Victor E Velculescu

Victor E Velculescu

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Victor E Velculescu

Victor E Velculescu

Publications by authors named "Victor E Velculescu"

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100Publications

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Neoadjuvant PD-1 Blockade in Resectable Lung Cancer.

N Engl J Med 2018 May 16;378(21):1976-1986. Epub 2018 Apr 16.

From the Bloomberg-Kimmel Institute for Cancer Immunotherapy and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore (P.M.F., K.N.S., V.A., T.R.C., M.Z., S.C.Y., S.B., R.J.B., J.N., K.A.M., F.V., H.G., J.Z., J.X.C., H.Y.C., J.-W.S., R.B.S., J.W., E.G., H.W., G.L.R., J.M.T., V.E.V., S.L.T., J.R.B., D.M.P.); Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine (J.E.C., M.D.H., D.R.J., M.J.V., N.R., Z.O., V.R., J.D.W., T.M.) and the Ludwig Collaborative (J.D.W., T.M.) - all in New York; the Parker Institute for Cancer Immunotherapy, San Francisco (J.D.W., T.M.); and Swim Across America Laboratory, Charlotte, NC (J.D.W., T.M.).

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May 2018

Cancer DNA in the Circulation: The Liquid Biopsy.

JAMA 2017 10;318(13):1272-1274

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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October 2017

Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations.

Cancer Cell 2017 09;32(3):360-376.e6

Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

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September 2017

The Effect of Preservative and Temperature on the Analysis of Circulating Tumor DNA.

Clin Cancer Res 2017 May 8;23(10):2471-2477. Epub 2016 Nov 8.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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May 2017

Genomic and Immunological Tumor Profiling Identifies Targetable Pathways and Extensive CD8+/PDL1+ Immune Infiltration in Inflammatory Breast Cancer Tumors.

Mol Cancer Ther 2016 07 19;15(7):1746-56. Epub 2016 Apr 19.

Translational R&D Oncology Group, Quintiles, Westmont, Illinois. Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois.

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July 2016

Beyond genomics: critical evaluation of cell line utility for ovarian cancer research.

Gynecol Oncol 2015 Oct 29;139(1):97-103. Epub 2015 Aug 29.

Dana-Farber Cancer Institute, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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October 2015

Notch1 mutations are drivers of oral tumorigenesis.

Cancer Prev Res (Phila) 2015 Apr 18;8(4):277-286. Epub 2014 Nov 18.

Department of Otolaryngology-Head and Neck Surgery and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD.

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April 2015

Circulating tumor DNA analysis as a real-time method for monitoring tumor burden in melanoma patients undergoing treatment with immune checkpoint blockade.

J Immunother Cancer 2014 16;2(1):42. Epub 2014 Dec 16.

Department of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD USA ; Ludwig Center for Cancer Genetics and Therapeutics and the Swim Across America Laboratory, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD USA.

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December 2014

Ganitumab (AMG 479) inhibits IGF-II-dependent ovarian cancer growth and potentiates platinum-based chemotherapy.

Clin Cancer Res 2014 Jun 11;20(11):2947-58. Epub 2014 Apr 11.

Authors' Affiliations: Oncology Research Therapeutic Area, Genomics Analysis Unit, Department of Pathology, Amgen Inc., Thousand Oaks; Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California; and The Ludwig Center and the Howard Hughes Medical Institute, Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland.

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June 2014

Blood-based analyses of cancer: circulating tumor cells and circulating tumor DNA.

Cancer Discov 2014 Jun 6;4(6):650-61. Epub 2014 May 6.

Authors' Affiliations:Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts; Howard Hughes Medical Institute, Chevy Chase; and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland

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June 2014

Integrated next-generation sequencing and avatar mouse models for personalized cancer treatment.

Clin Cancer Res 2014 May 14;20(9):2476-84. Epub 2014 Mar 14.

Authors' Affiliations: Spanish National Cancer Research Centre (CNIO), Madrid, Spain; Champions Oncology, Baltimore, Maryland; Personal Genome Diagnostics, Inc., Baltimore, Maryland; Laboratorio Dianas Terapéuticas, Hospital Universitario Madrid-Sanchinarro, Madrid, Spain; Centro Integral Oncológico Clara Campal, Hospital Universitario Madrid-Sanchinarro, Madrid, Spain; Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland.

