Vasily Gelfanov

Vasily Gelfanov

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Vasily Gelfanov

Vasily Gelfanov

Publications by authors named "Vasily Gelfanov"

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36Publications

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A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity.

ACS Chem Biol 2019 Aug 6;14(8):1829-1835. Epub 2019 Aug 6.

Novo Nordisk Research Center , Indianapolis , Indiana 46241 , United States.

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http://dx.doi.org/10.1021/acschembio.9b00420DOI Listing
August 2019

Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice.

Peptides 2019 Jul 23;120:170116. Epub 2019 Jul 23.

Novo Nordisk Research Center, Indianapolis, IN, 46241, USA.

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http://dx.doi.org/10.1016/j.peptides.2019.170116DOI Listing
July 2019

The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis.

Am J Physiol Endocrinol Metab 2019 Mar 8;316(3):E397-E409. Epub 2019 Jan 8.

Comprehensive Diabetes Center and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham , Birmingham, Alabama.

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http://dx.doi.org/10.1152/ajpendo.00235.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415717PMC
March 2019

Structurally Constrained Insulin Analogs by Directed Stepwise Crosslinking.

Protein Pept Lett 2018 ;25(12):1149-1154

Department of Chemistry, Indiana University, Bloomington, IN 47405, United States.

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http://dx.doi.org/10.2174/0929866525666181101103500DOI Listing
February 2019

Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism.

Mol Metab 2019 02 5;20:51-62. Epub 2018 Dec 5.

Department of Internal Medicine, University of Cincinnati-College of Medicine, Cincinnati, OH, 45267, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778183110
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http://dx.doi.org/10.1016/j.molmet.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358549PMC
February 2019

Optimization of peptide-based polyagonists for treatment of diabetes and obesity.

Bioorg Med Chem 2018 06 2;26(10):2873-2881. Epub 2017 Nov 2.

Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA; Department of Chemistry, Indiana University, Bloomington, IN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.10.047DOI Listing
June 2018

High-Yield Synthesis of Human Insulin-Like Peptide 5 Employing a Nonconventional Strategy.

Org Lett 2018 06 6;20(12):3695-3699. Epub 2018 Jun 6.

Novo Nordisk Research Center Indianapolis , Indianapolis , Indiana 46241 , United States.

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http://dx.doi.org/10.1021/acs.orglett.8b01501DOI Listing
June 2018

Synthesis and Characterization of the R27S Genetic Variant of Insulin-like Peptide 5.

ChemMedChem 2018 04 23;13(8):852-859. Epub 2018 Mar 23.

Novo Nordisk Research Center Indianapolis, 5225 Exploration Drive, Indianapolis, IN, 46241, USA.

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http://dx.doi.org/10.1002/cmdc.201800057DOI Listing
April 2018

Controlled intramolecular antagonism as a regulator of insulin receptor maximal activity.

Peptides 2018 02;100:18-23

Department of Chemistry, Indiana University, Bloomington, IN, 47405, United States; Novo Nordisk Research Center Indianapolis, Indianapolis, Indiana, 46241, United States. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2017.11.022DOI Listing
February 2018

Max Bergmann award lecture:Macromolecular medicinal chemistry as applied to metabolic diseases.

J Pept Sci 2018 Jan;24(1)

Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1002/psc.3056DOI Listing
January 2018

Synthetic Advances in Insulin-like Peptides Enable Novel Bioactivity.

Acc Chem Res 2017 08 3;50(8):1855-1865. Epub 2017 Aug 3.

Novo Nordisk Research Center Indianapolis , Indianapolis, Indiana 46241, United States.

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http://dx.doi.org/10.1021/acs.accounts.7b00227DOI Listing
August 2017

Synthesis of relaxin-2 and insulin-like peptide 5 enabled by novel tethering and traceless chemical excision.

J Pept Sci 2017 Jun 3;23(6):455-465. Epub 2017 May 3.

Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA.

