Publications by authors named "Vicente Alfaro"

37Publications

Effect of lurbinectedin on the QTc interval in patients with advanced solid tumors: an exposure-response analysis.

Authors:
Salvador Fudio Josep Tabernero Vivek Subbiah Sant P Chawla Victor Moreno Federico Longo Rafael Lopez Antonio Anton Jose Manuel Trigo Geoffrey Shapiro Woondong Jeong Victor Manuel Villalobos Rubin Lubomirov Carlos Fernandez-Teruel Vicente Alfaro Valentina Boni

Cancer Chemother Pharmacol 2021 Jan 27;87(1):113-124. Epub 2020 Oct 27.

START Madrid-CIOCC, Hospital Universitario San Chinarro, 28050, Madrid, Spain.

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January 2021

Antitumor activity of lurbinectedin in second-line small cell lung cancer patients who are candidates for re-challenge with the first-line treatment.

Authors:
Vivek Subbiah Luis Paz-Ares Benjamin Besse Victor Moreno Solange Peters María Angeles Sala José Antonio López-Vilariño Cristian Fernández Carmen Kahatt Vicente Alfaro Mariano Siguero Ali Zeaiter Khalil Zaman Rafael López Santiago Ponce Valentina Boni Jennifer Arrondeau Jean-Pierre Delord Maite Martínez Luciano Wannesson Antonio Antón Javier Valdivia Ahmad Awada Rebecca Kristeleit Maria Eugenia Olmedo María Jesús Rubio John Sarantopoulos Sant P Chawla Joaquín Mosquera-Martinez Manolo D' Arcangelo Armando Santoro Victor M Villalobos Jacob Sands José Trigo

Lung Cancer 2020 12 10;150:90-96. Epub 2020 Oct 10.

Hospital Universitario Virgen de la Victoria, Málaga, Spain.

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December 2020

Lurbinectedin as second-line treatment for patients with small-cell lung cancer: a single-arm, open-label, phase 2 basket trial.

Authors:
José Trigo Vivek Subbiah Benjamin Besse Victor Moreno Rafael López María Angeles Sala Solange Peters Santiago Ponce Cristian Fernández Vicente Alfaro Javier Gómez Carmen Kahatt Ali Zeaiter Khalil Zaman Valentina Boni Jennifer Arrondeau Maite Martínez Jean-Pierre Delord Ahmad Awada Rebecca Kristeleit Maria Eugenia Olmedo Luciano Wannesson Javier Valdivia María Jesús Rubio Antonio Anton John Sarantopoulos Sant P Chawla Joaquín Mosquera-Martinez Manolo D'Arcangelo Armando Santoro Victor M Villalobos Jacob Sands Luis Paz-Ares

Lancet Oncol 2020 05 27;21(5):645-654. Epub 2020 Mar 27.

Hospital Universitario 12 de Octubre, H120-CNIO Lung Cancer Unit, Universidad Complutense de Madrid, Madrid, Spain; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain.

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May 2020

Randomized phase III study (ADMYRE) of plitidepsin in combination with dexamethasone vs. dexamethasone alone in patients with relapsed/refractory multiple myeloma.

Authors:
Ivan Spicka Enrique M Ocio Heather E Oakervee Richard Greil Raymond H Banh Shang-Yi Huang James M D'Rozario Meletios A Dimopoulos Sara Martínez Sonia Extremera Carmen Kahatt Vicente Alfaro Angelo M Carella Nathalie Meuleman Roman Hájek Argiris Symeonidis Chang-Ki Min Paul Cannell Heinz Ludwig Pieter Sonneveld María Victoria Mateos

Ann Hematol 2019 Sep 25;98(9):2139-2150. Epub 2019 Jun 25.

Department of Hematology, University Hospital of Salamanca/IBSAL, Salamanca, Spain.

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September 2019

Multicenter Phase II Study of Lurbinectedin in BRCA-Mutated and Unselected Metastatic Advanced Breast Cancer and Biomarker Assessment Substudy.

Authors:
Cristina Cruz Alba Llop-Guevara Judy E Garber Banu K Arun José A Pérez Fidalgo Ana Lluch Melinda L Telli Cristian Fernández Carmen Kahatt Carlos M Galmarini Arturo Soto-Matos Vicente Alfaro Aitor Pérez de la Haza Susan M Domchek Silvia Antolin Linda Vahdat Nadine M Tung Rafael Lopez Joaquín Arribas Ana Vivancos José Baselga Violeta Serra Judith Balmaña Steven J Isakoff

J Clin Oncol 2018 11 21;36(31):3134-3143. Epub 2018 Sep 21.

Cristina Cruz and Judith Balmaña, Vall d'Hebron Hospital; Cristina Cruz, Alba Llop-Guevara, Joaquín Arribas, Ana Vivancos, Violeta Serra, and Judith Balmaña, Vall d'Hebron Institute of Oncology; José A. Pérez Fidalgo, Ana Lluch, Joaquín Arribas, and Violeta Serra, Centro de Investigación Biomédica en Red; Joaquín Arribas, Institució Catalana de Recerca i Estudis Avançats, Barcelona; José A. Pérez Fidalgo and Ana Lluch, Hospital Clínico de Valencia, Valencia; Cristian Fernández, Carmen Kahatt, Carlos M. Galmarini, Arturo Soto-Matos, Vicente Alfaro, and Aitor Pérez de la Haza, PharmaMar, Madrid; Silvia Antolin, Complejo Universitario Hospitalario La Coruña, La Coruña; Rafael Lopez, Complejo Hospitalario Universitario Santiago de Compostela, Santiago de Compostela, Spain; Judy E. Garber, Dana Farber Cancer Institute; Nadine M. Tung, Beth Israel Deaconess Medical Center; José Baselga and Steven J. Isakoff, Massachusetts General Hospital Cancer Center, Boston, MA; Banu K. Arun, MD Anderson Cancer Center, Houston, TX; Melinda L. Telli, Stanford University School of Medicine, Stanford, CA; Susan M. Domchek, University of Pennsylvania, Philadelphia, PA; and Linda Vahdat, Weill Cornell Medicine, New York, NY.

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November 2018

Higher antitumor activity of trabectedin in germline BRCA2 carriers with advanced breast cancer as compared to BRCA1 carriers: A subset analysis of a dedicated phase II trial.

Authors:
Amal Ghouadni Suzette Delaloge Pilar Lardelli Carmen Kahatt Tomasz Byrski Joanne L Blum Anthony Gonçalves Mario Campone Antonio Nieto Vicente Alfaro Martin Cullell-Young Jan Lubinski

Breast 2017 Aug 30;34:18-23. Epub 2017 Apr 30.

Pomeranian Medical University, International Hereditary Cancer Center, Sczeczin, Poland. Electronic address:

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August 2017

Phase I dose-escalation study of plitidepsin in combination with sorafenib or gemcitabine in patients with refractory solid tumors or lymphomas.

Authors:
Sandrine Aspeslagh Mark Stein Rastilav Bahleda Antoine Hollebecque Gilles Salles Emmanuel Gyan Salvador Fudio Sonia Extremera Vicente Alfaro Arturo Soto-Matos Jean-Charles Soria

Anticancer Drugs 2017 03;28(3):341-349

aGustave Roussy Cancer Centre, Paris-Saclay University, Drug Development Department (DITEP), Villejuif bHospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre Benite Cedex cHematology and Cellular Therapy Department, CIC INSERM 1415, University Hospital Centre, Tours, France dCancer Institute of New Jersey, New Brunswick, New Jersey, USA ePharmaMar, S.A., Colmenar Viejo, Madrid, Spain.

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March 2017

Trabectedin plus pegylated liposomal doxorubicin: retrospective analysis in heavily pretreated platinum-sensitive ovarian cancer.

Authors:
Maria Ornella Nicoletto Alessandra Baldoni Alessandra Casarin Giovanni Randon Margherita Nardin Zora Baretta Pilar Lardelli Antonio Nieto Vicente Alfaro Claudia Rigamonti Pier Franco Conte

Tumori 2015 Sep-Oct;101(5):506-10. Epub 2015 Jun 18.

Medical Oncology Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua - Italy.

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January 2016

First-in-human, phase I study of elisidepsin (PM02734) administered as a 30-min or as a 3-hour intravenous infusion every three weeks in patients with advanced solid tumors.

Authors:
Mark J Ratain David Geary Samir D Undevia Cinthya Coronado Vicente Alfaro Jorge L Iglesias Richard L Schilsky Bernardo Miguel-Lillo

Invest New Drugs 2015 Aug 8;33(4):901-10. Epub 2015 May 8.

Department of Medicine, University of Chicago, MC2115, 5841 South Maryland Avenue, Chicago, IL, 60637, USA,

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August 2015

[Encore abstracts in medical/scientific meetings].

Authors:
Vicente Alfaro

Med Clin (Barc) 2015 May 3;144(10):477-8. Epub 2014 Sep 3.

Departamento de Fisiología e Inmunología, Facultad de Biología, Universidad de Barcelona, Barcelona, España. Electronic address:

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May 2015

Phase II clinical trial of PM00104 (Zalypsis(®)) in urothelial carcinoma patients progressing after first-line platinum-based regimen.

Authors:
Daniel E Castellano Joaquim Bellmunt José Pablo Maroto Albert Font-Pous Rafael Morales-Barrera Ismael Ghanem Cristina Suarez Cristina Martín Lorente Olatz Etxaniz Laia Capdevila Cinthya Coronado Vicente Alfaro Mariano Siguero Carlos Fernández-Teruel Joan Carles

Cancer Chemother Pharmacol 2014 Apr 26;73(4):857-67. Epub 2014 Feb 26.

Hospital Universitario Doce de Octubre, Avda. Córdoba s/n, 28041, Madrid, Spain,

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April 2014

Phase I study of carboplatin in combination with PM00104 (Zalypsis®) in patients with advanced solid tumors.

Authors:
Ramón Salazar Antonio Calles Marta Gil Ignacio Durán Margarita García Manuel Hidalgo Cinthya Coronado Vicente Alfaro Mariano Siguero Carlos Fernández-Teruel Raquel Prados Emiliano Calvo

Invest New Drugs 2014 Aug 19;32(4):644-52. Epub 2014 Feb 19.

Instituto Catalán de Oncología, L'Hospitalet de Llobregat, Barcelona, Spain.

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August 2014

Randomised phase III trial of trabectedin versus doxorubicin-based chemotherapy as first-line therapy in translocation-related sarcomas.

Authors:
Jean-Yves Blay Michael G Leahy Binh Bui Nguyen Shreyaskumar R Patel Peter Hohenberger Armando Santoro Arthur P Staddon Nicolas Penel Sophie Piperno-Neumann Andrew Hendifar Pilar Lardelli Antonio Nieto Vicente Alfaro Sant P Chawla

Eur J Cancer 2014 Apr 7;50(6):1137-47. Epub 2014 Feb 7.

Sarcoma Oncology Center, Santa Monica, CA, USA.

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April 2014

A Phase II multicenter, open-label, clinical and pharmokinetic trial of PM00104 in patients with advanced Ewing Family of Tumors.

Authors:
Robin L Jones Stefano Ferrari Jean Yves Blay Fariba Navid Pilar Lardelli Vicente Alfaro Mariano Siguero Neelesh Soman Sant P Chawla

Invest New Drugs 2014 Feb 1;32(1):171-7. Epub 2013 Nov 1.

University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA, USA,

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February 2014

Phase I clinical and pharmacokinetic study of trabectedin and cisplatin given every three weeks in patients with advanced solid tumors.

Authors:
Cristiana Sessa Gianluca Del Conte Alexandre Christinat Sara Cresta Antonella Perotti Elisa Gallerani Pilar Lardelli Carmen Kahatt Vicente Alfaro Jorge L Iglesias Carlos Fernández-Teruel Luca Gianni

Invest New Drugs 2013 Oct 7;31(5):1236-43. Epub 2013 Mar 7.

Istituto Oncologico della Svizzera (IOSI), Ospedale San Giovanni, 6500, Bellinzona, Switzerland,

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October 2013

Complete and sustained objective response per RECIST to Irvalec (PM02734) in undifferentiated large cell esophageal adenocarcinoma: A case report and a review of the literature.

Authors:
Ramón Salazar Carmen Cuadra Marta Gil-Martín Andrea Vandermeeren Vicente Alfaro Cinthya Coronado

Case Rep Oncol 2012 May 5;5(2):354-8. Epub 2012 Jul 5.

Instituto Catalán de Oncología-IDIBELL, Barcelona, Spain.

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May 2012

A retrospective analysis of antitumour activity with trabectedin in translocation-related sarcomas.

Authors:
Axel Le Cesne Sara Cresta Robert G Maki Jean Yves Blay Jaap Verweij Andrés Poveda Paolo G Casali Carme Balaña Patrick Schöffski Federica Grosso Pilar Lardelli Antonio Nieto Vicente Alfaro George D Demetri

Eur J Cancer 2012 Nov 29;48(16):3036-44. Epub 2012 Jun 29.

Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France.

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November 2012

Phase I study of PM00104 (Zalypsis®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors.

Authors:
Christophe Massard Jane Margetts Nadia Amellal Yvette Drew Ratislav Bahleda Peter Stephens Peter Stevens Jean Pierre Armand Hilary Calvert Jean Charles Soria Cinthya Coronado Carmen Kahatt Vicente Alfaro Mariano Siguero Carlos Fernández-Teruel Ruth Plummer

Invest New Drugs 2013 Jun 12;31(3):623-30. Epub 2012 Jun 12.

SITEP (Service des Innovations Thérapeutiques Précoces), Institute Gustave Roussy, 114, rue Edouard Vaillant, 94800, Villejuif, France.

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June 2013

A comprehensive safety analysis confirms rhabdomyolysis as an uncommon adverse reaction in patients treated with trabectedin.

Authors:
Federica Grosso Maurizio D'Incalci Mirela Cartoafa Antonio Nieto Carlos Fernández-Teruel Vicente Alfaro Pilar Lardelli Elena Roy Javier Gómez Carmen Kahatt Arturo Soto-Matos Ian Judson

Cancer Chemother Pharmacol 2012 Jun 7;69(6):1557-65. Epub 2012 Apr 7.

SC Oncologia, SS Antonio and Biagio and C Arrigo General Hospital, Alessandria, Italy.

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June 2012

Trabectedin in patients with advanced non-small-cell lung cancer (NSCLC) with XPG and/or ERCC1 overexpression and BRCA1 underexpression and pretreated with platinum.

Authors:
Bartomeu Massuti Manuel Cobo Carlos Camps Manuel Dómine Mariano Provencio Vicente Alberola Nuria Viñolas Rafael Rosell Miguel Tarón Vanesa Gutiérrez-Calderón Pilar Lardelli Vicente Alfaro Antonio Nieto Dolores Isla

Lung Cancer 2012 Jun 23;76(3):354-61. Epub 2011 Dec 23.

Hospital General Universitario de Alicante, Alicante, Spain.

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June 2012