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May 2014

Insights into therapeutic resistance from whole-genome analyses of circulating tumor DNA.

Oncotarget 2013 Oct;4(10):1856-7

Johns Hopkins Kimmel Cancer Center, Baltimore, MD, USA.

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October 2013

Cancer genome landscapes.

Science 2013 Mar;339(6127):1546-58

The Ludwig Center and The Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA.

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March 2013

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.

Nat Genet 2013 Jan 2;45(1):12-7. Epub 2012 Dec 2.

Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA.

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January 2013

Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing.

Sci Transl Med 2012 Nov;4(162):162ra154

Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA.

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November 2012

Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma.

Cancer Discov 2012 Oct 9;2(10):899-905. Epub 2012 Aug 9.

Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institutions, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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October 2012

Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencing.

Clin Cancer Res 2012 Aug;18(16):4257-65

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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August 2012

The predictive capacity of personal genome sequencing.

Sci Transl Med 2012 May 2;4(133):133ra58. Epub 2012 Apr 2.

Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

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May 2012

Low-grade serous carcinomas of the ovary contain very few point mutations.

J Pathol 2012 Feb 20;226(3):413-20. Epub 2011 Dec 20.

Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

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February 2012

Understanding the enemy.

Sci Transl Med 2011 Aug;3(98):98ps37

Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA.

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August 2011

Patient-oriented gene set analysis for cancer mutation data.

Genome Biol 2010 23;11(11):R112. Epub 2010 Nov 23.

Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 N, Wolfe Street, Baltimore, MD 21205, USA.

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June 2011

Somatic mutations of PPP2R1A in ovarian and uterine carcinomas.

Am J Pathol 2011 Apr 26;178(4):1442-7. Epub 2011 Feb 26.

Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD21231, USA.

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April 2011

Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer.

Clin Cancer Res 2011 Mar 28;17(6):1591-602. Epub 2011 Jan 28.

Division of Hematology-Oncology, Department of Biomathematics and Biostatistics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

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March 2011

Sodium ion channel mutations in glioblastoma patients correlate with shorter survival.

Mol Cancer 2011 Feb 11;10:17. Epub 2011 Feb 11.

Department of Neurosurgery, Johns Hopkins University Medical School, Baltimore, MD 21231, USA.

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February 2011

Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma.

Science 2010 Oct 8;330(6001):228-31. Epub 2010 Sep 8.

Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

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October 2010

Distant metastasis occurs late during the genetic evolution of pancreatic cancer.

Nature 2010 Oct;467(7319):1114-7

Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.

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October 2010

International network of cancer genome projects.

