Victor L J Tybulewicz

Victor L J Tybulewicz

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Victor L J Tybulewicz

Publications by authors named "Victor L J Tybulewicz"

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Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years.

JAMA Neurol 2019 Feb;76(2):152-160

Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.

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http://dx.doi.org/10.1001/jamaneurol.2018.3616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439956PMC
February 2019

Rodent models in Down syndrome research: impact and future opportunities.

Dis Model Mech 2017 10;10(10):1165-1186

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, 1 rue Laurent Fries, 67404 Illkirch, France.

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http://dx.doi.org/10.1242/dmm.029728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665454PMC
October 2017

Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models.

Neurobiol Dis 2017 Sep 15;105:235-244. Epub 2017 Jun 15.

Department of Neurology and Alzheimer Research Center, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands; Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2017.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536154PMC
September 2017

TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.

J Exp Med 2017 05 29;214(5):1269-1280. Epub 2017 Mar 29.

The Francis Crick Institute, London NW1 1AT, England, UK

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http://dx.doi.org/10.1084/jem.20161117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413329PMC
May 2017

Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome.

PLoS One 2016;11(9):e0162974. Epub 2016 Sep 22.

Translational Imaging Group, Centre for Medical Image Computing, University College London, 3rd Floor, Wolfson House, 4 Stephenson Way, London NW1 2HE, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033246PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162974PLOS
September 2016

Long noncoding RNAs in B-cell development and activation.

Blood 2016 08 5;128(7):e10-9. Epub 2016 Jul 5.

The Francis Crick Institute, London, United Kingdom; Imperial College, London, United Kingdom.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2015-11
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http://dx.doi.org/10.1182/blood-2015-11-680843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000579PMC
August 2016

Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory.

Neurobiol Learn Mem 2016 Apr 8;130:118-28. Epub 2016 Feb 8.

School of Psychology, Cardiff University, CF10 3AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nlm.2016.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898594PMC
April 2016

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome.

Nat Rev Neurosci 2015 Sep 5;16(9):564-74. Epub 2015 Aug 5.

Division of Psychiatry, University College London, Maple House, 149 Tottenham Court Road, London W1T 7NF, UK.

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http://dx.doi.org/10.1038/nrn3983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678594PMC
September 2015

BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.

J Exp Med 2015 Jun 18;212(6):883-92. Epub 2015 May 18.

Division of Immune Cell Biology, MRC National Institute for Medical Research London, London NW7 1AA, England, UK

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http://dx.doi.org/10.1084/jem.20142127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451135PMC
June 2015

Syk tyrosine kinase is critical for B cell antibody responses and memory B cell survival.

J Immunol 2015 May 10;194(10):4650-6. Epub 2015 Apr 10.

Division of Immune Cell Biology, MRC National Institute for Medical Research, London NW7 1AA, United Kingdom; and

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http://dx.doi.org/10.4049/jimmunol.1500461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416743PMC
May 2015

Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9.

Eur J Immunol 2015 Feb 8;45(2):513-24. Epub 2014 Dec 8.

Center for Comparative Medicine, Department of Anatomy, Physiology, and Cell Biology, University of California Davis, Davis, CA, USA.

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http://dx.doi.org/10.1002/eji.201444744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324162PMC
February 2015

IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen.

J Exp Med 2014 Sep 15;211(10):2085-101. Epub 2014 Sep 15.

Division of Immune Cell Biology, MRC National Institute for Medical Research, London NW7 1AA, England, UK

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http://dx.doi.org/10.1084/jem.20132019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172221PMC
September 2014

Themis2 is not required for B cell development, activation, and antibody responses.

J Immunol 2014 Jul 6;193(2):700-7. Epub 2014 Jun 6.

Medical Research Council, National Institute for Medical Research, London NW7 1AA, United Kingdom; and

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http://dx.doi.org/10.4049/jimmunol.1400943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082722PMC
July 2014

A key regulatory role for Vav1 in controlling lipopolysaccharide endotoxemia via macrophage-derived IL-6.

J Immunol 2014 Mar 14;192(6):2830-2836. Epub 2014 Feb 14.

Medical Clinic 1, Friedrich-Alexander University of Erlangen-Nürnberg, University Hospital of Erlangen, Germany.

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http://dx.doi.org/10.4049/jimmunol.1300157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951479PMC
March 2014

Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain.

Hum Mol Genet 2013 May 24;22(9):1709-24. Epub 2013 Jan 24.

Department of Pediatrics, Linda Crnic Institute for Down Syndrome, University of Colorado Denver School of Medicine, 12700 E 19th Avenue, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1093/hmg/ddt017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613160PMC
May 2013

The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.

