Vera Grossmann

Vera Grossmann

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Vera Grossmann

Vera Grossmann

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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.

Authors:
Symen Ligthart Ahmad Vaez Urmo Võsa Maria G Stathopoulou Paul S de Vries Bram P Prins Peter J Van der Most Toshiko Tanaka Elnaz Naderi Lynda M Rose Ying Wu Robert Karlsson Maja Barbalic Honghuang Lin René Pool Gu Zhu Aurélien Macé Carlo Sidore Stella Trompet Massimo Mangino Maria Sabater-Lleal John P Kemp Ali Abbasi Tim Kacprowski Niek Verweij Albert V Smith Tao Huang Carola Marzi Mary F Feitosa Kurt K Lohman Marcus E Kleber Yuri Milaneschi Christian Mueller Mahmudul Huq Efthymia Vlachopoulou Leo-Pekka Lyytikäinen Christopher Oldmeadow Joris Deelen Markus Perola Jing Hua Zhao Bjarke Feenstra Marzyeh Amini Jari Lahti Katharina E Schraut Myriam Fornage Bhoom Suktitipat Wei-Min Chen Xiaohui Li Teresa Nutile Giovanni Malerba Jian'an Luan Tom Bak Nicholas Schork Fabiola Del Greco M Elisabeth Thiering Anubha Mahajan Riccardo E Marioni Evelin Mihailov Joel Eriksson Ayse Bilge Ozel Weihua Zhang Maria Nethander Yu-Ching Cheng Stella Aslibekyan Wei Ang Ilaria Gandin Loïc Yengo Laura Portas Charles Kooperberg Edith Hofer Kumar B Rajan Claudia Schurmann Wouter den Hollander Tarunveer S Ahluwalia Jing Zhao Harmen H M Draisma Ian Ford Nicholas Timpson Alexander Teumer Hongyan Huang Simone Wahl YongMei Liu Jie Huang Hae-Won Uh Frank Geller Peter K Joshi Lisa R Yanek Elisabetta Trabetti Benjamin Lehne Diego Vozzi Marie Verbanck Ginevra Biino Yasaman Saba Ingrid Meulenbelt Jeff R O'Connell Markku Laakso Franco Giulianini Patrik K E Magnusson Christie M Ballantyne Jouke Jan Hottenga Grant W Montgomery Fernando Rivadineira Rico Rueedi Maristella Steri Karl-Heinz Herzig David J Stott Cristina Menni Mattias Frånberg Beate St Pourcain Stephan B Felix Tune H Pers Stephan J L Bakker Peter Kraft Annette Peters Dhananjay Vaidya Graciela Delgado Johannes H Smit Vera Großmann Juha Sinisalo Ilkka Seppälä Stephen R Williams Elizabeth G Holliday Matthijs Moed Claudia Langenberg Katri Räikkönen Jingzhong Ding Harry Campbell Michele M Sale Yii-Der I Chen Alan L James Daniela Ruggiero Nicole Soranzo Catharina A Hartman Erin N Smith Gerald S Berenson Christian Fuchsberger Dena Hernandez Carla M T Tiesler Vilmantas Giedraitis David Liewald Krista Fischer Dan Mellström Anders Larsson Yunmei Wang William R Scott Matthias Lorentzon John Beilby Kathleen A Ryan Craig E Pennell Dragana Vuckovic Beverly Balkau Maria Pina Concas Reinhold Schmidt Carlos F Mendes de Leon Erwin P Bottinger Margreet Kloppenburg Lavinia Paternoster Michael Boehnke A W Musk Gonneke Willemsen David M Evans Pamela A F Madden Mika Kähönen Zoltán Kutalik Magdalena Zoledziewska Ville Karhunen Stephen B Kritchevsky Naveed Sattar Genevieve Lachance Robert Clarke Tamara B Harris Olli T Raitakari John R Attia Diana van Heemst Eero Kajantie Rossella Sorice Giovanni Gambaro Robert A Scott Andrew A Hicks Luigi Ferrucci Marie Standl Cecilia M Lindgren John M Starr Magnus Karlsson Lars Lind Jun Z Li John C Chambers Trevor A Mori Eco J C N de Geus Andrew C Heath Nicholas G Martin Juha Auvinen Brendan M Buckley Anton J M de Craen Melanie Waldenberger Konstantin Strauch Thomas Meitinger Rodney J Scott Mark McEvoy Marian Beekman Cristina Bombieri Paul M Ridker Karen L Mohlke Nancy L Pedersen Alanna C Morrison Dorret I Boomsma John B Whitfield David P Strachan Albert Hofman Peter Vollenweider Francesco Cucca Marjo-Riitta Jarvelin J Wouter Jukema Tim D Spector Anders Hamsten Tanja Zeller André G Uitterlinden Matthias Nauck Vilmundur Gudnason Lu Qi Harald Grallert Ingrid B Borecki Jerome I Rotter Winfried März Philipp S Wild Marja-Liisa Lokki Michael Boyle Veikko Salomaa Mads Melbye Johan G Eriksson James F Wilson Brenda W J H Penninx Diane M Becker Bradford B Worrall Greg Gibson Ronald M Krauss Marina Ciullo Gianluigi Zaza Nicholas J Wareham Albertine J Oldehinkel Lyle J Palmer Sarah S Murray Peter P Pramstaller Stefania Bandinelli Joachim Heinrich Erik Ingelsson Ian J Deary Reedik Mägi Liesbeth Vandenput Pim van der Harst Karl C Desch Jaspal S Kooner Claes Ohlsson Caroline Hayward Terho Lehtimäki Alan R Shuldiner Donna K Arnett Lawrence J Beilin Antonietta Robino Philippe Froguel Mario Pirastu Tine Jess Wolfgang Koenig Ruth J F Loos Denis A Evans Helena Schmidt George Davey Smith P Eline Slagboom Gudny Eiriksdottir Andrew P Morris Bruce M Psaty Russell P Tracy Ilja M Nolte Eric Boerwinkle Sophie Visvikis-Siest Alex P Reiner Myron Gross Joshua C Bis Lude Franke Oscar H Franco Emelia J Benjamin Daniel I Chasman Josée Dupuis Harold Snieder Abbas Dehghan Behrooz Z Alizadeh

