Victor E Marquez

Victor E Marquez

UNVERIFIED PROFILE

Are you Victor E Marquez?   Register this Author

Register author
Victor E Marquez

Victor E Marquez

Publications by authors named "Victor E Marquez"

Are you Victor E Marquez?   Register this Author

100Publications

1649Reads

43Profile Views

Coupling between conformational dynamics and catalytic function at the active site of the lead-dependent ribozyme.

RNA 2018 11 15;24(11):1542-1554. Epub 2018 Aug 15.

Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1261/rna.067579.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191710PMC
November 2018

Enzyme-Driven Chemo-and Radiation-Therapy with 12 Pyrimidine Nucleoside Analogs Not Yet in the Clinic.

Anticancer Agents Med Chem 2017 ;17(2):250-264

Deparment of Microbiology/ Immunology (R138), University of Miami, Miller School of Medicine, 1600 N.W.10th Ave Miami, FL 33136,United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1871520616666161013145853DOI Listing
May 2017

Selective Phosphorylation of South and North-Cytidine and Adenosine Methanocarba-Nucleosides by Human Nucleoside and Nucleotide Kinases Correlates with Their Growth Inhibitory Effects on Cultured Cells.

Nucleosides Nucleotides Nucleic Acids 2015 ;34(8):544-64

a Department of Anatomy, Physiology, and Biochemistry, Swedish University of Agricultural Sciences , VHC , Uppsala , Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15257770.2015.1031248DOI Listing
April 2016

Differentially methylated genes and androgen receptor re-expression in small cell prostate carcinomas.

Epigenetics 2016 03 18;11(3):184-93. Epub 2016 Feb 18.

f Department of Genitourinary Medical Oncology , Unit 1374, The University of Texas MD Anderson Cancer Center , 1515 Holcombe Blvd., Houston , Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15592294.2016.1146851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854553PMC
March 2016

Chemical biology of nucleic acids.

ACS Chem Biol 2015 Jun;10(6):1358-61

†Institute of Bioorganic Chemistry of the Polish Academy of Sciences, 61-704 Poznań, Poland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.5b00320DOI Listing
June 2015

EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors.

Nature 2015 Apr 28;520(7546):239-42. Epub 2015 Jan 28.

1] Stem Cell Program, Boston Children's Hospital, Boston, Massachusetts 02115, USA [2] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA [3] Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature14122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393352PMC
April 2015

Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.

Bioorg Med Chem 2014 Jun 20;22(12):3123-40. Epub 2014 Apr 20.

Laboratory of Organic Synthesis, Center of Research and Development in Chemistry, National Institute of Industrial Technology, Buenos Aires, Argentina. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2014.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104769PMC
June 2014

Diacylglycerol lactones targeting the structural features that distinguish the atypical C1 domains of protein kinase C ζ and ι from typical C1 domains.

J Med Chem 2014 May 17;57(9):3835-44. Epub 2014 Apr 17.

Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20892, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm500165nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310642PMC
May 2014

Lysine methylation promotes VEGFR-2 activation and angiogenesis.

Sci Signal 2013 Dec 3;6(304):ra104. Epub 2013 Dec 3.

1Departments of Pathology and Ophthalmology, School of Medicine, Boston University Medical Campus, Boston, MA 02118, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.2004289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108444PMC
December 2013

Enhancer of zeste homolog 2 silences microRNA-218 in human pancreatic ductal adenocarcinoma cells by inducing formation of heterochromatin.

Gastroenterology 2013 May 7;144(5):1086-1097.e9. Epub 2013 Feb 7.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2013.01.058DOI Listing
May 2013

Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis.

Ann Rheum Dis 2013 Apr 21;72(4):614-20. Epub 2012 Aug 21.

Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Ulmenweg 18, Erlangen D-91054, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2012-201615DOI Listing
April 2013

Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cells.

Neuro Oncol 2013 Feb 28;15(2):149-60. Epub 2012 Nov 28.

Department of Pediatrics and Section of Pediatric Hematology/Oncology/BMT, Children’s Hospital Colorado, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/neuonc/nos285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548579PMC
February 2013

Synthesis of a North-methanocarba-thymidine (N-MCT) analog.

Curr Protoc Nucleic Acid Chem 2012 Dec;Chapter 1:Unit1.29

J-Star Research, Inc., South Plainfield, New Jersey, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/0471142700.nc0129s51DOI Listing
December 2012

Differential furanose selection in the active sites of archaeal DNA polymerases probed by fixed-conformation nucleotide analogues.

Biochemistry 2012 Nov 30;51(45):9234-44. Epub 2012 Oct 30.

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi301043kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563936PMC
November 2012

Targeting the enhancer of zeste homologue 2 in medulloblastoma.

