Viacheslav O Nikolaev

Viacheslav O Nikolaev

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Viacheslav O Nikolaev

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Phosphodiesterases As Therapeutic Targets for Respiratory Diseases.

Pharmacol Ther 2019 Feb 10. Epub 2019 Feb 10.

Department of Molecular Pharmacology, University of Groningen, The Netherlands;; Groningen Research Institute for Asthma and COPD, GRIAC, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.pharmthera.2019.02.002DOI Listing
February 2019

Adenine nucleotides as paracrine mediators and intracellular second messengers in immunity and inflammation.

Biochem Soc Trans 2019 Jan 23. Epub 2019 Jan 23.

Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany

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http://dx.doi.org/10.1042/BST20180419DOI Listing
January 2019

Membrane-Permeable Octanoyloxybenzyl-Masked cNMPs As Novel Tools for Non-Invasive Cell Assays.

Molecules 2018 Nov 13;23(11). Epub 2018 Nov 13.

Organic Chemistry, Department of Chemistry, Faculty of Sciences, University of Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany.

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http://dx.doi.org/10.3390/molecules23112960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278358PMC
November 2018

RoMo: An efficient strategy for functional mosaic analysis via stochastic Cre recombination and gene targeting in the ROSA26 locus.

Biotechnol Bioeng 2018 Jul 31;115(7):1778-1792. Epub 2018 Mar 31.

Institute of Experimental Cardiovascular Research, University Medical Hamburg-Eppendorf, DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany.

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http://doi.wiley.com/10.1002/bit.26594
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http://dx.doi.org/10.1002/bit.26594DOI Listing
July 2018

Endothelial C-Type Natriuretic Peptide Acts on Pericytes to Regulate Microcirculatory Flow and Blood Pressure.

Circulation 2018 Jul;138(5):494-508

Institute of Physiology, University of Würzburg and Comprehensive Heart Failure Center, University Hospital Würzburg, Germany (K. Špiranec, W.C., S.C., F.W., T.N., F.K., P.E.-N., K. Schuh, M.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.033383DOI Listing
July 2018

Cigarette smoke up-regulates PDE3 and PDE4 to decrease cAMP in airway cells.

Br J Pharmacol 2018 Jul 3;175(14):2988-3006. Epub 2018 Jun 3.

Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1111/bph.14347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016635PMC
July 2018

Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP.

Nat Commun 2018 06 22;9(1):2446. Epub 2018 Jun 22.

Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Martnistr. 52, D-20246, Hamburg, Germany.

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http://dx.doi.org/10.1038/s41467-018-04891-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014982PMC
June 2018

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System.

J Vis Exp 2018 05 22(135). Epub 2018 May 22.

Department of Cardiology-Electrophysiology, cNEP (cardiac Neuro- and Electrophysiology research group), University Heart Center, University Hospital Hamburg-Eppendorf; DZHK (German Center for Cardiovascular Research);

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http://dx.doi.org/10.3791/57617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101334PMC
May 2018

cGMP Signaling in the Cardiovascular System-The Role of Compartmentation and Its Live Cell Imaging.

Int J Mol Sci 2018 Mar 10;19(3). Epub 2018 Mar 10.

Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg 20246, Germany.

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http://dx.doi.org/10.3390/ijms19030801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877662PMC
March 2018

FRET Microscopy for Real-Time Visualization of Second Messengers in Living Cells.

Methods Mol Biol 2017 ;1563:85-90

Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

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http://link.springer.com/10.1007/978-1-4939-6810-7_6
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http://dx.doi.org/10.1007/978-1-4939-6810-7_6DOI Listing
February 2018

Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes.

J Cardiovasc Dev Dis 2018 Jan 19;5(1). Epub 2018 Jan 19.

Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

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http://dx.doi.org/10.3390/jcdd5010004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872352PMC
January 2018

cGMP-Elevating Compounds and Ischemic Conditioning Provide Cardioprotection Against Ischemia and Reperfusion Injury via Cardiomyocyte-Specific BK Channels.

Circulation 2017 Dec 19;136(24):2337-2355. Epub 2017 Oct 19.

Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tuebingen, Germany (S.F., A.K., J.S., E.M., P.R., R.L.)

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.028723DOI Listing
December 2017

Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells.

PLoS One 2013 27;8(6):e65365. Epub 2013 Jun 27.

Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065365PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694969PMC
October 2017

Interactions of Calcium Fluctuations during Cardiomyocyte Contraction with Real-Time cAMP Dynamics Detected by FRET.

PLoS One 2016 8;11(12):e0167974. Epub 2016 Dec 8.

Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167974PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145230PMC
July 2017

Cyclic nucleotide imaging and cardiovascular disease.

Pharmacol Ther 2017 Jul 16;175:107-115. Epub 2017 Feb 16.

Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2017.02.038DOI Listing
July 2017

Protein kinase A activation by the anti-cancer drugs ABT-737 and thymoquinone is caspase-3-dependent and correlates with platelet inhibition and apoptosis.

Cell Death Dis 2017 06 29;8(6):e2898. Epub 2017 Jun 29.

Institute for Vascular Signalling, Centre for Molecular Medicine, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1038/cddis.2017.290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520940PMC
June 2017

Dysferlin mediates membrane tubulation and links T-tubule biogenesis to muscular dystrophy.

J Cell Sci 2017 03 19;130(5):841-852. Epub 2017 Jan 19.

Department of Child and Adolescent Health, University Medical Centre Göttingen, Göttingen 37075, Germany

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http://dx.doi.org/10.1242/jcs.198861DOI Listing
March 2017

Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure.

Circulation 2017 Feb 7;135(9):881-897. Epub 2016 Dec 7.

From Institute of Experimental and Clinical Pharmacology and Toxicology, Mannheim Medical Faculty (I.H.A.-T., N.M.W., K.S., C.V., S.L., T.W.), and Department of Internal Medicine III (H.-J.H., N.M.W., M.M., B.M., H.-A.K., L.H.L., J.B.), Heidelberg University, Heidelberg-Mannheim, Germany; Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany (I.H.A.-T., J.H., M.S., N.V., D.D.); Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Germany (A.E.-A., C.M.W., S.L.); Department of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Germany (A.E.-A.); Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Germany (V.O.N.); Department of Internal Medicine II, University of Regensburg, Germany (S.N.); Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, Hungary (I.B., A.V.); Division of Nephrology, New York University Langone Medical Center, New York (E.Y.S.); and DZHK (German Center for Cardiovascular Research), Partner Site HD/MA, Heidelberg-Mannheim, Germany (B.M., H.A.K., C.V., J.B., T.W.). The current affiliation for H.-J.H. is the Department of Cardiology and Angiology, University Hospital Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022852DOI Listing
February 2017

Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias.

Nat Commun 2017 01 27;8:14155. Epub 2017 Jan 27.

Department of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1038/ncomms14155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290156PMC
January 2017

Internalized Receptor for Glucose-dependent Insulinotropic Peptide stimulates adenylyl cyclase on early endosomes.

Biochem Pharmacol 2016 Nov 15;120:33-45. Epub 2016 Sep 15.

Laboratoire de Physique et Chimie des Nano-objets (LPCNO), team RTTC, Université de Toulouse, CNRS, INSA, INSERM, Université Paul Sabatier, Toulouse, France. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2016.09.009DOI Listing
November 2016

Redox Imaging Using Cardiac Myocyte-Specific Transgenic Biosensor Mice.

Circ Res 2016 Oct 23;119(9):1004-1016. Epub 2016 Aug 23.

From the Institute of Cardiovascular Physiology, Georg August University Göttingen, Germany (L.S., A.K., A.Z., A.G., A.J., A.B., M.S.N., D.M.K.); Institute of Pharmacology, Technical University Dresden, Germany (S.M.-R., A.E.-A.); Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany (C.V.); Cellular Biochemistry, Department of Biology, University of Kaiserslautern, Germany (B.M.); Department of Cellular Biochemistry, University Medical Center Göttingen, Germany (S.D.); Cardiovascular Division, King's College London, British Heart Foundation Centre, United Kingdom (A.M.S.); and German Center for Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (V.O.N.); and Institute of Experimental Cardiovascular Research, Hamburg, Germany (V.O.N.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.309551DOI Listing
October 2016

Microdomain-Specific Modulation of L-Type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart Failure.

