Vera Grossmann

Vera Grossmann

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Vera Grossmann

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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.

Authors:
Symen Ligthart Ahmad Vaez Urmo Võsa Maria G Stathopoulou Paul S de Vries Bram P Prins Peter J Van der Most Toshiko Tanaka Elnaz Naderi Lynda M Rose Ying Wu Robert Karlsson Maja Barbalic Honghuang Lin René Pool Gu Zhu Aurélien Macé Carlo Sidore Stella Trompet Massimo Mangino Maria Sabater-Lleal John P Kemp Ali Abbasi Tim Kacprowski Niek Verweij Albert V Smith Tao Huang Carola Marzi Mary F Feitosa Kurt K Lohman Marcus E Kleber Yuri Milaneschi Christian Mueller Mahmudul Huq Efthymia Vlachopoulou Leo-Pekka Lyytikäinen Christopher Oldmeadow Joris Deelen Markus Perola Jing Hua Zhao Bjarke Feenstra Marzyeh Amini Jari Lahti Katharina E Schraut Myriam Fornage Bhoom Suktitipat Wei-Min Chen Xiaohui Li Teresa Nutile Giovanni Malerba Jian'an Luan Tom Bak Nicholas Schork Fabiola Del Greco M Elisabeth Thiering Anubha Mahajan Riccardo E Marioni Evelin Mihailov Joel Eriksson Ayse Bilge Ozel Weihua Zhang Maria Nethander Yu-Ching Cheng Stella Aslibekyan Wei Ang Ilaria Gandin Loïc Yengo Laura Portas Charles Kooperberg Edith Hofer Kumar B Rajan Claudia Schurmann Wouter den Hollander Tarunveer S Ahluwalia Jing Zhao Harmen H M Draisma Ian Ford Nicholas Timpson Alexander Teumer Hongyan Huang Simone Wahl YongMei Liu Jie Huang Hae-Won Uh Frank Geller Peter K Joshi Lisa R Yanek Elisabetta Trabetti Benjamin Lehne Diego Vozzi Marie Verbanck Ginevra Biino Yasaman Saba Ingrid Meulenbelt Jeff R O'Connell Markku Laakso Franco Giulianini Patrik K E Magnusson Christie M Ballantyne Jouke Jan Hottenga Grant W Montgomery Fernando Rivadineira Rico Rueedi Maristella Steri Karl-Heinz Herzig David J Stott Cristina Menni Mattias Frånberg Beate St Pourcain Stephan B Felix Tune H Pers Stephan J L Bakker Peter Kraft Annette Peters Dhananjay Vaidya Graciela Delgado Johannes H Smit Vera Großmann Juha Sinisalo Ilkka Seppälä Stephen R Williams Elizabeth G Holliday Matthijs Moed Claudia Langenberg Katri Räikkönen Jingzhong Ding Harry Campbell Michele M Sale Yii-Der I Chen Alan L James Daniela Ruggiero Nicole Soranzo Catharina A Hartman Erin N Smith Gerald S Berenson Christian Fuchsberger Dena Hernandez Carla M T Tiesler Vilmantas Giedraitis David Liewald Krista Fischer Dan Mellström Anders Larsson Yunmei Wang William R Scott Matthias Lorentzon John Beilby Kathleen A Ryan Craig E Pennell Dragana Vuckovic Beverly Balkau Maria Pina Concas Reinhold Schmidt Carlos F Mendes de Leon Erwin P Bottinger Margreet Kloppenburg Lavinia Paternoster Michael Boehnke A W Musk Gonneke Willemsen David M Evans Pamela A F Madden Mika Kähönen Zoltán Kutalik Magdalena Zoledziewska Ville Karhunen Stephen B Kritchevsky Naveed Sattar Genevieve Lachance Robert Clarke Tamara B Harris Olli T Raitakari John R Attia Diana van Heemst Eero Kajantie Rossella Sorice Giovanni Gambaro Robert A Scott Andrew A Hicks Luigi Ferrucci Marie Standl Cecilia M Lindgren John M Starr Magnus Karlsson Lars Lind Jun Z Li John C Chambers Trevor A Mori Eco J C N de Geus Andrew C Heath Nicholas G Martin Juha Auvinen Brendan M Buckley Anton J M de Craen Melanie Waldenberger Konstantin Strauch Thomas Meitinger Rodney J Scott Mark McEvoy Marian Beekman Cristina Bombieri Paul M Ridker Karen L Mohlke Nancy L Pedersen Alanna C Morrison Dorret I Boomsma John B Whitfield David P Strachan Albert Hofman Peter Vollenweider Francesco Cucca Marjo-Riitta Jarvelin J Wouter Jukema Tim D Spector Anders Hamsten Tanja Zeller André G Uitterlinden Matthias Nauck Vilmundur Gudnason Lu Qi Harald Grallert Ingrid B Borecki Jerome I Rotter Winfried März Philipp S Wild Marja-Liisa Lokki Michael Boyle Veikko Salomaa Mads Melbye Johan G Eriksson James F Wilson Brenda W J H Penninx Diane M Becker Bradford B Worrall Greg Gibson Ronald M Krauss Marina Ciullo Gianluigi Zaza Nicholas J Wareham Albertine J Oldehinkel Lyle J Palmer Sarah S Murray Peter P Pramstaller Stefania Bandinelli Joachim Heinrich Erik Ingelsson Ian J Deary Reedik Mägi Liesbeth Vandenput Pim van der Harst Karl C Desch Jaspal S Kooner Claes Ohlsson Caroline Hayward Terho Lehtimäki Alan R Shuldiner Donna K Arnett Lawrence J Beilin Antonietta Robino Philippe Froguel Mario Pirastu Tine Jess Wolfgang Koenig Ruth J F Loos Denis A Evans Helena Schmidt George Davey Smith P Eline Slagboom Gudny Eiriksdottir Andrew P Morris Bruce M Psaty Russell P Tracy Ilja M Nolte Eric Boerwinkle Sophie Visvikis-Siest Alex P Reiner Myron Gross Joshua C Bis Lude Franke Oscar H Franco Emelia J Benjamin Daniel I Chasman Josée Dupuis Harold Snieder Abbas Dehghan Behrooz Z Alizadeh

