Vera Grossmann

Division of Cardiovascular Medicine, Department of Internal Medicine, Department of Human Genetics, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:

View Article and Find Full Text PDF

January 2017

A Low Frequency of Losses in 11q Chromosome Is Associated with Better Outcome and Lower Rate of Genomic Mutations in Patients with Chronic Lymphocytic Leukemia.

PLoS One 2015 2;10(11):e0143073. Epub 2015 Dec 2.

IBSAL, IBMCC, Centro de Investigación del Cáncer, Universidad de Salamanca,CSIC, Hospital Universitario de Salamanca, Spain.

View Article and Find Full Text PDF

June 2016

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.

Authors:

Paul S de Vries Daniel I Chasman Maria Sabater-Lleal Ming-Huei Chen Jennifer E Huffman Maristella Steri Weihong Tang Alexander Teumer Riccardo E Marioni Vera Grossmann Jouke J Hottenga Stella Trompet Martina Müller-Nurasyid Jing Hua Zhao Jennifer A Brody Marcus E Kleber Xiuqing Guo Jie Jin Wang Paul L Auer John R Attia Lisa R Yanek Tarunveer S Ahluwalia Jari Lahti Cristina Venturini Toshiko Tanaka Lawrence F Bielak Peter K Joshi Ares Rocanin-Arjo Ivana Kolcic Pau Navarro Lynda M Rose Christopher Oldmeadow Helene Riess Johanna Mazur Saonli Basu Anuj Goel Qiong Yang Mohsen Ghanbari Gonneke Willemsen Ann Rumley Edoardo Fiorillo Anton J M de Craen Anne Grotevendt Robert Scott Kent D Taylor Graciela E Delgado Jie Yao Annette Kifley Charles Kooperberg Rehan Qayyum Lorna M Lopez Tina L Berentzen Katri Räikkönen Massimo Mangino Stefania Bandinelli Patricia A Peyser Sarah Wild David-Alexandre Trégouët Alan F Wright Jonathan Marten Tatijana Zemunik Alanna C Morrison Bengt Sennblad Geoffrey Tofler Moniek P M de Maat Eco J C de Geus Gordon D Lowe Magdalena Zoledziewska Naveed Sattar Harald Binder Uwe Völker Melanie Waldenberger Kay-Tee Khaw Barbara Mcknight Jie Huang Nancy S Jenny Elizabeth G Holliday Lihong Qi Mark G Mcevoy Diane M Becker John M Starr Antti-Pekka Sarin Pirro G Hysi Dena G Hernandez Min A Jhun Harry Campbell Anders Hamsten Fernando Rivadeneira Wendy L Mcardle P Eline Slagboom Tanja Zeller Wolfgang Koenig Bruce M Psaty Talin Haritunians Jingmin Liu Aarno Palotie André G Uitterlinden David J Stott Albert Hofman Oscar H Franco Ozren Polasek Igor Rudan Pierre-Emmanuel Morange James F Wilson Sharon L R Kardia Luigi Ferrucci Tim D Spector Johan G Eriksson Torben Hansen Ian J Deary Lewis C Becker Rodney J Scott Paul Mitchell Winfried März Nick J Wareham Annette Peters Andreas Greinacher Philipp S Wild J Wouter Jukema Dorret I Boomsma Caroline Hayward Francesco Cucca Russell Tracy Hugh Watkins Alex P Reiner Aaron R Folsom Paul M Ridker Christopher J O'Donnell Nicholas L Smith David P Strachan Abbas Dehghan

Hum Mol Genet 2016 Jan 10;25(2):358-70. Epub 2015 Nov 10.

Department of Epidemiology,

View Article and Find Full Text PDF

January 2016

Sex-specific differences in genetic and nongenetic determinants of mean platelet volume: results from the Gutenberg Health Study.

Authors:

Marina Panova-Noeva Andreas Schulz M Iris Hermanns Vera Grossmann Evgenia Pefani Henri M H Spronk Dagmar Laubert-Reh Harald Binder Manfred Beutel Norbert Pfeiffer Stefan Blankenberg Tanja Zeller Thomas Münzel Karl J Lackner Hugo Ten Cate Philipp S Wild

Blood 2016 Jan 30;127(2):251-9. Epub 2015 Oct 30.

