Vicent Casadó

Vicent Casadó

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Vicent Casadó

Vicent Casadó

Publications by authors named "Vicent Casadó"

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The heterotetrameric structure of the adenosine A-dopamine D receptor complex: Pharmacological implication for restless legs syndrome.

Adv Pharmacol 2019 13;84:37-78. Epub 2019 Feb 13.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona, Spain; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/bs.apha.2019.01.001DOI Listing
December 2019

Targeting the receptor-based interactome of the dopamine D1 receptor: looking for heteromer-selective drugs.

Expert Opin Drug Discov 2019 12 11;14(12):1297-1312. Epub 2019 Sep 11.

Laboratory of Molecular Neurobiology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, (IBUB) , Barcelona , Spain.

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http://dx.doi.org/10.1080/17460441.2019.1664469DOI Listing
December 2019

Oligomerization of G protein-coupled receptors: Still doubted?

Prog Mol Biol Transl Sci 2020 12;169:297-321. Epub 2019 Dec 12.

Laboratori de Medicina Computacional, Unitat de Bioestadística, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.

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http://dx.doi.org/10.1016/bs.pmbts.2019.11.006DOI Listing
December 2019

Biased G Protein-Independent Signaling of Dopamine D-D Receptor Heteromers in the Nucleus Accumbens.

Mol Neurobiol 2019 Oct 27;56(10):6756-6769. Epub 2019 Mar 27.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1007/s12035-019-1564-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728209PMC
October 2019

Revisiting the Functional Role of Dopamine D Receptor Gene Polymorphisms: Heteromerization-Dependent Gain of Function of the D Receptor Variant.

Mol Neurobiol 2019 Jul 1;56(7):4778-4785. Epub 2018 Nov 1.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, 21224, USA.

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http://link.springer.com/10.1007/s12035-018-1413-1
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http://dx.doi.org/10.1007/s12035-018-1413-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494742PMC
July 2019

The Endocannabinoid System as a Target in Cancer Diseases: Are We There Yet?

Front Pharmacol 2019 5;10:339. Epub 2019 Apr 5.

Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Institute of Biomedicine (IBUB), University of Barcelona, Barcelona, Spain.

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https://www.frontiersin.org/article/10.3389/fphar.2019.00339
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http://dx.doi.org/10.3389/fphar.2019.00339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459931PMC
April 2019

Adenosine A-Dopamine D Receptor Heteromers Control the Excitability of the Spinal Motoneuron.

Mol Neurobiol 2019 Feb 24;56(2):797-811. Epub 2018 May 24.

Department of Anatomy and Neurobiology and Institute of Neurobiology, University of Puerto Rico, Medical Sciences, Rio Piedras and Cayey Campuses, San Juan, 00936, Puerto Rico.

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http://link.springer.com/10.1007/s12035-018-1120-y
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http://dx.doi.org/10.1007/s12035-018-1120-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252157PMC
February 2019

Reinterpreting anomalous competitive binding experiments within G protein-coupled receptor homodimers using a dimer receptor model.

Pharmacol Res 2019 01 22;139:337-347. Epub 2018 Nov 22.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain; Institute of Biomedicine of the University of Barcelona (IBUB), Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Av. Diagonal 643, 08028, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2018.11.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360119PMC
January 2019

α- and α-Adrenoceptors as Potential Targets for Dopamine and Dopamine Receptor Ligands.

Mol Neurobiol 2018 Nov 18;55(11):8438-8454. Epub 2018 Mar 18.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Triad Technology Building, 333 Cassell Drive, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1007/s12035-018-1004-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143434PMC
November 2018

Design of a True Bivalent Ligand with Picomolar Binding Affinity for a G Protein-Coupled Receptor Homodimer.

J Med Chem 2018 10 11;61(20):9335-9346. Epub 2018 Oct 11.

Biomaterials and Nanomedicine , Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) , Barcelona Science Park , 08028 Barcelona , Spain.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01249DOI Listing
October 2018

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase.

Nat Commun 2018 03 28;9(1):1242. Epub 2018 Mar 28.