Am J Hum Genet 2018 11;103(5):691-706

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183032
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http://dx.doi.org/10.1016/j.ajhg.2018.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218410PMC
November 2018

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study.

Authors:
Paul S de Vries Maria Sabater-Lleal Daniel I Chasman Stella Trompet Tarunveer S Ahluwalia Alexander Teumer Marcus E Kleber Ming-Huei Chen Jie Jin Wang John R Attia Riccardo E Marioni Maristella Steri Lu-Chen Weng Rene Pool Vera Grossmann Jennifer A Brody Cristina Venturini Toshiko Tanaka Lynda M Rose Christopher Oldmeadow Johanna Mazur Saonli Basu Mattias Frånberg Qiong Yang Symen Ligthart Jouke J Hottenga Ann Rumley Antonella Mulas Anton J M de Craen Anne Grotevendt Kent D Taylor Graciela E Delgado Annette Kifley Lorna M Lopez Tina L Berentzen Massimo Mangino Stefania Bandinelli Alanna C Morrison Anders Hamsten Geoffrey Tofler Moniek P M de Maat Harmen H M Draisma Gordon D Lowe Magdalena Zoledziewska Naveed Sattar Karl J Lackner Uwe Völker Barbara McKnight Jie Huang Elizabeth G Holliday Mark A McEvoy John M Starr Pirro G Hysi Dena G Hernandez Weihua Guan Fernando Rivadeneira Wendy L McArdle P Eline Slagboom Tanja Zeller Bruce M Psaty André G Uitterlinden Eco J C de Geus David J Stott Harald Binder Albert Hofman Oscar H Franco Jerome I Rotter Luigi Ferrucci Tim D Spector Ian J Deary Winfried März Andreas Greinacher Philipp S Wild Francesco Cucca Dorret I Boomsma Hugh Watkins Weihong Tang Paul M Ridker Jan W Jukema Rodney J Scott Paul Mitchell Torben Hansen Christopher J O'Donnell Nicholas L Smith David P Strachan Abbas Dehghan

PLoS One 2017 20;12(1):e0167742. Epub 2017 Jan 20.

Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167742PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249120PMC
August 2017

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function.

