Victor J Wroblewski

Victor J Wroblewski

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Victor J Wroblewski

Victor J Wroblewski

Publications by authors named "Victor J Wroblewski"

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38Publications

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Correlation between antidrug antibodies, pre-existing antidrug reactivity, and immunogenetics (MHC class II alleles) in cynomolgus macaque.

Immunogenetics 2019 11 27;71(10):605-615. Epub 2019 Nov 27.

Department of Drug Disposition, Lilly Research Laboratories; Eli Lilly and Company; Lilly Corporate Center, Indianapolis, IN, USA.

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http://dx.doi.org/10.1007/s00251-019-01136-7DOI Listing
November 2019

Peripheral and central nervous system distribution of the CGRP neutralizing antibody [I] galcanezumab in male rats.

Cephalalgia 2019 Sep 19;39(10):1241-1248. Epub 2019 Apr 19.

1 Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.

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http://journals.sagepub.com/doi/10.1177/0333102419844711
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http://dx.doi.org/10.1177/0333102419844711DOI Listing
September 2019

The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies.

MAbs 2015 4;7(6):1084-93. Epub 2015 Sep 4.

a Departments of Drug Disposition and Development/Commercialization, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center , Indianapolis , IN , USA.

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http://dx.doi.org/10.1080/19420862.2015.1075109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966429PMC
August 2016

Aberrant bispecific antibody pharmacokinetics linked to liver sinusoidal endothelium clearance mechanism in cynomolgus monkeys.

MAbs 2016 07;8(5):969-82

a Department of Drug Disposition, Development/ Commercialization , Lilly Research Laboratories, Lilly Corporate Center , Indianapolis , Indiana , USA.

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http://dx.doi.org/10.1080/19420862.2016.1178435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968112PMC
July 2016

A Modeling and Experimental Investigation of the Effects of Antigen Density, Binding Affinity, and Antigen Expression Ratio on Bispecific Antibody Binding to Cell Surface Targets.

J Biol Chem 2016 May 28;291(21):11337-47. Epub 2016 Mar 28.

From the Department of Drug Disposition, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.

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http://dx.doi.org/10.1074/jbc.M116.714287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900278PMC
May 2016

Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics.

MAbs 2015 ;7(3):483-93

a Department of Drug Disposition Development/Commercialization; Lilly Research Laboratories; Eli Lilly and Company Corporate Center , Indianapolis , IN USA.

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http://dx.doi.org/10.1080/19420862.2015.1016696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622971PMC
March 2016

Proteolytic cleavage of antigen extends the durability of an anti-PCSK9 monoclonal antibody.

J Lipid Res 2015 Nov 20;56(11):2124-32. Epub 2015 Sep 20.

Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285.

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http://dx.doi.org/10.1194/jlr.M061903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617399PMC
November 2015

Disposition of Basal Insulin Peglispro Compared with 20-kDa Polyethylene Glycol in Rats Following a Single Intravenous or Subcutaneous Dose.

Drug Metab Dispos 2015 Oct 14;43(10):1477-83. Epub 2015 Jul 14.

Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.

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http://dx.doi.org/10.1124/dmd.115.064337DOI Listing
October 2015

Translational Pharmacodynamics of Calcitonin Gene-Related Peptide Monoclonal Antibody LY2951742 in a Capsaicin-Induced Dermal Blood Flow Model.

J Pharmacol Exp Ther 2015 Sep 26;354(3):350-7. Epub 2015 Jun 26.

Center for Clinical Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven and University Hospitals Leuven, Campus Gasthuisberg, Leuven, Belgium (S.V., A.V.H., J.d.H.); Eli Lilly and Company, Indianapolis, Indiana (R.J.B., D.M., V.J.W., E.C.C.); and Atlas Venture, Cambridge, Massachusetts (D.G.)

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http://dx.doi.org/10.1124/jpet.115.224212DOI Listing
September 2015

Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys.

MAbs 2012 Mar-Apr;4(2):267-73. Epub 2012 Mar 1.

Eli Lilly Research Laboratories; Eli Lilly Corporate Center; Indianapolis, IN USA; Departments of Drug Disposition Development/Commercialization; Eli Lilly Research Laboratories; Eli Lilly Corporate Center; Indianapolis, IN USA.

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http://dx.doi.org/10.4161/mabs.4.2.19364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361662PMC
February 2015

Application of FcRn binding assays to guide mAb development.

Drug Metab Dispos 2014 Nov 14;42(11):1867-72. Epub 2014 Jul 14.

Department of Drug Disposition Development/Commercialization, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana

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http://dx.doi.org/10.1124/dmd.114.059089DOI Listing
November 2014

Qualification of a free ligand assay in the presence of anti-ligand antibody Fab fragments.