Center of Thrombosis and Hemostasis, Preventive Cardiology and Medical Prevention, Department of Medicine II, and DZHK, Partner Site Rhein-Main, Mainz, Germany; and.

View Article and Find Full Text PDF

January 2016

Rationale and design of three observational, prospective cohort studies including biobanking to evaluate and improve diagnostics, management strategies and risk stratification in venous thromboembolism: the VTEval Project.

Authors:

Bernd Frank Liana Ariza Heidrun Lamparter Vera Grossmann Jürgen H Prochaska Alexander Ullmann Florentina Kindler Gerhard Weisser Ulrich Walter Karl J Lackner Christine Espinola-Klein Thomas Münzel Stavros V Konstantinides Philipp S Wild

BMJ Open 2015 Jul 1;5(7):e008157. Epub 2015 Jul 1.

Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany Preventive Cardiology and Preventive Medicine, Department of Medicine 2, University Medical Center Mainz, Mainz, Germany German Center for Cardiovascular Research (DZHK), partner site RhineMain, Mainz, Germany.

View Article and Find Full Text PDF

July 2015

BRCC3 mutations in myeloid neoplasms.

Haematologica 2015 Aug 22;100(8):1051-7. Epub 2015 May 22.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA Department of Pathology and Tumor Biology, Kyoto University, Japan

View Article and Find Full Text PDF

August 2015

Profile of the Immune and Inflammatory Response in Individuals With Prediabetes and Type 2 Diabetes.

Authors:

Vera Grossmann Volker H Schmitt Tanja Zeller Marina Panova-Noeva Andreas Schulz Dagmar Laubert-Reh Claus Juenger Renate B Schnabel Tobias G J Abt Rafael Laskowski Jörg Wiltink Eberhard Schulz Stefan Blankenberg Karl J Lackner Thomas Münzel Philipp S Wild

Diabetes Care 2015 Jul 15;38(7):1356-64. Epub 2015 Apr 15.

Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany Preventive Cardiology and Preventive Medicine, Department of Medicine 2, University Medical Center Mainz, Mainz, Germany German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany

View Article and Find Full Text PDF

July 2015

Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study.

Authors:

M Iris Hermanns Vera Grossmann Henri M H Spronk Andreas Schulz Claus Jünger Dagmar Laubert-Reh Johanna Mazur Tommaso Gori Tanja Zeller Norbert Pfeiffer Manfred Beutel Stefan Blankenberg Thomas Münzel Karl J Lackner Arina J Ten Cate-Hoek Hugo Ten Cate Philipp S Wild

Int J Cardiol 2015 21;187:166-74. Epub 2015 Mar 21.

Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, Germany; Preventive Cardiology and Preventive Medicine, Dept. of Medicine 2, University Medical Center of the Johannes Gutenberg-University Mainz, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Rhine-Main, Mainz, Germany.

View Article and Find Full Text PDF

February 2016

Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome.

Authors:

Vikas Madan Deepika Kanojia Jia Li Ryoko Okamoto Aiko Sato-Otsubo Alexander Kohlmann Masashi Sanada Vera Grossmann Janani Sundaresan Yuichi Shiraishi Satoru Miyano Felicitas Thol Arnold Ganser Henry Yang Torsten Haferlach Seishi Ogawa H Phillip Koeffler

Nat Commun 2015 Jan 14;6:6042. Epub 2015 Jan 14.

1] Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, 12-01, Singapore 117599, Singapore [2] Cedars-Sinai Medical Center, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, California 90048, USA [3] National University Cancer Institute, National University Hospital Singapore, Singapore 119228, Singapore.

View Article and Find Full Text PDF

January 2015

Investigation of 305 patients with myelodysplastic syndromes and 20q deletion for associated cytogenetic and molecular genetic lesions and their prognostic impact.

Authors:

Ulrike Bacher Torsten Haferlach Susanne Schnittger Melanie Zenger Manja Meggendorfer Sabine Jeromin Andreas Roller Vera Grossmann Maria-Theresa Krauth Tamara Alpermann Wolfgang Kern Claudia Haferlach

Br J Haematol 2014 Mar 26;164(6):822-33. Epub 2013 Dec 26.

MLL Munich Leukemia Laboratory, Munich, Germany.