Circ Res 2016 Sep 29;119(8):944-55. Epub 2016 Aug 29.

From the Department of Cardiovascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute (J.L.S.-A., A.B., A.V.G., S.S., N.B., M.B.S., C.M., A.R.L., P.P.P., J.G.), Department of Medicine (Y.E.K.), and Department of Cardiothoracic Surgery, Hammersmith Hospital, National Heart and Lung Institute (P.P.P.), Imperial College London, United Kingdom; Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD (T.O., N.A.T.); NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London, United Kingdom (A.R.L.); Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (S.S., V.O.N.); and Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Telangana, India (A.B.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045818PMC
http://dx.doi.org/10.1161/CIRCRESAHA.116.308698DOI Listing
September 2016

Endothelial Actions of ANP Enhance Myocardial Inflammatory Infiltration in the Early Phase After Acute Infarction.

Circ Res 2016 07 3;119(2):237-48. Epub 2016 May 3.

From the Institute of Physiology (W.C., A.S., F.W., K.Š., M.K.), Comprehensive Heart Failure Center (D.M., J.W., U.H., S.F., M.K.), and Department of Experimental Biomedicine and Rudolf Virchow Center for Experimental Biomedicine (D.S.), University of Würzburg, Würzburg, Germany; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (V.O.N.); Institut für Pharmakologie und Klinische Pharmakologie und CARID, Universitätsklinikum der Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany (K.R., J.W.F.); Department of Obstetrics and Gynecology, University Hospital Würzburg, Würzburg, Germany (U.K.); Institute of Pathology, University Duisburg-Essen, Essen, Germany (H.A.B.); and Universitätsklinik und Poliklinik für Innere Medizin III, Universitätsklinikum Halle (Saale), Halle (Saale), Germany (U.H., S.F.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.307196DOI Listing
July 2016

Structure of smAKAP and its regulation by PKA-mediated phosphorylation.

FEBS J 2016 06 6;283(11):2132-48. Epub 2016 May 6.

Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands.

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http://dx.doi.org/10.1111/febs.13726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980077PMC
June 2016

Cyclic Nucleotide Control of Microtubule Dynamics for Axon Guidance.

J Neurosci 2016 05;36(20):5636-49

Laboratory for Neuronal Growth Mechanisms, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan,

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http://dx.doi.org/10.1523/JNEUROSCI.3596-15.2016DOI Listing
May 2016

Novel receptor-derived cyclopeptides to treat heart failure caused by anti-β1-adrenoceptor antibodies in a human-analogous rat model.

PLoS One 2015 20;10(2):e0117589. Epub 2015 Feb 20.

Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany; Rudolf-Virchow-Center/DFG-Research-Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany; Comprehensive Heart Failure Centre (CHFC), University Hospital of Würzburg, Würzburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117589PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336331PMC
December 2015

Generation of transgenic mice expressing FRET biosensors.

Methods Mol Biol 2015 ;1294:117-29

Heart Research Center Göttingen, University of Göttingen, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1007/978-1-4939-2537-7_9DOI Listing
December 2015

Sildenafil Does Not Prevent Heart Hypertrophy and Fibrosis Induced by Cardiomyocyte Angiotensin II Type 1 Receptor Signaling.

J Pharmacol Exp Ther 2015 Sep 8;354(3):406-16. Epub 2015 Jul 8.

Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen, Germany (J.S., V.S., N.B., R.L.); Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (H.S., V.O.N.); Physiologisches Institut I, Universität Würzburg, Würzburg, Germany (S.D., A.F.); Institut für Pharmakologie und Toxikologie, Ruhr-Universität Bochum, Bochum, Germany (M.R.); Internal Medicine III, Cardiology and Cardiovascular Medicine, University Hospital Tübingen, Tübingen, Germany (M.G.); Laboratory of Cardiac Development and Differentiation, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada (M.N.); and Institut de Recherches Cliniques de Montréal, Montreal, Quebec, Canada (M.N.)

