Vicki Keedy

Vicki Keedy

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Vicki Keedy

Vicki Keedy

Publications by authors named "Vicki Keedy"

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Pharmacokinetic characteristics of vactosertib, a new activin receptor-like kinase 5 inhibitor, in patients with advanced solid tumors in a first-in-human phase 1 study.

Invest New Drugs 2019 Jul 13. Epub 2019 Jul 13.

Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.

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http://dx.doi.org/10.1007/s10637-019-00835-yDOI Listing
July 2019

First-in-human phase I dose escalation study of MK-8033 in patients with advanced solid tumors.

Invest New Drugs 2018 10 29;36(5):860-868. Epub 2018 Jan 29.

Center for Oncology and Blood Disorders, Houston, TX, USA.

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http://dx.doi.org/10.1007/s10637-018-0567-zDOI Listing
October 2018

BRAF Inhibition in BRAF-Mutant Gliomas: Results From the VE-BASKET Study.

J Clin Oncol 2018 Oct 23:JCO2018789990. Epub 2018 Oct 23.

Thomas Kaley, Lisa M. DeAngelis, Jose Baselga, and David M. Hyman, Memorial Sloan Kettering Cancer Center; Thomas Kaley, Lisa M. DeAngelis, Jose Baselga, and David M. Hyman, Weill Cornell Medical College, New York; Igor Puzanov, Roswell Park Cancer Institute, Buffalo, NY; Mehdi Touat and Antoine Hollebecque, Institut Gustave Roussy, Villejuif; Franck Bielle, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Paris; Florence Joly, Centre François Baclesse, Caen; Jean-Yves Blay, Centre Léon Bérard, Lyon, France; Vivek Subbiah, MD Anderson Cancer Center, Houston, TX; Jordi Rodon, Vall d'Hebron University Hospital, Barcelona, Spain; A. Craig Lockhart, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL; Vicki Keedy, Vanderbilt University Medical Center, Nashville, TN; Ralf-Dieter Hofheinz, Universitätsmedizin Mannheim, Mannheim; Jurgen Wolf, Universitätsklinikum Köln, Cologne, Germany; Ian Chau, The Royal Marsden National Health Service Foundation Trust, London, United Kingdom; Noopur S. Raje, Massachusetts General Hospital, Boston, MA; Martina Makrutzki, F Hoffmann-La Roche, Basel, Switzerland; Todd Riehl, Genentech, South San Francisco, CA; and Bethany Pitcher, F Hoffmann-La Roche, Mississauga, Ontario, Canada.

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http://ascopubs.org/doi/10.1200/JCO.2018.78.9990
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http://dx.doi.org/10.1200/JCO.2018.78.9990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286161PMC
October 2018

The current landscape of early drug development for patients with sarcoma in the immunotherapy era.

Future Oncol 2018 May 27;14(12):1197-1211. Epub 2018 Apr 27.

Sarcoma Unit, Royal Marsden Hospital NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK.

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http://dx.doi.org/10.2217/fon-2017-0565DOI Listing
May 2018

The Current Landscape of Early Drug Development for Patients With Sarcoma.

Am Soc Clin Oncol Educ Book 2017 ;37:807-810

From the Sylvester Comprehensive Cancer Center, Miami, FL; Royal Marsden Hospital, The Institute of Cancer Research, London, United Kingdom; Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1200/EDBK_174701DOI Listing
November 2017

PICASSO III: A Phase III, Placebo-Controlled Study of Doxorubicin With or Without Palifosfamide in Patients With Metastatic Soft Tissue Sarcoma.

J Clin Oncol 2016 11 30;34(32):3898-3905. Epub 2016 Sep 30.