Authors:
Thomas J Hudson Warwick Anderson Axel Artez Anna D Barker Cindy Bell Rosa R Bernabé M K Bhan Fabien Calvo Iiro Eerola Daniela S Gerhard Alan Guttmacher Mark Guyer Fiona M Hemsley Jennifer L Jennings David Kerr Peter Klatt Patrik Kolar Jun Kusada David P Lane Frank Laplace Lu Youyong Gerd Nettekoven Brad Ozenberger Jane Peterson T S Rao Jacques Remacle Alan J Schafer Tatsuhiro Shibata Michael R Stratton Joseph G Vockley Koichi Watanabe Huanming Yang Matthew M F Yuen Bartha M Knoppers Martin Bobrow Anne Cambon-Thomsen Lynn G Dressler Stephanie O M Dyke Yann Joly Kazuto Kato Karen L Kennedy Pilar Nicolás Michael J Parker Emmanuelle Rial-Sebbag Carlos M Romeo-Casabona Kenna M Shaw Susan Wallace Georgia L Wiesner Nikolajs Zeps Peter Lichter Andrew V Biankin Christian Chabannon Lynda Chin Bruno Clément Enrique de Alava Françoise Degos Martin L Ferguson Peter Geary D Neil Hayes Thomas J Hudson Amber L Johns Arek Kasprzyk Hidewaki Nakagawa Robert Penny Miguel A Piris Rajiv Sarin Aldo Scarpa Tatsuhiro Shibata Marc van de Vijver P Andrew Futreal Hiroyuki Aburatani Mónica Bayés David D L Botwell Peter J Campbell Xavier Estivill Daniela S Gerhard Sean M Grimmond Ivo Gut Martin Hirst Carlos López-Otín Partha Majumder Marco Marra John D McPherson Hidewaki Nakagawa Zemin Ning Xose S Puente Yijun Ruan Tatsuhiro Shibata Michael R Stratton Hendrik G Stunnenberg Harold Swerdlow Victor E Velculescu Richard K Wilson Hong H Xue Liu Yang Paul T Spellman Gary D Bader Paul C Boutros Peter J Campbell Paul Flicek Gad Getz Roderic Guigó Guangwu Guo David Haussler Simon Heath Tim J Hubbard Tao Jiang Steven M Jones Qibin Li Nuria López-Bigas Ruibang Luo Lakshmi Muthuswamy B F Francis Ouellette John V Pearson Xose S Puente Victor Quesada Benjamin J Raphael Chris Sander Tatsuhiro Shibata Terence P Speed Lincoln D Stein Joshua M Stuart Jon W Teague Yasushi Totoki Tatsuhiko Tsunoda Alfonso Valencia David A Wheeler Honglong Wu Shancen Zhao Guangyu Zhou Lincoln D Stein Roderic Guigó Tim J Hubbard Yann Joly Steven M Jones Arek Kasprzyk Mark Lathrop Nuria López-Bigas B F Francis Ouellette Paul T Spellman Jon W Teague Gilles Thomas Alfonso Valencia Teruhiko Yoshida Karen L Kennedy Myles Axton Stephanie O M Dyke P Andrew Futreal Daniela S Gerhard Chris Gunter Mark Guyer Thomas J Hudson John D McPherson Linda J Miller Brad Ozenberger Kenna M Shaw Arek Kasprzyk Lincoln D Stein Junjun Zhang Syed A Haider Jianxin Wang Christina K Yung Anthony Cros Anthony Cross Yong Liang Saravanamuttu Gnaneshan Jonathan Guberman Jack Hsu Martin Bobrow Don R C Chalmers Karl W Hasel Yann Joly Terry S H Kaan Karen L Kennedy Bartha M Knoppers William W Lowrance Tohru Masui Pilar Nicolás Emmanuelle Rial-Sebbag Laura Lyman Rodriguez Catherine Vergely Teruhiko Yoshida Sean M Grimmond Andrew V Biankin David D L Bowtell Nicole Cloonan Anna deFazio James R Eshleman Dariush Etemadmoghadam Brooke B Gardiner Brooke A Gardiner James G Kench Aldo Scarpa Robert L Sutherland Margaret A Tempero Nicola J Waddell Peter J Wilson John D McPherson Steve Gallinger Ming-Sound Tsao Patricia A Shaw Gloria M Petersen Debabrata Mukhopadhyay Lynda Chin Ronald A DePinho Sarah Thayer Lakshmi Muthuswamy Kamran