Authors:
Philipp S Wild Janine F Felix Arne Schillert Alexander Teumer Ming-Huei Chen Maarten J G Leening Uwe Völker Vera Großmann Jennifer A Brody Marguerite R Irvin Sanjiv J Shah Setia Pramana Wolfgang Lieb Reinhold Schmidt Alice V Stanton Dörthe Malzahn Albert Vernon Smith Johan Sundström Cosetta Minelli Daniela Ruggiero Leo-Pekka Lyytikäinen Daniel Tiller J Gustav Smith Claire Monnereau Marco R Di Tullio Solomon K Musani Alanna C Morrison Tune H Pers Michael Morley Marcus E Kleber Jayashri Aragam Emelia J Benjamin Joshua C Bis Egbert Bisping Ulrich Broeckel Susan Cheng Jaap W Deckers Fabiola Del Greco M Frank Edelmann Myriam Fornage Lude Franke Nele Friedrich Tamara B Harris Edith Hofer Albert Hofman Jie Huang Alun D Hughes Mika Kähönen Knhi Investigators Jochen Kruppa Karl J Lackner Lars Lannfelt Rafael Laskowski Lenore J Launer Margrét Leosdottir Honghuang Lin Cecilia M Lindgren Christina Loley Calum A MacRae Deborah Mascalzoni Jamil Mayet Daniel Medenwald Andrew P Morris Christian Müller Martina Müller-Nurasyid Stefania Nappo Peter M Nilsson Sebastian Nuding Teresa Nutile Annette Peters Arne Pfeufer Diana Pietzner Peter P Pramstaller Olli T Raitakari Kenneth M Rice Fernando Rivadeneira Jerome I Rotter Saku T Ruohonen Ralph L Sacco Tandaw E Samdarshi Helena Schmidt Andrew S P Sharp Denis C Shields Rossella Sorice Nona Sotoodehnia Bruno H Stricker Praveen Surendran Simon Thom Anna M Töglhofer André G Uitterlinden Rolf Wachter Henry Völzke Andreas Ziegler Thomas Münzel Winfried März Thomas P Cappola Joel N Hirschhorn Gary F Mitchell Nicholas L Smith Ervin R Fox Nicole D Dueker Vincent W V Jaddoe Olle Melander Martin Russ Terho Lehtimäki Marina Ciullo Andrew A Hicks Lars Lind Vilmundur Gudnason Burkert Pieske Anthony J Barron Robert Zweiker Heribert Schunkert Erik Ingelsson Kiang Liu Donna K Arnett Bruce M Psaty Stefan Blankenberg Martin G Larson Stephan B Felix Oscar H Franco Tanja Zeller Ramachandran S Vasan Marcus Dörr

J Clin Invest 2017 May 10;127(5):1798-1812. Epub 2017 Apr 10.

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https://www.jci.org/articles/view/84840
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http://dx.doi.org/10.1172/JCI84840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409098PMC
May 2017

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.

Authors:
Frank J A van Rooij Rehan Qayyum Albert V Smith Yi Zhou Stella Trompet Toshiko Tanaka Margaux F Keller Li-Ching Chang Helena Schmidt Min-Lee Yang Ming-Huei Chen James Hayes Andrew D Johnson Lisa R Yanek Christian Mueller Leslie Lange James S Floyd Mohsen Ghanbari Alan B Zonderman J Wouter Jukema Albert Hofman Cornelia M van Duijn Karl C Desch Yasaman Saba Ayse B Ozel Beverly M Snively Jer-Yuarn Wu Reinhold Schmidt Myriam Fornage Robert J Klein Caroline S Fox Koichi Matsuda Naoyuki Kamatani Philipp S Wild David J Stott Ian Ford P Eline Slagboom Jaden Yang Audrey Y Chu Amy J Lambert André G Uitterlinden Oscar H Franco Edith Hofer David Ginsburg Bella Hu Brendan Keating Ursula M Schick Jennifer A Brody Jun Z Li Zhao Chen Tanja Zeller Jack M Guralnik Daniel I Chasman Luanne L Peters Michiaki Kubo Diane M Becker Jin Li Gudny Eiriksdottir Jerome I Rotter Daniel Levy Vera Grossmann Kushang V Patel Chien-Hsiun Chen Paul M Ridker Hua Tang Lenore J Launer Kenneth M Rice Ruifang Li-Gao Luigi Ferrucci Michelle K Evans Avik Choudhuri Eirini Trompouki Brian J Abraham Song Yang Atsushi Takahashi Yoichiro Kamatani Charles Kooperberg Tamara B Harris Sun Ha Jee Josef Coresh Fuu-Jen Tsai Dan L Longo Yuan-Tsong Chen Janine F Felix Qiong Yang Bruce M Psaty Eric Boerwinkle Lewis C Becker Dennis O Mook-Kanamori James G Wilson Vilmundur Gudnason Christopher J O'Donnell Abbas Dehghan L Adrienne Cupples Michael A Nalls Andrew P Morris Yukinori Okada Alexander P Reiner Leonard I Zon Santhi K Ganesh

Am J Hum Genet 2017 Jan 22;100(1):51-63. Epub 2016 Dec 22.

Division of Cardiovascular Medicine, Department of Internal Medicine, Department of Human Genetics, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:

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http://www.cell.com/ajhg/pdf/S0002-9297(16)30520-1.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S000292971630520
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http://dx.doi.org/10.1016/j.ajhg.2016.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223059PMC
January 2017

A Low Frequency of Losses in 11q Chromosome Is Associated with Better Outcome and Lower Rate of Genomic Mutations in Patients with Chronic Lymphocytic Leukemia.

Authors:
José Ángel Hernández María Hernández-Sánchez Ana Eugenia Rodríguez-Vicente Vera Grossmann Rosa Collado Cecilia Heras Anna Puiggros Ana África Martín Noemí Puig Rocío Benito Cristina Robledo Julio Delgado Teresa González José Antonio Queizán Josefina Galende Ignacio de la Fuente Guillermo Martín-Núñez José María Alonso Pau Abrisqueta Elisa Luño Isabel Marugán Isabel González-Gascón Francesc Bosch Alexander Kohlmann Marcos González Blanca Espinet Jesús María Hernández-Rivas

PLoS One 2015 2;10(11):e0143073. Epub 2015 Dec 2.