Integrative Neurobiology Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1038/s41467-018-03522-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871782PMC
March 2018

Molecular Evidence of Adenosine Deaminase Linking Adenosine A Receptor and CD26 Proteins.

Front Pharmacol 2018 15;9:106. Epub 2018 Feb 15.

Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.3389/fphar.2018.00106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818423PMC
February 2018

Heteroreceptor Complexes Formed by Dopamine D, Histamine H, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer's Disease.

Mol Neurobiol 2017 08 1;54(6):4537-4550. Epub 2016 Jul 1.

Molecular Neurobiology laboratory, Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1007/s12035-016-9995-yDOI Listing
August 2017

Functional μ-Opioid-Galanin Receptor Heteromers in the Ventral Tegmental Area.

J Neurosci 2017 02 22;37(5):1176-1186. Epub 2016 Dec 22.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.2442-1
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http://dx.doi.org/10.1523/JNEUROSCI.2442-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296795PMC
February 2017

Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease.

Neurobiol Dis 2016 Dec 24;96:47-53. Epub 2016 Aug 24.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09699961163020
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http://dx.doi.org/10.1016/j.nbd.2016.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102769PMC
December 2016

Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum.

Mol Neurobiol 2016 10 9;53(8):5436-45. Epub 2015 Oct 9.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Valderrebollo 5, 28031, Madrid, Spain.

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http://dx.doi.org/10.1007/s12035-015-9468-8DOI Listing
October 2016

Targeting the dopamine D3 receptor: an overview of drug design strategies.

Expert Opin Drug Discov 2016 Jul 30;11(7):641-64. Epub 2016 May 30.

a Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) , Spain.

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http://dx.doi.org/10.1080/17460441.2016.1185413DOI Listing
July 2016

A Significant Role of the Truncated Ghrelin Receptor GHS-R1b in Ghrelin-induced Signaling in Neurons.

J Biol Chem 2016 Jun 25;291(25):13048-62. Epub 2016 Apr 25.

the Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224

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http://dx.doi.org/10.1074/jbc.M116.715144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933222PMC
June 2016

Evidence for the heterotetrameric structure of the adenosine A2A-dopamine D2 receptor complex.

Biochem Soc Trans 2016 Apr;44(2):595-600

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain Institute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain

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http://dx.doi.org/10.1042/BST20150276DOI Listing
April 2016

Stronger Dopamine D1 Receptor-Mediated Neurotransmission in Dyskinesia.

Mol Neurobiol 2015 Dec 26;52(3):1408-1420. Epub 2014 Oct 26.

Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Diagonal 645, Prevosti Building, 08028, Barcelona, Spain.

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http://link.springer.com/content/pdf/10.1007%2Fs12035-014-89
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http://link.springer.com/10.1007/s12035-014-8936-x
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http://dx.doi.org/10.1007/s12035-014-8936-xDOI Listing
December 2015

Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer.

Proc Natl Acad Sci U S A 2015 Jul 22;112(27):E3609-18. Epub 2015 Jun 22.

Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, and Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas and Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain;

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http://dx.doi.org/10.1073/pnas.1507704112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500251PMC
July 2015

A solid-phase combinatorial approach for indoloquinolizidine-peptides with high affinity at D(1) and D(2) dopamine receptors.

Eur J Med Chem 2015 Jun 28;97:173-80. Epub 2015 Apr 28.

Combinatorial Chemistry Unit, Barcelona Science Park, University of Barcelona, 08028 Barcelona, Spain; CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, 08028 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.04.052DOI Listing
June 2015

Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine.

J Neurosci 2015 Apr;35(17):6639-53

Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Center for Biomedical Research in Neurodegenerative Diseases Network and Institute of Biomedicine of the University of Barcelona, 08028 Barcelona, Spain, School of Pharmacy, University of East Anglia, Norwich, NR4 7TJ, United Kingdom, and

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.4364-14.2
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http://dx.doi.org/10.1523/JNEUROSCI.4364-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412889PMC
April 2015

Moonlighting adenosine deaminase: a target protein for drug development.