MAbs 2013 Mar-Apr;5(2):288-96. Epub 2013 Feb 8.

Drug Disposition, Eli Lilly and Company, Indianapolis, IN, USA.

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http://dx.doi.org/10.4161/mabs.23508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893239PMC
December 2013

FcRn affinity-pharmacokinetic relationship of five human IgG4 antibodies engineered for improved in vitro FcRn binding properties in cynomolgus monkeys.

Drug Metab Dispos 2012 Aug 14;40(8):1545-55. Epub 2012 May 14.

Departments of Drug Disposition Development/Commercialization, Lilly Research Laboratories, Eli Lilly & Company, Lilly Corporate Center, S. Delaware St., Indianapolis, IN 46285, USA.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.112.045864
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http://dx.doi.org/10.1124/dmd.112.045864DOI Listing
August 2012

A dual-monoclonal sandwich ELISA specific for hepcidin-25.

Clin Chem 2010 Nov 16;56(11):1725-32. Epub 2010 Sep 16.

Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.

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http://www.clinchem.org/cgi/doi/10.1373/clinchem.2010.151522
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http://dx.doi.org/10.1373/clinchem.2010.151522DOI Listing
November 2010

Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency.

Br J Haematol 2009 Mar 20;144(5):789-93. Epub 2008 Dec 20.

Department of Medicine II, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07535.xDOI Listing
March 2009

Neonatal Fc receptor mediates internalization of Fc in transfected human endothelial cells.

Mol Biol Cell 2008 Dec 8;19(12):5490-505. Epub 2008 Oct 8.

Department of Drug Disposition Development/Commercialization, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.

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http://www.molbiolcell.org/doi/10.1091/mbc.e07-02-0101
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http://dx.doi.org/10.1091/mbc.e07-02-0101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592658PMC
December 2008

Behavioral, biochemical, and genetic analysis of iron metabolism in high-intensity blood donors.

Transfusion 2008 Oct 24;48(10):2197-204. Epub 2008 Jul 24.

Blood Research Institute, Blood Center of Wisconsin, Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226-3548, USA.

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http://dx.doi.org/10.1111/j.1537-2995.2008.01823.xDOI Listing
October 2008

Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry.

Blood 2007 Aug 13;110(3):1048-54. Epub 2007 Apr 13.

Department of Drug Disposition Bioproducts, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-11-05
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http://dx.doi.org/10.1182/blood-2006-11-057471DOI Listing
August 2007

Development of a sensitive and specific in situ hybridization technique for the cellular localization of antisense oligodeoxynucleotide drugs in tissue sections.

Toxicol Pathol 2007 Jun;35(4):541-8

Eli Lilly & Company, Drug Disposition Development/Commercialization. Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1080/01926230701338958DOI Listing
June 2007

The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.

Endocrinology 2007 Feb 26;148(2):774-81. Epub 2006 Oct 26.

Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, Indiana 46285, USA.

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http://dx.doi.org/10.1210/en.2006-1168DOI Listing
February 2007

Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates.

Drug Metab Dispos 2007 Jan 18;35(1):86-94. Epub 2006 Oct 18.

Lilly Research Laboratories, Eli Lilly & Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1124/dmd.106.011734DOI Listing
January 2007

Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor.

J Biol Chem 2007 Jan 29;282(3):1709-17. Epub 2006 Nov 29.

Department of Drug Disposition Development/Commercialization and Biotechnology Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.

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http://dx.doi.org/10.1074/jbc.M607161200DOI Listing
January 2007

In vivo deamidation characterization of monoclonal antibody by LC/MS/MS.

Anal Chem 2005 Mar;77(5):1432-9

Biopharmaceutical Product Development, Biotechnology Discovery Research, Drug Disposition Development/Commercialization, and Manufacturing Science and Technology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.

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http://dx.doi.org/10.1021/ac0494174DOI Listing
March 2005

Pharmacokinetics, metabolic stability, and subcutaneous bioavailability of a genetically engineered analog of DcR3, FLINT [DcR3(R218Q)], in cynomolgus monkeys and mice.

Drug Metab Dispos 2003 Apr;31(4):502-7

Department of Drug Disposition Development/Commercialization, Lilly Research Laboratories, Eli Lilly & Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1124/dmd.31.4.502DOI Listing
April 2003

Decoy receptor 3 (DcR3) is proteolytically processed to a metabolic fragment having differential activities against Fas ligand and LIGHT.

Biochem Pharmacol 2003 Feb;65(4):657-67

Department of Drug Disposition Development/Commercialization, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1016/s0006-2952(02)01612-xDOI Listing
February 2003