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http://dx.doi.org/10.1124/jpet.115.226092DOI Listing
September 2015

Imaging alterations of cardiomyocyte cAMP microdomains in disease.

Front Pharmacol 2015 25;6:172. Epub 2015 Aug 25.

German Center for Cardiovascular Research, University Medical Center Hamburg-Eppendorf , Hamburg, Germany ; Institute of Experimental Cardiovascular Research , Hamburg, Germany.

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http://dx.doi.org/10.3389/fphar.2015.00172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548481PMC
September 2015

Adenylyl cyclases 5 and 6 underlie PIP3-dependent regulation.

FASEB J 2015 Aug 30;29(8):3458-71. Epub 2015 Apr 30.

*Faculty of Pharmacy, Philipps University, Marburg, Marburg, Germany; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; and Interfakultäres Institut für Biochemie, University of Tübingen, Tübingen, Germany

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http://dx.doi.org/10.1096/fj.14-268466DOI Listing
August 2015

Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII.

Cardiovasc Res 2015 Jul 18;107(1):184-96. Epub 2015 May 18.

Klinik für Kardiologie und Pneumologie/Herzzentrum, Georg-August-Universität Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany DZHK (German Center for Cardiovascular Research), partner site Göttingen, Göttingen, Germany

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http://dx.doi.org/10.1093/cvr/cvv153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476413PMC
July 2015

Role of membrane microdomains in compartmentation of cAMP signaling.

PLoS One 2014 21;9(4):e95835. Epub 2014 Apr 21.

Department of Pharmacology, University of Nevada School of Medicine, Reno, Nevada, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095835PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994114PMC
June 2015

Functional non-nucleoside adenylyl cyclase inhibitors.

Chem Biol Drug Des 2015 May 6;85(5):633-7. Epub 2014 Nov 6.

Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.

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http://dx.doi.org/10.1111/cbdd.12452DOI Listing
May 2015

Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy.

Circ Res 2015 Apr 16;116(8):1304-11. Epub 2015 Feb 16.

From the Emmy Noether Group of the DFG, European Heart Research Institute Göttingen, Göttingen, Germany (R.K.P., J.U.S., D.H., V.O.N.); Heart Research Center Göttingen, Georg August University Medical Center, Göttingen, Germany (R.K.P., J.U.S., J.H.S., D.H., S.E.L., A.E.-A., V.O.N.); Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (R.K.P, J.U.S., V.O.N.); German Center for Cardiovascular Research (DZHK; S.E.L., V.O.N.) and Instutite of Physiology (M.A., K.S.), University of Würzburg, Würzburg, Germany; and Institute of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany (A.E.-A).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.306082DOI Listing
April 2015

Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles.

Proc Natl Acad Sci U S A 2015 Apr 16;112(17):5527-32. Epub 2015 Mar 16.

Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030;

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http://dx.doi.org/10.1073/pnas.1423598112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418852PMC
April 2015

In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease.

Nat Commun 2015 Apr 28;6:6965. Epub 2015 Apr 28.

1] Emmy Noether Group of the DFG, European Heart Research Institute Göttingen, University Medical Center Göttingen, D-37075 Göttingen, Germany [2] Department of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center Göttingen, Georg August University, D-37075 Göttingen, Germany [3] Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany [4] German Center for Cardiovascular Research (DZHK), D-93053 Regensburg, Germany.

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http://dx.doi.org/10.1038/ncomms7965DOI Listing
April 2015

Atrial natriuretic peptide locally counteracts the deleterious effects of cardiomyocyte mineralocorticoid receptor activation.

Circ Heart Fail 2014 Sep 15;7(5):814-21. Epub 2014 Jul 15.

From the Institute of Physiology (H.N., H.O., B.G., M.K.) and Comprehensive Heart Failure Center (H.N., S.F., M.K.), University Würzburg, Würzburg, Germany; Emmy Noether Group of the Deutsche Forschungsgemeinschaft, Department of Cardiology and Pneumology, University Göttingen, Göttingen, Germany (V.O.N.); Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany (S.U., H.W, S.F.); First Department of Internal Medicine, Nara Medical University, Kashihara, Japan (Y.S.); and Institute of Pathology, University Duisburg-Essen, Essen, Germany (H.A.B.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.113.000885DOI Listing
September 2014

Tubulin polymerization disrupts cardiac β-adrenergic regulation of late INa.

Cardiovasc Res 2014 Jul 8;103(1):168-77. Epub 2014 May 8.

Department of Internal Medicine II, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, Regensburg 93053, Germany

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
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http://dx.doi.org/10.1093/cvr/cvu120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133594PMC
July 2014

Transgenic mice for real-time visualization of cGMP in intact adult cardiomyocytes.

Circ Res 2014 Apr 5;114(8):1235-45. Epub 2014 Mar 5.

From Emmy Noether Group of the DFG, Department of Cardiology and Pneumology, European Heart Research Institute Göttingen, Georg August University Medical Center, University of Göttingen, Göttingen, Germany (K.R.G., J.U.S., R.K.P., J.H.S., S.E.L., V.O.N.); Institute of Physiology, University of Würzburg, Würzburg, Germany (M.K.); Department of Cardiovascular Sciences, National Heart and Lung Institute, Imperial College, London, United Kingdom (J.G.); and Institut de Recherche Experimentale et Clinique (IREC), Pole of Pharmacology and Therapeutics (FATH), University Catholique de Louvain, and Department of Medicine, Cliniques Universitaires Saint-Luc, Brussels, Belgium (J.-L.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.114.302437DOI Listing
April 2014

Enhanced expression of β3-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase.

Circulation 2014 Jan 4;129(4):451-62. Epub 2013 Nov 4.

Institut de Recherche Expérimentale et Clinique (IREC), Pole of Pharmacology and Therapeutics (FATH), Université Catholique de Louvain, Brussels, Belgium (C.B., J. Hammond, E.D.-D., B.M., J. Hamelet, A.M., H.E., K.J., I.L., C.D., J.-L.B.); Pole of Cardiovascular Pathology and Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium (C.B., A.-C.P., L.B.); the Division of Cardiology and Pneumology, University of Goettingen, Goettingen, Germany (K.R.G., V.O.N.); the Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Belgium (A.V., P.H.); the Department of Medicine and Surgery, University of Salerno and RCCS "Multimedica," Milano, Italy (G.I.); Molecular Cardiology, Medizinische Hochschule Hannover, Germany (D.H.-K.); and Université Paul Sabatier, Inserm UMR 1048 - I2MC, Hôpitaux de Toulouse, France (G.T., D.L.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.004940DOI Listing
January 2014

Advances and techniques to measure cGMP in intact cardiomyocytes.

Methods Mol Biol 2013 ;1020:121-9

Emmy Noether Group of the DFG, Department of Cardiology and Pneumology, European Heart Research Institute Göttingen, Universität Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1007/978-1-62703-459-3_7DOI Listing
December 2013

Assessing FRET using spectral techniques.

Cytometry A 2013 Oct 8;83(10):898-912. Epub 2013 Aug 8.

Department of Chemical and Biomolecular Engineering, University of South Alabama, Mobile, Alabama, 36688; Department of Pharmacology, University of South Alabama, Mobile, Alabama, 36688.

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http://dx.doi.org/10.1002/cyto.a.22340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374658PMC
October 2013

In vivo genetic dissection of O2-evoked cGMP dynamics in a Caenorhabditis elegans gas sensor.

Proc Natl Acad Sci U S A 2013 Aug 12;110(35):E3301-10. Epub 2013 Aug 12.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1217428110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761592PMC
August 2013

Biophysical techniques for detection of cAMP and cGMP in living cells.

Int J Mol Sci 2013 Apr 12;14(4):8025-46. Epub 2013 Apr 12.

Emmy Noether Group of the DFG, Department of Cardiology and Pneumology, European Heart Research Insitute Göttingen, Georg August University Medical Center, University of Göttingen, Göttingen 37075, Germany.

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http://dx.doi.org/10.3390/ijms14048025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645729PMC
April 2013

The oligopeptide DT-2 is a specific PKG I inhibitor only in vitro, not in living cells.