Int J Cancer 2012 Oct 30;131(8):1800-9. Epub 2012 Jul 30.

Department of Pediatrics, The Children's Hospital and University of Colorado, Anschutz Medical Campus, CO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.27455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375399PMC
October 2012

Polycomb genes and cancer: time for clinical application?

Crit Rev Oncol Hematol 2012 Aug 22;83(2):184-93. Epub 2011 Nov 22.

Department of Internal Medicine, Division of Pharmacology, University of Pisa, Via Roma 55, 56100 Pisa, Italy.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S104084281100251
Publisher Site
http://dx.doi.org/10.1016/j.critrevonc.2011.10.007DOI Listing
August 2012

Synergistic antileukemic action of a combination of inhibitors of DNA methylation and histone methylation.

Leuk Res 2012 Aug 1;36(8):1049-54. Epub 2012 Apr 1.

Département de Pharmacologie, Université de Montréal, Montréal, Québec, Canada.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S014521261200123
Publisher Site
http://dx.doi.org/10.1016/j.leukres.2012.03.001DOI Listing
August 2012

Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene epigenetically deregulated in hyperparathyroid tumors by histone H3 lysine modification.

J Clin Endocrinol Metab 2012 Jul 27;97(7):E1307-15. Epub 2012 Apr 27.

Department of Surgical Sciences, Uppsala University, Uppsala University Hospital, Entrance 70, third floor, SE-75185 Uppsala, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2011-3136DOI Listing
July 2012

The effect on quadruplex stability of North-nucleoside derivatives in the loops of the thrombin-binding aptamer.

Bioorg Med Chem 2012 Jul 9;20(14):4186-93. Epub 2012 Jun 9.

Institute for Research in Biomedicine (IRB Barcelona), Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) and Institute for Advanced Chemistry of Catalonia (IQAC), CSIC, Baldiri Reixac 10, E-08028 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2012.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534854PMC
July 2012

A nucleotide-analogue-induced gain of function corrects the error-prone nature of human DNA polymerase iota.

J Am Chem Soc 2012 Jun 14;134(25):10698-705. Epub 2012 Jun 14.

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja304176qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392044PMC
June 2012

Molecular basis for failure of "atypical" C1 domain of Vav1 to bind diacylglycerol/phorbol ester.

J Biol Chem 2012 Apr 18;287(16):13137-58. Epub 2012 Feb 18.

Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.320010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340006PMC
April 2012

The conformationally constrained N-methanocarba-dT analogue adopts an unexpected C4'-exo sugar pucker in the structure of a DNA hairpin.

Biochemistry 2012 Apr 20;51(13):2639-41. Epub 2012 Mar 20.

Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi300215kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330753PMC
April 2012

Derivation of new human embryonic stem cell lines reveals rapid epigenetic progression in vitro that can be prevented by chemical modification of chromatin.

Hum Mol Genet 2012 Feb 4;21(4):751-64. Epub 2011 Nov 4.

Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddr506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263987PMC
February 2012

Synthesis of conformationally North-locked pyrimidine nucleosides built on an oxabicyclo[3.1.0]hexane scaffold.

J Org Chem 2012 Jan 31;77(2):815-24. Epub 2011 Oct 31.

Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jo201716cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534852PMC
January 2012

EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR.

Cancer Res 2012 Jan 8;72(1):315-24. Epub 2011 Nov 8.

Cell & Molecular Biology Section, National Cancer Institute, NIH, Bethesda, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-11-0961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487161PMC
January 2012

PRC2 directly methylates GATA4 and represses its transcriptional activity.

Genes Dev 2012 Jan;26(1):37-42

Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.173930.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258964PMC
January 2012

Influence of sugar ring conformation on the transportability of nucleosides by human nucleoside transporters.

Chembiochem 2011 Dec 4;12(18):2774-8. Epub 2011 Nov 4.

Department of Oncology, Cross Cancer Institute, University of Alberta, 11560 University Avenue NW, Edmonton, Alberta T6G 1Z2, Canada.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/cbic.201100567
Publisher Site
http://dx.doi.org/10.1002/cbic.201100567DOI Listing
December 2011

Epigenetic regulation of CIITA expression in human T-cells.

Biochem Pharmacol 2011 Nov 2;82(10):1430-7. Epub 2011 Jun 2.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2011.05.026DOI Listing
November 2011

(-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells.

Carcinogenesis 2011 Oct 27;32(10):1525-32. Epub 2011 Jul 27.

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
Publisher Site
http://dx.doi.org/10.1093/carcin/bgr171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179425PMC
October 2011

A direct, efficient method for the preparation of siRNAs containing ribo-like North bicyclo[3.1.0]hexane pseudosugars.