Shazand Timothy Beck Michelle Sam Lee Timms Vanessa Ballin Youyong Lu Jiafu Ji Xiuqing Zhang Feng Chen Xueda Hu Guangyu Zhou Qi Yang Geng Tian Lianhai Zhang Xiaofang Xing Xianghong Li Zhenggang Zhu Yingyan Yu Jun Yu Huanming Yang Mark Lathrop Jörg Tost Paul Brennan Ivana Holcatova David Zaridze Alvis Brazma Lars Egevard Egor Prokhortchouk Rosamonde Elizabeth Banks Mathias Uhlén Anne Cambon-Thomsen Juris Viksna Fredrik Ponten Konstantin Skryabin Michael R Stratton P Andrew Futreal Ewan Birney Ake Borg Anne-Lise Børresen-Dale Carlos Caldas John A Foekens Sancha Martin Jorge S Reis-Filho Andrea L Richardson Christos Sotiriou Hendrik G Stunnenberg Giles Thoms Marc van de Vijver Laura van't Veer Fabien Calvo Daniel Birnbaum Hélène Blanche Pascal Boucher Sandrine Boyault Christian Chabannon Ivo Gut Jocelyne D Masson-Jacquemier Mark Lathrop Iris Pauporté Xavier Pivot Anne Vincent-Salomon Eric Tabone Charles Theillet Gilles Thomas Jörg Tost Isabelle Treilleux Fabien Calvo Paulette Bioulac-Sage Bruno Clément Thomas Decaens Françoise Degos Dominique Franco Ivo Gut Marta Gut Simon Heath Mark Lathrop Didier Samuel Gilles Thomas Jessica Zucman-Rossi Peter Lichter Roland Eils Benedikt Brors Jan O Korbel Andrey Korshunov Pablo Landgraf Hans Lehrach Stefan Pfister Bernhard Radlwimmer Guido Reifenberger Michael D Taylor Christof von Kalle Partha P Majumder Rajiv Sarin T S Rao M K Bhan Aldo Scarpa Paolo Pederzoli Rita A Lawlor Massimo Delledonne Alberto Bardelli Andrew V Biankin Sean M Grimmond Thomas Gress David Klimstra Giuseppe Zamboni Tatsuhiro Shibata Yusuke Nakamura Hidewaki Nakagawa Jun Kusada Tatsuhiko Tsunoda Satoru Miyano Hiroyuki Aburatani Kazuto Kato Akihiro Fujimoto Teruhiko Yoshida Elias Campo Carlos López-Otín Xavier Estivill Roderic Guigó Silvia de Sanjosé Miguel A Piris Emili Montserrat Marcos González-Díaz Xose S Puente Pedro Jares Alfonso Valencia Heinz Himmelbauer Heinz Himmelbaue Victor Quesada Silvia Bea Michael R Stratton P Andrew Futreal Peter J Campbell Anne Vincent-Salomon Andrea L Richardson Jorge S Reis-Filho Marc van de Vijver Gilles Thomas Jocelyne D Masson-Jacquemier Samuel Aparicio Ake Borg Anne-Lise Børresen-Dale Carlos Caldas John A Foekens Hendrik G Stunnenberg Laura van't Veer Douglas F Easton Paul T Spellman Sancha Martin Anna D Barker Lynda Chin Francis S Collins Carolyn C Compton Martin L Ferguson Daniela S Gerhard Gad Getz Chris Gunter Alan Guttmacher Mark Guyer D Neil Hayes Eric S Lander Brad Ozenberger Robert Penny Jane Peterson Chris Sander Kenna M Shaw Terence P Speed Paul T Spellman Joseph G Vockley David A Wheeler Richard K Wilson Thomas J Hudson Lynda Chin Bartha M Knoppers Eric S Lander Peter Lichter Lincoln D Stein Michael R Stratton Warwick Anderson Anna D Barker Cindy Bell Martin Bobrow Wylie Burke Francis S Collins Carolyn C Compton Ronald A DePinho Douglas F Easton P Andrew Futreal Daniela S Gerhard Anthony R Green Mark Guyer Stanley R Hamilton Tim J Hubbard Olli P Kallioniemi Karen L Kennedy Timothy J Ley Edison T Liu Youyong Lu Partha Majumder Marco Marra Brad Ozenberger Jane Peterson Alan J Schafer Paul T Spellman Hendrik G Stunnenberg Brandon J Wainwright Richard K Wilson Huanming Yang