Immunity 2013 Mar 28;38(3):475-88. Epub 2013 Feb 28.

Division of Immune Cell Biology, MRC National Institute for Medical Research, London NW7 1AA, UK.

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http://dx.doi.org/10.1016/j.immuni.2012.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627223PMC
March 2013

Mechanism and function of Vav1 localisation in TCR signalling.

J Cell Sci 2012 Nov 6;125(Pt 22):5302-14. Epub 2012 Sep 6.

Division of Immune Cell Biology, MRC National Institute for Medical Research, London NW7 1AA, UK.

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http://dx.doi.org/10.1242/jcs.105148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561853PMC
November 2012

Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.

Proc Natl Acad Sci U S A 2012 Aug 6;109(34):13722-7. Epub 2012 Aug 6.

Medical Research Council (MRC) Prion Unit, University College London (UCL) Institute of Neurology, London, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1208917109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427081PMC
August 2012

Mouse models of aneuploidy.

ScientificWorldJournal 2012 3;2012:214078. Epub 2012 Jan 3.

Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

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http://dx.doi.org/10.1100/2012/214078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259538PMC
June 2012

Vav1 GEF activity is required for T cell mediated allograft rejection.

Transpl Immunol 2012 Jun 21;26(4):212-9. Epub 2012 Mar 21.

Novartis Institutes of BioMedical Research, Autoimmunity, Transplantation & Inflammation, 4002 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.trim.2012.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485565PMC
June 2012

Genomically humanized mice: technologies and promises.

Nat Rev Genet 2011 Dec 16;13(1):14-20. Epub 2011 Dec 16.

Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

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http://dx.doi.org/10.1038/nrg3116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782217PMC
December 2011

Down syndrome: searching for the genetic culprits.

Dis Model Mech 2011 Sep;4(5):586-95

MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK.

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http://dx.doi.org/10.1242/dmm.008078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180222PMC
September 2011

Structural correlates of active-staining following magnetic resonance microscopy in the mouse brain.

Neuroimage 2011 Jun 16;56(3):974-83. Epub 2011 Feb 16.

Centre for Advanced Biomedical Imaging, Department of Medicine and Institute of Child Health, University College London, London, UK.

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http://dx.doi.org/10.1016/j.neuroimage.2011.01.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590453PMC
June 2011

Critical roles for Rac GTPases in T-cell migration to and within lymph nodes.

Blood 2010 Dec 24;116(25):5536-47. Epub 2010 Sep 24.

Medical Research Council National Institute for Medical Research, London, UK.

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http://dx.doi.org/10.1182/blood-2010-08-299438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368586PMC
December 2010

Generation of a panel of antibodies against proteins encoded on human chromosome 21.

J Negat Results Biomed 2010 Aug 20;9. Epub 2010 Aug 20.

Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.

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http://dx.doi.org/10.1186/1477-5751-9-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936279PMC
August 2010

The SYK tyrosine kinase: a crucial player in diverse biological functions.

Nat Rev Immunol 2010 Jun;10(6):387-402

Department of Physiology, Semmelweis University School of Medicine, 1094 Budapest, Hungary.

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http://dx.doi.org/10.1038/nri2765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782221PMC
June 2010

Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome.

Blood 2010 Apr 12;115(14):2928-37. Epub 2010 Feb 12.

Division of Immune Cell Biology, Medical Research Council National Institute for Medical Research, London, UK.

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http://dx.doi.org/10.1182/blood-2009-06-227629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854435PMC
April 2010

A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.

J Exp Med 2010 Apr 22;207(4):837-53. Epub 2010 Mar 22.

Division of Immune Cell Biology, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK.

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http://dx.doi.org/10.1084/jem.20091489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856036PMC
April 2010

Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21.

J Biomed Res 2010 Mar;24(2):87-99

Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.1016/S1674-8301(10)60016-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596542PMC
March 2010

New approaches for modelling sporadic genetic disease in the mouse.

Dis Model Mech 2009 Sep-Oct;2(9-10):446-53

Department of Neurodegenerative Disease, UCL Institute of Neurology, London WC1N3BG, UK.

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http://dx.doi.org/10.1242/dmm.001644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737055PMC
January 2010

Rho family GTPases and their regulators in lymphocytes.

Nat Rev Immunol 2009 Sep 21;9(9):630-44. Epub 2009 Aug 21.

Division of Immune Cell Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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http://www.nature.com/articles/nri2606
Publisher Site
http://dx.doi.org/10.1038/nri2606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898593PMC
September 2009

Essential role of Rac1 and Rac3 GTPases in neuronal development.