Am J Hum Genet 2018 11;103(5):691-706

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183032
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http://dx.doi.org/10.1016/j.ajhg.2018.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218410PMC
November 2018

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study.

PLoS One 2017 20;12(1):e0167742. Epub 2017 Jan 20.

Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167742PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249120PMC
August 2017

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function.

Authors:
Philipp S Wild Janine F Felix Arne Schillert Alexander Teumer Ming-Huei Chen Maarten J G Leening Uwe Völker Vera Großmann Jennifer A Brody Marguerite R Irvin Sanjiv J Shah Setia Pramana Wolfgang Lieb Reinhold Schmidt Alice V Stanton Dörthe Malzahn Albert Vernon Smith Johan Sundström Cosetta Minelli Daniela Ruggiero Leo-Pekka Lyytikäinen Daniel Tiller J Gustav Smith Claire Monnereau Marco R Di Tullio Solomon K Musani Alanna C Morrison Tune H Pers Michael Morley Marcus E Kleber Jayashri Aragam Emelia J Benjamin Joshua C Bis Egbert Bisping Ulrich Broeckel Susan Cheng Jaap W Deckers Fabiola Del Greco M Frank Edelmann Myriam Fornage Lude Franke Nele Friedrich Tamara B Harris Edith Hofer Albert Hofman Jie Huang Alun D Hughes Mika Kähönen Knhi Investigators Jochen Kruppa Karl J Lackner Lars Lannfelt Rafael Laskowski Lenore J Launer Margrét Leosdottir Honghuang Lin Cecilia M Lindgren Christina Loley Calum A MacRae Deborah Mascalzoni Jamil Mayet Daniel Medenwald Andrew P Morris Christian Müller Martina Müller-Nurasyid Stefania Nappo Peter M Nilsson Sebastian Nuding Teresa Nutile Annette Peters Arne Pfeufer Diana Pietzner Peter P Pramstaller Olli T Raitakari Kenneth M Rice Fernando Rivadeneira Jerome I Rotter Saku T Ruohonen Ralph L Sacco Tandaw E Samdarshi Helena Schmidt Andrew S P Sharp Denis C Shields Rossella Sorice Nona Sotoodehnia Bruno H Stricker Praveen Surendran Simon Thom Anna M Töglhofer André G Uitterlinden Rolf Wachter Henry Völzke Andreas Ziegler Thomas Münzel Winfried März Thomas P Cappola Joel N Hirschhorn Gary F Mitchell Nicholas L Smith Ervin R Fox Nicole D Dueker Vincent W V Jaddoe Olle Melander Martin Russ Terho Lehtimäki Marina Ciullo Andrew A Hicks Lars Lind Vilmundur Gudnason Burkert Pieske Anthony J Barron Robert Zweiker Heribert Schunkert Erik Ingelsson Kiang Liu Donna K Arnett Bruce M Psaty Stefan Blankenberg Martin G Larson Stephan B Felix Oscar H Franco Tanja Zeller Ramachandran S Vasan Marcus Dörr

J Clin Invest 2017 May 10;127(5):1798-1812. Epub 2017 Apr 10.

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https://www.jci.org/articles/view/84840
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http://dx.doi.org/10.1172/JCI84840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409098PMC
May 2017

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.

Authors:
Frank J A van Rooij Rehan Qayyum Albert V Smith Yi Zhou Stella Trompet Toshiko Tanaka Margaux F Keller Li-Ching Chang Helena Schmidt Min-Lee Yang Ming-Huei Chen James Hayes Andrew D Johnson Lisa R Yanek Christian Mueller Leslie Lange James S Floyd Mohsen Ghanbari Alan B Zonderman J Wouter Jukema Albert Hofman Cornelia M van Duijn Karl C Desch Yasaman Saba Ayse B Ozel Beverly M Snively Jer-Yuarn Wu Reinhold Schmidt Myriam Fornage Robert J Klein Caroline S Fox Koichi Matsuda Naoyuki Kamatani Philipp S Wild David J Stott Ian Ford P Eline Slagboom Jaden Yang Audrey Y Chu Amy J Lambert André G Uitterlinden Oscar H Franco Edith Hofer David Ginsburg Bella Hu Brendan Keating Ursula M Schick Jennifer A Brody Jun Z Li Zhao Chen Tanja Zeller Jack M Guralnik Daniel I Chasman Luanne L Peters Michiaki Kubo Diane M Becker Jin Li Gudny Eiriksdottir Jerome I Rotter Daniel Levy Vera Grossmann Kushang V Patel Chien-Hsiun Chen Paul M Ridker Hua Tang Lenore J Launer Kenneth M Rice Ruifang Li-Gao Luigi Ferrucci Michelle K Evans Avik Choudhuri Eirini Trompouki Brian J Abraham Song Yang Atsushi Takahashi Yoichiro Kamatani Charles Kooperberg Tamara B Harris Sun Ha Jee Josef Coresh Fuu-Jen Tsai Dan L Longo Yuan-Tsong Chen Janine F Felix Qiong Yang Bruce M Psaty Eric Boerwinkle Lewis C Becker Dennis O Mook-Kanamori James G Wilson Vilmundur Gudnason Christopher J O'Donnell Abbas Dehghan L Adrienne Cupples Michael A Nalls Andrew P Morris Yukinori Okada Alexander P Reiner Leonard I Zon Santhi K Ganesh

Am J Hum Genet 2017 Jan 22;100(1):51-63. Epub 2016 Dec 22.

Division of Cardiovascular Medicine, Department of Internal Medicine, Department of Human Genetics, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:

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http://www.cell.com/ajhg/pdf/S0002-9297(16)30520-1.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S000292971630520
Publisher Site
http://dx.doi.org/10.1016/j.ajhg.2016.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223059PMC
January 2017

Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study.

Int J Cardiol 2015 21;187:166-74. Epub 2015 Mar 21.

Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, Germany; Preventive Cardiology and Preventive Medicine, Dept. of Medicine 2, University Medical Center of the Johannes Gutenberg-University Mainz, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Rhine-Main, Mainz, Germany.

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http://dx.doi.org/10.1016/j.ijcard.2015.03.330DOI Listing
February 2016

Sex-specific differences in genetic and nongenetic determinants of mean platelet volume: results from the Gutenberg Health Study.

Blood 2016 Jan 30;127(2):251-9. Epub 2015 Oct 30.

Center of Thrombosis and Hemostasis, Preventive Cardiology and Medical Prevention, Department of Medicine II, and DZHK, Partner Site Rhein-Main, Mainz, Germany; and.

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http://dx.doi.org/10.1182/blood-2015-07-660308DOI Listing
January 2016

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.

Authors:
Paul S de Vries Daniel I Chasman Maria Sabater-Lleal Ming-Huei Chen Jennifer E Huffman Maristella Steri Weihong Tang Alexander Teumer Riccardo E Marioni Vera Grossmann Jouke J Hottenga Stella Trompet Martina Müller-Nurasyid Jing Hua Zhao Jennifer A Brody Marcus E Kleber Xiuqing Guo Jie Jin Wang Paul L Auer John R Attia Lisa R Yanek Tarunveer S Ahluwalia Jari Lahti Cristina Venturini Toshiko Tanaka Lawrence F Bielak Peter K Joshi Ares Rocanin-Arjo Ivana Kolcic Pau Navarro Lynda M Rose Christopher Oldmeadow Helene Riess Johanna Mazur Saonli Basu Anuj Goel Qiong Yang Mohsen Ghanbari Gonneke Willemsen Ann Rumley Edoardo Fiorillo Anton J M de Craen Anne Grotevendt Robert Scott Kent D Taylor Graciela E Delgado Jie Yao Annette Kifley Charles Kooperberg Rehan Qayyum Lorna M Lopez Tina L Berentzen Katri Räikkönen Massimo Mangino Stefania Bandinelli Patricia A Peyser Sarah Wild David-Alexandre Trégouët Alan F Wright Jonathan Marten Tatijana Zemunik Alanna C Morrison Bengt Sennblad Geoffrey Tofler Moniek P M de Maat Eco J C de Geus Gordon D Lowe Magdalena Zoledziewska Naveed Sattar Harald Binder Uwe Völker Melanie Waldenberger Kay-Tee Khaw Barbara Mcknight Jie Huang Nancy S Jenny Elizabeth G Holliday Lihong Qi Mark G Mcevoy Diane M Becker John M Starr Antti-Pekka Sarin Pirro G Hysi Dena G Hernandez Min A Jhun Harry Campbell Anders Hamsten Fernando Rivadeneira Wendy L Mcardle P Eline Slagboom Tanja Zeller Wolfgang Koenig Bruce M Psaty Talin Haritunians Jingmin Liu Aarno Palotie André G Uitterlinden David J Stott Albert Hofman Oscar H Franco Ozren Polasek Igor Rudan Pierre-Emmanuel Morange James F Wilson Sharon L R Kardia Luigi Ferrucci Tim D Spector Johan G Eriksson Torben Hansen Ian J Deary Lewis C Becker Rodney J Scott Paul Mitchell Winfried März Nick J Wareham Annette Peters Andreas Greinacher Philipp S Wild J Wouter Jukema Dorret I Boomsma Caroline Hayward Francesco Cucca Russell Tracy Hugh Watkins Alex P Reiner Aaron R Folsom Paul M Ridker Christopher J O'Donnell Nicholas L Smith David P Strachan Abbas Dehghan

Hum Mol Genet 2016 Jan 10;25(2):358-70. Epub 2015 Nov 10.

Department of Epidemiology,

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http://hmg.oxfordjournals.org/content/early/2015/12/08/hmg.d
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http://www.hmg.oxfordjournals.org/lookup/doi/10.1093/hmg/ddv
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http://dx.doi.org/10.1093/hmg/ddv454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715256PMC
January 2016

Profile of the Immune and Inflammatory Response in Individuals With Prediabetes and Type 2 Diabetes.

Diabetes Care 2015 Jul 15;38(7):1356-64. Epub 2015 Apr 15.

Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany Preventive Cardiology and Preventive Medicine, Department of Medicine 2, University Medical Center Mainz, Mainz, Germany German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc14-300
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http://dx.doi.org/10.2337/dc14-3008DOI Listing
July 2015

Rationale and design of three observational, prospective cohort studies including biobanking to evaluate and improve diagnostics, management strategies and risk stratification in venous thromboembolism: the VTEval Project.

BMJ Open 2015 Jul 1;5(7):e008157. Epub 2015 Jul 1.

Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany Preventive Cardiology and Preventive Medicine, Department of Medicine 2, University Medical Center Mainz, Mainz, Germany German Center for Cardiovascular Research (DZHK), partner site RhineMain, Mainz, Germany.

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http://dx.doi.org/10.1136/bmjopen-2015-008157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499722PMC
July 2015

Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome.

Nat Commun 2015 Jan 14;6:6042. Epub 2015 Jan 14.

1] Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, 12-01, Singapore 117599, Singapore [2] Cedars-Sinai Medical Center, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, California 90048, USA [3] National University Cancer Institute, National University Hospital Singapore, Singapore 119228, Singapore.

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http://www.nature.com/articles/ncomms7042
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http://dx.doi.org/10.1038/ncomms7042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349895PMC
January 2015

Next-generation sequencing - feasibility and practicality in haematology.

Br J Haematol 2013 Mar 7;160(6):736-53. Epub 2013 Jan 7.

MLL Munich Leukaemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1111/bjh.12194DOI Listing
March 2013

Integration of next-generation sequencing into clinical practice: are we there yet?

Semin Oncol 2012 Feb;39(1):26-36

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1053/j.seminoncol.2011.11.008DOI Listing
February 2012

R453Plus1Toolbox: an R/Bioconductor package for analyzing Roche 454 Sequencing data.

Bioinformatics 2011 Apr 23;27(8):1162-3. Epub 2011 Feb 23.

Department of Medical Informatics and Biomathematics, University of Münster, Münster and Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btr102DOI Listing
April 2011

"Essentially" pure trisomy 3q27 --> qter: further delineation of the partial trisomy 3q phenotype.

Am J Med Genet A 2009 Nov;149A(11):2522-6

Department of Medical Genetics, Molecular and Clinical Pharmacology, Division of Clinical Genetics, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1002/ajmg.a.33058DOI Listing
November 2009