Vassilis Aidinis

Vassilis Aidinis

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Vassilis Aidinis

Vassilis Aidinis

Publications by authors named "Vassilis Aidinis"

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56Publications

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Synthesis of novel 2-pyrrolidinone and pyrrolidine derivatives and study of their inhibitory activity against autotaxin enzyme.

Bioorg Med Chem 2020 Jan 9;28(2):115216. Epub 2019 Dec 9.

Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens 15771, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.115216DOI Listing
January 2020

Autotaxin and chronic inflammatory diseases.

J Autoimmun 2019 Nov 28;104:102327. Epub 2019 Aug 28.

Biomedical Sciences Research Center Alexander Fleming, 16672, Athens, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2019.102327DOI Listing
November 2019

Role of dual-specificity protein phosphatase DUSP10/MKP-5 in pulmonary fibrosis.

Am J Physiol Lung Cell Mol Physiol 2019 11 4;317(5):L678-L689. Epub 2019 Sep 4.

Department of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1152/ajplung.00264.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879900PMC
November 2019

Orotracheal treprostinil administration attenuates bleomycin-induced lung injury, vascular remodeling, and fibrosis in mice.

Pulm Circ 2019 Oct-Dec;9(4):2045894019881954. Epub 2019 Nov 15.

GP Livanos and M Simou Laboratories,1st Department of Critical Care & Pulmonary Services, Medical School, National & Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece.

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http://dx.doi.org/10.1177/2045894019881954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883672PMC
November 2019

Deregulated Lysophosphatidic Acid Metabolism and Signaling in Liver Cancer.

Cancers (Basel) 2019 Oct 23;11(11). Epub 2019 Oct 23.

Biomedical Sciences Research Center "Alexander Fleming", 16672 Athens, Greece.

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http://dx.doi.org/10.3390/cancers11111626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893780PMC
October 2019

Development and therapeutic potential of autotaxin small molecule inhibitors: From bench to advanced clinical trials.

Med Res Rev 2019 05 21;39(3):976-1013. Epub 2018 Nov 21.

Division of Immunology, Biomedical Sciences Research Center "Alexander Fleming", Athens, Greece.

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http://dx.doi.org/10.1002/med.21551DOI Listing
May 2019

Vitamin D prevents experimental lung fibrosis and predicts survival in patients with idiopathic pulmonary fibrosis.

Pulm Pharmacol Ther 2019 04 16;55:17-24. Epub 2019 Jan 16.

1st Academic Department of Respiratory Medicine, Medical School, National and Kapodistrian University of Athens, Hospital for Diseases of the Chest, "Sotiria", Athens, Greece; Biomedical Sciences Research Center, "Alexander Fleming", Division of Immunology, Athens, Greece. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10945539183023
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http://dx.doi.org/10.1016/j.pupt.2019.01.003DOI Listing
April 2019

Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism.

J Lipid Res 2018 10 2;59(10):1805-1817. Epub 2018 Aug 2.

Dalhousie Medicine New Brunswick, Department of Biochemistry and Molecular Biology, Dalhousie University, Saint John, New Brunswick E2L 4L5, Canada

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http://dx.doi.org/10.1194/jlr.M082008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168304PMC
October 2018

Pharmacologic targeting of the ATX/LPA axis attenuates bleomycin-induced pulmonary fibrosis.

Pulm Pharmacol Ther 2018 10 7;52:32-40. Epub 2018 Sep 7.

Division of Immunology, Biomedical Sciences Research Center Alexander Fleming, Athens, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.pupt.2018.08.003DOI Listing
October 2018

Bleomycin Revisited: A Direct Comparison of the Intratracheal Micro-Spraying and the Oropharyngeal Aspiration Routes of Bleomycin Administration in Mice.

Front Med (Lausanne) 2018 24;5:269. Epub 2018 Sep 24.

Division of Immunology, Biomedical Sciences Research Center Alexander Fleming, Athens, Greece.

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http://dx.doi.org/10.3389/fmed.2018.00269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165886PMC
September 2018

Autotaxin in Pathophysiology and Pulmonary Fibrosis.

