Publications by authors named "Venhar Ceyhan"

3 Publications

  • Page 1 of 1

The Effect of Betamethasone Dosing Interval on Perinatal Outcomes: 12 Hours or 24 Hours Apart.

Am J Perinatol 2021 Sep 20. Epub 2021 Sep 20.

Department of Obstetrics and Gynecology, Istanbul Medipol University, Istanbul, Turkey.

Objective:  Antenatal steroids are commonly used to stimulate fetal lung maturation, particularly in pregnancies at risk of early preterm labor. This study aimed to compare the effects of administering betamethasone at a 12- versus 24-hour interval on perinatal outcomes.

Study Design:  This retrospective study included 423 early preterm births from 26 to 33 weeks of gestation. Patients received betamethasone at either a 12- or 24-hour dosing interval.

Results:  When all patients in each group were evaluated together, there was no statistically significant difference between both groups for complications of prematurity, including respiratory distress syndrome (RDS). When the two groups were divided by gestational age (GA), the 32 to 33-week group that received betamethasone at a 24-hour interval had statistically lower 1- and 5-minute APGAR scores ( = 0.06 and  = 0.02, respectively). They also had a greater need for neonatal intensive care unit (NICU), NICU length of stay, RDS, and need for surfactant ( = 0.20,  = 0.09,  = 0.27, and  = 0.23, respectively) than did the infants at 32 to 33 weeks, who received betamethasone at a 12-hour interval. In the group with GA between 28 and 29 weeks, the 1-minute APGAR score was lower ( = 0.22), and the durations of hospital stay, and mechanical ventilation were longer ( = 0.048,  = 0.21, respectively) in the 24-hour interval group. No statistically significant difference was observed for all parameters in other GA groups.

Conclusion:  A 12-hour dosing interval for betamethasone appears to be more appropriate, as it results in a reduction in some neonatal complications and provides a short dose interval.

Key Points: · RDS is reduced when betamethasone is used 12 hours apart.. · When betamethasone is used 12 hours apart, the need for surfactant is reduced.. · The use of betamethasone 12 hours apart is advantageous with its short dose interval..
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http://dx.doi.org/10.1055/s-0041-1735962DOI Listing
September 2021

Exercise and outcomes in macrosomic pregnancies.

J Matern Fetal Neonatal Med 2021 Dec 11;34(23):3958-3962. Epub 2021 Apr 11.

Department of Obstetrics and Gynecology, Erciyes University, Faculty of Medicine, Kayseri, Turkey.

Objective: Pregnancy is generally known to be a period when physical activity is partially or totally restricted to avoid negative outcomes such as miscarriage or premature birth. The aim of this study was to evaluate the effect on maternal and fetal outcomes of exercise in pregnancies complicated by macrosomia.

Material And Method: In this retrospective study, the data were retrospectively screened of women who gave birth at ≥38 weeks with infant birthweight of ≥4000 gr. The patients were separated into two groups as those who followed an exercise program of walking regularly for 30-60 mins at least 1 day a week throughout pregnancy and those who did not. The maternal and fetal complications were compared between the groups. A total of 252 patients were included in the study as 84 women who exercised during pregnancy and 168 women selected at random in the ratio of 2:1 who did not exercise.

Results: When the gestational week at birth was examined, a statistically significantly higher rate of patients in the non-exercise group gave birth at ≥40 gestational weeks. Although not at a statistically significant level, maternal and fetal complications were observed more in the non-exercise group.

Conclusions: The results of this study showed that excessive maternal weight gain was statistically significantly reduced, and although not at a statistically significant level, maternal and fetal trauma were reduced in macrosomic pregnancies with regular exercise. As recommended by ACOG, for pregnant women at risk of macrosomic fetus, exercise of walking for 30-60 mins several days a week will have positive effects on both the mother and infant.
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http://dx.doi.org/10.1080/14767058.2021.1875447DOI Listing
December 2021

Evaluation of the labour process with serial transperineal ultrasonography and prediction of the type of birth.

J Perinat Med 2020 Sep 7;49(1):36-42. Epub 2020 Sep 7.

Department of Obstetrics and Gynecology, Kayseri City Training and Research Hospital, Kayseri, Turkey.

Objectives: The purpose of this study is to follow the birth process with transperineal ultrasonography (TPU) and predict the delivery method using angle of progression (AOP).

Methods: The study included 134 patients. The AOP was examined with TPU in the lithotomy position applied at 4-h intervals, not at a time of straining or contractions. The relationship was examined between AOP and those who continued with vaginal delivery, and those who underwent caesarean section delivery.

Results: A total of 122 (91%) patients had vaginal delivery and 12 (9%) patients had cesarean delivery. In patients giving vaginal delivery, progress in AOP was observed in every 4-h measurement, but not in patients with cesarean section. In the ROC analysis, if 70% sensitivity and 75% specificity with AOP degree >132.5°, the patient was expected to have vaginal delivery with a probability of 77.5% (95% CI 0.62-0.93; p=0.002).

Conclusions: Rather than repeating digital examinations, the labour process can be monitored with serial TPU and the type of delivery can be predicted. There is a need for further studies for the measurement of AOP with TPU to become a part of clinical practice in the monitoring of the whole labour process.
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http://dx.doi.org/10.1515/jpm-2020-0323DOI Listing
September 2020
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