Vicky M Avery

Vicky M Avery

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A Meroisoprenoid, Heptenolides, and -Benzylated Flavonoids from ssp. .

J Nat Prod 2020 Feb 18. Epub 2020 Feb 18.

Department of Chemistry and Molecular Biology , University of Gothenburg , SE-412 96 Gothenburg , Sweden.

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http://dx.doi.org/10.1021/acs.jnatprod.9b00721DOI Listing
February 2020

Antiplasmodial Bis-Indole Alkaloids from the Bark of Flindersia pimenteliana.

Planta Med 2020 Jan 29;86(1):19-25. Epub 2019 Oct 29.

Environmental Futures Research Institute, Griffith University, Southport, Gold Coast, Australia.

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http://dx.doi.org/10.1055/a-1028-7786DOI Listing
January 2020

Orthoscuticellines A-E, β-Carboline Alkaloids from the Bryozoan Collected in Australia.

J Nat Prod 2020 Jan 21. Epub 2020 Jan 21.

Environmental Futures Research Institute , Griffith University , Gold Coast , QLD 4222 , Australia.

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http://dx.doi.org/10.1021/acs.jnatprod.9b00933DOI Listing
January 2020

Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation.

Eur J Med Chem 2019 Dec 4;183:111667. Epub 2019 Sep 4.

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, CZ-16610, Prague 6, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.111667DOI Listing
December 2019

Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparum Gametocytogenesis and Transmission to Mosquitoes.

Cell Rep 2019 Dec;29(12):3796-3806.e4

The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville 3010, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.11.073DOI Listing
December 2019

The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor.

Int J Mol Sci 2019 Oct 29;20(21). Epub 2019 Oct 29.

Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland 4111, Australia.

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http://dx.doi.org/10.3390/ijms20215384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861939PMC
October 2019

Desymmetrization Reactions of Indigo with Grignard Reagents for the Synthesis of Selective Antiplasmodial [1,3']-3-Aryl-2,2'-diindol-3'-ones.

J Org Chem 2019 Sep 15;84(17):11228-11239. Epub 2019 Aug 15.

School of Chemistry & Molecular Bioscience, Molecular Horizons , University of Wollongong, and Illawarra Health & Medical Research Institute , Wollongong , New South Wales 2522 , Australia.

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http://dx.doi.org/10.1021/acs.joc.9b01442DOI Listing
September 2019

Total Synthesis of the Antimalarial Ascidian Natural Product Albopunctatone.

Org Lett 2019 Jul 9;21(14):5519-5523. Epub 2019 Jul 9.

Discovery Biology, Griffith Institute for Drug Discovery , Griffith University , Nathan , Queensland , Australia.

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http://dx.doi.org/10.1021/acs.orglett.9b01838DOI Listing
July 2019

Acrotrione: An Oxidized Xanthene from the Roots of Acronychia pubescens.

J Nat Prod 2019 Apr 13;82(4):1019-1023. Epub 2019 Mar 13.

Environmental Futures Research Institute , Griffith University , Gold Coast Campus , Southport 4222 , Australia.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.8b00956
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http://dx.doi.org/10.1021/acs.jnatprod.8b00956DOI Listing
April 2019

8-Aminoquinolines with an Aminoxyalkyl Side Chain Exert in vitro Dual-Stage Antiplasmodial Activity.

ChemMedChem 2019 02 14;14(4):501-511. Epub 2019 Jan 14.

Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225, Düsseldorf, Germany.

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http://dx.doi.org/10.1002/cmdc.201800691DOI Listing
February 2019

Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases.

J Med Chem 2019 01 4;62(2):622-640. Epub 2019 Jan 4.

Department of Microbiology, Biomedicine Discovery Institute , Monash University, Clayton , Melbourne , VIC 3800 , Australia.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01310DOI Listing
January 2019

β-Triketone-Monoterpene Hybrids from the Flowers of the Australian Tree Corymbia intermedia.

J Nat Prod 2018 11 6;81(11):2455-2461. Epub 2018 Nov 6.

Environmental Futures Research Institute , Griffith University , Gold Coast , QLD 4222 , Australia.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.8b00494
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http://dx.doi.org/10.1021/acs.jnatprod.8b00494DOI Listing
November 2018

Plasmodium falciparum In Vitro Culture - The Highs and Lows.

