182/blood-2005-05-1994	DOI Listing

January 2006

Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.

Authors:

Owen J T McCarty Mark K Larson Jocelyn M Auger Neena Kalia Ben T Atkinson Andrew C Pearce Sandra Ruf Robert B Henderson Victor L J Tybulewicz Laura M Machesky Steve P Watson

J Biol Chem 2005 Nov 29;280(47):39474-84. Epub 2005 Sep 29.

Centre for Cardiovascular Sciences, the Institute of Biomedical Research, School of Biosciences, University of Birmingham, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M504672200	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1395485	PMC

November 2005

Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells.

Authors:

Antonella Prisco Lesley Vanes Sandra Ruf Cesar Trigueros Victor L J Tybulewicz

Immunity 2005 Sep;23(3):263-74

Division of Immune Cell Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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http://dx.doi.org/10.1016/j.immuni.2005.07.007	DOI Listing

September 2005

An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.

Authors:

Aideen O'Doherty Sandra Ruf Claire Mulligan Victoria Hildreth Mick L Errington Sam Cooke Abdul Sesay Sonie Modino Lesley Vanes Diana Hernandez Jacqueline M Linehan Paul T Sharpe Sebastian Brandner Timothy V P Bliss Deborah J Henderson Dean Nizetic Victor L J Tybulewicz Elizabeth M C Fisher

Science 2005 Sep;309(5743):2033-7

Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK.

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http://dx.doi.org/10.1126/science.1114535	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1378183	PMC

September 2005

Vav-family proteins in T-cell signalling.

Authors:

Victor L J Tybulewicz

Curr Opin Immunol 2005 Jun;17(3):267-74

Division of Immune Cell Biology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.

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http://dx.doi.org/10.1016/j.coi.2005.04.003	DOI Listing

June 2005

Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen.

Authors:

Masayuki Kohno Sho Yamasaki Victor L J Tybulewicz Takashi Saito

Blood 2005 Mar 12;105(5):2059-65. Epub 2004 Nov 12.

Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.

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http://dx.doi.org/10.1182/blood-2004-07-2639	DOI Listing

March 2005

Distinct roles for the linker region tyrosines of Syk in FcepsilonRI signaling in primary mast cells.

Authors:

Maria Simon Lesley Vanes Robert L Geahlen Victor L J Tybulewicz

J Biol Chem 2005 Feb 2;280(6):4510-7. Epub 2004 Dec 2.

Division of Immune Cell Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M410326200	DOI Listing

February 2005

Commentary: New insights into the complexity of phosphatidylinositol lipid signaling in B lymphocytes.

Authors:

Victor L J Tybulewicz

Eur J Immunol 2004 Nov;34(11):2964-7

Division of Immune Cell Biology, National Institute for Medical Research, London, UK.

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http://dx.doi.org/10.1002/eji.200425593	DOI Listing

November 2004

Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming.

Authors:

Federica Benvenuti Stephanie Hugues Marita Walmsley Sandra Ruf Luc Fetler Michel Popoff Victor L J Tybulewicz Sebastian Amigorena

Science 2004 Aug;305(5687):1150-3

Unité INSERM 365, Institut Curie, 26 rue d'Ulm, 75005 Paris, France.

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http://dx.doi.org/10.1126/science.1099159	DOI Listing

August 2004

Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1.

Authors:

Lucinda F Reynolds Carine de Bettignies Trisha Norton Alexander Beeser Jonathan Chernoff Victor L J Tybulewicz

J Biol Chem 2004 Apr 5;279(18):18239-46. Epub 2004 Feb 5.

Division of Immune Cell Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M400257200	DOI Listing

April 2004

The tyrosine kinase Syk is required for light chain isotype exclusion but dispensable for the negative selection of B cells.

Authors:

Josephine Meade Victor L J Tybulewicz Martin Turner

Eur J Immunol 2004 Apr;34(4):1102-10

Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, The Babraham Institute, Cambridge, GB.

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http://dx.doi.org/10.1002/eji.200324309	DOI Listing

April 2004

ERM proteins regulate cytoskeleton relaxation promoting T cell-APC conjugation.

Authors:

Sophie Faure Laura Inés Salazar-Fontana Monique Semichon Victor L J Tybulewicz Georges Bismuth Alain Trautmann Ronald N Germain Jérôme Delon

Nat Immunol 2004 Mar 1;5(3):272-9. Epub 2004 Feb 1.

Institut Cochin, Département de Biologie Cellulaire, Institut National de la Santé et de la Recherche Médicale U567/Centre National de la Recherche Scientifique UMR 8104, Université René Descartes, 22 rue Méchain, 75014 Paris, France.

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