IBSAL, IBMCC, Centro de Investigación del Cáncer, Universidad de Salamanca,CSIC, Hospital Universitario de Salamanca, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143073PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667902PMC
June 2016

Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study.

Authors:
M Iris Hermanns Vera Grossmann Henri M H Spronk Andreas Schulz Claus Jünger Dagmar Laubert-Reh Johanna Mazur Tommaso Gori Tanja Zeller Norbert Pfeiffer Manfred Beutel Stefan Blankenberg Thomas Münzel Karl J Lackner Arina J Ten Cate-Hoek Hugo Ten Cate Philipp S Wild

Int J Cardiol 2015 21;187:166-74. Epub 2015 Mar 21.

Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, Germany; Preventive Cardiology and Preventive Medicine, Dept. of Medicine 2, University Medical Center of the Johannes Gutenberg-University Mainz, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Rhine-Main, Mainz, Germany.

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http://dx.doi.org/10.1016/j.ijcard.2015.03.330DOI Listing
February 2016

Sex-specific differences in genetic and nongenetic determinants of mean platelet volume: results from the Gutenberg Health Study.

Authors:
Marina Panova-Noeva Andreas Schulz M Iris Hermanns Vera Grossmann Evgenia Pefani Henri M H Spronk Dagmar Laubert-Reh Harald Binder Manfred Beutel Norbert Pfeiffer Stefan Blankenberg Tanja Zeller Thomas Münzel Karl J Lackner Hugo Ten Cate Philipp S Wild

Blood 2016 Jan 30;127(2):251-9. Epub 2015 Oct 30.

Center of Thrombosis and Hemostasis, Preventive Cardiology and Medical Prevention, Department of Medicine II, and DZHK, Partner Site Rhein-Main, Mainz, Germany; and.

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http://dx.doi.org/10.1182/blood-2015-07-660308DOI Listing
January 2016

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.

Authors:
Paul S de Vries Daniel I Chasman Maria Sabater-Lleal Ming-Huei Chen Jennifer E Huffman Maristella Steri Weihong Tang Alexander Teumer Riccardo E Marioni Vera Grossmann Jouke J Hottenga Stella Trompet Martina Müller-Nurasyid Jing Hua Zhao Jennifer A Brody Marcus E Kleber Xiuqing Guo Jie Jin Wang Paul L Auer John R Attia Lisa R Yanek Tarunveer S Ahluwalia Jari Lahti Cristina Venturini Toshiko Tanaka Lawrence F Bielak Peter K Joshi Ares Rocanin-Arjo Ivana Kolcic Pau Navarro Lynda M Rose Christopher Oldmeadow Helene Riess Johanna Mazur Saonli Basu Anuj Goel Qiong Yang Mohsen Ghanbari Gonneke Willemsen Ann Rumley Edoardo Fiorillo Anton J M de Craen Anne Grotevendt Robert Scott Kent D Taylor Graciela E Delgado Jie Yao Annette Kifley Charles Kooperberg Rehan Qayyum Lorna M Lopez Tina L Berentzen Katri Räikkönen Massimo Mangino Stefania Bandinelli Patricia A Peyser Sarah Wild David-Alexandre Trégouët Alan F Wright Jonathan Marten Tatijana Zemunik Alanna C Morrison Bengt Sennblad Geoffrey Tofler Moniek P M de Maat Eco J C de Geus Gordon D Lowe Magdalena Zoledziewska Naveed Sattar Harald Binder Uwe Völker Melanie Waldenberger Kay-Tee Khaw Barbara Mcknight Jie Huang Nancy S Jenny Elizabeth G Holliday Lihong Qi Mark G Mcevoy Diane M Becker John M Starr Antti-Pekka Sarin Pirro G Hysi Dena G Hernandez Min A Jhun Harry Campbell Anders Hamsten Fernando Rivadeneira Wendy L Mcardle P Eline Slagboom Tanja Zeller Wolfgang Koenig Bruce M Psaty Talin Haritunians Jingmin Liu Aarno Palotie André G Uitterlinden David J Stott Albert Hofman Oscar H Franco Ozren Polasek Igor Rudan Pierre-Emmanuel Morange James F Wilson Sharon L R Kardia Luigi Ferrucci Tim D Spector Johan G Eriksson Torben Hansen Ian J Deary Lewis C Becker Rodney J Scott Paul Mitchell Winfried März Nick J Wareham Annette Peters Andreas Greinacher Philipp S Wild J Wouter Jukema Dorret I Boomsma Caroline Hayward Francesco Cucca Russell Tracy Hugh Watkins Alex P Reiner Aaron R Folsom Paul M Ridker Christopher J O'Donnell Nicholas L Smith David P Strachan Abbas Dehghan

Hum Mol Genet 2016 Jan 10;25(2):358-70. Epub 2015 Nov 10.