Christopher W. Ryan, Oregon Health & Science University, Portland, OR; Ofer Merimsky, Sackler School of Medicine, Tel-Aviv, Israel; Mark Agulnik, Northwestern University, Chicago, IL; Jean-Yves Blay, Centre Léon Bérard, Lyon; Antoine Italiano, Institut Bergonié, Bordeaux, France; Scott M. Schuetze, University of Michigan, Ann Arbor, MI; Brian A. Van Tine, Washington University in St Louis, St Louis, MO; Robin L. Jones and Ian R. Judson, The Royal Marsden Hospital, London, United Kingdom; Anthony D. Elias, University of Colorado-Denver, Aurora, CO; Edwin Choy, Massachusetts General Hospital; Jill Y. Buck and Francois Lebel, ZIOPHARM Oncology, Boston, MA; Thierry Alcindor, McGill University Health Center, Montreal, Quebec, Canada; Vicki L. Keedy, Vanderbilt University Medical Center, Nashville, TN; Damon R. Reed, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Robert N. Taub, Columbia University Medical Center; Jonathan J. Lewis, Samus Therapeutics and Molecular Ninja Group; Robert G. Maki, Mount Sinai School of Medicine, New York, NY; Xavier Garcia del Muro, Institut Català d'Oncologia L'Hospitalet, Barcelona, Spain; and Patrick Schöffski, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1200/JCO.2016.67.6684DOI Listing
November 2016

Factors affecting the pharmacokinetics and pharmacodynamics of PEGylated liposomal irinotecan (IHL-305) in patients with advanced solid tumors.

Int J Nanomedicine 2015 10;10:1201-9. Epub 2015 Feb 10.

UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA ; UNC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA ; UNC Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina, Chapel Hill, NC, USA ; Carolina Center for Cancer Nanotechology Excellence, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.2147/IJN.S62911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334335PMC
May 2016

Histology-Specific Uses of Tyrosine Kinase Inhibitors in Non-gastrointestinal Stromal Tumor Sarcomas.

Curr Treat Options Oncol 2016 Feb;17(2):11

Department of Medicine, Division of Hematology-Oncology, Vanderbilt University Medical Center, 2220 Pierce Ave, 777 Preston Research Building, Nashville, TN, 37232-6307, USA.

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http://dx.doi.org/10.1007/s11864-015-0382-0DOI Listing
February 2016

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.

N Engl J Med 2015 Jul;373(5):428-37

From Memorial Sloan Kettering Cancer Center (W.D.T., J.H.H.) and Weill Cornell Medical College (W.D.T.) - both in New York; University of California, Los Angeles, Medical Center, Los Angeles (Z.A.W., B.C., A.S.S.), Plexxikon, Berkeley (P.N.I., C.Z., J.Z., G.H., Y.Z., E.A.B., G.V., L.S., P.S., H.N., M.J.K., A.M., G.T., R.S., C.G., B.L.W., P.H., K.N., H.H.H., P.S.L., S.T.-S., G.B.), and Stanford University School of Medicine, Stanford (M.R.) - all in California; Evergreen Hematology and Oncology, Spokane, WA (S.P.A.); University of Pennsylvania School of Medicine, Philadelphia (A.P.S.); Rocky Mountain Cancer Centers, Denver (A.L.C.); Dana-Farber Cancer Institute (G.I.S., A.J.W.) and Massachusetts General Hospital (E.L.K.) - both in Boston; Vanderbilt University Medical Center, Nashville (V.L.K., I.P.); Virginia G. Piper Cancer Center at Scottsdale Healthcare-Translational Genomics Research Institute (TGen), Scottsdale, AZ (D.D.V.H., G.J.W., R.K.R.); and Spire Sciences, Boca Raton, FL (C.P.).

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http://dx.doi.org/10.1056/NEJMoa1411366DOI Listing
July 2015

Cytotoxic chemotherapy for adult soft-tissue sarcomas: a lesson in humility.

Authors:
Vicki L Keedy

Oncology (Williston Park) 2015 Jan;29(1):53-4

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January 2015

Adult neuroblastoma complicated by increased intracranial pressure: a case report and review of the literature.

Case Rep Oncol Med 2014 25;2014:341980. Epub 2014 Sep 25.

Division of Pediatric Hematology and Oncology, Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center 2220 Pierce Avenue, 397 PRB, Nashville, TN 37232-6310, USA.

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http://dx.doi.org/10.1155/2014/341980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190830PMC
October 2014

Phase II study of bendamustine in relapsed chemotherapy sensitive or resistant small-cell lung cancer.

J Thorac Oncol 2014 Apr;9(4):559-62

*Department of Internal Medicine, Meharry Medical College, Nashville, Tennessee; †Department of Biostatistics, Center for Quantitative Science, Vanderbilt University Medical Center, Nashville, Tennessee; ‡South Carolina Oncology Associates, Columbia, South Carolina; §Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health and Science University, OHSU Knight Cancer Institute, Portland, Oregon; ‖Department of Medicine, Division of Medical Oncology, The Ohio State University Medical Center, Arthur G. James Cancer Hospital, Columbus, Ohio; ¶Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas; and #Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.