View Article and Find Full Text PDF

March 2014

EZH2 mutations are frequent and represent an early event in follicular lymphoma.

Blood 2013 Oct 19;122(18):3165-8. Epub 2013 Sep 19.

Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, United Kingdom;

View Article and Find Full Text PDF

October 2013

Comprehensive mutational profiling in advanced systemic mastocytosis.

Blood 2013 Oct 19;122(14):2460-6. Epub 2013 Aug 19.

III. Medizinische Klinik, Hämatologie und Onkologie, Universitätsmedizin Mannheim, Mannheim, Germany;

View Article and Find Full Text PDF

October 2013

Robustness of amplicon deep sequencing underlines its utility in clinical applications.

Authors:

Vera Grossmann Andreas Roller Hans-Ulrich Klein Sandra Weissmann Wolfgang Kern Claudia Haferlach Martin Dugas Torsten Haferlach Susanne Schnittger Alexander Kohlmann

J Mol Diagn 2013 Jul 14;15(4):473-84. Epub 2013 May 14.

MLL Munich Leukemia Laboratory, Munich, Germany.

View Article and Find Full Text PDF

July 2013

CEBPA double-mutated acute myeloid leukaemia harbours concomitant molecular mutations in 76·8% of cases with TET2 and GATA2 alterations impacting prognosis.

Authors:

Vera Grossmann Claudia Haferlach Niroshan Nadarajah Annette Fasan Sandra Weissmann Andreas Roller Christiane Eder Elisa Stopp Wolfgang Kern Torsten Haferlach Alexander Kohlmann Susanne Schnittger

Br J Haematol 2013 Jun 25;161(5):649-58. Epub 2013 Mar 25.

MLL Munich Leukemia Laboratory, Munich, Germany.

View Article and Find Full Text PDF

June 2013

Frequency and prognostic impact of CEBPA proximal, distal and core promoter methylation in normal karyotype AML: a study on 623 cases.

Authors:

Annette Fasan Tamara Alpermann Claudia Haferlach Vera Grossmann Andreas Roller Alexander Kohlmann Christiane Eder Wolfgang Kern Torsten Haferlach Susanne Schnittger

PLoS One 2013 1;8(2):e54365. Epub 2013 Feb 1.

MLL Munich Leukemia Laboratory, Munich, Germany.

View Article and Find Full Text PDF

July 2013

The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL.

Authors:

Vera Grossmann Claudia Haferlach Sandra Weissmann Andreas Roller Sonja Schindela Franziska Poetzinger Kathrin Stadler Frauke Bellos Wolfgang Kern Torsten Haferlach Susanne Schnittger Alexander Kohlmann

Genes Chromosomes Cancer 2013 Apr 23;52(4):410-22. Epub 2013 Jan 23.

MLL Munich Leukemia Laboratory, Max-Lebsche-Platz 31, 81377 Munich, Germany.

View Article and Find Full Text PDF

April 2013

Next-generation sequencing - feasibility and practicality in haematology.

Authors:

Alexander Kohlmann Vera Grossmann Niroshan Nadarajah Torsten Haferlach

Br J Haematol 2013 Mar 7;160(6):736-53. Epub 2013 Jan 7.

MLL Munich Leukaemia Laboratory, Munich, Germany.

View Article and Find Full Text PDF

March 2013

High frequencies of SF3B1 and JAK2 mutations in refractory anemia with ring sideroblasts associated with marked thrombocytosis strengthen the assignment to the category of myelodysplastic/myeloproliferative neoplasms.

Authors:

Sabine Jeromin Torsten Haferlach Vera Grossmann Tamara Alpermann Andreas Kowarsch Claudia Haferlach Wolfgang Kern Susanne Schnittger

Haematologica 2013 Feb 28;98(2):e15-7. Epub 2012 Aug 28.

MLL Munich Leukemia Laboratory, Germany.

View Article and Find Full Text PDF

February 2013

SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML).

Authors:

Manja Meggendorfer Andreas Roller Torsten Haferlach Christiane Eder Frank Dicker Vera Grossmann Alexander Kohlmann Tamara Alpermann Kenichi Yoshida Seishi Ogawa H Phillip Koeffler Wolfgang Kern Claudia Haferlach Susanne Schnittger

Blood 2012 Oct 23;120(15):3080-8. Epub 2012 Aug 23.