Department of Epidemiology,

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http://hmg.oxfordjournals.org/content/early/2015/12/08/hmg.d
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http://www.hmg.oxfordjournals.org/lookup/doi/10.1093/hmg/ddv
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http://dx.doi.org/10.1093/hmg/ddv454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715256PMC
January 2016

BRCC3 mutations in myeloid neoplasms.

Authors:
Dayong Huang Yasunobu Nagata Vera Grossmann Tomas Radivoyevitch Yusuke Okuno Genta Nagae Naoko Hosono Susanne Schnittger Masashi Sanada Bartlomiej Przychodzen Ayana Kon Chantana Polprasert Wenyi Shen Michael J Clemente James G Phillips Tamara Alpermann Kenichi Yoshida Niroshan Nadarajah Mikkael A Sekeres Kevin Oakley Nhu Nguyen Yuichi Shiraishi Yusuke Shiozawa Kenichi Chiba Hiroko Tanaka H Phillip Koeffler Hans-Ulrich Klein Martin Dugas Hiroyuki Aburatani Satoru Miyano Claudia Haferlach Wolfgang Kern Torsten Haferlach Yang Du Seishi Ogawa Hideki Makishima

Haematologica 2015 Aug 22;100(8):1051-7. Epub 2015 May 22.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA Department of Pathology and Tumor Biology, Kyoto University, Japan

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http://dx.doi.org/10.3324/haematol.2014.111989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004421PMC
August 2015

Profile of the Immune and Inflammatory Response in Individuals With Prediabetes and Type 2 Diabetes.

Authors:
Vera Grossmann Volker H Schmitt Tanja Zeller Marina Panova-Noeva Andreas Schulz Dagmar Laubert-Reh Claus Juenger Renate B Schnabel Tobias G J Abt Rafael Laskowski Jörg Wiltink Eberhard Schulz Stefan Blankenberg Karl J Lackner Thomas Münzel Philipp S Wild

Diabetes Care 2015 Jul 15;38(7):1356-64. Epub 2015 Apr 15.

Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany Preventive Cardiology and Preventive Medicine, Department of Medicine 2, University Medical Center Mainz, Mainz, Germany German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc14-300
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http://dx.doi.org/10.2337/dc14-3008DOI Listing
July 2015

Rationale and design of three observational, prospective cohort studies including biobanking to evaluate and improve diagnostics, management strategies and risk stratification in venous thromboembolism: the VTEval Project.

Authors:
Bernd Frank Liana Ariza Heidrun Lamparter Vera Grossmann Jürgen H Prochaska Alexander Ullmann Florentina Kindler Gerhard Weisser Ulrich Walter Karl J Lackner Christine Espinola-Klein Thomas Münzel Stavros V Konstantinides Philipp S Wild

BMJ Open 2015 Jul 1;5(7):e008157. Epub 2015 Jul 1.

Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany Preventive Cardiology and Preventive Medicine, Department of Medicine 2, University Medical Center Mainz, Mainz, Germany German Center for Cardiovascular Research (DZHK), partner site RhineMain, Mainz, Germany.

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http://dx.doi.org/10.1136/bmjopen-2015-008157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499722PMC
July 2015

Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome.

Authors:
Vikas Madan Deepika Kanojia Jia Li Ryoko Okamoto Aiko Sato-Otsubo Alexander Kohlmann Masashi Sanada Vera Grossmann Janani Sundaresan Yuichi Shiraishi Satoru Miyano Felicitas Thol Arnold Ganser Henry Yang Torsten Haferlach Seishi Ogawa H Phillip Koeffler

Nat Commun 2015 Jan 14;6:6042. Epub 2015 Jan 14.

1] Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, 12-01, Singapore 117599, Singapore [2] Cedars-Sinai Medical Center, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, California 90048, USA [3] National University Cancer Institute, National University Hospital Singapore, Singapore 119228, Singapore.

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http://www.nature.com/articles/ncomms7042
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http://dx.doi.org/10.1038/ncomms7042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349895PMC
January 2015

Investigation of 305 patients with myelodysplastic syndromes and 20q deletion for associated cytogenetic and molecular genetic lesions and their prognostic impact.

Authors:
Ulrike Bacher Torsten Haferlach Susanne Schnittger Melanie Zenger Manja Meggendorfer Sabine Jeromin Andreas Roller Vera Grossmann Maria-Theresa Krauth Tamara Alpermann Wolfgang Kern Claudia Haferlach

Br J Haematol 2014 Mar 26;164(6):822-33. Epub 2013 Dec 26.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1111/bjh.12710DOI Listing
March 2014

Comprehensive mutational profiling in advanced systemic mastocytosis.