Trends Parasitol 2018 10 17;34(10):812-813. Epub 2018 Aug 17.

Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland, 4111, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pt.2018.07.010DOI Listing
October 2018

One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites.

Eur J Med Chem 2018 Oct 7;158:801-813. Epub 2018 Sep 7.

Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany; Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Medical Faculty, Leipzig University, Brüderstraße 34, 04103, Leipzig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195125PMC
October 2018

Cascade reactions of indigo with oxiranes and aziridines: efficient access to dihydropyrazinodiindoles and spiro-oxazocinodiindoles.

Org Biomol Chem 2018 08;16(33):6006-6016

School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.

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http://dx.doi.org/10.1039/c8ob00865eDOI Listing
August 2018

Routine In Vitro Culture of Plasmodium falciparum: Experimental Consequences?

Trends Parasitol 2018 07 22;34(7):564-575. Epub 2018 May 22.

Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland, 4111, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pt.2018.04.005DOI Listing
July 2018

Antiplasmodial β-Triketone-Flavanone Hybrids from the Flowers of the Australian Tree Corymbia torelliana.

J Nat Prod 2018 07 3;81(7):1588-1597. Epub 2018 Jul 3.

Environmental Futures Research Institute , Griffith University , Gold Coast , QLD 4222 , Australia.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.8b00154
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http://dx.doi.org/10.1021/acs.jnatprod.8b00154DOI Listing
July 2018

HSQC-TOCSY Fingerprinting-Directed Discovery of Antiplasmodial Polyketides from the Marine Ascidian-Derived sp. (USC-16018).

Mar Drugs 2018 May 30;16(6). Epub 2018 May 30.

Environmental Futures Research Institute, School of Environment and Science, Griffith University, Gold Coast Campus, QLD 4222, Australia.

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http://dx.doi.org/10.3390/md16060189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025042PMC
May 2018

HSQC-TOCSY Fingerprinting for Prioritization of Polyketide- and Peptide-Producing Microbial Isolates.

J Nat Prod 2018 04 2;81(4):957-965. Epub 2018 Mar 2.

Environmental Futures Research Institute , Griffith University , Gold Coast Campus, Southport , Queensland 4222 , Australia.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.7b01063
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http://dx.doi.org/10.1021/acs.jnatprod.7b01063DOI Listing
April 2018

Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca.

J Nat Prod 2018 04 13;81(4):1079-1083. Epub 2018 Mar 13.

Griffith Institute for Drug Discovery, Griffith University , Brisbane , QLD 4111 , Australia.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.7b00992
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http://dx.doi.org/10.1021/acs.jnatprod.7b00992DOI Listing
April 2018

3-pyridyl inhibitors with novel activity against Trypanosoma cruzi reveal in vitro profiles can aid prediction of putative cytochrome P450 inhibition.

Sci Rep 2018 03 20;8(1):4901. Epub 2018 Mar 20.

Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia.

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http://www.nature.com/articles/s41598-018-22043-z
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http://dx.doi.org/10.1038/s41598-018-22043-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861127PMC
March 2018

Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins.

BMC Cancer 2018 01 6;18(1):41. Epub 2018 Jan 6.

Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Building N27, Brisbane Innovation Park, Nathan, QLD, 4111, Australia.

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http://dx.doi.org/10.1186/s12885-017-3953-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756400PMC
January 2018

Plasmodium falciparum in vitro continuous culture conditions: A comparison of parasite susceptibility and tolerance to anti-malarial drugs throughout the asexual intra-erythrocytic life cycle.

Int J Parasitol Drugs Drug Resist 2017 12 15;7(3):295-302. Epub 2017 Jul 15.

Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland, 4111, Australia.

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http://dx.doi.org/10.1016/j.ijpddr.2017.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522918PMC
December 2017

Pimentelamines A-C, Indole Alkaloids Isolated from the Leaves of the Australian Tree Flindersia pimenteliana.

J Nat Prod 2017 12 13;80(12):3211-3217. Epub 2017 Dec 13.

Environmental Futures Research Institute, Griffith University , Southport 4222, Gold Coast, Australia.