Nature 2010 Apr;464(7291):993-8

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April 2010

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells.

Nature 2010 Mar 3;464(7288):610-4. Epub 2010 Mar 3.

The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA.

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March 2010

Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.

Proc Natl Acad Sci U S A 2010 Feb 20;107(6):2598-603. Epub 2010 Jan 20.

The Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

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February 2010

Development of personalized tumor biomarkers using massively parallel sequencing.

Sci Transl Med 2010 Feb;2(20):20ra14

Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

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February 2010

Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells.

Science 2009 Sep 6;325(5947):1555-9. Epub 2009 Aug 6.

Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

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September 2009

Sensitive digital quantification of DNA methylation in clinical samples.

Nat Biotechnol 2009 Sep 16;27(9):858-63. Epub 2009 Aug 16.

The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

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September 2009

Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations.

Cancer Res 2009 Aug 4;69(16):6660-7. Epub 2009 Aug 4.

Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland 21218, USA.

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August 2009

Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma.

Am J Pathol 2009 May 6;174(5):1597-601. Epub 2009 Apr 6.

Departments of Pathology, Howard Hughes Medical Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

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May 2009

Identification of microbial DNA in human cancer.

BMC Med Genomics 2009 May 8;2:22. Epub 2009 May 8.

Preston Robert Tisch Brain Tumor Center, Pediatric Brain Tumor Foundation Institute, Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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May 2009

IDH1 and IDH2 mutations in gliomas.

N Engl J Med 2009 Feb;360(8):765-73

Department of Pathology, Pediatric Brain Tumor Foundation Institute, Duke University Medical Center, Durham, NC 27710, USA.

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February 2009

The antisense transcriptomes of human cells.

Science 2008 Dec 4;322(5909):1855-7. Epub 2008 Dec 4.

Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

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December 2008

Defining the blueprint of the cancer genome.

Carcinogenesis 2008 Jun 20;29(6):1087-91. Epub 2008 May 20.

Ludwig Center for Cancer Genetics and Therapeutics, The Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

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June 2008

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers.

Proc Natl Acad Sci U S A 2008 Mar 25;105(9):3443-8. Epub 2008 Feb 25.

The Ludwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.

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March 2008

Comparative lesion sequencing provides insights into tumor evolution.

Proc Natl Acad Sci U S A 2008 Mar 12;105(11):4283-8. Epub 2008 Mar 12.

The Ludwig Center for Cancer Genetics and Therapeutics, Department of Biostatistics, Howard Hughes Medical Institute, and Sidney Kimmel Cancer Center at The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.

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March 2008

Digital karyotyping.

Nat Protoc 2007 ;2(8):1973-86

The Ludwig Center for Cancer Genetics and Therapeutics, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA.

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December 2007

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.

Science 2007 Dec;318(5857):1744-8

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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December 2007

Genetic progression and the waiting time to cancer.

PLoS Comput Biol 2007 Nov;3(11):e225

Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts, United States of America.

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November 2007

Serial assessment of human tumor burdens in mice by the analysis of circulating DNA.

Cancer Res 2007 Oct;67(19):9364-70

The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute, Baltimore, Maryland, USA.

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October 2007

A multidimensional analysis of genes mutated in breast and colorectal cancers.

Genome Res 2007 Sep 10;17(9):1304-18. Epub 2007 Aug 10.

Ludwig Center for Cancer Genetics and Therapeutics, and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA.

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September 2007

Gene expression analysis goes digital.

Nat Biotechnol 2007 Aug;25(8):878-80

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August 2007

Large-scale identification of novel transcripts in the human genome.

Genome Res 2007 Mar 31;17(3):287-92. Epub 2007 Jan 31.

The Ludwig Center for Cancer Genetics and Therapeutics, The Johns Hopkins University Kimmel Cancer Center, Baltimore, Maryland 21231, USA.

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March 2007

Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.

Proc Natl Acad Sci U S A 2007 Mar 21;104(10):4060-4. Epub 2007 Feb 21.

Department of Genetics and Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

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March 2007

The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT.

Nat Biotechnol 2006 Dec 19;24(12):1573-80. Epub 2006 Nov 19.

The Howard Hughes Medical Institute, The Ludwig Center for Cancer Genetics & Therapeutics, The Sidney Kimmel Comprehensive Cancer Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.

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December 2006

Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers.

Hum Mutat 2006 Oct;27(10):1060-1

The Ludwig Center for Cancer Genetics and Therapeutics, The Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA.

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October 2006

Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms.

Cancer Biol Ther 2006 Jul 26;5(7):779-85. Epub 2006 Jul 26.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.

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July 2006

Homozygous deletion of MKK4 in ovarian serous carcinoma.

Cancer Biol Ther 2006 Jun 9;5(6):630-4. Epub 2006 Jun 9.

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.

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June 2006

The colorectal microRNAome.

Proc Natl Acad Sci U S A 2006 Mar 27;103(10):3687-92. Epub 2006 Feb 27.

The Sidney Kimmel Comprehensive Cancer Center and Howard Hughes Medical Institute, Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA.

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March 2006

Colorectal cancer: mutations in a signalling pathway.

Nature 2005 Aug;436(7052):792

The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA.

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August 2005

Mutant PIK3CA promotes cell growth and invasion of human cancer cells.

Cancer Cell 2005 Jun;7(6):561-73

The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA.

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June 2005