Med Res Rev 2015 Jan 16;35(1):85-125. Epub 2014 Jun 16.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Institute of Biomedicine of the University of Barcelona (IBUB), Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1002/med.21324DOI Listing
January 2015

G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives.

Pharmacol Rev 2014 10;66(2):413-34. Epub 2014 Feb 10.

Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes on Drug Abuse, Department of Health and Human Services, 333 Cassell Drive, Baltimore, Maryland 21224.

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http://dx.doi.org/10.1124/pr.113.008052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973609PMC
December 2014

Functional selectivity of allosteric interactions within G protein-coupled receptor oligomers: the dopamine D1-D3 receptor heterotetramer.

Mol Pharmacol 2014 Oct 5;86(4):417-29. Epub 2014 Aug 5.

National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland (X.G., H.Y., N.-S.C., M.S.-S., S.K.-B., Y.T.N., S.F.); Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain (G.N., E.M., J.M., A.C., C.L., E.I.C., V.C., P.J.M.); and School of Pharmacy, University of East Anglia, Norwich, United Kingdom (P.J.M.)

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.114.09
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http://dx.doi.org/10.1124/mol.114.093096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164978PMC
October 2014

G-protein-coupled receptor heteromers as key players in the molecular architecture of the central nervous system.

CNS Neurosci Ther 2014 Aug 9;20(8):703-9. Epub 2014 May 9.

Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona (UB), Barcelona, Spain; Centro investigación biomédica en red enfermedades neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.

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http://dx.doi.org/10.1111/cns.12277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493065PMC
August 2014

L-DOPA-treatment in primates disrupts the expression of A(2A) adenosine-CB(1) cannabinoid-D(2) dopamine receptor heteromers in the caudate nucleus.

Neuropharmacology 2014 Apr 11;79:90-100. Epub 2013 Nov 11.

Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain; Centro de Investigación Médica Aplicada, Universidad de Navarra, 31008 Pamplona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2013.10.036DOI Listing
April 2014

L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies.

Exp Neurol 2014 Mar 9;253:180-91. Epub 2014 Jan 9.

Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain; Centro de Investigación Médica Aplicada, Universidad de Navarra, 31008 Pamplona, Spain.

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http://dx.doi.org/10.1016/j.expneurol.2013.12.021DOI Listing
March 2014

Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects.

J Neurosci 2014 Mar;34(10):3545-58

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Institute of Biomedicine of the University of Barcelona (IBUB) and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, 08028 Spain, Neuroscience Institute and Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitat Autónoma de Barcelona, 08193 Bellaterra, Spain, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, and School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, United Kingdom NR4 7TJ.

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http://dx.doi.org/10.1523/JNEUROSCI.4147-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942573PMC
March 2014

Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers.

PLoS One 2013 18;8(4):e61245. Epub 2013 Apr 18.

Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Institute of Biomedicine of the University of Barcelona (IBUB) and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061245PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630156PMC
December 2013

A1R-A2AR heteromers coupled to Gs and G i/0 proteins modulate GABA transport into astrocytes.

Purinergic Signal 2013 Sep 10;9(3):433-49. Epub 2013 May 10.

Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of Lisbon, Av. Professor Egas Moniz, Edificio Egas Moniz, 1649-028, Lisbon, Portugal.

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http://dx.doi.org/10.1007/s11302-013-9364-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757138PMC
September 2013

Homodimerization of adenosine A₁ receptors in brain cortex explains the biphasic effects of caffeine.

Neuropharmacology 2013 Aug 22;71:56-69. Epub 2013 Mar 22.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Faculty of Biology, University of Barcelona, Av. Diagonal 643, 08028 Barcelona, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S002839081300101
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http://dx.doi.org/10.1016/j.neuropharm.2013.03.005DOI Listing
August 2013

Detection of receptor heteromers involving dopamine receptors by the sequential BRET-FRET technology.

Methods Mol Biol 2013 ;964:95-105

Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1007/978-1-62703-251-3_7DOI Listing
June 2013

Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans.