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http://doi.wiley.com/10.1002/psc.3010
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http://dx.doi.org/10.1002/psc.3010DOI Listing
June 2017

Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation.

J Org Chem 2017 04 27;82(7):3506-3512. Epub 2017 Mar 27.

Department of Chemistry, Indiana University , Bloomington, Indiana 47405, United States.

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http://dx.doi.org/10.1021/acs.joc.6b03078DOI Listing
April 2017

Biomimetic Synthesis of Insulin Enabled by Oxime Ligation and Traceless "C-Peptide" Chemical Excision.

Org Lett 2017 02 26;19(3):706-709. Epub 2017 Jan 26.

Department of Chemistry, Indiana University , Bloomington, Indiana 47405, United States.

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http://dx.doi.org/10.1021/acs.orglett.6b03876DOI Listing
February 2017

Synthetic Route to Human Relaxin-2 via Iodine-Free Sequential Disulfide Bond Formation.

Org Lett 2016 11 18;18(21):5516-5519. Epub 2016 Oct 18.

Department of Chemistry, Indiana University , Bloomington, Indiana 47405, United States.

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http://dx.doi.org/10.1021/acs.orglett.6b02751DOI Listing
November 2016

Pyridyl-alanine as a Hydrophilic, Aromatic Element in Peptide Structural Optimization.

J Med Chem 2016 09 25;59(17):8061-7. Epub 2016 Aug 25.

Novo Nordisk Research Center , Indianapolis, Indiana 46241, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00840DOI Listing
September 2016

Unimolecular Polypharmacy for Treatment of Diabetes and Obesity.

Cell Metab 2016 07;24(1):51-62

Department of Chemistry, Indiana University, Bloomington, IN 47405, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.06.021DOI Listing
July 2016

Three-chain insulin analogs demonstrate the importance of insulin secondary structure to bioactivity.

J Pept Sci 2015 Mar 9;21(3):223-30. Epub 2015 Feb 9.

Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA.

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http://dx.doi.org/10.1002/psc.2744DOI Listing
March 2015

Chemical synthesis of insulin analogs through a novel precursor.

ACS Chem Biol 2014 Mar 2;9(3):683-91. Epub 2014 Jan 2.

Indiana University , Department of Chemistry, Bloomington, Indiana 47405, United States of America.

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http://dx.doi.org/10.1021/cb400792sDOI Listing
March 2014

Discovery of high potency, single-chain insulin analogs with a shortened B-chain and nonpeptide linker.

ACS Chem Biol 2013 Aug 18;8(8):1822-9. Epub 2013 Jun 18.

Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.

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http://pubs.acs.org/doi/10.1021/cb4002624
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http://dx.doi.org/10.1021/cb4002624DOI Listing
August 2013

Functional association of the N-terminal residues with the central region in glucagon-related peptides.

J Pept Sci 2011 Oct 10;17(10):659-66. Epub 2011 Jun 10.

Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.

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http://dx.doi.org/10.1002/psc.1385DOI Listing
October 2011

A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1.

ACS Chem Biol 2011 Feb 4;6(2):135-45. Epub 2010 Nov 4.

Department of Chemistry, Indiana University , Bloomington, Indiana 47405, United States.

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http://dx.doi.org/10.1021/cb1002015DOI Listing
February 2011

Optimization of the native glucagon sequence for medicinal purposes.

J Diabetes Sci Technol 2010 Nov 1;4(6):1322-31. Epub 2010 Nov 1.

Department of Chemistry, Indiana University, Bloomington, IN 47405-7102, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005041PMC
http://dx.doi.org/10.1177/193229681000400605DOI Listing
November 2010

Glucagon regulation of energy metabolism.

Physiol Behav 2010 Jul 8;100(5):545-8. Epub 2010 Apr 8.

Division of Endocrinology, Department of Medicine University of Cincinnati, Metabolic Diseases Institute, Cincinnati, Ohio 45237, United States.

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http://dx.doi.org/10.1016/j.physbeh.2010.03.019DOI Listing
July 2010