Org Lett 2011 Jun 9;13(11):2888-91. Epub 2011 May 9.

Institute for Research in Biomedicine (IRB Barcelona), Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ol200909jDOI Listing
June 2011

4'-C-methyl-2'-deoxyadenosine and 4'-C-ethyl-2'-deoxyadenosine inhibit HIV-1 replication.

Antimicrob Agents Chemother 2011 May 22;55(5):2379-89. Epub 2011 Feb 22.

HIV Drug Resistance Program, NCI-Frederick, P.O. Box B, Building 539, Frederick, MD 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01290-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088259PMC
May 2011

Effect of north bicyclo[3.1.0]hexane 2'-deoxy-pseudosugars on RNA interference: a novel class of siRNA modification.

Chembiochem 2011 May 30;12(7):1056-65. Epub 2011 Mar 30.

Institute for Research in Biomedicine, CIBER-BBN, Spanish Research Council, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201000791DOI Listing
May 2011

PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins.

Biochem Biophys Res Commun 2011 May 12;408(3):393-8. Epub 2011 Apr 12.

Center for Vascular and Tumor Biology, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 31096, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2011.04.025DOI Listing
May 2011

Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer.

Mol Cancer 2011 Apr 18;10:40. Epub 2011 Apr 18.

Cancer Stem Cell Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.

View Article

Download full-text PDF

Source
http://molecular-cancer.biomedcentral.com/articles/10.1186/1
Publisher Site
http://dx.doi.org/10.1186/1476-4598-10-40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100246PMC
April 2011

Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2.

Biochem Pharmacol 2011 Feb 27;81(4):510-7. Epub 2010 Nov 27.

Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00062952100081
Publisher Site
http://dx.doi.org/10.1016/j.bcp.2010.11.014DOI Listing
February 2011

Understanding the effects of carbocyclic sugars constrained to north and south conformations on RNA nanodesign.

J Mol Graph Model 2011 Feb 19;29(5):624-34. Epub 2010 Nov 19.

Center for Cancer Research Nanobiology Program (CCRNP), National Cancer Institute at Frederick, Frederick, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmgm.2010.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040123PMC
February 2011

Dynamic patterns of histone lysine methylation in the developing retina.

Invest Ophthalmol Vis Sci 2010 Dec 29;51(12):6784-92. Epub 2010 Jul 29.

Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.09-4730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055777PMC
December 2010

Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.

Neuro Oncol 2010 Dec 16;12(12):1244-56. Epub 2010 Sep 16.

Department of Neurology, Children's Hospital Boston, Boston, MA 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/neuonc/noq091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018940PMC
December 2010

Synthesis of conformationally locked carbocyclic nucleoside phosphonates to probe the active site of HIV-1 RT.

Nucleic Acids Symp Ser (Oxf) 2008 (52):623-4

Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nass/nrn315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727548PMC
November 2010

Synthesis of conformationally locked carbocyclic 1,3-diazepinone nucleosides as inhibitors of cytidine deaminase.

Nucleic Acids Symp Ser (Oxf) 2008 (52):659-60

Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nass/nrn333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730941PMC
November 2010

Synthesis of conformationally locked L-deoxythreosyl phosphonate nucleosides built on a bicyclo[3.1.0]hexane template.

J Org Chem 2010 Nov 21;75(22):7659-69. Epub 2010 Oct 21.

Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, United States.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/jo101475p
Publisher Site
http://dx.doi.org/10.1021/jo101475pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041872PMC
November 2010

Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues.

Angew Chem Int Ed Engl 2010 Oct;49(41):7481-5

Department of Biochemistry, Center in Molecular Toxicology and Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201003168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011974PMC
October 2010

Epigenetic analysis of KSHV latent and lytic genomes.

PLoS Pathog 2010 Jul 22;6(7):e1001013. Epub 2010 Jul 22.

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

View Article

Download full-text PDF

Source
https://dx.plos.org/10.1371/journal.ppat.1001013
Publisher Site
http://dx.doi.org/10.1371/journal.ppat.1001013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908616PMC
July 2010

Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications.

Carcinogenesis 2010 Jun 6;31(6):974-83. Epub 2010 Jan 6.

Laboratory of Molecular Pathology, Department of Pharmacy, College of Pharmacy, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgp336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878357PMC
June 2010

Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines.

Mol Cancer 2010 Jun 17;9:151. Epub 2010 Jun 17.

Dept. of Human and Animal Cell Lines, DSMZ - German Collection of Microorganisms and Cell Cultures, Inhoffenstr. 7B, 38124 Braunschweig, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1476-4598-9-151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894765PMC
June 2010

The use of conformationally rigid nucleoside probes to study the role of sugar pucker and nucleobase orientation in the thrombin binding aptamer.