Authors:
Juliana Schwaab Susanne Schnittger Karl Sotlar Christoph Walz Alice Fabarius Markus Pfirrmann Alexander Kohlmann Vera Grossmann Manja Meggendorfer Hans-Peter Horny Peter Valent Mohamad Jawhar Martina Teichmann Georgia Metzgeroth Philipp Erben Thomas Ernst Andreas Hochhaus Torsten Haferlach Wolf-Karsten Hofmann Nicholas C P Cross Andreas Reiter

Blood 2013 Oct 19;122(14):2460-6. Epub 2013 Aug 19.

III. Medizinische Klinik, Hämatologie und Onkologie, Universitätsmedizin Mannheim, Mannheim, Germany;

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http://dx.doi.org/10.1182/blood-2013-04-496448DOI Listing
October 2013

EZH2 mutations are frequent and represent an early event in follicular lymphoma.

Authors:
Csaba Bödör Vera Grossmann Nikolay Popov Jessica Okosun Ciarán O'Riain King Tan Jacek Marzec Shamzah Araf Jun Wang Abigail M Lee Andrew Clear Silvia Montoto Janet Matthews Sameena Iqbal Hajnalka Rajnai Andreas Rosenwald German Ott Elias Campo Lisa M Rimsza Erlend B Smeland Wing C Chan Rita M Braziel Louis M Staudt George Wright T Andrew Lister Olivier Elemento Robert Hills John G Gribben Claude Chelala András Matolcsy Alexander Kohlmann Torsten Haferlach Randy D Gascoyne Jude Fitzgibbon

Blood 2013 Oct 19;122(18):3165-8. Epub 2013 Sep 19.

Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, United Kingdom;

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http://dx.doi.org/10.1182/blood-2013-04-496893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814734PMC
October 2013

Frequency and prognostic impact of CEBPA proximal, distal and core promoter methylation in normal karyotype AML: a study on 623 cases.

Authors:
Annette Fasan Tamara Alpermann Claudia Haferlach Vera Grossmann Andreas Roller Alexander Kohlmann Christiane Eder Wolfgang Kern Torsten Haferlach Susanne Schnittger

PLoS One 2013 1;8(2):e54365. Epub 2013 Feb 1.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054365PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562230PMC
July 2013

Robustness of amplicon deep sequencing underlines its utility in clinical applications.

Authors:
Vera Grossmann Andreas Roller Hans-Ulrich Klein Sandra Weissmann Wolfgang Kern Claudia Haferlach Martin Dugas Torsten Haferlach Susanne Schnittger Alexander Kohlmann

J Mol Diagn 2013 Jul 14;15(4):473-84. Epub 2013 May 14.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1016/j.jmoldx.2013.03.003DOI Listing
July 2013

CEBPA double-mutated acute myeloid leukaemia harbours concomitant molecular mutations in 76·8% of cases with TET2 and GATA2 alterations impacting prognosis.

Authors:
Vera Grossmann Claudia Haferlach Niroshan Nadarajah Annette Fasan Sandra Weissmann Andreas Roller Christiane Eder Elisa Stopp Wolfgang Kern Torsten Haferlach Alexander Kohlmann Susanne Schnittger

Br J Haematol 2013 Jun 25;161(5):649-58. Epub 2013 Mar 25.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1111/bjh.12297DOI Listing
June 2013

The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL.

Authors:
Vera Grossmann Claudia Haferlach Sandra Weissmann Andreas Roller Sonja Schindela Franziska Poetzinger Kathrin Stadler Frauke Bellos Wolfgang Kern Torsten Haferlach Susanne Schnittger Alexander Kohlmann

Genes Chromosomes Cancer 2013 Apr 23;52(4):410-22. Epub 2013 Jan 23.

MLL Munich Leukemia Laboratory, Max-Lebsche-Platz 31, 81377 Munich, Germany.

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http://dx.doi.org/10.1002/gcc.22039DOI Listing
April 2013

Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements.

Authors:
Andrew Chase Catherine Bryant Joannah Score Claudia Haferlach Vera Grossmann Juliana Schwaab Wolf-Karsten Hofmann Andreas Reiter Nicholas C P Cross

Haematologica 2013 Mar 8;98(3):404-8. Epub 2012 Aug 8.

Faculty of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.3324/haematol.2012.067959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659945PMC
March 2013

Next-generation sequencing - feasibility and practicality in haematology.

Authors:
Alexander Kohlmann Vera Grossmann Niroshan Nadarajah Torsten Haferlach

Br J Haematol 2013 Mar 7;160(6):736-53. Epub 2013 Jan 7.

MLL Munich Leukaemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1111/bjh.12194DOI Listing
March 2013

High frequencies of SF3B1 and JAK2 mutations in refractory anemia with ring sideroblasts associated with marked thrombocytosis strengthen the assignment to the category of myelodysplastic/myeloproliferative neoplasms.