FASEB J 2009 May 6;23(5):1347-57. Epub 2009 Jan 6.

Cell Adhesion Unit, San Raffaele Scientific Institute and University Vita-Salute San Raffaele, Via Olgettina 58-20132 Milano, Italy.

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http://www.fasebj.org/content/23/5/1347.full.pdf
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http://www.fasebj.org/cgi/doi/10.1096/fj.08-121574
Publisher Site
http://dx.doi.org/10.1096/fj.08-121574DOI Listing
May 2009

Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome.

Mol Cell Proteomics 2009 Apr 10;8(4):585-95. Epub 2008 Nov 10.

Institute of Mass-Spectrometry, School of Medicine, Swansea University, Singleton Park, Swansea SA2 8PP, United Kingdom.

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http://dx.doi.org/10.1074/mcp.M800256-MCP200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667343PMC
April 2009

Rac GTPases play critical roles in early T-cell development.

Blood 2009 Apr 16;113(17):3990-8. Epub 2008 Dec 16.

Division of Immune Cell Biology, Medical Research Council (MRC) National Institute for Medical Research, London, UK.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-09-18
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http://dx.doi.org/10.1182/blood-2008-09-181180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673125PMC
April 2009

Lymphocyte signaling: beyond knockouts.

Nat Immunol 2009 Apr 19;10(4):361-4. Epub 2009 Mar 19.

Medical Research Council National Institute for Medical Research, London, UK.

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http://dx.doi.org/10.1038/ni.1709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898592PMC
April 2009

Down syndrome--recent progress and future prospects.

Hum Mol Genet 2009 Apr;18(R1):R75-83

Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.1093/hmg/ddp010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657943PMC
April 2009

Species-specific transcription in mice carrying human chromosome 21.

Science 2008 Oct 11;322(5900):434-8. Epub 2008 Sep 11.

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1126/science.1160930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717767PMC
October 2008

Crucial structural role for the PH and C1 domains of the Vav1 exchange factor.

EMBO Rep 2008 Jul 30;9(7):655-61. Epub 2008 May 30.

Division of Molecular Structure, and National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.

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http://dx.doi.org/10.1038/embor.2008.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427238PMC
July 2008

Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome.

Learn Mem 2008 Jul 14;15(7):492-500. Epub 2008 Jul 14.

Division of Neurophysiology, National Institute for Medical Research, London NW7 1AA, United Kingdom.

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http://dx.doi.org/10.1101/lm.969608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2505316PMC
July 2008

Characterization of the roles of Rac1 and Rac2 GTPases in lymphocyte development.

Methods Enzymol 2008 ;439:235-54

Division of Immune Cell Biology, National Institute for Medical Research, London, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00766879070041
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http://dx.doi.org/10.1016/S0076-6879(07)00418-1DOI Listing
June 2008

Redundant role for Zap70 in B cell development and activation.

Eur J Immunol 2008 Jun;38(6):1721-33

Division of Immune Cell Biology, MRC National Institute for Medical Research, London, UK.

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http://doi.wiley.com/10.1002/eji.200738026
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http://dx.doi.org/10.1002/eji.200738026DOI Listing
June 2008

CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand.

Nat Immunol 2008 Jan 2;9(1):63-72. Epub 2007 Dec 2.

Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

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http://www.nature.com/articles/ni1547
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http://dx.doi.org/10.1038/ni1547DOI Listing
January 2008

Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation.

Immunity 2008 Jan;28(1):88-99

Lymphocyte Interaction Laboratory, Cancer Research UK, London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S107476130700581
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http://dx.doi.org/10.1016/j.immuni.2007.12.003DOI Listing
January 2008

Cutting edge: Rac GTPases sensitize activated T cells to die via Fas.

J Immunol 2007 Nov;179(10):6384-8

Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.179.10.6384DOI Listing
November 2007

Functional analysis of activating receptor LMIR4 as a counterpart of inhibitory receptor LMIR3.

J Biol Chem 2007 Jun 16;282(25):17997-8008. Epub 2007 Apr 16.

Division of Cellular Therapy, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M701100200
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http://dx.doi.org/10.1074/jbc.M701100200DOI Listing
June 2007

GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.

Arterioscler Thromb Vasc Biol 2007 Feb 16;27(2):422-9. Epub 2006 Nov 16.

Centre for Cardiovascular Sciences, Institute of Biomedical Research, University of Birmingham, UK.

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http://dx.doi.org/10.1161/01.ATV.0000252826.96134.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990469PMC
February 2007

New techniques to understand chromosome dosage: mouse models of aneuploidy.