Front Med (Lausanne) 2018 13;5:180. Epub 2018 Jun 13.

Division of Immunology, Alexander Fleming Biomedical Sciences Research Center, Athens, Greece.

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http://dx.doi.org/10.3389/fmed.2018.00180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008954PMC
June 2018

Hydroxamic Acids Constitute a Novel Class of Autotaxin Inhibitors that Exhibit in Vivo Efficacy in a Pulmonary Fibrosis Model.

J Med Chem 2018 04 18;61(8):3697-3711. Epub 2018 Apr 18.

Laboratory of Organic Chemistry, Department of Chemistry , National and Kapodistrian University of Athens , Panepistimiopolis , Athens 15771 , Greece.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00232DOI Listing
April 2018

Exploring Animal Models That Resemble Idiopathic Pulmonary Fibrosis.

Front Med (Lausanne) 2017 28;4:118. Epub 2017 Jul 28.

Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, United States.

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http://dx.doi.org/10.3389/fmed.2017.00118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532376PMC
July 2017

Biomarkers in Idiopathic Pulmonary Fibrosis: A RAGE-ing Bull in the Arena.

Ann Am Thorac Soc 2017 05;14(5):613-614

1 Division of Immunology, Biomedical Sciences Research Center "Alexander Fleming"; and.

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http://dx.doi.org/10.1513/AnnalsATS.201701-024EDDOI Listing
May 2017

Extracellular matrix remodeling in idiopathic pulmonary fibrosis. It is the 'bed' that counts and not 'the sleepers'.

Expert Rev Respir Med 2017 04 8;11(4):299-309. Epub 2017 Mar 8.

a Respiratory Medicine Department , 'Attikon' University Hospital, Athens Medical School, National and Kapodistrian University of Athens , Athens , Greece.

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http://dx.doi.org/10.1080/17476348.2017.1300533DOI Listing
April 2017

Diagnostic and prognostic challenges in Idiopathic Pulmonary Fibrosis: A patient's "Q and A" approach.

Pulm Pharmacol Ther 2017 02 12;42:21-24. Epub 2016 Dec 12.

First Academic Department of Pneumonology, Hospital for Diseases of the Chest, "Sotiria", Medical School, National and Kapodistrian University of Athens, Greece.

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http://dx.doi.org/10.1016/j.pupt.2016.12.002DOI Listing
February 2017

Autotaxin and Endotoxin-Induced Acute Lung Injury.

PLoS One 2015 21;10(7):e0133619. Epub 2015 Jul 21.

Division of Immunology, Biomedical Sciences Research Center "Alexander Fleming", Athens, Greece.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133619PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509763PMC
May 2016

Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer.

Prog Lipid Res 2015 Apr 20;58:76-96. Epub 2015 Feb 20.

Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Athens 15771, Greece.

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http://dx.doi.org/10.1016/j.plipres.2015.02.001DOI Listing
April 2015

Lysoglycerophospholipids in chronic inflammatory disorders: the PLA(2)/LPC and ATX/LPA axes.

Biochim Biophys Acta 2013 Jan 31;1831(1):42-60. Epub 2012 Jul 31.

Institute of Immunology, Biomedical Sciences Research Center, Athens, Greece.

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http://dx.doi.org/10.1016/j.bbalip.2012.07.019DOI Listing
January 2013

Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis.

Am J Respir Cell Mol Biol 2012 Nov 28;47(5):566-74. Epub 2012 Jun 28.

Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Athens, Greece.

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http://dx.doi.org/10.1165/rcmb.2012-0004OCDOI Listing
November 2012

CreZOO--the European virtual repository of Cre and other targeted conditional driver strains.

Database (Oxford) 2012 21;2012:bas029. Epub 2012 Jun 21.

Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, 34 Fleming Street, 16672 Athens, Greece.

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http://dx.doi.org/10.1093/database/bas029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381224PMC
September 2012

Modeling pulmonary fibrosis with bleomycin.

Curr Opin Pulm Med 2011 Sep;17(5):355-61

Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Athens, Greece.