Nucleic Acids Symp Ser (Oxf) 2009 (53):109-10

Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nass/nrp055DOI Listing
May 2010

Use of Drosophila deoxynucleoside kinase to study mechanism of toxicity and mutagenicity of deoxycytidine analogs in Escherichia coli.

DNA Repair (Amst) 2010 Feb 11;9(2):153-60. Epub 2009 Dec 11.

Department of Chemistry, Wayne State University, Detroit, MI 48202, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2009.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819640PMC
February 2010

Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells.

Mol Cancer Ther 2009 Dec;8(12):3191-202

Cancer Biology and Pharmacology, Genome Institute of Singapore, 60 Biopolis Street, #02-01 Genome, Singapore 138672.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-09-0479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794891PMC
December 2009

EZH2 is essential for glioblastoma cancer stem cell maintenance.

Cancer Res 2009 Dec;69(24):9211-8

Division of Experimental Pathology, Institute of Pathology, University of Lausanne, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-09-1622DOI Listing
December 2009

Lipid-modulated pharmacophore nanorods assembled at the air/water interface.

Chemphyschem 2009 Oct;10(15):2615-9

Department of Chemistry and the Ilse Katz Institute for Nanotechnology, Ben Gurion University of the Negev, Beer Sheva 84105, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cphc.200900539DOI Listing
October 2009

A greener enantioselective synthesis of the antiviral agent North-methanocarbathymidine (N-MCT) from 2-deoxy-d-ribose.

Tetrahedron 2009 Oct;65(41):8461-8467

Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S004040200901232
Publisher Site
http://dx.doi.org/10.1016/j.tet.2009.08.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900805PMC
October 2009

Conformationally rigid nucleoside probes help understand the role of sugar pucker and nucleobase orientation in the thrombin-binding aptamer.

Nucleic Acids Res 2009 Sep 20;37(17):5589-601. Epub 2009 Jul 20.

Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkp598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761269PMC
September 2009

Synthesis and conformational analysis of locked carbocyclic analogues of 1,3-diazepinone riboside, a high-affinity cytidine deaminase inhibitor.

J Org Chem 2009 Aug;74(16):6212-23

Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jo901127aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727169PMC
August 2009

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

Mol Cancer Ther 2009 Jun 9;8(6):1579-88. Epub 2009 Jun 9.

Department of Urology, USC Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-09-0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186068PMC
June 2009

Contrasting behavior of conformationally locked carbocyclic nucleosides of adenosine and cytidine as substrates for deaminases.

Nucleosides Nucleotides Nucleic Acids 2009 May;28(5):614-32

Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15257770903091904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910114PMC
May 2009

Ceramides: branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency.

Bioorg Med Chem 2009 Feb 11;17(4):1498-505. Epub 2009 Jan 11.

Laboratory of Medicinal Chemistry, National Cancer Institute, National Institutes of Health, Bldg 376/104, Frederick, MD 21702, United States.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S096808960900035
Publisher Site
http://dx.doi.org/10.1016/j.bmc.2009.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980351PMC
February 2009

Synthesis and hybridization properties of modified oligodeoxynucleotides carrying non-natural bases.

Chem Biodivers 2009 Feb;6(2):117-26

Institute for Research in Biomedicine, IQAC-CSIC, CIBER-BBN Networking Center on Bioengineering, Biomaterials and Nanomedicine, Edifici Helix, Baldiri Reixac 15, E-08028 Barcelona.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/cbdv.200800239
Publisher Site
http://dx.doi.org/10.1002/cbdv.200800239DOI Listing
February 2009

Synthesis of conformationally locked versions of puromycin analogues.

J Org Chem 2008 Dec;73(23):9435-8

Laboratory of Medicinal Chemistry, Center for Cancer Research, NCI-Frederick, Maryland 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jo8016132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765511PMC
December 2008

Activation of p16 gene silenced by DNA methylation in cancer cells by phosphoramidate derivatives of 2'-deoxyzebularine.

J Med Chem 2008 Dec;51(23):7593-601

Department of Biochemistry, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm8005965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659950PMC
December 2008

Synthesis of enantiomerically pure (S)-methanocarbaribo uracil nucleoside derivatives for use as antiviral agents and P2Y receptor ligands.

J Org Chem 2008 Oct 24;73(20):8085-8. Epub 2008 Sep 24.

Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, New York 13699, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jo801224jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677375PMC
October 2008

Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice.

Cancer Prev Res (Phila) 2008 Sep 19;1(4):233-40. Epub 2008 Mar 19.

Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033-9181, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1940-6207.CAPR-07-0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959547PMC
September 2008