Authors:
Sabine Jeromin Torsten Haferlach Vera Grossmann Tamara Alpermann Andreas Kowarsch Claudia Haferlach Wolfgang Kern Susanne Schnittger

Haematologica 2013 Feb 28;98(2):e15-7. Epub 2012 Aug 28.

MLL Munich Leukemia Laboratory, Germany.

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http://dx.doi.org/10.3324/haematol.2012.072538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561444PMC
February 2013

Use of CBL exon 8 and 9 mutations in diagnosis of myeloproliferative neoplasms and myelodysplastic/myeloproliferative disorders: an analysis of 636 cases.

Authors:
Susanne Schnittger Ulrike Bacher Tamara Alpermann Andreas Reiter Madlen Ulke Frank Dicker Christiane Eder Alexander Kohlmann Vera Grossmann Andreas Kowarsch Wolfgang Kern Claudia Haferlach Torsten Haferlach

Haematologica 2012 Dec 24;97(12):1890-4. Epub 2012 Jun 24.

MLL Munich Leukemia Laboratory, Max-Lebsche-Platz 31, 81377 Munich, Germany.

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http://dx.doi.org/10.3324/haematol.2012.065375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685285PMC
December 2012

Three novel cytogenetically cryptic EVI1 rearrangements associated with increased EVI1 expression and poor prognosis identified in 27 acute myeloid leukemia cases.

Authors:
Claudia Haferlach Ulrike Bacher Vera Grossmann Sonja Schindela Melanie Zenger Alexander Kohlmann Wolfgang Kern Torsten Haferlach Susanne Schnittger

Genes Chromosomes Cancer 2012 Dec 8;51(12):1079-85. Epub 2012 Aug 8.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1002/gcc.21992DOI Listing
December 2012

Molecular analyses of 15,542 patients with suspected BCR-ABL1-negative myeloproliferative disorders allow to develop a stepwise diagnostic workflow.

Authors:
Susanne Schnittger Ulrike Bacher Christiane Eder Frank Dicker Tamara Alpermann Vera Grossmann Alexander Kohlmann Wolfgang Kern Claudia Haferlach Torsten Haferlach

Haematologica 2012 Oct 17;97(10):1582-5. Epub 2012 Apr 17.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.3324/haematol.2012.064683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487560PMC
October 2012

A novel hierarchical prognostic model of AML solely based on molecular mutations.

Authors:
Vera Grossmann Susanne Schnittger Alexander Kohlmann Christiane Eder Andreas Roller Frank Dicker Christoph Schmid Clemens-Martin Wendtner Peter Staib Hubert Serve Karl-Anton Kreuzer Wolfgang Kern Torsten Haferlach Claudia Haferlach

Blood 2012 Oct 20;120(15):2963-72. Epub 2012 Aug 20.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1182/blood-2012-03-419622DOI Listing
October 2012

SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML).

Authors:
Manja Meggendorfer Andreas Roller Torsten Haferlach Christiane Eder Frank Dicker Vera Grossmann Alexander Kohlmann Tamara Alpermann Kenichi Yoshida Seishi Ogawa H Phillip Koeffler Wolfgang Kern Claudia Haferlach Susanne Schnittger

Blood 2012 Oct 23;120(15):3080-8. Epub 2012 Aug 23.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-01-40
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http://dx.doi.org/10.1182/blood-2012-01-404863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580040PMC
October 2012

EZH2 mutations and their association with PICALM-MLLT10 positive acute leukaemia.

Authors:
Vera Grossmann Ulrike Bacher Alexander Kohlmann Valentina Artusi Hans-Ulrich Klein Martin Dugas Susanne Schnittger Tamara Alpermann Wolfgang Kern Torsten Haferlach Claudia Haferlach

Br J Haematol 2012 May 12;157(3):387-90. Epub 2012 Jan 12.

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http://doi.wiley.com/10.1111/j.1365-2141.2011.08986.x
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http://dx.doi.org/10.1111/j.1365-2141.2011.08986.xDOI Listing
May 2012

Multilineage dysplasia does not influence prognosis in CEBPA-mutated AML, supporting the WHO proposal to classify these patients as a unique entity.

Authors:
Ulrike Bacher Susanne Schnittger Katja Macijewski Vera Grossmann Alexander Kohlmann Tamara Alpermann Andreas Kowarsch Niroshan Nadarajah Wolfgang Kern Claudia Haferlach Torsten Haferlach

Blood 2012 May 22;119(20):4719-22. Epub 2012 Mar 22.

Department for Stem Cell Transplantation, University of Hamburg, Germany.

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http://dx.doi.org/10.1182/blood-2011-12-395574DOI Listing
May 2012

Development and validation of a real-time quantification assay to detect and monitor BRAFV600E mutations in hairy cell leukemia.

