Verena Keitel

Verena Keitel

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Verena Keitel

Verena Keitel

Publications by authors named "Verena Keitel"

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70Publications

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Allogeneic haematopoietic stem cell transplantation eliminates alloreactive inhibitory antibodies after liver transplantation for bile salt export pump deficiency.

J Hepatol 2018 Oct 21;69(4):961-965. Epub 2018 Jun 21.

University Children's Hospital, Pediatric Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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October 2018

Cholestasis induced liver pathology results in dysfunctional immune responses after arenavirus infection.

Sci Rep 2018 Aug 15;8(1):12179. Epub 2018 Aug 15.

Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University, Universitätsstrasse. 1, 40225, Düsseldorf, Germany.

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August 2018

Bile acid receptors in the biliary tree: TGR5 in physiology and disease.

Biochim Biophys Acta 2018 Apr 25;1864(4 Pt B):1319-1325. Epub 2017 Aug 25.

Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty at Heinrich-Heine-University, Moorenstrasse 5, 40225 Düsseldorf, Germany. Electronic address:

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April 2018

Post-transplant Recurrent Bile Salt Export Pump Disease: A Form of Antibody-mediated Graft Dysfunction and Utilization of C4d.

J Pediatr Gastroenterol Nutr 2017 Oct;65(4):364-369

*Department of Pathology and Immunology†Department of Pediatrics (Section of Hepatology), Baylor College of Medicine and Texas Children's Hospital, TX‡Department of Gastroenterology, Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany.

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October 2017

Analysis of the Bile Salt Export Pump (ABCB11) Interactome Employing Complementary Approaches.

PLoS One 2016 29;11(7):e0159778. Epub 2016 Jul 29.

Institute of Biochemistry, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

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August 2017

Defective Platelet Activation and Bleeding Complications upon Cholestasis in Mice.

Cell Physiol Biochem 2017 20;41(6):2133-2149. Epub 2017 Apr 20.

Department of Clinical and Experimental Hemostasis, Hemotherapy and Transfusion Medicine, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

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July 2017

Role of the G Protein-Coupled Bile Acid Receptor TGR5 in Liver Damage.

Dig Dis 2017 1;35(3):235-240. Epub 2017 Mar 1.

Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

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May 2017

Ammonia Attenuates LPS-Induced Upregulation of Pro-Inflammatory Cytokine mRNA in Co-Cultured Astrocytes and Microglia.

Neurochem Res 2017 Mar 21;42(3):737-749. Epub 2016 Sep 21.

Clinic for Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, D-40225, Düsseldorf, Germany.

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March 2017

Dual role of the bile acid receptor Takeda G-protein-coupled receptor 5 for hepatic lipid metabolism in feast and famine.

Hepatology 2017 03 6;65(3):767-770. Epub 2017 Feb 6.

Clinic for Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Düsseldorf, Germany.

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March 2017

Hepatitis C Virus Activates a Neuregulin-Driven Circuit to Modify Surface Expression of Growth Factor Receptors of the ErbB Family.

PLoS One 2016 17;11(2):e0148711. Epub 2016 Feb 17.

Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital, Heinrich Heine University of Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany.

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July 2016

Cooperative role of lymphotoxin β receptor and tumor necrosis factor receptor p55 in murine liver regeneration.

J Hepatol 2016 May 19;64(5):1108-1117. Epub 2015 Dec 19.

Institute of Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany. Electronic address:

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May 2016

TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro.

Gut 2016 Mar 29;65(3):487-501. Epub 2015 Sep 29.

Clinic for Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Düsseldorf, Germany.

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March 2016

Molecular Mechanisms of Glutamine Synthetase Mutations that Lead to Clinically Relevant Pathologies.

PLoS Comput Biol 2016 Feb 2;12(2):e1004693. Epub 2016 Feb 2.

Institute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University, Düsseldorf, Germany.

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February 2016

Multidrug resistance-associated protein 4 expression in ammonia-treated cultured rat astrocytes and cerebral cortex of cirrhotic patients with hepatic encephalopathy.

Glia 2015 Nov 23;63(11):2092-2105. Epub 2015 Jun 23.

Clinic for Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine University, Düsseldorf, Germany.

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November 2015

Mutational mapping of the transmembrane binding site of the G-protein coupled receptor TGR5 and binding mode prediction of TGR5 agonists.

Eur J Med Chem 2015 Nov 24;104:57-72. Epub 2015 Sep 24.

Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University, Universitätsstr. 1, 40225 Düsseldorf, Germany. Electronic address:

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November 2015

TGR5: pathogenetic role and/or therapeutic target in fibrosing cholangitis?

Clin Rev Allergy Immunol 2015 Jun;48(2-3):218-25

Clinic for Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, 40225, Düsseldorf, Germany,

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June 2015

Autoimmune BSEP disease: disease recurrence after liver transplantation for progressive familial intrahepatic cholestasis.

Clin Rev Allergy Immunol 2015 Jun;48(2-3):273-84

Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany,

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June 2015

Conjugated bilirubin triggers anemia by inducing erythrocyte death.