Hum Mol Genet 2006 Oct;15 Spec No 2:R103-9

Division of Immune Cell Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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http://dx.doi.org/10.1093/hmg/ddl179DOI Listing
October 2006

Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.

J Biol Chem 2005 Nov 29;280(47):39474-84. Epub 2005 Sep 29.

Centre for Cardiovascular Sciences, the Institute of Biomedical Research, School of Biosciences, University of Birmingham, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M504672200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1395485PMC
November 2005

Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells.

Immunity 2005 Sep;23(3):263-74

Division of Immune Cell Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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http://dx.doi.org/10.1016/j.immuni.2005.07.007DOI Listing
September 2005

Vav-family proteins in T-cell signalling.

Curr Opin Immunol 2005 Jun;17(3):267-74

Division of Immune Cell Biology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.

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http://dx.doi.org/10.1016/j.coi.2005.04.003DOI Listing
June 2005

Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen.

Blood 2005 Mar 12;105(5):2059-65. Epub 2004 Nov 12.

Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.

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http://dx.doi.org/10.1182/blood-2004-07-2639DOI Listing
March 2005

Distinct roles for the linker region tyrosines of Syk in FcepsilonRI signaling in primary mast cells.

J Biol Chem 2005 Feb 2;280(6):4510-7. Epub 2004 Dec 2.

Division of Immune Cell Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M410326200DOI Listing
February 2005

Commentary: New insights into the complexity of phosphatidylinositol lipid signaling in B lymphocytes.

Eur J Immunol 2004 Nov;34(11):2964-7

Division of Immune Cell Biology, National Institute for Medical Research, London, UK.

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http://dx.doi.org/10.1002/eji.200425593DOI Listing
November 2004

Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming.

Science 2004 Aug;305(5687):1150-3

Unité INSERM 365, Institut Curie, 26 rue d'Ulm, 75005 Paris, France.

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http://dx.doi.org/10.1126/science.1099159DOI Listing
August 2004

Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1.

J Biol Chem 2004 Apr 5;279(18):18239-46. Epub 2004 Feb 5.

Division of Immune Cell Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M400257200DOI Listing
April 2004

The tyrosine kinase Syk is required for light chain isotype exclusion but dispensable for the negative selection of B cells.

Eur J Immunol 2004 Apr;34(4):1102-10

Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, The Babraham Institute, Cambridge, GB.

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http://dx.doi.org/10.1002/eji.200324309DOI Listing
April 2004

ERM proteins regulate cytoskeleton relaxation promoting T cell-APC conjugation.

Nat Immunol 2004 Mar 1;5(3):272-9. Epub 2004 Feb 1.

Institut Cochin, Département de Biologie Cellulaire, Institut National de la Santé et de la Recherche Médicale U567/Centre National de la Recherche Scientifique UMR 8104, Université René Descartes, 22 rue Méchain, 75014 Paris, France.

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http://dx.doi.org/10.1038/ni1039DOI Listing
March 2004

Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling.

Science 2003 Oct;302(5644):459-62

Division of Immune Cell Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1089709
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http://dx.doi.org/10.1126/science.1089709DOI Listing
October 2003

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

Nat Immunol 2003 Jun 11;4(6):565-72. Epub 2003 May 11.

Department of Immunology, Pasteur Institute, 25-28 rue Dr Roux, 75015 Paris, France.

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http://www.nature.com/articles/ni930
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http://dx.doi.org/10.1038/ni930DOI Listing
June 2003

Vav1: a key signal transducer downstream of the TCR.

Immunol Rev 2003 Apr;192:42-52

Division of Immune Cell Biology, National Institute for Medical Research, London, UK.

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http://dx.doi.org/10.1034/j.1600-065x.2003.00032.xDOI Listing
April 2003

Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion.

Immunity 2003 Apr;18(4):523-33

National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

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http://dx.doi.org/10.1016/s1074-7613(03)00082-7DOI Listing
April 2003

Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse.

Eur J Immunol 2003 Mar;33(3):790-7

National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, Great Britain.

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http://dx.doi.org/10.1002/eji.200323858DOI Listing
March 2003

Chemokines and the immunological synapse.

Immunology 2002 Jul;106(3):287-8

National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782730PMC
http://dx.doi.org/10.1046/j.1365-2567.2002.01467.xDOI Listing
July 2002

Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases.

Nat Immunol 2002 Mar 11;3(3):288-94. Epub 2002 Feb 11.

Laboratory for Cytokines and Lymphoid Development, The Pasteur Institute, Paris, France.

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http://dx.doi.org/10.1038/ni764DOI Listing
March 2002