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https://insights.ovid.com/crossref?an=00063198-201109000-000
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http://dx.doi.org/10.1097/MCP.0b013e328349ac2bDOI Listing
September 2011

Research funding. Sustaining the data and bioresource commons.

Science 2010 Oct;330(6004):592-3

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.

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http://dx.doi.org/10.1126/science.1191506DOI Listing
October 2010

The pattern of inflammatory/anti-inflammatory cytokines and chemokines in type 1 diabetic patients over time.

Ann Med 2010 Sep;42(6):426-38

Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, GR-11527, Athens, Greece.

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http://dx.doi.org/10.3109/07853890.2010.495951DOI Listing
September 2010

Mouse Resource Browser--a database of mouse databases.

Database (Oxford) 2010 Jul 6;2010:baq010. Epub 2010 Jul 6.

Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, 34 Fleming Street, 16672 Athens, Greece.

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http://dx.doi.org/10.1093/database/baq010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911845PMC
July 2010

Toll-like receptor 7-triggered immune response in the lung mediates acute and long-lasting suppression of experimental asthma.

Am J Respir Crit Care Med 2010 Jun 11;181(11):1207-16. Epub 2010 Mar 11.

Center for Immunology and Transplantation, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.

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http://dx.doi.org/10.1164/rccm.200908-1255OCDOI Listing
June 2010

ATX expression and LPA signalling are vital for the development of the nervous system.

Dev Biol 2010 Mar 15;339(2):451-64. Epub 2010 Jan 15.

Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, 16672 Athens, Greece.

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http://dx.doi.org/10.1016/j.ydbio.2010.01.007DOI Listing
March 2010

A critical role for gelsolin in ventilator-induced lung injury.

Am J Respir Cell Mol Biol 2009 Oct 6;41(4):426-32. Epub 2009 Feb 6.

Marianthi Simou Lab, Evaggelismos Hospital, University of Athens Medical School, Athens, Greece.

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http://dx.doi.org/10.1165/rcmb.2008-0144OCDOI Listing
October 2009

Models for financial sustainability of biological databases and resources.

Database (Oxford) 2009 23;2009:bap017. Epub 2009 Oct 23.

Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, 34 Fleming Street, 16672 Athens, Greece, MRC Mary Lyon Centre, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, European Bioinformatics Institute, EMBL, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK, Experimental Mouse Genetics, Helmholtz Centre for Infection Research & University of Veterinary Medicine, Hannover, Inhoffenstrabe 7, D-38124 Braunschweig, Germany, EMBL-Monterotondo Outstation, Via Ramarini 32, 00015 Monterotondo-Scalo (RM), Italy, Bioinformatics Group, MRC Harwell, Harwell, Oxfordshire, OX11 0RD and Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK.

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http://dx.doi.org/10.1093/database/bap017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790311PMC
October 2009

Global impairment of CD4+CD25+FOXP3+ regulatory T cells in idiopathic pulmonary fibrosis.

Am J Respir Crit Care Med 2009 Jun 2;179(12):1121-30. Epub 2009 Apr 2.

Department of Hematology, Democritus University of Thrace, Medical School Dragana, Alexandroupolis, Greece.

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http://dx.doi.org/10.1164/rccm.200812-1936OCDOI Listing
June 2009

Comparative expression profiling in pulmonary fibrosis suggests a role of hypoxia-inducible factor-1alpha in disease pathogenesis.

Am J Respir Crit Care Med 2007 Dec 29;176(11):1108-19. Epub 2007 Aug 29.

Department of Pneumonology, Medical School, Democritus University of Thrace, and University Hospital of Alexandroupolis, Alexandroupolis, Greece.

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http://dx.doi.org/10.1164/rccm.200705-683OCDOI Listing
December 2007

Functional analysis of an arthritogenic synovial fibroblast.

Arthritis Res Ther 2003 14;5(3):R140-57. Epub 2003 Mar 14.

Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Athens, Greece.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165045PMC
http://dx.doi.org/10.1186/ar749DOI Listing
August 2003