Hepatology 2015 Jan 24;61(1):275-84. Epub 2014 Nov 24.

Department of Gastroenterology, Hepatology and Infectious Diseases, University of Düsseldorf, Düsseldorf, Germany; Department of Physiology, University of Tübingen, Tübingen, Germany.

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January 2015

Monoterpene (-)-citronellal affects hepatocarcinoma cell signaling via an olfactory receptor.

Arch Biochem Biophys 2015 Jan 13;566:100-9. Epub 2014 Dec 13.

Department of Cell Physiology, Ruhr-University Bochum, 44801 Bochum, Germany. Electronic address:

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January 2015

Characterization of animal models for primary sclerosing cholangitis (PSC).

J Hepatol 2014 Jun 19;60(6):1290-303. Epub 2014 Feb 19.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Austria. Electronic address:

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June 2014

Role of macrophages in bile acid-induced inflammatory response of fetal lung during maternal cholestasis.

J Mol Med (Berl) 2014 Apr 7;92(4):359-72. Epub 2013 Dec 7.

Laboratory of Experimental Hepatology and Drug Targeting (HEVEFARM), IBSAL, University of Salamanca, Salamanca, Spain.

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April 2014

A membrane-proximal, C-terminal α-helix is required for plasma membrane localization and function of the G Protein-coupled receptor (GPCR) TGR5.

J Biol Chem 2014 Feb 13;289(6):3689-702. Epub 2013 Dec 13.

From the Clinic for Gastroenterology, Hepatology, and Infectious Diseases and.

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February 2014

Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages.

J Leukoc Biol 2013 Dec 29;94(6):1253-64. Epub 2013 Aug 29.

1.Hepatology und Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, D-40225 Düsseldorf, Germany.

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December 2013

Precipitants of hepatic encephalopathy induce rapid astrocyte swelling in an oxidative stress dependent manner.

Arch Biochem Biophys 2013 Aug 24;536(2):143-51. Epub 2013 May 24.

Clinic for Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University, Düsseldorf, Germany.

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August 2013

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Arch Toxicol 2013 Aug 23;87(8):1315-530. Epub 2013 Aug 23.

Leibniz Research Centre for Working Environment and Human Factors (IFADO), 44139, Dortmund, Germany.

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August 2013

TGR5 in cholangiocytes.

Curr Opin Gastroenterol 2013 May;29(3):299-304

Clinic for Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Düsseldorf, Germany.

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May 2013

Short-term feedback regulation of bile salt uptake by bile salts in rodent liver.

Hepatology 2012 Dec;56(6):2387-97

Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.

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December 2012

Perspective: TGR5 (Gpbar-1) in liver physiology and disease.

Clin Res Hepatol Gastroenterol 2012 Oct 18;36(5):412-9. Epub 2012 Apr 18.

Clinic for Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, 40225 Düsseldorf, Germany.

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October 2012

Ammonia increases nitric oxide, free Zn(2+), and metallothionein mRNA expression in cultured rat astrocytes.

Biol Chem 2011 Dec;392(12):1155-65

University Clinic of Düsseldorf, Clinic for Gastroenterology, Hepatology and Infectiology, Moorenstrasse 5, 40225 Düsseldorf, Germany.

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December 2011

TGR5 in the biliary tree.

Dig Dis 2011 17;29(1):45-7. Epub 2011 Jun 17.

Clinic of Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Düsseldorf, Germany.

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October 2011

TGR5 sequence variation in primary sclerosing cholangitis.

Dig Dis 2011 17;29(1):78-84. Epub 2011 Jun 17.

Norwegian PSC Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital Rikshospitalet, Oslo, Norway.

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October 2011

Microglia activation in hepatic encephalopathy in rats and humans.

Hepatology 2011 Jul;54(1):204-15

Clinic for Gastroenterology, Hepatology, and Infectiology, Heinrich-Heine University, Düsseldorf, Germany.

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July 2011

Locomotor impairment and cerebrocortical oxidative stress in portal vein ligated rats in vivo.

J Hepatol 2011 Feb 15;54(2):251-7. Epub 2010 Sep 15.

Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich-Heine-University, Düsseldorf, Germany.

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February 2011

The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain.

Glia 2010 Nov;58(15):1794-805

Clinic for Gastroenterology, Hepatology, and Infectiology, Heinrich-Heine-University, Moorenstrasse 5, 40225 Düsseldorf, Germany.

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November 2010

Protein kinase C induces endocytosis of the sodium taurocholate cotransporting polypeptide.

Am J Physiol Gastrointest Liver Physiol 2010 Aug 10;299(2):G320-8. Epub 2010 Jun 10.

Dept. of Gastroenterology, Hepatology and Infectiology, Heinrich-Heine Univ. of Düsseldorf, Germany.

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August 2010

The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes.

Biol Chem 2010 Jul;391(7):785-9

Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Moorenstrasse 5, D-40225 Düsseldorf, Germany.

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July 2010

Ammonia triggers exocytotic release of L-glutamate from cultured rat astrocytes.

Glia 2010 Apr;58(6):691-705

Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Düsseldorf, Germany.

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April 2010

The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders.

Hepatology 2009 Sep;50(3):861-70

Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich-Heine-University, Düsseldorf, Germany.

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September 2009

De novo bile salt transporter antibodies as a possible cause of recurrent graft failure after liver transplantation: a novel mechanism of cholestasis.

Hepatology 2009 Aug;50(2):510-7

Department of Gastroenterology, Heinrich-Heine-University of Düsseldorf, Moorenstrasse 5, D-40225 Düsseldorf, Germany.

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August 2009

Expression and localization of atypical PKC isoforms in liver parenchymal cells.

Biol Chem 2009 Mar;390(3):235-44

Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.

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March 2009

Hypoosmotic swelling affects zinc homeostasis in cultured rat astrocytes.

Glia 2009 Jan;57(1):79-92

Clinic for Gastroenterology, Hepatology and Infectiology, Düsseldorf Heinrich-Heine University, Düsseldorf, Germany.

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January 2009

Endocrine and paracrine role of bile acids.

World J Gastroenterol 2008 Oct;14(37):5620-9

Clinic of Gastroenterology, Hepatology and Infectiology, Heinrich-Heine-University, Moorenstrasse 5, Dusseldorf D-40225, Germany.

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October 2008

Ammonia induces RNA oxidation in cultured astrocytes and brain in vivo.

Hepatology 2008 Aug;48(2):567-79

Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich-Heine University, Düsseldorf, Germany.

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August 2008

Expression and function of the bile acid receptor TGR5 in Kupffer cells.

Biochem Biophys Res Commun 2008 Jul 9;372(1):78-84. Epub 2008 May 9.

Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich-Heine-University, Moorenstrasse 5, D-40225 Düsseldorf, Germany.

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July 2008

Amplification of CD95 activation by caspase 8-induced endosomal acidification in rat hepatocytes.

J Biol Chem 2008 Jan 28;283(4):2211-22. Epub 2007 Nov 28.

Clinic for Gastroenterology, Hepatology, and Infectiology, Heinrich-Heine-University Düsseldorf, D-40225 Düsseldorf, Germany.

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January 2008

Modulation of gene expression profiles by hyperosmolarity and insulin.

Cell Physiol Biochem 2007 ;20(5):369-86

Heinrich-Heine-University, Clinic for Gastroenterology, Hepatology, and Infectiology, Düsseldorf, Germany.

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September 2007

CD95 tyrosine phosphorylation is required for CD95 oligomerization.

Apoptosis 2007 Apr 29;12(4):719-29. Epub 2006 Dec 29.

Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich-Heine-University Düsseldorf, D-40225 Düsseldorf, Germany.

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April 2007

The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells.

Hepatology 2007 Mar;45(3):695-704

Department of Gastroenterology, Hepatology and Infectiology, Heinrich-Heine University, Düsseldorf, Germany.

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March 2007

CD133+ hepatic stellate cells are progenitor cells.

Biochem Biophys Res Commun 2007 Jan 15;352(2):410-7. Epub 2006 Nov 15.

Clinic of Gastroenterology, Hepatology and Infectiology, Heinrich-Heine-University, Moorenstrasse 5, 40225 Düsseldorf, Germany.

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January 2007

Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis of pregnancy.

Gastroenterology 2006 Aug;131(2):624-9

Department of Gastroenterology, Hepatology and Infectiology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

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August 2006

Inflammatory cytokines induce protein tyrosine nitration in rat astrocytes.

Arch Biochem Biophys 2006 May 9;449(1-2):104-14. Epub 2006 Mar 9.

Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich-Heine-University, Düsseldorf, Germany.

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May 2006

Benign recurrent intrahepatic cholestasis associated with mutations of the bile salt export pump.

J Clin Gastroenterol 2006 Feb;40(2):171-5

Department of Gastroenterology, Hepatology and Infectiology, Heinrich-Heine University, Düsseldorf, Germany.

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February 2006

Inborn errors of biliary canalicular transport systems.

Methods Enzymol 2005 ;400:558-69

Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich-Heine University Düsseldorf, Germany.

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February 2006

Bile salt-induced apoptosis involves NADPH oxidase isoform activation.

Gastroenterology 2005 Dec;129(6):2009-31

Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

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December 2005

Degradation of the sodium taurocholate cotransporting polypeptide (NTCP) by the ubiquitin-proteasome system.

Biol Chem 2005 Oct;386(10):1065-74

Department of Gastroenterology, Hepatology and Infectiology, Heinrich-Heine University, D-40225 Düsseldorf, Germany.

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October 2005

Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis.

Hepatology 2005 May;41(5):1160-72

Klinik für Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universität, Düsseldorf, Germany.

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May 2005

A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2).

Am J Physiol Gastrointest Liver Physiol 2003 Jan 2;284(1):G165-74. Epub 2002 Oct 2.

Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, D-69120 Heidelberg, Germany.

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January 2003