Br J Pharmacol 2012 Oct;167(4):826-38

Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1111/j.1476-5381.2012.02044.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575782PMC
October 2012

FRET microscopy for real-time monitoring of signaling events in live cells using unimolecular biosensors.

J Vis Exp 2012 Aug 20(66):e4081. Epub 2012 Aug 20.

Emmy Noether Group of the DFG, Department of Cardiology and Pneumology, European Heart Research Insitute Göttingen, Georg August University Medical Center, Göttingen, Germany.

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http://dx.doi.org/10.3791/4081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486761PMC
August 2012

Endocytosis in the mouse oocyte and its contribution to cAMP signaling during meiotic arrest.

Reproduction 2011 Jun 16;141(6):737-47. Epub 2011 Mar 16.

Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.

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http://dx.doi.org/10.1530/REP-10-0461DOI Listing
June 2011

Distinct pharmacological properties of morphine metabolites at G(i)-protein and β-arrestin signaling pathways activated by the human μ-opioid receptor.

Biochem Pharmacol 2011 May 17;81(10):1248-54. Epub 2011 Mar 17.

Institute of Pharmacology, University of Würzburg, Versbacher Strasse 9, Germany.

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http://dx.doi.org/10.1016/j.bcp.2011.03.001DOI Listing
May 2011

FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells.

Nat Protoc 2011 Apr 10;6(4):427-38. Epub 2011 Mar 10.

Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1038/nprot.2010.198DOI Listing
April 2011

Epidermal growth factor receptor kinase activity is required for gap junction closure and for part of the decrease in ovarian follicle cGMP in response to LH.

Reproduction 2010 Nov 8;140(5):655-62. Epub 2010 Sep 8.

Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06032, USA.

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http://dx.doi.org/10.1530/REP-10-0288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119707PMC
November 2010

Real-time monitoring of somatostatin receptor-cAMP signaling in live pituitary.

Endocrinology 2010 Sep 7;151(9):4560-5. Epub 2010 Jul 7.

Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.

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http://dx.doi.org/10.1210/en.2010-0341DOI Listing
September 2010

Imaging of persistent cAMP signaling by internalized G protein-coupled receptors.

J Mol Endocrinol 2010 Jul 8;45(1):1-8. Epub 2010 Apr 8.

Rudolf Virchow Center, DFG-Research Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1677/JME-10-0014DOI Listing
July 2010

Signaling by internalized G-protein-coupled receptors.

Trends Pharmacol Sci 2010 May 18;31(5):221-8. Epub 2010 Mar 18.

Rudolf Virchow Center, DFG-Research Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1016/j.tips.2010.02.002DOI Listing
May 2010

A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation.

J Biol Chem 2010 Mar 18;285(12):8793-800. Epub 2010 Jan 18.

Institute of Pharmacology and Toxicology and the Rudolf Virchow Center, University of Würzburg, 97078 Würzburg, Germany.

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http://dx.doi.org/10.1074/jbc.M109.098517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838301PMC
March 2010

Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation.

Science 2010 Mar 25;327(5973):1653-7. Epub 2010 Feb 25.

Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK.

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http://dx.doi.org/10.1126/science.1185988DOI Listing
March 2010

Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells.

Am J Physiol Cell Physiol 2010 Feb 4;298(2):C324-32. Epub 2009 Nov 4.

University of Marburg, Institute of Pharmacology and Toxicology, Karl-von-Frisch-Strasse 1, 35033 Marburg, Germany.

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http://dx.doi.org/10.1152/ajpcell.00197.2009DOI Listing
February 2010

Distinct pools of cAMP centre on different isoforms of adenylyl cyclase in pituitary-derived GH3B6 cells.

J Cell Sci 2010 Jan;123(Pt 1):95-106

Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, England, UK.

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http://dx.doi.org/10.1242/jcs.058594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794711PMC
January 2010

A technique for monitoring multiple signals with a combination of prism-based total internal reflection fluorescence microscopy and epifluorescence microscopy.

Pflugers Arch 2009 Nov 13;459(1):227-34. Epub 2009 Aug 13.

Department of Physiology, Hamamatsu University School of Medicine, Handa-yama 1-20-1, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan.