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http://dx.doi.org/10.1021/acs.jnatprod.7b00587DOI Listing
December 2017

Leishmaniasis drug discovery: recent progress and challenges in assay development.

Drug Discov Today 2017 10 21;22(10):1516-1531. Epub 2017 Jun 21.

Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland 4111, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2017.06.004DOI Listing
October 2017

Design and Synthesis of Terephthalic Acid-Based Histone Deacetylase Inhibitors with Dual-Stage Anti-Plasmodium Activity.

ChemMedChem 2017 10 13;12(19):1627-1636. Epub 2017 Sep 13.

Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.

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http://dx.doi.org/10.1002/cmdc.201700360DOI Listing
October 2017

Screening a Natural Product-Based Library against Kinetoplastid Parasites.

Molecules 2017 Oct 12;22(10). Epub 2017 Oct 12.

Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland 4111, Australia.

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http://dx.doi.org/10.3390/molecules22101715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151456PMC
October 2017

Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery.

Antimicrob Agents Chemother 2017 09 24;61(9). Epub 2017 Aug 24.

Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia

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http://dx.doi.org/10.1128/AAC.00379-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571359PMC
September 2017

Synthesis of antimalarial amide analogues based on the plant serrulatane diterpenoid 3,7,8-trihydroxyserrulat-14-en-19-oic acid.

Bioorg Med Chem Lett 2017 09 15;27(17):4091-4095. Epub 2017 Jul 15.

Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.07.039DOI Listing
September 2017

Antiplasmodial β-triketones from the flowers of the Australian tree Angophora woodsiana.

Bioorg Med Chem Lett 2017 06 24;27(11):2602-2607. Epub 2017 Mar 24.

Environmental Futures Research Institute, Griffith University, Gold Coast, QLD 4222, Australia; Griffith School of Environment, Griifth University, Gold Coast, QLD 4222, Australia; Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.03.065DOI Listing
June 2017

Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages.

Malar J 2017 05 15;16(1):192. Epub 2017 May 15.

Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106, Braunschweig, Germany.

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http://dx.doi.org/10.1186/s12936-017-1839-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430599PMC
May 2017

The need to compare: assessing the level of agreement of three high-throughput assays against Plasmodium falciparum mature gametocytes.

Sci Rep 2017 04 5;7:45992. Epub 2017 Apr 5.

Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, 4111 Nathan, Queensland, Australia.

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http://dx.doi.org/10.1038/srep45992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380998PMC
April 2017

Three Chalconoids and a Pterocarpene from the Roots of Tephrosia aequilata.

Molecules 2017 Feb 20;22(2). Epub 2017 Feb 20.

Department of Chemistry, University of Nairobi, P.O. Box 30197, 00100 Nairobi, Kenya.

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http://www.mdpi.com/1420-3049/22/2/318
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http://dx.doi.org/10.3390/molecules22020318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155904PMC
February 2017

Polyoxygenated Cyclohexenes and Other Constituents of Cleistochlamys kirkii Leaves.

J Nat Prod 2017 01 21;80(1):114-125. Epub 2016 Dec 21.

Department of Chemistry and Molecular Biology, University of Gothenburg , SE-412 96 Gothenburg, Sweden.

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http://dx.doi.org/10.1021/acs.jnatprod.6b00759DOI Listing
January 2017

Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway.

Parasit Vectors 2016 11 17;9(1):589. Epub 2016 Nov 17.

Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia.

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http://dx.doi.org/10.1186/s13071-016-1860-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114727PMC
November 2016

Expression of the thioredoxin system in an in vivo-like cancer cell environment upon auranofin treatment.

Eur J Cell Biol 2016 Oct 21;95(10):378-388. Epub 2016 Aug 21.

School of Natural Sciences, Griffith University, Nathan, Qld 4111, Australia; Eskitis Institute for Drug Discovery, Griffith University, Nathan, Qld 4111, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ejcb.2016.08.003DOI Listing
October 2016

Future treatment options for human African trypanosomiasis.

Expert Rev Anti Infect Ther 2015 28;13(12):1429-32. Epub 2015 Sep 28.

a Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Don Young Road, Nathan, Brisbane, 4111, Australia.