Authors:
Susanne Schnittger Ulrike Bacher Torsten Haferlach Nicole Wendland Madlen Ulke Frank Dicker Vera Grossmann Claudia Haferlach Wolfgang Kern

Blood 2012 Mar 13;119(13):3151-4. Epub 2012 Feb 13.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1182/blood-2011-10-383323DOI Listing
March 2012

Integration of next-generation sequencing into clinical practice: are we there yet?

Authors:
Alexander Kohlmann Vera Grossmann Torsten Haferlach

Semin Oncol 2012 Feb;39(1):26-36

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1053/j.seminoncol.2011.11.008DOI Listing
February 2012

The corepressors BCOR and BCORL1: two novel players in acute myeloid leukemia.

Authors:
Enrico Tiacci Vera Grossmann Maria Paola Martelli Alexander Kohlmann Torsten Haferlach Brunangelo Falini

Haematologica 2012 Jan;97(1):3-5

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http://dx.doi.org/10.3324/haematol.2011.057901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248923PMC
January 2012

Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia.

Authors:
Vera Grossmann Wolfgang Kern Stefan Harbich Tamara Alpermann Sabine Jeromin Susanne Schnittger Claudia Haferlach Torsten Haferlach Alexander Kohlmann

Haematologica 2011 Dec 9;96(12):1874-7. Epub 2011 Aug 9.

MLL Munich Leukemia Laboratory, Max-Lebsche-Platz 31, 81377 Munich, Germany.

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http://dx.doi.org/10.3324/haematol.2011.043919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232273PMC
December 2011

Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype.

Authors:
Vera Grossmann Enrico Tiacci Antony B Holmes Alexander Kohlmann Maria Paola Martelli Wolfgang Kern Ariele Spanhol-Rosseto Hans-Ulrich Klein Martin Dugas Sonja Schindela Vladimir Trifonov Susanne Schnittger Claudia Haferlach Renato Bassan Victoria A Wells Orietta Spinelli Joseph Chan Roberta Rossi Stefano Baldoni Luca De Carolis Katharina Goetze Hubert Serve Rudolf Peceny Karl-Anton Kreuzer Daniel Oruzio Giorgina Specchia Francesco Di Raimondo Francesco Fabbiano Marco Sborgia Arcangelo Liso Laurent Farinelli Alessandro Rambaldi Laura Pasqualucci Raul Rabadan Torsten Haferlach Brunangelo Falini

Blood 2011 Dec 19;118(23):6153-63. Epub 2011 Oct 19.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-07-36
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http://dx.doi.org/10.1182/blood-2011-07-365320DOI Listing
December 2011

R453Plus1Toolbox: an R/Bioconductor package for analyzing Roche 454 Sequencing data.

Authors:
Hans-Ulrich Klein Christoph Bartenhagen Alexander Kohlmann Vera Grossmann Christian Ruckert Torsten Haferlach Martin Dugas

Bioinformatics 2011 Apr 23;27(8):1162-3. Epub 2011 Feb 23.

Department of Medical Informatics and Biomathematics, University of Münster, Münster and Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btr102DOI Listing
April 2011

Strategy for robust detection of insertions, deletions, and point mutations in CEBPA, a GC-rich content gene, using 454 next-generation deep-sequencing technology.

Authors:
Vera Grossmann Susanne Schnittger Sonja Schindela Hans-Ulrich Klein Christiane Eder Martin Dugas Wolfgang Kern Torsten Haferlach Claudia Haferlach Alexander Kohlmann

J Mol Diagn 2011 Mar;13(2):129-36

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1016/j.jmoldx.2010.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128616PMC
March 2011

Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8% of chronic myelomonocytic leukemia by detecting frequent alterations in TET2, CBL, RAS, and RUNX1.

Authors:
Alexander Kohlmann Vera Grossmann Hans-Ulrich Klein Sonja Schindela Tamara Weiss Beray Kazak Frank Dicker Susanne Schnittger Martin Dugas Wolfgang Kern Claudia Haferlach Torsten Haferlach

J Clin Oncol 2010 Aug 19;28(24):3858-65. Epub 2010 Jul 19.

MLL Munich Leukemia Laboratory, München, Germany.

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http://dx.doi.org/10.1200/JCO.2009.27.1361DOI Listing
August 2010

"Essentially" pure trisomy 3q27 --> qter: further delineation of the partial trisomy 3q phenotype.

Authors:
Vera Grossmann Doris Müller Wilfried Müller Friedrich Fresser Martin Erdel Andreas R Janecke Johannes Zschocke Gerd Utermann Dieter Kotzot

Am J Med Genet A 2009 Nov;149A(11):2522-6

Department of Medical Genetics, Molecular and Clinical Pharmacology, Division of Clinical Genetics, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1002/ajmg.a.33058DOI Listing
November 2009