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http://dx.doi.org/10.1007/s00424-009-0705-8DOI Listing
November 2009

Persistent cAMP-signals triggered by internalized G-protein-coupled receptors.

PLoS Biol 2009 Aug 18;7(8):e1000172. Epub 2009 Aug 18.

Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1371/journal.pbio.1000172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718703PMC
August 2009

GPCR and G proteins: drug efficacy and activation in live cells.

Mol Endocrinol 2009 May 5;23(5):590-9. Epub 2009 Feb 5.

Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1210/me.2008-0204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419261PMC
May 2009

Novel techniques for real-time monitoring of cGMP in living cells.

Handb Exp Pharmacol 2009 (191):229-43

Rudolf Virchow Center, University of Würzburg, Germany.

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http://dx.doi.org/10.1007/978-3-540-68964-5_11DOI Listing
March 2009

Real-time monitoring of phosphodiesterase inhibition in intact cells.

Cell Signal 2008 Aug 26;20(8):1423-31. Epub 2008 Mar 26.

Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.cellsig.2008.03.011DOI Listing
August 2008

Cytoplasmic cAMP concentrations in intact cardiac myocytes.

Am J Physiol Cell Physiol 2008 Aug 11;295(2):C414-22. Epub 2008 Jun 11.

Dept. of Physiology and Biophysics, Case Western Reserve Univ., 10900 Euclid Ave., Cleveland, OH 44106-4970, USA.

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http://dx.doi.org/10.1152/ajpcell.00038.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518413PMC
August 2008

Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation.

J Clin Invest 2008 Aug;118(8):2747-57

Université Pierre et Marie Curie-Paris 6, INSERM UMR S 621, Pharmacology Department, Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

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http://dx.doi.org/10.1172/JCI35067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2467383PMC
August 2008

Kinetic analysis of G protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells.

Adv Protein Chem 2007 ;74:167-88

Institute of Pharmacology and Toxicology, University of Würzburg, D-97078 Würzburg, Germany.

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http://dx.doi.org/10.1016/S0065-3233(07)74005-6DOI Listing
June 2008

Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases.

Circ Res 2008 May 27;102(9):1091-100. Epub 2008 Mar 27.

INSERM U-769, Université Paris-Sud 11, Faculté de Pharmacie, 5, Rue J.-B. Clément, F-92296 Châtenay-Malabry Cedex, France.

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http://dx.doi.org/10.1161/CIRCRESAHA.107.167817DOI Listing
May 2008

Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors.

Trends Pharmacol Sci 2008 Mar 11;29(3):159-65. Epub 2008 Feb 11.

Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1016/j.tips.2007.12.002DOI Listing
March 2008

Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling.

Nat Chem Biol 2008 Feb 13;4(2):126-31. Epub 2008 Jan 13.

Center of Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, CPZN 8-218, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nchembio.64DOI Listing
February 2008

Monitoring receptor signaling by intramolecular FRET.

Curr Opin Pharmacol 2007 Oct 4;7(5):547-53. Epub 2007 Oct 4.

Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, 97078 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.coph.2007.08.007DOI Listing
October 2007

Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors.

J Biol Chem 2007 Sep 6;282(37):27126-32. Epub 2007 Jul 6.

Institute of Pharmacology and Toxicology and Bio-Imaging Center, University of Würzburg, Versbacherstrasse 9, D-97078 Würzburg, Germany.

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http://dx.doi.org/10.1074/jbc.M703272200DOI Listing
September 2007

A novel fluorescence method for the rapid detection of functional beta1-adrenergic receptor autoantibodies in heart failure.

J Am Coll Cardiol 2007 Jul 13;50(5):423-31. Epub 2007 Jul 13.

Institut für Pharmakologie und Toxikologie, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1016/j.jacc.2007.03.051DOI Listing
July 2007

cAMP microdomains and L-type Ca2+ channel regulation in guinea-pig ventricular myocytes.

J Physiol 2007 May 8;580(Pt.3):765-76. Epub 2007 Feb 8.

Department of Physiology and Biophysics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4970, USA.

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http://dx.doi.org/10.1113/jphysiol.2006.124891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075464PMC
May 2007