Neuropharmacology 2013 Apr 19;67:476-84. Epub 2012 Dec 19.

National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, 251 Bayview Blvd, Baltimore, MD, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00283908120057
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http://dx.doi.org/10.1016/j.neuropharm.2012.11.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562388PMC
April 2013

The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors.

FASEB J 2013 Mar 27;27(3):1048-61. Epub 2012 Nov 27.

Laboratory of Molecular Neurobiology, Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Av. Diagonal 643, 08028 Barcelona, Spain.

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http://www.fasebj.org/doi/10.1096/fj.12-212621
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http://dx.doi.org/10.1096/fj.12-212621DOI Listing
March 2013

NCS-1 associates with adenosine A(2A) receptors and modulates receptor function.

Front Mol Neurosci 2012 18;5:53. Epub 2012 Apr 18.

Faculty of Biology, Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas and Department of Biochemistry and Molecular Biology, University of Barcelona Barcelona, Spain.

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http://dx.doi.org/10.3389/fnmol.2012.00053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328853PMC
October 2012

Modulation of GABA transport by adenosine A1R-A2AR heteromers, which are coupled to both Gs- and G(i/o)-proteins.

J Neurosci 2011 Nov;31(44):15629-39

Institute of Pharmacology and Neurosciences, Faculty of Medicine, Unit of Neurosciences, Institute of Molecular Medicine, University of Lisbon, 1649-028 Lisbon, Portugal.

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http://dx.doi.org/10.1523/JNEUROSCI.2526-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6623011PMC
November 2011

Adenosine A(2A) Receptors and A(2A) Receptor Heteromers as Key Players in Striatal Function.

Front Neuroanat 2011 17;5:36. Epub 2011 Jun 17.

National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, U.S. Department of Health and Human Services Baltimore, MD, USA.

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http://dx.doi.org/10.3389/fnana.2011.00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118889PMC
July 2011

A2A adenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase.

Biochem J 2011 May;435(3):701-9

Centro de Investigacón Biomédica en Red sobre Enfermedades Neurodegenerativas, and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Avda. Diagonal 645, 08028 Barcelona, Spain.

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http://www.biochemj.org/content/ppbiochemj/435/3/701.full.pd
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http://www.tara.tcd.ie/bitstream/handle/2262/54859/PEER_stag
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http://biochemj.org/lookup/doi/10.1042/BJ20101749
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http://dx.doi.org/10.1042/BJ20101749DOI Listing
May 2011

Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors.

Eur Heart J 2011 Mar 22;32(6):721-9. Epub 2010 Dec 22.

Cell Physiology Laboratory, Centro de Investigación Cardiovascular CSIC-ICCC Hospital de Sant Pau, Barcelona, Spain.

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https://academic.oup.com/eurheartj/article-lookup/doi/10.109
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http://dx.doi.org/10.1093/eurheartj/ehq464DOI Listing
March 2011

Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway.

J Biol Chem 2011 Feb 20;286(7):5846-54. Epub 2010 Dec 20.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Diagonal 645, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1074/jbc.M110.161489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037697PMC
February 2011

Biotin ergopeptide probes for dopamine receptors.

J Med Chem 2011 Feb 31;54(4):1080-90. Epub 2011 Jan 31.

Combinatorial Chemistry Unit, Barcelona Science Park, University of Barcelona, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1021/jm101566dDOI Listing
February 2011

Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine.

Proc Natl Acad Sci U S A 2010 Oct 18;107(43):18676-81. Epub 2010 Oct 18.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1073/pnas.1008911107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972946PMC
October 2010

G protein-coupled receptor heteromers as new targets for drug development.

Prog Mol Biol Transl Sci 2010 ;91:41-52

National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1016/S1877-1173(10)91002-8DOI Listing
September 2010

Gi protein coupling to adenosine A1-A2A receptor heteromers in human brain caudate nucleus.

J Neurochem 2010 Aug 13;114(4):972-80. Epub 2010 May 13.

Biochemistry and Molecular Biology Department, University of Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, CIBERNED, Barcelona, Spain.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06810.xDOI Listing
August 2010

Interactions between intracellular domains as key determinants of the quaternary structure and function of receptor heteromers.

J Biol Chem 2010 Aug 18;285(35):27346-59. Epub 2010 Jun 18.

Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas, 08028 Barcelona, Spain.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.115634
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http://dx.doi.org/10.1074/jbc.M110.115634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930733PMC
August 2010

Platforms for the identification of GPCR targets, and of orthosteric and allosteric modulators.

Expert Opin Drug Discov 2010 Apr;5(4):391-403

Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), Pamplona, Spain +34 94 819 4700 ext. 2033 ; +34 94 819 4715 ;

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http://dx.doi.org/10.1517/17460441003653163DOI Listing
April 2010

A hybrid indoloquinolizidine peptide as allosteric modulator of dopamine D1 receptors.

J Pharmacol Exp Ther 2010 Mar 21;332(3):876-85. Epub 2009 Dec 21.

Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1124/jpet.109.158824DOI Listing
March 2010

Useful pharmacological parameters for G-protein-coupled receptor homodimers obtained from competition experiments. Agonist-antagonist binding modulation.

Biochem Pharmacol 2009 Dec 28;78(12):1456-63. Epub 2009 Jul 28.

Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Avda. Diagonal 465, 08028 Barcelona, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S000629520900642
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http://dx.doi.org/10.1016/j.bcp.2009.07.012DOI Listing
December 2009

GPCR homomers and heteromers: a better choice as targets for drug development than GPCR monomers?

Pharmacol Ther 2009 Nov 5;124(2):248-57. Epub 2009 Aug 5.

Departament de Bioquímica i Biologia Molecular, CIBERNED (Centro de Investigación en Red de Enfermedades Neurodegenerativas) and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1016/j.pharmthera.2009.07.005DOI Listing
November 2009

Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors.

J Biol Chem 2009 Oct 24;284(41):28058-68. Epub 2009 Jul 24.

Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas, and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1074/jbc.M109.034231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788857PMC
October 2009

Indoloquinolizidine-peptide hybrids as multiple agonists for D1 and D2 dopamine receptors.

ChemMedChem 2009 Sep;4(9):1514-22

Combinatorial Chemistry Unit, Barcelona Science Park, University of Barcelona, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1002/cmdc.200900149DOI Listing
September 2009

Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers.

J Med Chem 2009 Sep;52(18):5590-602

Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), and Department of Biochemistry and Molecular Biology, University of Barcelona, Avenida Diagonal 645, E-08028 Barcelona, Spain.

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http://pubs.acs.org/doi/abs/10.1021/jm900298c
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September 2009

Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors.

Br J Pharmacol 2009 May;157(1):64-75

Molecular Neurobiology Unit, IDIBAPS, CIBERNED, Department of Biochemistry and Molecular Biology, School of Biology, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1111/j.1476-5381.2009.00152.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697789PMC
May 2009

Human adenosine deaminase as an allosteric modulator of human A(1) adenosine receptor: abolishment of negative cooperativity for [H](R)-pia binding to the caudate nucleus.

J Neurochem 2008 Oct 2;107(1):161-70. Epub 2008 Aug 2.

Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University of Barcelona, Spain.

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http://doi.wiley.com/10.1111/j.1471-4159.2008.05602.x
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http://dx.doi.org/10.1111/j.1471-4159.2008.05602.xDOI Listing
October 2008

Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer.

ScientificWorldJournal 2008 Oct 11;8:1088-97. Epub 2008 Oct 11.

Institut d'Investigacions Biomèdiques August Pi i Sunyer Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, y Departamento de Bioquímica y Biología Molecular, Facultad de Biología, Universitat de Barcelona, Spain.

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http://www.hindawi.com/journals/tswj/2008/396128/abs/
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http://dx.doi.org/10.1100/tsw.2008.136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848735PMC
October 2008

Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function.

Neuropharmacology 2008 Aug 16;55(2):190-7. Epub 2008 May 16.

Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, University of Barcelona, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.neuropharm.2008.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435196PMC
August 2008

Detection of heteromerization of more than two proteins by sequential BRET-FRET.

Nat Methods 2008 Aug 29;5(8):727-33. Epub 2008 Jun 29.

Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, University of Barcelona, Avda. Diagonal 645, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1038/nmeth.1229DOI Listing
August 2008

Novel pharmacological targets based on receptor heteromers.

Brain Res Rev 2008 Aug 20;58(2):475-82. Epub 2008 Jun 20.

Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S016501730800069
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http://dx.doi.org/10.1016/j.brainresrev.2008.06.002DOI Listing
August 2008

Basic concepts in G-protein-coupled receptor homo- and heterodimerization.

ScientificWorldJournal 2007 Nov 2;7:48-57. Epub 2007 Nov 2.

Institut d'Investigació Biomèdica August Pi i Sunyer, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas and Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1100/tsw.2007.197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901144PMC
November 2007

Novel ergopeptides as dual ligands for adenosine and dopamine receptors.

J Med Chem 2007 Jun 1;50(13):3062-9. Epub 2007 Jun 1.

Combinatorial Chemistry Unit, Barcelona Science Park, Department of Biochemistry and Molecular Biology, Molecular Neurobiology Unit, IDIBAPS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, IRB Barcelona, Barcelona Science Park, Barcelona, Spain.

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http://dx.doi.org/10.1021/jm060947xDOI Listing
June 2007

Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release.

Cardiovasc Res 2006 Nov 29;72(2):292-302. Epub 2006 Jul 29.

Cell Physiology Laboratory, Cardiology Department, Hospital de la Santa Creu i Sant Pau, Institut Catalá de Ciencies Cardiovasculars, Universitat Autònoma de Barcelona, St Antoni M(a) Claret 167, 08025 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.cardiores.2006.07.020DOI Listing
November 2006

The two-state dimer receptor model: a general model for receptor dimers.

Mol Pharmacol 2006 Jun 24;69(6):1905-12. Epub 2006 Feb 24.

Dept. Bioquimica i Biologia Molecular, Universitat de Barcelona, Av. Diagonal 645, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1124/mol.105.020685DOI Listing
June 2006

Partners for adenosine A1 receptors.

J Mol Neurosci 2005 ;26(2-3):221-32

Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1385/JMN:26:2-3:221DOI Listing
October 2005

Dimer-based model for heptaspanning membrane receptors.

Trends Biochem Sci 2005 Jul;30(7):360-6

Department Bioquímica i Biologia Molecular, Universitat de Barcelona, A. Diagonal, 645. 08028 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.tibs.2005.05.010DOI Listing
July 2005

Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease.

J Neurochem 2004 Nov;91(3):547-57

Department of Biochemistry and Molecular Biology, School of Chemistry, Universitat de Barcelona, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02771.xDOI Listing
November 2004

Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation.

J Biol Chem 2004 Aug 7;279(32):33352-8. Epub 2004 Jun 7.

Department of Biochemistry and Molecular Biology, University of Barcelona, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1074/jbc.M401761200DOI Listing
August 2004

Regulation of heptaspanning-membrane-receptor function by dimerization and clustering.

Trends Biochem Sci 2003 May;28(5):238-43

Department of Biochemistry and Molecular Biology of the University of Barcelona, Martí Franquès 1, Spain.

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http://dx.doi.org/10.1016/S0968-0004(03)00065-3DOI Listing
May 2003

Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.

Proc Natl Acad Sci U S A 2002 Sep 20;99(18):11940-5. Epub 2002 Aug 20.

Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Intramural Research Program, Baltimore, MD 21224, U SA.

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http://dx.doi.org/10.1073/pnas.172393799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129373PMC
September 2002

Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction.

Biochem J 2002 Jan;361(Pt 2):203-9

Department of Biochemistry and Molecular Biology, University of Barcelona, Martí i Franquès 1, 08028 Barcelona, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222300PMC
http://dx.doi.org/10.1042/0264-6021:3610203DOI Listing
January 2002