MLL Munich Leukemia Laboratory, Munich, Germany.

View Article and Find Full Text PDF

October 2012

A novel hierarchical prognostic model of AML solely based on molecular mutations.

Authors:

Vera Grossmann Susanne Schnittger Alexander Kohlmann Christiane Eder Andreas Roller Frank Dicker Christoph Schmid Clemens-Martin Wendtner Peter Staib Hubert Serve Karl-Anton Kreuzer Wolfgang Kern Torsten Haferlach Claudia Haferlach

Blood 2012 Oct 20;120(15):2963-72. Epub 2012 Aug 20.

MLL Munich Leukemia Laboratory, Munich, Germany.

View Article and Find Full Text PDF

October 2012

Three novel cytogenetically cryptic EVI1 rearrangements associated with increased EVI1 expression and poor prognosis identified in 27 acute myeloid leukemia cases.

Authors:

Claudia Haferlach Ulrike Bacher Vera Grossmann Sonja Schindela Melanie Zenger Alexander Kohlmann Wolfgang Kern Torsten Haferlach Susanne Schnittger

Genes Chromosomes Cancer 2012 Dec 8;51(12):1079-85. Epub 2012 Aug 8.

MLL Munich Leukemia Laboratory, Munich, Germany.

View Article and Find Full Text PDF

December 2012

Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements.

Authors:

Andrew Chase Catherine Bryant Joannah Score Claudia Haferlach Vera Grossmann Juliana Schwaab Wolf-Karsten Hofmann Andreas Reiter Nicholas C P Cross

Haematologica 2013 Mar 8;98(3):404-8. Epub 2012 Aug 8.

Faculty of Medicine, University of Southampton, Southampton, UK.

View Article and Find Full Text PDF

March 2013

Use of CBL exon 8 and 9 mutations in diagnosis of myeloproliferative neoplasms and myelodysplastic/myeloproliferative disorders: an analysis of 636 cases.

Authors:

Susanne Schnittger Ulrike Bacher Tamara Alpermann Andreas Reiter Madlen Ulke Frank Dicker Christiane Eder Alexander Kohlmann Vera Grossmann Andreas Kowarsch Wolfgang Kern Claudia Haferlach Torsten Haferlach

Haematologica 2012 Dec 24;97(12):1890-4. Epub 2012 Jun 24.

MLL Munich Leukemia Laboratory, Max-Lebsche-Platz 31, 81377 Munich, Germany.

View Article and Find Full Text PDF

December 2012

Molecular analyses of 15,542 patients with suspected BCR-ABL1-negative myeloproliferative disorders allow to develop a stepwise diagnostic workflow.

Authors:

Susanne Schnittger Ulrike Bacher Christiane Eder Frank Dicker Tamara Alpermann Vera Grossmann Alexander Kohlmann Wolfgang Kern Claudia Haferlach Torsten Haferlach

Haematologica 2012 Oct 17;97(10):1582-5. Epub 2012 Apr 17.

MLL Munich Leukemia Laboratory, Munich, Germany.

View Article and Find Full Text PDF

October 2012

Multilineage dysplasia does not influence prognosis in CEBPA-mutated AML, supporting the WHO proposal to classify these patients as a unique entity.

Authors:

Ulrike Bacher Susanne Schnittger Katja Macijewski Vera Grossmann Alexander Kohlmann Tamara Alpermann Andreas Kowarsch Niroshan Nadarajah Wolfgang Kern Claudia Haferlach Torsten Haferlach

Blood 2012 May 22;119(20):4719-22. Epub 2012 Mar 22.

Department for Stem Cell Transplantation, University of Hamburg, Germany.

View Article and Find Full Text PDF

May 2012

Development and validation of a real-time quantification assay to detect and monitor BRAFV600E mutations in hairy cell leukemia.

Authors:

Susanne Schnittger Ulrike Bacher Torsten Haferlach Nicole Wendland Madlen Ulke Frank Dicker Vera Grossmann Claudia Haferlach Wolfgang Kern

Blood 2012 Mar 13;119(13):3151-4. Epub 2012 Feb 13.

MLL Munich Leukemia Laboratory, Munich, Germany.