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http://dx.doi.org/10.1586/14787210.2015.1094374DOI Listing
September 2016

Cancer drug discovery: recent innovative approaches to tumor modeling.

Expert Opin Drug Discov 2016 Sep;11(9):885-94

a Discovery Biology, Eskitis Institute for Drug Discovery , Griffith University , Nathan , Australia.

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http://dx.doi.org/10.1080/17460441.2016.1214562DOI Listing
September 2016

Development of ethynyl-2'-deoxyuridine chemical probes for cell proliferation.

Bioorg Med Chem 2016 09 12;24(18):4272-4280. Epub 2016 Jul 12.

Eskitis Institute for Drug Discovery, Griffith University, Don Young Road, Nathan, Queensland 4111, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.07.021DOI Listing
September 2016

Assessing Drug Efficacy in a Miniaturized Pancreatic Cancer In Vitro 3D Cell Culture Model.

Assay Drug Dev Technol 2016 09;14(7):367-80

Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University , Nathan, Australia .

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http://dx.doi.org/10.1089/adt.2016.737DOI Listing
September 2016

Selective anti-malarial minor groove binders.

Bioorg Med Chem Lett 2016 07 13;26(14):3326-3329. Epub 2016 May 13.

WestCHEM Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.

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http://dx.doi.org/10.1016/j.bmcl.2016.05.039DOI Listing
July 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics.

Eur J Med Chem 2016 Jun 29;116:116-125. Epub 2016 Mar 29.

WestCHEM Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.

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http://dx.doi.org/10.1016/j.ejmech.2016.03.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872591PMC
June 2016

Large-scale production of Plasmodium falciparum gametocytes for malaria drug discovery.

Nat Protoc 2016 May 28;11(5):976-92. Epub 2016 Apr 28.

Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia.

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http://dx.doi.org/10.1038/nprot.2016.056DOI Listing
May 2016

Luciferase-Based, High-Throughput Assay for Screening and Profiling Transmission-Blocking Compounds against Plasmodium falciparum Gametocytes.

Antimicrob Agents Chemother 2016 Apr 25;60(4):2097-107. Epub 2016 Mar 25.

Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia

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http://dx.doi.org/10.1128/AAC.01949-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808229PMC
April 2016

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.

Eur J Med Chem 2016 Mar 13;110:43-64. Epub 2016 Jan 13.

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, VIC 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.01.015DOI Listing
March 2016

Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites.

Int J Parasitol Drugs Drug Resist 2015 12 20;5(3):117-26. Epub 2015 Jun 20.

Eskitis Institute for Drug Discovery, Griffith University, Queensland, Australia.

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http://dx.doi.org/10.1016/j.ijpddr.2015.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506969PMC
December 2015

Identification and Characterization of FTY720 for the Treatment of Human African Trypanosomiasis.

Antimicrob Agents Chemother 2015 Dec 14;60(3):1859-61. Epub 2015 Dec 14.

Eskitis Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Queensland, Australia.

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http://aac.asm.org/content/60/3/1859.full.pdf
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http://aac.asm.org/content/early/2015/12/08/AAC.02116-15.ful
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http://aac.asm.org/lookup/doi/10.1128/AAC.02116-15
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http://dx.doi.org/10.1128/AAC.02116-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775930PMC
December 2015

Development and application of a sensitive, phenotypic, high-throughput image-based assay to identify compound activity against Trypanosoma cruzi amastigotes.

Int J Parasitol Drugs Drug Resist 2015 12 14;5(3):215-28. Epub 2015 Oct 14.

Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia.

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http://dx.doi.org/10.1016/j.ijpddr.2015.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847003PMC
December 2015

A simple and predictive phenotypic High Content Imaging assay for Plasmodium falciparum mature gametocytes to identify malaria transmission blocking compounds.

Sci Rep 2015 Nov 10;5:16414. Epub 2015 Nov 10.

Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, Viale Regina Elena n. 299, 00161 Roma, Italy.

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http://dx.doi.org/10.1038/srep16414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639769PMC
November 2015

6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors.

J Med Chem 2015 Sep 30;58(17):6753-65. Epub 2015 Aug 30.

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus) , 381 Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00438DOI Listing
September 2015

Splenic retention of Plasmodium falciparum gametocytes to block the transmission of malaria.

Antimicrob Agents Chemother 2015 Jul 4;59(7):4206-14. Epub 2015 May 4.

Centre d'Immunologie et des Maladies Infectieuses de Paris (CIMI-Paris), INSERM U1135, UPMC CR7, CNRS ERL 8255, Paris, France Laboratoire d'Excellence GR-Ex, Paris, France

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http://dx.doi.org/10.1128/AAC.05030-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468678PMC
July 2015

Evaluation of chemotherapeutics in a three-dimensional breast cancer model.

J Cancer Res Clin Oncol 2015 May 15;141(5):951-9. Epub 2015 Mar 15.

Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Building N27, Brisbane Innovation Park, Nathan, QLD, 4111, Australia,

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http://dx.doi.org/10.1007/s00432-015-1950-1DOI Listing
May 2015

Design and Synthesis of a Screening Library Using the Natural Product Scaffold 3-Chloro-4-hydroxyphenylacetic Acid.

J Nat Prod 2015 Apr 24;78(4):914-8. Epub 2015 Mar 24.

†Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia.

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http://dx.doi.org/10.1021/np500856uDOI Listing
April 2015

The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs.

Bioorg Med Chem Lett 2015 Jan 21;25(2):327-32. Epub 2014 Nov 21.

Department of Chemistry and Biochemistry, Northern Illinois University, 300 Normal Road, Dekalb, IL 60115, USA.

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http://dx.doi.org/10.1016/j.bmcl.2014.11.039DOI Listing
January 2015

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors.

J Med Chem 2014 Nov 24;57(21):9168-83. Epub 2014 Oct 24.

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1021/jm501323aDOI Listing
November 2014

Blood schizontocidal and gametocytocidal activity of 3-hydroxy-N'-arylidenepropanehydrazonamides: a new class of antiplasmodial compounds.

J Med Chem 2014 Oct 25;57(19):7971-6. Epub 2014 Sep 25.

Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität Düsseldorf , Universitätsstrasse 1, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1021/jm500811pDOI Listing
October 2014

Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei.

J Med Chem 2014 Aug 17;57(15):6393-402. Epub 2014 Jul 17.

Medicinal Chemistry, ‡Centre for Drug Candidate Optimisation, and §Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1021/jm500191uDOI Listing
August 2014

A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway.

Malar J 2014 Aug 31;13:343. Epub 2014 Aug 31.

Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Queensland 4111, Australia.

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http://dx.doi.org/10.1186/1475-2875-13-343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168161PMC
August 2014

Total synthesis and antiplasmodial activity of pohlianin C and analogues.

Bioorg Med Chem Lett 2014 Jun 29;24(12):2645-7. Epub 2014 Apr 29.

School of Chemistry, UNSW Australia, Sydney, NSW 2052, Australia; School of Chemistry, The University of Sydney, NSW 2006, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.04.071DOI Listing
June 2014

Advanced cell culture techniques for cancer drug discovery.

Biology (Basel) 2014 May 30;3(2):345-67. Epub 2014 May 30.

Discovery Biology, Griffith University, N27, Don Young Road, Nathan, Queensland, 4111, Australia.

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http://dx.doi.org/10.3390/biology3020345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085612PMC
May 2014

Facile Synthesis and Preliminary Structure-Activity Analysis of New Sulfonamides Against Trypanosoma brucei.

ACS Med Chem Lett 2014 May 10;5(5):496-500. Epub 2014 Mar 10.

School of Chemistry, University of Wollongong , Wollongong 2522, Australia.

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http://dx.doi.org/10.1021/ml400487tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027789PMC
May 2014

Synthesis, antimalarial properties, and SAR studies of alkoxyurea-based HDAC inhibitors.

ChemMedChem 2014 Mar 4;9(3):665-70. Epub 2014 Feb 4.

Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, 40225 Düsseldorf (Germany).

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http://dx.doi.org/10.1002/cmdc.201300469DOI Listing
March 2014

Miniaturized three-dimensional cancer model for drug evaluation.

Assay Drug Dev Technol 2013 Sep;11(7):435-48

Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University , Nathan, Australia .

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http://dx.doi.org/10.1089/adt.2012.483DOI Listing
September 2013