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http://dx.doi.org/10.1097/JTO.0000000000000079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990869PMC
April 2014

Population pharmacokinetics of PEGylated liposomal CPT-11 (IHL-305) in patients with advanced solid tumors.

Eur J Clin Pharmacol 2013 Dec 30;69(12):2073-81. Epub 2013 Aug 30.

UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s00228-013-1580-yDOI Listing
December 2013

Complications of targeted drug therapies for solid malignancies: manifestations and mechanisms.

AJR Am J Roentgenol 2013 Mar;200(3):475-83

Department of Radiology and Radiological Science, Vanderbilt University School of Medicine, 1161 21st Ave S, CCC-1121 MCN, Nashville, TN 37232-2675, USA.

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http://dx.doi.org/10.2214/AJR.12.9049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652983PMC
March 2013

Identifying barriers associated with enrollment of patients with lung cancer into clinical trials.

Clin Lung Cancer 2013 Jan 15;14(1):14-8. Epub 2012 May 15.

Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.cllc.2012.03.008DOI Listing
January 2013

Nuclear p63 expression in osteoblastic tumors.

Tumour Biol 2012 Oct 25;33(5):1639-44. Epub 2012 May 25.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Medical Center North, C-3322, 1161 21st Ave. South, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1007/s13277-012-0419-yDOI Listing
October 2012

Treating metastatic soft-tissue or bone sarcomas - potential role of ridaforolimus.

Authors:
Vicki L Keedy

Onco Targets Ther 2012 22;5:153-60. Epub 2012 Aug 22.

Vanderbilt University Medical Center, Nashville, TN, USA.

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http://www.dovepress.com/treating-metastatic-soft-tissue-or-
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http://dx.doi.org/10.2147/OTT.S19055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428242PMC
October 2012

Foamy cell angiosarcoma: a rare and deceptively bland variant of cutaneous angiosarcoma.

J Cutan Pathol 2010 Aug 8;37(8):901-6. Epub 2010 Feb 8.

Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1111/j.1600-0560.2010.01512.xDOI Listing
August 2010

Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma.

J Pathol 2010 Apr;220(5):608-17

Chordoma Foundation, Greensboro, NC, USA, and Division of Medical Oncology, Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA.

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http://doi.wiley.com/10.1002/path.2679
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http://dx.doi.org/10.1002/path.2679DOI Listing
April 2010

Prognostic significance of c-Myc expression in soft tissue leiomyosarcoma.

Mod Pathol 2009 Nov 24;22(11):1432-8. Epub 2009 Jul 24.

Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/modpathol.2009.113DOI Listing
November 2009

Cyclooxygenase 2 expression in soft tissue leiomyosarcoma.

Anticancer Res 2009 Aug;29(8):2913-7

Orthopaedics and Rehabilitation Department, Vanderbilt Orthopaedic Institute, 1215 21st Avenue South, Nashville, TN 37232, USA.

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http://ar.iiarjournals.org/content/29/8/2913.full.pdf
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August 2009

Does gefitinib shorten lung cancer survival? Chaos redux.

J Clin Oncol 2008 May 31;26(15):2428-30. Epub 2008 Mar 31.

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http://ascopubs.org/doi/10.1200/JCO.2008.16.0374
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http://dx.doi.org/10.1200/JCO.2008.16.0374DOI Listing
May 2008

Inhibition of angiogenesis in the treatment of non-small cell lung cancer.

Cancer Sci 2007 Dec 24;98(12):1825-30. Epub 2007 Sep 24.

Vanderbilt-Ingram Cancer Center, Vanderbilt University, Department of Medicine, 2220 Pierce Avenue, 777 Preston Research Building, Nashville, TN 37272-6307, USA.

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http://dx.doi.org/10.1111/j.1349-7006.2007.00620.xDOI Listing
December 2007

Adjuvant and neoadjuvant approaches to treat surgically resectable pancreatic cancer.

Curr Treat Options Oncol 2006 Sep;7(5):381-8

Vanderbilt University Medical Center, 777 Preston Research Building, Nashville, TN 37232, USA.

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September 2006