View Article and Find Full Text PDF

March 2012

Integration of next-generation sequencing into clinical practice: are we there yet?

Authors:

Alexander Kohlmann Vera Grossmann Torsten Haferlach

Semin Oncol 2012 Feb;39(1):26-36

MLL Munich Leukemia Laboratory, Munich, Germany.

View Article and Find Full Text PDF

February 2012

EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia.

Authors:

Vera Grossmann Ulrike Bacher Alexander Kohlmann Valentina Artusi Hans-Ulrich Klein Martin Dugas Susanne Schnittger Tamara Alpermann Wolfgang Kern Torsten Haferlach Claudia Haferlach

Br J Haematol 2012 May 12;157(3):387-90. Epub 2012 Jan 12.

View Article and Find Full Text PDF

May 2012

The corepressors BCOR and BCORL1: two novel players in acute myeloid leukemia.

Authors:

Enrico Tiacci Vera Grossmann Maria Paola Martelli Alexander Kohlmann Torsten Haferlach Brunangelo Falini

Haematologica 2012 Jan;97(1):3-5

View Article and Find Full Text PDF

January 2012

Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype.

Blood 2011 Dec 19;118(23):6153-63. Epub 2011 Oct 19.

MLL Munich Leukemia Laboratory, Munich, Germany.

View Article and Find Full Text PDF

December 2011

Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia.

Authors:

Vera Grossmann Wolfgang Kern Stefan Harbich Tamara Alpermann Sabine Jeromin Susanne Schnittger Claudia Haferlach Torsten Haferlach Alexander Kohlmann

Haematologica 2011 Dec 9;96(12):1874-7. Epub 2011 Aug 9.

MLL Munich Leukemia Laboratory, Max-Lebsche-Platz 31, 81377 Munich, Germany.

View Article and Find Full Text PDF

December 2011

Strategy for robust detection of insertions, deletions, and point mutations in CEBPA, a GC-rich content gene, using 454 next-generation deep-sequencing technology.

Authors:

Vera Grossmann Susanne Schnittger Sonja Schindela Hans-Ulrich Klein Christiane Eder Martin Dugas Wolfgang Kern Torsten Haferlach Claudia Haferlach Alexander Kohlmann

J Mol Diagn 2011 Mar;13(2):129-36

MLL Munich Leukemia Laboratory, Munich, Germany.

View Article and Find Full Text PDF

March 2011

R453Plus1Toolbox: an R/Bioconductor package for analyzing Roche 454 Sequencing data.

Authors:

Hans-Ulrich Klein Christoph Bartenhagen Alexander Kohlmann Vera Grossmann Christian Ruckert Torsten Haferlach Martin Dugas

Bioinformatics 2011 Apr 23;27(8):1162-3. Epub 2011 Feb 23.

Department of Medical Informatics and Biomathematics, University of Münster, Münster and Munich Leukemia Laboratory, Munich, Germany.

View Article and Find Full Text PDF

April 2011

Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8% of chronic myelomonocytic leukemia by detecting frequent alterations in TET2, CBL, RAS, and RUNX1.

Authors:

Alexander Kohlmann Vera Grossmann Hans-Ulrich Klein Sonja Schindela Tamara Weiss Beray Kazak Frank Dicker Susanne Schnittger Martin Dugas Wolfgang Kern Claudia Haferlach Torsten Haferlach

J Clin Oncol 2010 Aug 19;28(24):3858-65. Epub 2010 Jul 19.

MLL Munich Leukemia Laboratory, München, Germany.

View Article and Find Full Text PDF

August 2010

"Essentially" pure trisomy 3q27 --> qter: further delineation of the partial trisomy 3q phenotype.

Authors:

Vera Grossmann Doris Müller Wilfried Müller Friedrich Fresser Martin Erdel Andreas R Janecke Johannes Zschocke Gerd Utermann Dieter Kotzot

Am J Med Genet A 2009 Nov;149A(11):2522-6

Department of Medical Genetics, Molecular and Clinical Pharmacology, Division of Clinical Genetics, Innsbruck Medical University, Innsbruck, Austria.

View Article and Find Full Text PDF

November 2009

Publications by authors named "Vera Grossmann"

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors:

Authors: